Aliases for NR4A2 Gene
External Ids for NR4A2 Gene
Previous HGNC Symbols for NR4A2 Gene
Previous GeneCards Identifiers for NR4A2 Gene
This gene encodes a member of the steroid-thyroid hormone-retinoid receptor superfamily. The encoded protein may act as a transcription factor. Mutations in this gene have been associated with disorders related to dopaminergic dysfunction, including Parkinson disease, schizophernia, and manic depression. Misregulation of this gene may be associated with rheumatoid arthritis. Alternatively spliced transcript variants have been described, but their biological validity has not been determined. [provided by RefSeq, Jul 2008]
GeneCards Summary for NR4A2 Gene
NR4A2 (Nuclear Receptor Subfamily 4 Group A Member 2) is a Protein Coding gene. Diseases associated with NR4A2 include Parkinson Disease, Late-Onset and Extraosseous Chondrosarcoma. Among its related pathways are Aldosterone synthesis and secretion and Parathyroid hormone synthesis, secretion and action. Gene Ontology (GO) annotations related to this gene include DNA-binding transcription factor activity and protein heterodimerization activity. An important paralog of this gene is NR4A3.
UniProtKB/Swiss-Prot Summary for NR4A2 Gene
Transcriptional regulator which is important for the differentiation and maintenance of meso-diencephalic dopaminergic (mdDA) neurons during development. It is crucial for expression of a set of genes such as SLC6A3, SLC18A2, TH and DRD2 which are essential for development of mdDA neurons (By similarity).