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Aliases for NR4A2 Gene

Aliases for NR4A2 Gene

  • Nuclear Receptor Subfamily 4 Group A Member 2 2 3 3 5
  • Transcriptionally-Inducible Nuclear Receptor 3 4
  • Immediate-Early Response Protein NOT 3 4
  • Orphan Nuclear Receptor NURR1 3 4
  • NURR1 3 4
  • TINUR 3 4
  • NOT 3 4
  • Transcriptionally Inducible Nuclear Receptor Related 1 3
  • NGFI-B/Nur77 Beta-Type Transcription Factor Homolog 3
  • Nuclear Receptor Subfamily 4, Group A, Member 2 2
  • Nur Related Protein-1, Human Homolog Of 3
  • Intermediate-Early Receptor Protein 3
  • Orphan Nuclear Receptor NR4A2 3
  • T-Cell Nuclear Receptor NOT 3
  • Nuclear Receptor Related 1 3
  • HZF-3 3
  • RNR1 3

External Ids for NR4A2 Gene

Previous HGNC Symbols for NR4A2 Gene

  • NURR1

Previous GeneCards Identifiers for NR4A2 Gene

  • GC02M155112
  • GC02M155709
  • GC02M157144
  • GC02M157383
  • GC02M157006
  • GC02M156889
  • GC02M149066
  • GC02M157180

Summaries for NR4A2 Gene

Entrez Gene Summary for NR4A2 Gene

  • This gene encodes a member of the steroid-thyroid hormone-retinoid receptor superfamily. The encoded protein may act as a transcription factor. Mutations in this gene have been associated with disorders related to dopaminergic dysfunction, including Parkinson disease, schizophernia, and manic depression. Misregulation of this gene may be associated with rheumatoid arthritis. Alternatively spliced transcript variants have been described, but their biological validity has not been determined. [provided by RefSeq, Jul 2008]

GeneCards Summary for NR4A2 Gene

NR4A2 (Nuclear Receptor Subfamily 4 Group A Member 2) is a Protein Coding gene. Diseases associated with NR4A2 include Parkinson Disease, Late-Onset and Arthritis. Among its related pathways are Gene Expression and Dopaminergic Neurogenesis. Gene Ontology (GO) annotations related to this gene include DNA binding transcription factor activity and protein heterodimerization activity. An important paralog of this gene is NR4A3.

UniProtKB/Swiss-Prot for NR4A2 Gene

  • Transcriptional regulator which is important for the differentiation and maintenance of meso-diencephalic dopaminergic (mdDA) neurons during development. It is crucial for expression of a set of genes such as SLC6A3, SLC18A2, TH and DRD2 which are essential for development of mdDA neurons (By similarity).

Tocris Summary for NR4A2 Gene

Gene Wiki entry for NR4A2 Gene

Additional gene information for NR4A2 Gene

No data available for CIViC summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NR4A2 Gene

Genomics for NR4A2 Gene

GeneHancer (GH) Regulatory Elements for NR4A2 Gene

Promoters and enhancers for NR4A2 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH02J156338 Promoter/Enhancer 2.9 UCNEbase EPDnew Ensembl ENCODE dbSUPER 650.7 +1.1 1081 6.3 PKNOX1 FOXA2 SMAD1 ARNT SIN3A IRF4 YY1 POLR2B ZNF766 ZNF213 NR4A2 PIR58752 GC02M156343 GPD2 ENSG00000282440
GH02J156331 Promoter/Enhancer 2.7 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 660.8 +8.6 8574 5 FEZF1 IRF4 YY1 ZNF213 ZNF143 SP3 NFYC MEF2D ZNF610 GLIS1 NR4A2 GPD2 LINC01876 ENSG00000282440
GH02J156434 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE dbSUPER 10.2 -94.7 -94739 4.9 HDGF PKNOX1 SIN3A YY1 POLR2B GLIS2 GATA2 E2F8 FOS ZNF263 GPD2 NR4A2 PIR36097
GH02J156319 Promoter/Enhancer 1.4 Ensembl ENCODE dbSUPER 11.8 +21.8 21846 1.8 CTCF ATF1 SUZ12 MAX SIN3A RAD21 ETS1 POLR2A EGR1 VEZF1 ENSG00000282440 NR4A2 LINC01876
GH02J156463 Enhancer 0.9 Ensembl ENCODE dbSUPER 10 -122.7 -122652 2.4 JUN ZNF133 HMBOX1 CBFA2T3 GABPA GPD2 NR4A2 PIR36097 LOC105373707
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around NR4A2 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the NR4A2 gene promoter:
  • C/EBPalpha
  • ATF-2

Genomic Locations for NR4A2 Gene

Genomic Locations for NR4A2 Gene
chr2:156,324,432-156,342,348
(GRCh38/hg38)
Size:
17,917 bases
Orientation:
Minus strand
chr2:157,180,944-157,198,860
(GRCh37/hg19)
Size:
17,917 bases
Orientation:
Minus strand

Genomic View for NR4A2 Gene

Genes around NR4A2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
NR4A2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for NR4A2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NR4A2 Gene

Proteins for NR4A2 Gene

  • Protein details for NR4A2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P43354-NR4A2_HUMAN
    Recommended name:
    Nuclear receptor subfamily 4 group A member 2
    Protein Accession:
    P43354
    Secondary Accessions:
    • Q16311
    • Q53RZ2
    • Q6NXU0

    Protein attributes for NR4A2 Gene

    Size:
    598 amino acids
    Molecular mass:
    66591 Da
    Quaternary structure:
    • Interacts with SFPQ, NCOR2, SIN3A and HADC1. The interaction with NCOR2 increases in the absence of PITX3. Interacts with PER2 (By similarity).

    Three dimensional structures from OCA and Proteopedia for NR4A2 Gene

    Alternative splice isoforms for NR4A2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for NR4A2 Gene

Post-translational modifications for NR4A2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for NR4A2 Gene

Domains & Families for NR4A2 Gene

Gene Families for NR4A2 Gene

HGNC:
IUPHAR :
Human Protein Atlas (HPA):
  • Cancer-related genes
  • Nuclear receptors
  • Predicted intracellular proteins
  • Transcription factors

Graphical View of Domain Structure for InterPro Entry

P43354

UniProtKB/Swiss-Prot:

NR4A2_HUMAN :
  • the ligand-binding domain (LBD) contains no cavity as a result of the tight packing of side chains from several bulky hydrophobic residues in the region normally occupied by ligands. NR4A2 lacks a classical binding site for coactivators (PubMed:12774125).
  • Belongs to the nuclear hormone receptor family. NR4 subfamily.
Domain:
  • the ligand-binding domain (LBD) contains no cavity as a result of the tight packing of side chains from several bulky hydrophobic residues in the region normally occupied by ligands. NR4A2 lacks a classical binding site for coactivators (PubMed:12774125).
Family:
  • Belongs to the nuclear hormone receptor family. NR4 subfamily.
genes like me logo Genes that share domains with NR4A2: view

Function for NR4A2 Gene

Molecular function for NR4A2 Gene

UniProtKB/Swiss-Prot Function:
Transcriptional regulator which is important for the differentiation and maintenance of meso-diencephalic dopaminergic (mdDA) neurons during development. It is crucial for expression of a set of genes such as SLC6A3, SLC18A2, TH and DRD2 which are essential for development of mdDA neurons (By similarity).
GENATLAS Biochemistry:
nuclear receptor subfamily 4,group A,member 2,steroid/thyroid receptor superfamily,rapidly and transiently expressed after cell activation,exclusively in the brain,likely functioning as a general coactivation of gene transcription,NGF1-B/nur 77

Phenotypes From GWAS Catalog for NR4A2 Gene

Gene Ontology (GO) - Molecular Function for NR4A2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000977 RNA polymerase II regulatory region sequence-specific DNA binding IBA,IEA --
GO:0000978 RNA polymerase II proximal promoter sequence-specific DNA binding IEA --
GO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding NAS 19274049
GO:0001077 transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding ISS --
GO:0001228 transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding IEA --
genes like me logo Genes that share ontologies with NR4A2: view
genes like me logo Genes that share phenotypes with NR4A2: view

Human Phenotype Ontology for NR4A2 Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Models for NR4A2 Gene

MGI Knock Outs for NR4A2:

Animal Model Products

  • Taconic Biosciences Mouse Models for NR4A2

Clone Products

  • Addgene plasmids for NR4A2

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targets and HOMER Transcription for NR4A2 Gene

Localization for NR4A2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for NR4A2 Gene

Cytoplasm. Nucleus. Note=Mostly nuclear; oxidative stress promotes cytoplasmic localization.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for NR4A2 gene
Compartment Confidence
nucleus 5
mitochondrion 2
extracellular 1
cytoskeleton 1
peroxisome 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nuclear speckles (3)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for NR4A2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA,TAS 16243425
GO:0005654 nucleoplasm TAS --
GO:0005667 transcription factor complex IBA --
GO:0005737 cytoplasm IEA --
GO:0016607 nuclear speck IDA --
genes like me logo Genes that share ontologies with NR4A2: view

Pathways & Interactions for NR4A2 Gene

genes like me logo Genes that share pathways with NR4A2: view

SIGNOR curated interactions for NR4A2 Gene

Is activated by:
Is inactivated by:

Gene Ontology (GO) - Biological Process for NR4A2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000122 negative regulation of transcription by RNA polymerase II TAS 22988876
GO:0001666 response to hypoxia IEA --
GO:0001764 neuron migration TAS 16243425
GO:0001975 response to amphetamine IEA --
GO:0006351 transcription, DNA-templated IDA,IEA 17184956
genes like me logo Genes that share ontologies with NR4A2: view

Drugs & Compounds for NR4A2 Gene

(10) Drugs for NR4A2 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(11) Additional Compounds for NR4A2 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with NR4A2: view

Transcripts for NR4A2 Gene

mRNA/cDNA for NR4A2 Gene

Unigene Clusters for NR4A2 Gene

Nuclear receptor subfamily 4, group A, member 2:
Representative Sequences:

Clone Products

  • Addgene plasmids for NR4A2

Alternative Splicing Database (ASD) splice patterns (SP) for NR4A2 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5a · 5b · 5c · 5d · 5e · 5f · 5g · 5h ^ 6a · 6b ^ 7 ^ 8 ^ 9a · 9b ^ 10
SP1: - -
SP2: - - - -
SP3: -
SP4: - - -
SP5: -
SP6: - -
SP7: - - - -
SP8: - - -
SP9: - - - - -

Relevant External Links for NR4A2 Gene

GeneLoc Exon Structure for
NR4A2
ECgene alternative splicing isoforms for
NR4A2

Expression for NR4A2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for NR4A2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for NR4A2 Gene

This gene is overexpressed in Ovary (x6.7).

Protein differential expression in normal tissues from HIPED for NR4A2 Gene

This gene is overexpressed in Adipocyte (55.7) and Bone (12.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for NR4A2 Gene



Protein tissue co-expression partners for NR4A2 Gene

NURSA nuclear receptor signaling pathways regulating expression of NR4A2 Gene:

NR4A2

SOURCE GeneReport for Unigene cluster for NR4A2 Gene:

Hs.563344

mRNA Expression by UniProt/SwissProt for NR4A2 Gene:

P43354-NR4A2_HUMAN
Tissue specificity: Expressed in a number of cell lines of T-cell, B-cell and fibroblast origin. Strong expression in brain tissue.

Evidence on tissue expression from TISSUES for NR4A2 Gene

  • Nervous system(5)
  • Blood(4.3)
  • Skin(4.1)
  • Adrenal gland(3)
  • Bone marrow(2.2)
genes like me logo Genes that share expression patterns with NR4A2: view

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for NR4A2 Gene

Orthologs for NR4A2 Gene

This gene was present in the common ancestor of animals.

Orthologs for NR4A2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia NR4A2 34 33
  • 99.78 (n)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia NR4A2 34
  • 99 (a)
OneToOne
dog
(Canis familiaris)
Mammalia NR4A2 34 33
  • 96.99 (n)
OneToOne
cow
(Bos Taurus)
Mammalia NR4A2 34 33
  • 96.21 (n)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia NR4A2 34
  • 96 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Nr4a2 16 34 33
  • 93.59 (n)
rat
(Rattus norvegicus)
Mammalia Nr4a2 33
  • 93.59 (n)
chicken
(Gallus gallus)
Aves NR4A2 34 33
  • 87.18 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia NR4A2 34
  • 77 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia nr4a2 33
  • 80.71 (n)
zebrafish
(Danio rerio)
Actinopterygii nr4a2a 34 33
  • 77.18 (n)
OneToMany
nr4a2b 34
  • 74 (a)
OneToMany
Dr.12803 33
fruit fly
(Drosophila melanogaster)
Insecta Hr38 34 35
  • 27 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea nhr-6 34 35
  • 26 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 25 (a)
OneToMany
Species where no ortholog for NR4A2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for NR4A2 Gene

ENSEMBL:
Gene Tree for NR4A2 (if available)
TreeFam:
Gene Tree for NR4A2 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for NR4A2: view image

Paralogs for NR4A2 Gene

Paralogs for NR4A2 Gene

(35) SIMAP similar genes for NR4A2 Gene using alignment to 13 proteins:

  • NR4A2_HUMAN
  • C0KWD1_HUMAN
  • C0KWD2_HUMAN
  • C9IYM5_HUMAN
  • C9J8W4_HUMAN
  • C9JWQ1_HUMAN
  • E9PBQ4_HUMAN
  • F1D8N6_HUMAN
  • F1DAL2_HUMAN
  • F5H4G9_HUMAN
  • F8W6I3_HUMAN
  • H7BZ00_HUMAN
  • Q6NXU0_HUMAN
genes like me logo Genes that share paralogs with NR4A2: view

Variants for NR4A2 Gene

Sequence variations from dbSNP and Humsavar for NR4A2 Gene

SNP ID Clin Chr 02 pos Variation AA Info Type
rs1001640448 uncertain-significance, Parkinson Disease, Dominant/Recessive 156,324,922(-) T/C/G 3_prime_UTR_variant, non_coding_transcript_variant
rs1034257543 uncertain-significance, Parkinson Disease, Dominant/Recessive 156,324,433(-) T/C 3_prime_UTR_variant, downstream_transcript_variant, genic_downstream_transcript_variant, non_coding_transcript_variant
rs1046859724 uncertain-significance, Parkinson Disease, Dominant/Recessive 156,332,740(-) T/A/G 5_prime_UTR_variant, genic_upstream_transcript_variant, non_coding_transcript_variant, upstream_transcript_variant
rs114461423 likely-benign, Parkinson Disease, Dominant/Recessive 156,332,576(-) G/A 5_prime_UTR_variant, genic_upstream_transcript_variant, non_coding_transcript_variant, upstream_transcript_variant
rs115393922 likely-benign, Parkinson Disease, Dominant/Recessive 156,325,392(-) G/T 3_prime_UTR_variant, non_coding_transcript_variant

Variation tolerance for NR4A2 Gene

Residual Variation Intolerance Score: 27.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.94; 19.38% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for NR4A2 Gene

Human Gene Mutation Database (HGMD)
NR4A2
SNPedia medical, phenotypic, and genealogical associations of SNPs for
NR4A2

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for NR4A2 Gene

Disorders for NR4A2 Gene

MalaCards: The human disease database

(8) MalaCards diseases for NR4A2 Gene - From: HGMD, GTR, DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
parkinson disease, late-onset
  • pd
arthritis
  • inflammatory disorder of joint
chondrosarcoma, extraskeletal myxoid
  • emc
rheumatoid arthritis
  • ra
synucleinopathy
  • alpha synucleinopathies
- elite association - COSMIC cancer census association via MalaCards
Search NR4A2 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for NR4A2

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with NR4A2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for NR4A2 Gene

Publications for NR4A2 Gene

  1. cDNA cloning of a NGFI-B/nur77-related transcription factor from an apoptotic human T cell line. (PMID: 7706727) Okabe T … Watanabe T (Journal of immunology (Baltimore, Md. : 1950) 1995) 2 3 4 22 58
  2. Haplotypes of the NR4A2/NURR1 gene and cardiovascular disease: the Rotterdam Study. (PMID: 19156841) Kardys I … de Maat MP (Human mutation 2009) 3 22 44 58
  3. [Association of the polymorphisms in NURR1 gene with Parkinson's disease]. (PMID: 19065535) Wu Y … Yuan G (Zhonghua yi xue yi chuan xue za zhi = Zhonghua yixue yichuanxue zazhi = Chinese journal of medical genetics 2008) 3 22 44 58
  4. Induction of tyrosine hydroxylase expression by the transcription factor Pitx3. (PMID: 17184956) Messmer K … Fishman PS (International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience 2007) 3 4 22 58
  5. Nuclear receptor NR4A2 IVS6 +18insG and brain derived neurotrophic factor (BDNF) V66M polymorphisms and risk of Taiwanese Parkinson's disease. (PMID: 17427185) Chen CM … Wu YR (American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics 2007) 3 22 44 58

Products for NR4A2 Gene

Sources for NR4A2 Gene

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