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Aliases for NR4A3 Gene

Aliases for NR4A3 Gene

  • Nuclear Receptor Subfamily 4 Group A Member 3 2 3 3 5
  • Mitogen-Induced Nuclear Orphan Receptor 3 4
  • Neuron-Derived Orphan Receptor 1 3 4
  • Nuclear Hormone Receptor NOR-1 3 4
  • MINOR 3 4
  • CSMF 3 4
  • NOR1 3 4
  • CHN 3 4
  • TEC 3 4
  • Chondrosarcoma, Extraskeletal Myxoid, Fused To EWS 3
  • Nuclear Receptor Subfamily 4, Group A, Member 3 2
  • Translocated In Extraskeletal Chondrosarcoma 3

External Ids for NR4A3 Gene

Previous GeneCards Identifiers for NR4A3 Gene

  • GC09P093384
  • GC09P094327
  • GC09P096041
  • GC09P097963
  • GC09P099663
  • GC09P101623
  • GC09P102584
  • GC09P072183

Summaries for NR4A3 Gene

Entrez Gene Summary for NR4A3 Gene

  • This gene encodes a member of the steroid-thyroid hormone-retinoid receptor superfamily. The encoded protein may act as a transcriptional activator. The protein can efficiently bind the NGFI-B Response Element (NBRE). Three different versions of extraskeletal myxoid chondrosarcomas (EMCs) are the result of reciprocal translocations between this gene and other genes. The translocation breakpoints are associated with Nuclear Receptor Subfamily 4, Group A, Member 3 (on chromosome 9) and either Ewing Sarcome Breakpoint Region 1 (on chromosome 22), RNA Polymerase II, TATA Box-Binding Protein-Associated Factor, 68-KD (on chromosome 17), or Transcription factor 12 (on chromosome 15). Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2010]

GeneCards Summary for NR4A3 Gene

NR4A3 (Nuclear Receptor Subfamily 4 Group A Member 3) is a Protein Coding gene. Diseases associated with NR4A3 include Chondrosarcoma, Extraskeletal Myxoid and Epithelial-Myoepithelial Carcinoma. Among its related pathways are Gene Expression and Transcriptional misregulation in cancer. Gene Ontology (GO) annotations related to this gene include DNA binding transcription factor activity and transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding. An important paralog of this gene is NR4A2.

UniProtKB/Swiss-Prot for NR4A3 Gene

  • Transcriptional activator that binds to regulatory elements in promoter regions in a cell- and response element (target)-specific manner. Induces gene expression by binding as monomers to the NR4A1 response element (NBRE) 5-AAAAGGTCA-3 site and as homodimers to the Nur response element (NurRE) site in the promoter of their regulated target genes (By similarity). Plays a role in the regulation of proliferation, survival and differentiation of many different cell types and also in metabolism and inflammation. Mediates proliferation of vascular smooth muscle, myeloid progenitor cell and type B pancreatic cells; promotes mitogen-induced vascular smooth muscle cell proliferation through transactivation of SKP2 promoter by binding a NBRE site (By similarity). Upon PDGF stimulation, stimulates vascular smooth muscle cell proliferation by regulating CCND1 and CCND2 expression. In islets, induces type B pancreatic cell proliferation through up-regulation of genes that activate cell cycle, as well as genes that cause degradation of the CDKN1A (By similarity). Negatively regulates myeloid progenitor cell proliferation by repressing RUNX1 in a NBRE site-independent manner. During inner ear, plays a role as a key mediator of the proliferative growth phase of semicircular canal development (By similarity). Mediates also survival of neuron and smooth muscle cells; mediates CREB-induced neuronal survival, and during hippocampus development, plays a critical role in pyramidal cell survival and axonal guidance. Is required for S phase entry of the cell cycle and survival of smooth muscle cells by inducing CCND1, resulting in RB1 phosphorylation. Binds to NBRE motif in CCND1 promoter, resulting in the activation of the promoter and CCND1 transcription (By similarity). Plays also a role in inflammation; upon TNF stimulation, mediates monocyte adhesion by inducing the expression of VCAM1 and ICAM1 by binding to the NBRE consensus site (By similarity) (PubMed:20558821). In mast cells activated by Fc-epsilon receptor cross-linking, promotes the synthesis and release of cytokines but impairs events leading to degranulation (By similarity). Plays also a role in metabolism; by modulating feeding behavior; and by playing a role in energy balance by inhibiting the glucocorticoid-induced orexigenic neuropeptides AGRP expression, at least in part by forming a complex with activated NR3C1 on the AGRP- glucocorticoid response element (GRE), and thus weakening the DNA binding activity of NR3C1. Upon catecholamines stimulation, regulates gene expression that controls oxidative metabolism in skeletal muscle (By similarity). Plays a role in glucose transport by regulating translocation of the SLC2A4 glucose transporter to the cell surface (PubMed:24022864). Finally, during gastrulation plays a crucial role in the formation of anterior mesoderm by controlling cell migration. Inhibits adipogenesis (By similarity). Also participates in cardiac hypertrophy by activating PARP1 (By similarity).

Gene Wiki entry for NR4A3 Gene

Additional gene information for NR4A3 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NR4A3 Gene

Genomics for NR4A3 Gene

GeneHancer (GH) Regulatory Elements for NR4A3 Gene

Promoters and enhancers for NR4A3 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH09J099818 Promoter/Enhancer 2.6 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 676.3 -0.1 -114 6.7 FEZF1 DMAP1 IRF4 YY1 ZNF213 E2F8 ZNF143 ZNF263 SP3 MEF2D NR4A3 LOC101928438 GC09M099818 TEX10 INVS MSANTD3 ERP44
GH09J099905 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 10.9 +85.2 85220 2.4 HDGF SMAD1 ARID4B SIN3A FEZF1 DMAP1 ZNF2 ZBTB7B YY1 POLR2B STX17 STX17-AS1 NR4A3 LOC101928438 TEX10 INVS ENSG00000254571
GH09J100209 Enhancer 0.9 Ensembl ENCODE 10.3 +388.4 388409 1 HDAC1 MEIS2 IRF2 PKNOX1 ATF1 NFATC3 ARNT BATF MTA3 STAT2 INVS STX17 RN7SL75P ERP44 NR4A3 LOC101928438 MSANTD3 MSANTD3-TMEFF1 TMEFF1 GC09P100176
GH09J099590 Enhancer 1.1 FANTOM5 Ensembl ENCODE 8.3 -230.9 -230878 1.3 PKNOX1 MAX ELF1 DPF2 BATF POLR2A IKZF1 EED ETV6 IKZF2 NR4A3 TGFBR1 ENSG00000234860 LOC101928438 GC09M099818
GH09J099659 Enhancer 1.3 FANTOM5 Ensembl ENCODE 6.3 -161.5 -161543 1 HDGF PKNOX1 STAT5A BMI1 BATF KLF5 IRF4 ATF7 ETV6 BCLAF1 NR4A3 ERP44 ENSG00000234860 GC09M099818 LOC101928438
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around NR4A3 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the NR4A3 gene promoter:
  • AML1a

Genomic Locations for NR4A3 Gene

Genomic Locations for NR4A3 Gene
chr9:99,821,855-99,866,893
(GRCh38/hg38)
Size:
45,039 bases
Orientation:
Plus strand
chr9:102,584,137-102,629,173
(GRCh37/hg19)
Size:
45,037 bases
Orientation:
Plus strand

Genomic View for NR4A3 Gene

Genes around NR4A3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
NR4A3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for NR4A3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NR4A3 Gene

Proteins for NR4A3 Gene

  • Protein details for NR4A3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q92570-NR4A3_HUMAN
    Recommended name:
    Nuclear receptor subfamily 4 group A member 3
    Protein Accession:
    Q92570
    Secondary Accessions:
    • A2A3I7
    • Q12935
    • Q14979
    • Q16420
    • Q4VXA8
    • Q4VXA9
    • Q9UEK2
    • Q9UEK3

    Protein attributes for NR4A3 Gene

    Size:
    626 amino acids
    Molecular mass:
    68230 Da
    Quaternary structure:
    • Interacts with SIX3 (via homeobox); differentially regulates the transcriptional activities of NR4A3 (PubMed:12543801). Interacts with the constituents of DNA-PK heterotrimer PRKDC, XRCC6 and XRCC5; phosphorylates and prevents NR4A3 ubiquitinylation and degradation (PubMed:25852083). Interacts with NCOA2; potentiates the activity of the NR4A3. Interacts with NCOA1, NCOA3, MED1 and KAT2B. Interacts with EP300 and NCOA2; mediates the recruitment of MED1 in the coactivator complex (By similarity). Interacts with NR3C1 (via nuclear receptor DNA-binding domain); the interactions represses transcription activity of NR4A3 on the POMC promoter Nur response element (NurRE). Interacts with TRIM28; the interactions potentiates NR4A3 activity on NurRE promoter. Binds DNA as a monomer and homodimer. Interacts with PARP1; activates PARP1 by improving acetylation of PARP1 and suppressing the interaction between PARP1 and SIRT1 (By similarity).
    SequenceCaution:
    • Sequence=AAB02581.1; Type=Frameshift; Positions=4, 20; Evidence={ECO:0000305}; Sequence=AAB36006.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for NR4A3 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for NR4A3 Gene

Post-translational modifications for NR4A3 Gene

Other Protein References for NR4A3 Gene

No data available for DME Specific Peptides for NR4A3 Gene

Domains & Families for NR4A3 Gene

Gene Families for NR4A3 Gene

HGNC:
IUPHAR :
Human Protein Atlas (HPA):
  • Cancer-related genes
  • Disease related genes
  • Nuclear receptors
  • Predicted intracellular proteins
  • Transcription factors

Suggested Antigen Peptide Sequences for NR4A3 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q92570

UniProtKB/Swiss-Prot:

NR4A3_HUMAN :
  • The AF-1 domain mediates transcription activation. The N-terminal region (1-292) directly interacts with the C-terminal LBD (380-627): the interaction is potentiated by AF-1-mediated recruitment of NCOA2.
  • Belongs to the nuclear hormone receptor family. NR4 subfamily.
Domain:
  • The AF-1 domain mediates transcription activation. The N-terminal region (1-292) directly interacts with the C-terminal LBD (380-627): the interaction is potentiated by AF-1-mediated recruitment of NCOA2.
Family:
  • Belongs to the nuclear hormone receptor family. NR4 subfamily.
genes like me logo Genes that share domains with NR4A3: view

Function for NR4A3 Gene

Molecular function for NR4A3 Gene

UniProtKB/Swiss-Prot Function:
Transcriptional activator that binds to regulatory elements in promoter regions in a cell- and response element (target)-specific manner. Induces gene expression by binding as monomers to the NR4A1 response element (NBRE) 5-AAAAGGTCA-3 site and as homodimers to the Nur response element (NurRE) site in the promoter of their regulated target genes (By similarity). Plays a role in the regulation of proliferation, survival and differentiation of many different cell types and also in metabolism and inflammation. Mediates proliferation of vascular smooth muscle, myeloid progenitor cell and type B pancreatic cells; promotes mitogen-induced vascular smooth muscle cell proliferation through transactivation of SKP2 promoter by binding a NBRE site (By similarity). Upon PDGF stimulation, stimulates vascular smooth muscle cell proliferation by regulating CCND1 and CCND2 expression. In islets, induces type B pancreatic cell proliferation through up-regulation of genes that activate cell cycle, as well as genes that cause degradation of the CDKN1A (By similarity). Negatively regulates myeloid progenitor cell proliferation by repressing RUNX1 in a NBRE site-independent manner. During inner ear, plays a role as a key mediator of the proliferative growth phase of semicircular canal development (By similarity). Mediates also survival of neuron and smooth muscle cells; mediates CREB-induced neuronal survival, and during hippocampus development, plays a critical role in pyramidal cell survival and axonal guidance. Is required for S phase entry of the cell cycle and survival of smooth muscle cells by inducing CCND1, resulting in RB1 phosphorylation. Binds to NBRE motif in CCND1 promoter, resulting in the activation of the promoter and CCND1 transcription (By similarity). Plays also a role in inflammation; upon TNF stimulation, mediates monocyte adhesion by inducing the expression of VCAM1 and ICAM1 by binding to the NBRE consensus site (By similarity) (PubMed:20558821). In mast cells activated by Fc-epsilon receptor cross-linking, promotes the synthesis and release of cytokines but impairs events leading to degranulation (By similarity). Plays also a role in metabolism; by modulating feeding behavior; and by playing a role in energy balance by inhibiting the glucocorticoid-induced orexigenic neuropeptides AGRP expression, at least in part by forming a complex with activated NR3C1 on the AGRP- glucocorticoid response element (GRE), and thus weakening the DNA binding activity of NR3C1. Upon catecholamines stimulation, regulates gene expression that controls oxidative metabolism in skeletal muscle (By similarity). Plays a role in glucose transport by regulating translocation of the SLC2A4 glucose transporter to the cell surface (PubMed:24022864). Finally, during gastrulation plays a crucial role in the formation of anterior mesoderm by controlling cell migration. Inhibits adipogenesis (By similarity). Also participates in cardiac hypertrophy by activating PARP1 (By similarity).
UniProtKB/Swiss-Prot Induction:
Induced by inflammatory stimuli in endothelial cells through an NF-kappa-B-dependent transactivation of the NR4A3 Promoter.
GENATLAS Biochemistry:
nuclear receptor subfamily 4,group A,member 3, the steroid/thyroid receptor superfamily,with variants generated by alternative splicing,involved in extraskeletal and skeletal myxoid chondrosarcoma EMC with translocation t(9;22)(q22;q12) see EWS,EWSR,and in neural development processes

Phenotypes From GWAS Catalog for NR4A3 Gene

Gene Ontology (GO) - Molecular Function for NR4A3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000977 RNA polymerase II regulatory region sequence-specific DNA binding IBA --
GO:0000978 RNA polymerase II proximal promoter sequence-specific DNA binding IEA --
GO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding NAS 19274049
GO:0001046 core promoter sequence-specific DNA binding IEA,ISS --
GO:0001077 transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding IDA,IEA 20558821
genes like me logo Genes that share ontologies with NR4A3: view
genes like me logo Genes that share phenotypes with NR4A3: view

Human Phenotype Ontology for NR4A3 Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Models for NR4A3 Gene

MGI Knock Outs for NR4A3:

Animal Model Products

  • Taconic Biosciences Mouse Models for NR4A3

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for NR4A3

Clone Products

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targets and HOMER Transcription for NR4A3 Gene

Localization for NR4A3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for NR4A3 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for NR4A3 gene
Compartment Confidence
nucleus 5
lysosome 2
extracellular 1
cytoskeleton 1
mitochondrion 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for NR4A3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus NAS 8634690
GO:0005654 nucleoplasm TAS --
GO:0005667 transcription factor complex IEA --
GO:0042629 mast cell granule IEA --
genes like me logo Genes that share ontologies with NR4A3: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for NR4A3 Gene

Pathways & Interactions for NR4A3 Gene

genes like me logo Genes that share pathways with NR4A3: view

Pathways by source for NR4A3 Gene

1 BioSystems pathway for NR4A3 Gene
1 KEGG pathway for NR4A3 Gene

SIGNOR curated interactions for NR4A3 Gene

Is activated by:
Is inactivated by:

Gene Ontology (GO) - Biological Process for NR4A3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000122 negative regulation of transcription by RNA polymerase II ISS --
GO:0001707 mesoderm formation IEA --
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0006367 transcription initiation from RNA polymerase II promoter TAS --
genes like me logo Genes that share ontologies with NR4A3: view

Drugs & Compounds for NR4A3 Gene

(3) Drugs for NR4A3 Gene - From: DrugBank, FDA Approved Drugs, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Dasatinib Approved, Investigational Pharma Target Kinase Inhibitors, SRC/BCR-ABL tyrosine kinase inhibitors 295
Sprycel Approved June 2006 Pharma 0

(2) Additional Compounds for NR4A3 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with NR4A3: view

Transcripts for NR4A3 Gene

mRNA/cDNA for NR4A3 Gene

Unigene Clusters for NR4A3 Gene

Nuclear receptor subfamily 4, group A, member 3:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for NR4A3

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for NR4A3 Gene

No ASD Table

Relevant External Links for NR4A3 Gene

GeneLoc Exon Structure for
NR4A3
ECgene alternative splicing isoforms for
NR4A3

Expression for NR4A3 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for NR4A3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for NR4A3 Gene

This gene is overexpressed in Heart - Atrial Appendage (x6.1), Muscle - Skeletal (x4.8), Artery - Tibial (x4.7), and Adipose - Visceral (Omentum) (x4.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for NR4A3 Gene



NURSA nuclear receptor signaling pathways regulating expression of NR4A3 Gene:

NR4A3

SOURCE GeneReport for Unigene cluster for NR4A3 Gene:

Hs.279522

mRNA Expression by UniProt/SwissProt for NR4A3 Gene:

Q92570-NR4A3_HUMAN
Tissue specificity: Isoform alpha is highly expressed in skeletal muscle. Isoform beta is highly expressed in skeletal muscle and low expressed in fetal brain and placenta.

Evidence on tissue expression from TISSUES for NR4A3 Gene

  • Muscle(4.6)
  • Heart(4.4)
  • Nervous system(4.4)
  • Blood(4.2)
  • Adrenal gland(2.1)

Phenotype-based relationships between genes and organs from Gene ORGANizer for NR4A3 Gene

Germ Layers:
  • mesoderm
Systems:
  • skeleton
Regions:
Head and neck:
  • head
  • jaw
  • mandible
  • maxilla
  • mouth
  • neck
  • skull
Thorax:
  • chest wall
  • clavicle
  • rib
  • rib cage
  • scapula
  • sternum
Pelvis:
  • pelvis
Limb:
  • ankle
  • arm
  • digit
  • elbow
  • femur
  • fibula
  • finger
  • foot
  • forearm
  • hand
  • hip
  • humerus
  • knee
  • lower limb
  • radius
  • shin
  • shoulder
  • thigh
  • tibia
  • toe
  • ulna
  • upper limb
  • wrist
General:
  • spinal column
  • vertebrae
genes like me logo Genes that share expression patterns with NR4A3: view

No data available for Protein differential expression in normal tissues and Protein tissue co-expression partners for NR4A3 Gene

Orthologs for NR4A3 Gene

This gene was present in the common ancestor of animals.

Orthologs for NR4A3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia NR4A3 34 33
  • 99.37 (n)
OneToOne
cow
(Bos Taurus)
Mammalia NR4A3 34 33
  • 92.31 (n)
OneToOne
dog
(Canis familiaris)
Mammalia NR4A3 33
  • 91.37 (n)
mouse
(Mus musculus)
Mammalia Nr4a3 16 34 33
  • 88.96 (n)
rat
(Rattus norvegicus)
Mammalia Nr4a3 33
  • 88.66 (n)
oppossum
(Monodelphis domestica)
Mammalia NR4A3 34
  • 80 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia NR4A3 34
  • 77 (a)
OneToOne
chicken
(Gallus gallus)
Aves NR4A3 34 33
  • 79.34 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia NR4A3 34
  • 77 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia nr4a3 33
  • 62.02 (n)
Str.5118 33
zebrafish
(Danio rerio)
Actinopterygii nr4a3 34 33
  • 60.78 (n)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta Hr38 34 35
  • 27 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea nhr-6 34
  • 26 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 24 (a)
OneToMany
Species where no ortholog for NR4A3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for NR4A3 Gene

ENSEMBL:
Gene Tree for NR4A3 (if available)
TreeFam:
Gene Tree for NR4A3 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for NR4A3: view image

Paralogs for NR4A3 Gene

Paralogs for NR4A3 Gene

(4) SIMAP similar genes for NR4A3 Gene using alignment to 1 proteins:

  • NR4A3_HUMAN
genes like me logo Genes that share paralogs with NR4A3: view

Variants for NR4A3 Gene

Sequence variations from dbSNP and Humsavar for NR4A3 Gene

SNP ID Clin Chr 09 pos Variation AA Info Type
rs1000009968 -- 99,850,661(+) T/C genic_downstream_transcript_variant, intron_variant
rs1000123128 -- 99,821,161(+) A/G upstream_transcript_variant
rs1000165899 -- 99,843,242(+) C/T genic_downstream_transcript_variant, intron_variant
rs1000313591 -- 99,863,295(+) C/T genic_downstream_transcript_variant, intron_variant
rs1000332340 -- 99,828,921(+) C/G/T coding_sequence_variant, synonymous_variant

Structural Variations from Database of Genomic Variants (DGV) for NR4A3 Gene

Variant ID Type Subtype PubMed ID
esv1004519 CNV insertion 20482838
nsv528025 CNV gain 19592680
nsv831668 CNV gain+loss 17160897

Variation tolerance for NR4A3 Gene

Residual Variation Intolerance Score: 26.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 8.15; 84.68% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for NR4A3 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
NR4A3

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NR4A3 Gene

Disorders for NR4A3 Gene

MalaCards: The human disease database

(9) MalaCards diseases for NR4A3 Gene - From: OMIM, GTR, Orphanet, DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
chondrosarcoma, extraskeletal myxoid
  • emc
epithelial-myoepithelial carcinoma
  • emc
chondrosarcoma
  • chondrosarcoma of bone
myxoid chondrosarcoma
fetal adenoma
  • microfollicular adenoma
- elite association - COSMIC cancer census association via MalaCards
Search NR4A3 in MalaCards View complete list of genes associated with diseases

UniProtKB/Swiss-Prot

NR4A3_HUMAN
  • Ewing sarcoma (ES) [MIM:612219]: A highly malignant, metastatic, primitive small round cell tumor of bone and soft tissue that affects children and adolescents. It belongs to the Ewing sarcoma family of tumors, a group of morphologically heterogeneous neoplasms that share the same cytogenetic features. They are considered neural tumors derived from cells of the neural crest. Ewing sarcoma represents the less differentiated form of the tumors. Note=The gene represented in this entry is involved in disease pathogenesis. A chromosomal aberration involving NR4A3 is found in patients with Erwing sarcoma. Translocation t(9;22)(q22-31;q11-12) with EWSR1.
  • Note=A chromosomal aberration involving NR4A3 is a cause of a form of extraskeletal myxoid chondrosarcomas (EMC). Translocation t(9;17)(q22;q11) with TAF2N.

Additional Disease Information for NR4A3

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with NR4A3: view

No data available for Genatlas for NR4A3 Gene

Publications for NR4A3 Gene

  1. The isolation and characterization of MINOR, a novel mitogen-inducible nuclear orphan receptor. (PMID: 8614405) Hedvat CV … Irving SG (Molecular endocrinology (Baltimore, Md.) 1995) 2 3 4 22 58
  2. The homeotic protein Six3 is a coactivator of the nuclear receptor NOR-1 and a corepressor of the fusion protein EWS/NOR-1 in human extraskeletal myxoid chondrosarcomas. (PMID: 12543801) Laflamme C … Labelle Y (Cancer research 2003) 3 4 22 58
  3. Alternative splicing generates isoforms of human neuron-derived orphan receptor-1 (NOR-1) mRNA. (PMID: 9573341) Ohkura N … Miki K (Gene 1998) 3 4 22 58
  4. Fusion of the EWS gene to CHN, a member of the steroid/thyroid receptor gene superfamily, in a human myxoid chondrosarcoma. (PMID: 8570200) Clark J … Cooper CS (Oncogene 1996) 3 4 22 58
  5. Oncogenic conversion of a novel orphan nuclear receptor by chromosome translocation. (PMID: 8634690) Labelle Y … Peter M (Human molecular genetics 1995) 3 4 22 58

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