NRADDP Gene (Pseudogene)

Neurotrophin Receptor Associated Death Domain, Pseudogene

GC03P047010
GIFtS:
10
The neurotrophin receptor alike death domain proteins belong to the death domain superfamily and are involved in mediating apoptosis. This gene has been inactivated by mutation and is nonfunctional in humans. [provided by RefSeq, Oct 2008] See more...

Aliases for NRADDP Gene

Aliases for NRADDP Gene

  • Neurotrophin Receptor Associated Death Domain, Pseudogene 2 3 5
  • NRADD Pseudogene 3

External Ids for NRADDP Gene

Previous GeneCards Identifiers for NRADDP Gene

  • GC03P047054

Summaries for NRADDP Gene

Entrez Gene Summary for NRADDP Gene

  • The neurotrophin receptor alike death domain proteins belong to the death domain superfamily and are involved in mediating apoptosis. This gene has been inactivated by mutation and is nonfunctional in humans. [provided by RefSeq, Oct 2008]

GeneCards Summary for NRADDP Gene

NRADDP (Neurotrophin Receptor Associated Death Domain, Pseudogene) is a Pseudogene.

Additional gene information for NRADDP Gene

No data available for CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for NRADDP Gene

Genomics for NRADDP Gene

GeneHancer (GH) Regulatory Elements for NRADDP Gene

Promoters and enhancers for NRADDP Gene
GeneHancer (GH) Identifier GH Type GH
Score		 GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites		 Gene Targets
GH03J047008 Promoter/Enhancer 1.8 Ensembl ENCODE CraniofacialAtlas dbSUPER 500.7 -1.1 -1125 2.4 SP1 ZIC2 ZNF423 PRPF4 POLR2A NFYB HDAC2 KLF9 SP2 ZNF207 NRADDP lnc-NBEAL2-1 NBEAL2 CCDC12 KIF9 KLHL18 piR-54199
GH03J047013 Enhancer 0.4 Ensembl 0.7 +2.5 2477 0.6 POLR2G EGR1 AGO2 POLR2A RF00017-3980 lnc-NBEAL2-1 NBEAL2 CCDC12 PTH1R MYL3 NRADDP
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around NRADDP on UCSC Golden Path with GeneCards custom track

Genomic Locations for NRADDP Gene

Genomic Locations for NRADDP Gene
chr3:47,010,824-47,013,467
(GRCh38/hg38)
Size:
2,644 bases
Orientation:
Plus strand
chr3:47,053,032-47,054,957
(GRCh37/hg19)
Size:
1,926 bases
Orientation:
Plus strand

Genomic View for NRADDP Gene

Genes around NRADDP on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
NRADDP Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for NRADDP Gene
GeneLoc Logo Genomic Neighborhood • Exon Structure • Gene Density

RefSeq DNA sequence for NRADDP Gene

Proteins for NRADDP Gene

Products:

  1. Antibody
  2. Protein
  3. Assay

Post-translational modifications for NRADDP Gene

No Post-translational modifications

No data available for DME Specific Peptides for NRADDP Gene

Domains & Families for NRADDP Gene

No data available for Gene Families , Protein Domains , Suggested Antigen Peptide Sequences , Graphical View of Domain Structure and UniProtKB/Swiss-Prot for NRADDP Gene

Function for NRADDP Gene

Products:

  1. Animal Model
  2. CRISPR
  3. miRNA
  4. Inhibitory RNA
  5. Clone
  6. Cell Line

Phenotypes From GWAS Catalog for NRADDP Gene

Animal Model Products

CRISPR Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for NRADDP Gene

Localization for NRADDP Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for NRADDP Gene

Pathways & Interactions for NRADDP Gene

PathCards logo

SuperPathways for NRADDP Gene

No Data Available
;

Gene Ontology (GO) - Biological Process for NRADDP Gene

None

No data available for Pathways by source , Interacting Proteins and SIGNOR curated interactions for NRADDP Gene

Drugs & Compounds for NRADDP Gene

Products:

  1. Drug
No Compound Related Data Available

Transcripts for NRADDP Gene

Products:

  1. CRISPR
  2. miRNA
  3. Inhibitory RNA
  4. Clone

mRNA/cDNA for NRADDP Gene

1 NCBI additional mRNA sequence :
2 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Alternative Splicing Database (ASD) splice patterns (SP) for NRADDP Gene

No ASD Table

Relevant External Links for NRADDP Gene

GeneLoc Exon Structure for
NRADDP

Expression for NRADDP Gene

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  1. Primer
  2. Gene Expression Assay

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for NRADDP Gene

mRNA expression in normal human tissues for NRADDP Gene
mRNA expression by GTEx for NRADDP Gene

mRNA differential expression in normal tissues according to GTEx for NRADDP Gene

This gene is overexpressed in Whole Blood (x8.2), Skin - Not Sun Exposed (Suprapubic) (x5.3), and Esophagus - Mucosa (x4.5).

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for NRADDP

SOURCE GeneReport for Unigene cluster for NRADDP Gene:

Hs.201522
genes like me logo Genes that share expression patterns with NRADDP: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for NRADDP Gene

Orthologs for NRADDP Gene

Evolution for NRADDP Gene

ENSEMBL:
Gene Tree for NRADDP (if available)
TreeFam:
Gene Tree for NRADDP (if available)

No data available for Orthologs for NRADDP Gene

Paralogs for NRADDP Gene

No data available for Paralogs for NRADDP Gene

Variants for NRADDP Gene

Products:

  1. SNP Genotyping and Copy Number Assay

Structural Variations from Database of Genomic Variants (DGV) for NRADDP Gene

Variant ID Type Subtype PubMed ID
esv3596073 CNV loss 21293372
nsv428417 CNV loss 18775914
nsv954479 CNV deletion 24416366
nsv997261 CNV gain 25217958

Additional Variant Information for NRADDP Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
NRADDP

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP , Additional dbSNP identifiers (rs#s) and Variation tolerance for NRADDP Gene

Disorders for NRADDP Gene

Additional Disease Information for NRADDP

ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for NRADDP Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for NRADDP Gene

Publications for NRADDP Gene

  1. Identification and analysis of unitary pseudogenes: historic and contemporary gene losses in humans and other primates. (PMID: 20210993) Zhang ZD … Gerstein M (Genome biology 2010) 2 3 54
  2. Comparative genomics search for losses of long-established genes on the human lineage. (PMID: 18085818) Zhu J … Haussler D (PLoS computational biology 2007) 2 3 54
  3. NRADD, a novel membrane protein with a death domain involved in mediating apoptosis in response to ER stress. (PMID: 12728256) Wang X … Vincenz C (Cell death and differentiation 2003) 3 54
  4. PLAIDD, a type II death domain protein that interacts with p75 neurotrophin receptor. (PMID: 12095158) Frankowski H … Bredesen DE (Neuromolecular medicine 2002) 3 54

ExternalLinks

View latest publications for NRADDP gene in Mastermind

Products for NRADDP Gene

Sources for NRADDP Gene