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This gene encodes a member of the steroid-thyroid hormone-retinoid receptor superfamily. Expression is induced by phytohemagglutinin in human lymphocytes and by serum stimulation of arrested fibroblasts. The encoded protein acts as a nuclear transcription factor. Translocation of the protein from the nucleus to mitochondria induces apoptosis. Multiple transcript variants encodi... See more...
Aliases for NR4A1 Gene
Aliases for NR4A1 Gene
External Ids for NR4A1 Gene
- HGNC: 7980
- Entrez Gene: 3164
- Ensembl: ENSG00000123358
- OMIM: 139139
- UniProtKB: P22736
Previous HGNC Symbols for NR4A1 Gene
- HMR
- GFRP1
Previous GeneCards Identifiers for NR4A1 Gene
- GC12M052494
- GC12P052474
- GC12P052154
- GC12P050723
- GC12P050717
- GC12P052432
- GC12P049478
- GC12P052416
Summaries for NR4A1 Gene
-
This gene encodes a member of the steroid-thyroid hormone-retinoid receptor superfamily. Expression is induced by phytohemagglutinin in human lymphocytes and by serum stimulation of arrested fibroblasts. The encoded protein acts as a nuclear transcription factor. Translocation of the protein from the nucleus to mitochondria induces apoptosis. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2011]
GeneCards Summary for NR4A1 Gene
NR4A1 (Nuclear Receptor Subfamily 4 Group A Member 1) is a Protein Coding gene. Diseases associated with NR4A1 include Pseudohypoaldosteronism and Salivary Gland Carcinoma. Among its related pathways are Nur77 Signaling in T-Cell and RET signaling. Gene Ontology (GO) annotations related to this gene include DNA-binding transcription factor activity and sequence-specific DNA binding. An important paralog of this gene is NR4A2.
UniProtKB/Swiss-Prot Summary for NR4A1 Gene
-
Orphan nuclear receptor. May act concomitantly with NURR1 in regulating the expression of delayed-early genes during liver regeneration. Binds the NGFI-B response element (NBRE) 5'-AAAAGGTCA-3' (By similarity). May inhibit NF-kappa-B transactivation of IL2. Participates in energy homeostasis by sequestrating the kinase STK11 in the nucleus, thereby attenuating cytoplasmic AMPK activation. Plays a role in the vascular response to injury (By similarity).
Additional gene information for NR4A1 Gene
- HGNC(7980)
- Entrez Gene(3164)
- Ensembl(ENSG00000123358)
- OMIM(139139)
- UniProtKB(P22736)
- Open Targets Platform(ENSG00000123358)
- Monarch Initiative
- Search for NR4A1 at DataMed
- Search for NR4A1 at HumanCyc
No data available for CIViC Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for NR4A1 Gene
Genomics for NR4A1 Gene
GeneHancer (GH) Regulatory Elements Pubs
Promoters and enhancers for NR4A1 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication |
Request up-to-date GeneHancer data (full dataset)
GeneHancers around NR4A1 on the GeneHancer Hub at the UCSC Golden Path
Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for NR4A1
- Top Transcription factor binding sites by QIAGEN in the NR4A1 gene promoter:
-
- c-Myc
- CREB
- deltaCREB
- Max1
- SRF
Genomic Locations for NR4A1 Gene
Genomic Locations for NR4A1 Gene
- chr12:52,022,832-52,059,507
- (GRCh38/hg38)
- Size:
- 36,676 bases
- Orientation:
- Plus strand
- chr12:52,416,616-52,453,291
- (GRCh37/hg19)
- Size:
- 36,676 bases
- Orientation:
- Plus strand
Genomic View for NR4A1 Gene
Genes around NR4A1 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 12q13.13 by HGNC
- 12q13.13 by Entrez Gene
- 12q13.13 by Ensembl
NR4A1 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for NR4A1 Gene
Proteins for NR4A1 Gene
-
Protein details for NR4A1 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- P22736-NR4A1_HUMAN
- Recommended name:
- Nuclear receptor subfamily 4 group A member 1
- Protein Accession:
- P22736
- B4DML7
- Q15627
- Q53Y00
- Q6IBU8
Protein attributes for NR4A1 Gene
- Size:
- 598 amino acids
- Molecular mass:
- 64463 Da
- Quaternary structure:
-
- Binds DNA as a monomer (By similarity). Interacts with GADD45GIP1 (PubMed:15459248). Interacts with STK11 (PubMed:22983157). Interacts with IFI27 (PubMed:22427340). Heterodimer (via DNA-binding domain) with RXRA (via C-terminus); DNA-binding of the heterodimer is enhanced by 9-cis retinoic acid (PubMed:17761950, PubMed:15509776). Competes for the RXRA interaction with EP300 and thereby attenuates EP300 mediated acetylation of RXRA (PubMed:17761950).
Three dimensional structures from OCA and Proteopedia for NR4A1 Gene
Protein Expression for NR4A1 Gene
Post-translational modifications for NR4A1 Gene
- Phosphorylated at Ser-351 by RPS6KA1 and RPS6KA3 in response to mitogenic or stress stimuli.
- Acetylated by p300/CBP, acetylation increases stability. Deacetylated by HDAC1.
- Modification sites at PhosphoSitePlus
- Modification sites at neXtProt
Other Protein References for NR4A1 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- LifeSpan BioSciences NR4A1 / NUR77 Antibody (LS-A3386) and NR4A1 / NUR77 Antibody (LS-B114)
- G Biosciences Immunotag™ NR4A1 Antibody
- Creative Diagnostics Magic™ Anti-NUR77 (Phospho S351) polyclonal antibody
- BioLegend Nur77 Antibody (653501), Nur77 Antibody (653502), and Nur77 Antibody (653504)
-
Custom Antibody ServicesOriGene Antibodies for NR4A1
- Novus Biologicals Antibodies for NR4A1
-
Abcam antibodies for NR4A1
- Invitrogen Antibodies for NR4A1 (AFLGC-NR4A1)
- antibodies-online: Show 60 available NR4A1 Antibodies ranked by validation data
- Compare Top NR4A1 Antibodies
-
Recommended
- 142 WB Antibodies (anti-human)
- 21 IHC (p) Antibodies (anti-human)
- 12 IF (p) Antibodies (anti-human)
- 10 IHC Antibodies (anti-human)
- 4 DB Antibodies (anti-human)
- 2 FACS Antibodies (anti-human)
- 1 EIA Antibody (anti-human)
- 1 ICC Antibody (anti-human)
- 1 IF Antibody (anti-human)
- 1 IP Antibody (anti-human)
- 75 WB Antibodies (anti-mouse)
- 12 IF (p) Antibodies (anti-mouse)
- 4 IHC Antibodies (anti-mouse)
- 4 IHC (p) Antibodies (anti-mouse)
- 2 FACS Antibodies (anti-mouse)
- 1 IF Antibody (anti-mouse)
- 48 WB Antibodies (anti-rat)
- 12 IF (p) Antibodies (anti-rat)
- 4 IHC Antibodies (anti-rat)
- 4 IHC (p) Antibodies (anti-rat)
-
Santa Cruz Biotechnology (SCBT) Antibodies for NR4A1
Protein Products
-
OriGene Purified Proteins for NR4A1
- Search Origene for MassSpec and Protein Over-expression Lysates for NR4A1
- Origene Custom Protein Services for NR4A1
- Novus Biologicals proteins for NR4A1
-
Abcam proteins for NR4A1
Assay Products
-
Boster Bio ELISA Kits for NR4A1
No data available for DME Specific Peptides for NR4A1 Gene
Domains & Families for NR4A1 Gene
Gene Families for NR4A1 Gene
- HGNC:
- IUPHAR :
- Human Protein Atlas (HPA):
-
- Nuclear receptors
- Predicted intracellular proteins
- Transcription factors
Protein Domains for NR4A1 Gene
- InterPro:
- Blocks:
-
- Steroid hormone receptor signature
- Orphan nuclear receptor (4A nuclear receptor) family signature
- Orphan nuclear receptor HMR signature
- ProtoNet:
Suggested Antigen Peptide Sequences for NR4A1 Gene
- GenScript: Design optimal peptide antigens:
-
- cDNA FLJ55987, highly similar to Orphan nuclear receptor NR4A1 (B4DML7_HUMAN)
- Testicular receptor 3 (NR4A1_HUMAN)
- cDNA, FLJ95235, Homo sapiens nuclear receptor subfamily 4, group A, member 1(NR4A1), transcript variant 3, mRNA (Q15627_HUMAN)
- Nuclear receptor subfamily 4, group A, member 1, isoform CRA_d (Q53Y00_HUMAN)
- NR4A1 protein (Q6IBU8_HUMAN)
Graphical View of Domain Structure for InterPro Entry
P22736- Family:
-
- Belongs to the nuclear hormone receptor family. NR4 subfamily.
Function for NR4A1 Gene
Molecular function for NR4A1 Gene
- UniProtKB/Swiss-Prot Function:
- Orphan nuclear receptor. May act concomitantly with NURR1 in regulating the expression of delayed-early genes during liver regeneration. Binds the NGFI-B response element (NBRE) 5'-AAAAGGTCA-3' (By similarity). May inhibit NF-kappa-B transactivation of IL2. Participates in energy homeostasis by sequestrating the kinase STK11 in the nucleus, thereby attenuating cytoplasmic AMPK activation. Plays a role in the vascular response to injury (By similarity).
- UniProtKB/Swiss-Prot Induction:
- By growth-stimulating agents.
- GENATLAS Biochemistry:
- nuclear receptor subfamily 4,group A,member 1,steroid/thyroid receptor superfamily,likely functionning as a general coactivation of gene transcription
Phenotypes From GWAS Catalog for NR4A1 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000977 | RNA polymerase II regulatory region sequence-specific DNA binding | IBA | 21873635 |
| GO:0000978 | RNA polymerase II proximal promoter sequence-specific DNA binding | IBA | 21873635 |
| GO:0000981 | DNA-binding transcription factor activity, RNA polymerase II-specific | ISM | 19274049 |
| GO:0001228 | DNA-binding transcription activator activity, RNA polymerase II-specific | ISS | -- |
| GO:0003677 | DNA binding | ISS | -- |
Phenotypes for NR4A1 Gene
- MGI mutant phenotypes for NR4A1:
-
inferred from 3 alleles
- immune system phenotype
- normal phenotype
- cardiovascular system phenotype
- behavior/neurological phenotype
- mortality/aging
- growth/size/body region phenotype
- liver/biliary system phenotype
- neoplasm
- endocrine/exocrine gland phenotype
- reproductive system phenotype
- hematopoietic system phenotype
- integument phenotype
- GenomeRNAi human phenotypes for NR4A1:
Animal Model Products
-
Taconic Biosciences Mouse Models for NR4A1
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for NR4A1 - Select products 50% OFF >
- * NR4A1 CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
OriGene CRISPR knockouts for NR4A1
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for NR4A1
-
Santa Cruz Biotechnology (SCBT) CRISPR for NR4A1
miRNA for NR4A1 Gene
- miRTarBase miRNAs that target NR4A1
Targeted motifs for NR4A1 Gene
HOMER Transcription Factor Regulatory Elements motif NR4A1
- Consensus sequence: TGACCTTTNCNT Submotif: canonical Cell Type: K562 GEO ID: GSE31363
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for NR4A1
- Browse OriGene Inhibitory RNA Products For NR4A1
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for NR4A1
Clone Products
- Applied Biological Materials (abm): Clones for NR4A1 - Select products 50% OFF >
- * NR4A1 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
- MG209316
- MR209316
- MR209316L1
- MR209316L2
- MR209316L3
- MR209316L4
- RC202202
- RC202202L1
- RC202202L2
- RC202202L3
- RC202202L4
- RC222958
- RC222958L3
- RC222958L4
- RC234560
- RC239210
- RG202202
- RG222958
- RG234560
- RR201006
- RR201006L3
- RR201006L4
- MR209316L1V
- MR209316L2V
- MR209316L3V
- MR209316L4V
- RC202202L1V
- RC202202L2V
- RC202202L3V
- RC202202L4V
- RC222958L3V
- RC222958L4V
- RR201006L3V
- RR201006L4V
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Sino Biological Human cDNA Clone for NR4A1
- Addgene plasmids for NR4A1
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for NR4A1
Cell Line Products
-
Horizon Cell Lines for NR4A1
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models and Transcription Factor Targets for NR4A1 Gene
Localization for NR4A1 Gene
Subcellular locations from UniProtKB/Swiss-Prot for NR4A1 Gene
- Nucleus. Cytoplasm. Mitochondrion. Note=Nuclear export to the cytoplasm is XPO1-mediated and positively regulated by IFI27 (PubMed:22427340). Translocation to the mitochondrion upon interaction with RXRA and upon the presence of 9-cis retinoic acid (PubMed:17761950). {ECO:0000269 PubMed:17761950, ECO:0000269 PubMed:22427340}.
| Compartment | Confidence |
|---|---|
| nucleus | 5 |
| cytosol | 5 |
| mitochondrion | 4 |
| plasma membrane | 2 |
| extracellular | 2 |
| cytoskeleton | 2 |
| peroxisome | 2 |
| endoplasmic reticulum | 2 |
| lysosome | 2 |
| endosome | 1 |
| golgi apparatus | 1 |
- Cytosol (3)
- Nucleoplasm (3)
- Nuclear membrane (2)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000790 | nuclear chromatin | ISA | -- |
| GO:0005634 | nucleus | IBA,ISS | -- |
| GO:0005654 | nucleoplasm | TAS | -- |
| GO:0005667 | transcription factor complex | IBA | 21873635 |
| GO:0005737 | cytoplasm | IEA | -- |
Pathways & Interactions for NR4A1 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | RET signaling |
.92
|
|
| 2 | GAB1 signalosome |
.89
|
|
| 3 | Aldosterone synthesis and secretion |
.41
|
|
| 4 | MAPK signaling pathway | ||
| 5 | Constitutive Signaling by AKT1 E17K in Cancer | ||
Pathways by source for NR4A1 Gene
1 Sino Biological pathway for NR4A1 Gene
7 BioSystems pathways for NR4A1 Gene
27 Reactome pathways for NR4A1 Gene
5 KEGG pathways for NR4A1 Gene
2 GeneGo (Thomson Reuters) pathways for NR4A1 Gene
- Immune response Function of MEF2 in T lymphocytes
- Signal transduction Activation of PKC via G-Protein coupled receptor
5 Qiagen pathways for NR4A1 Gene
- Calcium Mediated T-Cell Apoptosis
- CRHR Pathway
- NK1R-mediated Non-Apoptotic PCD
- Nur77 Signaling in T-Cell
- Nur77-Induced AICD in Macrophage
3 Cell Signaling Technology pathways for NR4A1 Gene
Interacting Proteins for NR4A1 Gene
Selected Interacting proteins:
P22736-NR4A1_HUMAN
ENSP00000440864
for NR4A1 Gene via
UniProtKB
MINT
STRING
IID
GPS-Prot Interaction Network for NR4A1
SIGNOR curated interactions for NR4A1 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0001938 | positive regulation of endothelial cell proliferation | IMP | 18059339 |
| GO:0002042 | cell migration involved in sprouting angiogenesis | IDA | 18059339 |
| GO:0006355 | regulation of transcription, DNA-templated | IEA | -- |
| GO:0006367 | transcription initiation from RNA polymerase II promoter | TAS | -- |
| GO:0006915 | apoptotic process | IEA | -- |
Transcripts for NR4A1 Gene
mRNA/cDNA for NR4A1 Gene
- 5 REFSEQ mRNAs :
- 17 NCBI additional mRNA sequence :
- 22 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
-
- ENST00000243050 2678 nts (view in UCSC)
- ENST00000360284 2589 nts (view in UCSC)
- ENST00000394824 2639 nts (view in UCSC)
- ENST00000394825 2485 nts (view in UCSC)
- ENST00000478250 1820 nts (view in UCSC)
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for NR4A1 - Select products 50% OFF >
- * NR4A1 CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
OriGene CRISPR knockouts for NR4A1
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for NR4A1
-
Santa Cruz Biotechnology (SCBT) CRISPR for NR4A1
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for NR4A1
- Browse OriGene Inhibitory RNA Products For NR4A1
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for NR4A1
Clone Products
- Applied Biological Materials (abm): Clones for NR4A1 - Select products 50% OFF >
- * NR4A1 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
- MG209316
- MR209316
- MR209316L1
- MR209316L2
- MR209316L3
- MR209316L4
- RC202202
- RC202202L1
- RC202202L2
- RC202202L3
- RC202202L4
- RC222958
- RC222958L3
- RC222958L4
- RC234560
- RC239210
- RG202202
- RG222958
- RG234560
- RR201006
- RR201006L3
- RR201006L4
- MR209316L1V
- MR209316L2V
- MR209316L3V
- MR209316L4V
- RC202202L1V
- RC202202L2V
- RC202202L3V
- RC202202L4V
- RC222958L3V
- RC222958L4V
- RR201006L3V
- RR201006L4V
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Sino Biological Human cDNA Clone for NR4A1
- Addgene plasmids for NR4A1
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for NR4A1
| ExUns: | 1 | ^ | 2 | ^ | 3a | · | 3b | ^ | 4a | · | 4b | · | 4c | ^ | 5a | · | 5b | · | 5c | ^ | 6a | · | 6b | · | 6c | ^ | 7a | · | 7b | ^ | 8a | · | 8b | ^ | 9 | ^ | 10 | ^ | 11a | · | 11b | · | 11c | ^ | 12a | · | 12b | ^ | 13a | · | 13b | · |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||||
| SP2: | - | - | - | - | - | - | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||
| SP3: | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||
| SP4: | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||||
| SP5: | - | |||||||||||||||||||||||||||||||||||||||||||||||||||
| SP6: | - | |||||||||||||||||||||||||||||||||||||||||||||||||||
| SP7: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP8: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP9: | - | - | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||
| SP10: | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||||
| SP11: | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||||||
| SP12: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP13: | - | - | - | - | - | - |
| ExUns: | 13c |
|---|---|
| SP1: | |
| SP2: | |
| SP3: | |
| SP4: | |
| SP5: | |
| SP6: | |
| SP7: | |
| SP8: | |
| SP9: | |
| SP10: | |
| SP11: | |
| SP12: | |
| SP13: |
Relevant External Links for NR4A1 Gene
- GeneLoc Exon Structure for
- NR4A1
Expression for NR4A1 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
- Brain (Nervous System)
-
Blood (Cardiovascular System)
- Double Positive Thymocytes Thymus
- Hematopoietic Stem Cells Hematopoietic Bone Marrow
-
Ovary (Reproductive System)
- Mature Granulosa Cells Antral Follicle
-
Thymus (Hematopoietic System)
- Double Positive Thymocytes Thymus
-
Pancreas (Endocrine System)
- Duct Cells Pancreatic Ducts
-
Epithelial Cells
- Duct Cells Pancreatic Ducts
- Heart (Cardiovascular System)
- Adipose (Muscoskeletal System)
-
Adrenal Gland (Endocrine System)
mRNA differential expression in normal tissues according to GTEx for NR4A1 Gene
This gene is overexpressed in Ovary (x4.8).
This gene is overexpressed in Ovary (38.3) and Islet of Langerhans (30.7).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for NR4A1 Gene
Transcriptomic regulation report from SPP (The Signaling Pathways Project) for NR4A1
SOURCE GeneReport for Unigene cluster for NR4A1 Gene:
Hs.524430mRNA Expression by UniProt/SwissProt for NR4A1 Gene:
P22736-NR4A1_HUMAN
Tissue specificity:
Fetal muscle and adult liver, brain and thyroid.
Evidence on tissue expression from TISSUES for NR4A1 Gene
- Nervous system(4.9)
- Muscle(4.8)
- Heart(4.7)
- Skin(4.6)
- Adrenal gland(3.7)
- Lung(3.7)
- Intestine(3.5)
- Kidney(3.5)
- Thyroid gland(3.1)
- Liver(3.1)
- Lymph node(3)
- Spleen(2.9)
- Pancreas(2.9)
- Bone marrow(2.8)
- Blood(2.7)
- Eye(2.7)
- Stomach(2.5)
- Gall bladder(2.4)
Primer Products
-
OriGene qPCR primer pairs for NR4A1
-
OriGene qPCR primer pairs and template standards for NR4A1
Gene Expression Assay Products
No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for NR4A1 Gene
Orthologs for NR4A1 Gene
This gene was present in the common ancestor of animals.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| Chimpanzee (Pan troglodytes) |
Mammalia | NR4A1 30 31 |
|
OneToOne | |
| Cow (Bos Taurus) |
Mammalia | NR4A1 30 31 |
|
OneToOne | |
| Dog (Canis familiaris) |
Mammalia | NR4A1 30 31 |
|
OneToOne | |
| Rat (Rattus norvegicus) |
Mammalia | Nr4a1 30 |
|
||
| Mouse (Mus musculus) |
Mammalia | Nr4a1 30 17 31 |
|
OneToOne | |
| Lizard (Anolis carolinensis) |
Reptilia | NR4A1 31 |
|
OneToOne | |
| Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | nr4a1 30 |
|
||
| Zebrafish (Danio rerio) |
Actinopterygii | nr4a1 30 31 |
|
OneToOne | |
| Fruit Fly (Drosophila melanogaster) |
Insecta | Hr38 31 32 |
|
OneToMany | |
| Worm (Caenorhabditis elegans) |
Secernentea | nhr-6 31 |
|
OneToMany | |
| Sea Squirt (Ciona savignyi) |
Ascidiacea | -- 31 |
|
OneToMany |
- Species where no ortholog for NR4A1 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Eremothecium gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- Alpha proteobacteria (Wolbachia pipientis)
- Amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- Baker's yeast (Saccharomyces cerevisiae)
- Barley (Hordeum vulgare)
- Beta proteobacteria (Neisseria meningitidis)
- Bread mold (Neurospora crassa)
- Chicken (Gallus gallus)
- Chromalveolata (Phytophthora infestans)
- Common water flea (Daphnia pulex)
- Corn (Zea mays)
- E. coli (Escherichia coli)
- Filamentous fungi (Aspergillus nidulans)
- Firmicute Bacteria (Streptococcus pneumoniae)
- Fission Yeast (Schizosaccharomyces pombe)
- Green Algae (Chlamydomonas reinhardtii)
- Honey Bee (Apis mellifera)
- K. Lactis Yeast (Kluyveromyces lactis)
- Loblloly Pine (Pinus taeda)
- Malaria Parasite (Plasmodium falciparum)
- Medicago Trunc (Medicago Truncatula)
- Moss (Physcomitrella patens)
- Oppossum (Monodelphis domestica)
- Orangutan (Pongo pygmaeus)
- Pig (Sus scrofa)
- Platypus (Ornithorhynchus anatinus)
- Rainbow Trout (Oncorhynchus mykiss)
- Rice (Oryza sativa)
- Rice Blast Fungus (Magnaporthe grisea)
- Schistosome Parasite (Schistosoma mansoni)
- Sea Anemone (Nematostella vectensis)
- Sea Vase (Ciona intestinalis)
- Sea Urchin (Strongylocentrotus purpuratus)
- Sorghum (Sorghum bicolor)
- Soybean (Glycine max)
- Stem Rust Fungus (Puccinia graminis)
- Sugarcane (Saccharum officinarum)
- Thale Cress (Arabidopsis thaliana)
- Tomato (Lycopersicon esculentum)
- Toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- Wheat (Triticum aestivum)
Evolution for NR4A1 Gene
- ENSEMBL:
- Gene Tree for NR4A1 (if available)
- TreeFam:
- Gene Tree for NR4A1 (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for NR4A1: view image
Paralogs for NR4A1 Gene
(23) SIMAP similar genes for NR4A1 Gene using alignment to 8 proteins:
- NR4A1_HUMAN
- F5GXF0_HUMAN
- F8VVX9_HUMAN
- H3BPN8_HUMAN
- H3BQG5_HUMAN
- H3BSB9_HUMAN
- H3BSM8_HUMAN
- H3BT85_HUMAN
Variants for NR4A1 Gene
Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for NR4A1 Gene
| SNP ID | Clinical significance and condition | Chr 12 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| 734627 | Likely Benign: not provided | 52,056,107(+) | C/T | SYNONYMOUS_VARIANT | |
| 737337 | Benign: not provided | 52,054,400(+) | C/T | SYNONYMOUS_VARIANT | |
| 739666 | Likely Benign: not provided | 52,057,119(+) | C/T | SYNONYMOUS_VARIANT | |
| 739824 | Benign: not provided | 52,054,448(+) | C/T | SYNONYMOUS_VARIANT | |
| 742291 | Likely Benign: not provided | 52,055,099(+) | C/T | SYNONYMOUS_VARIANT |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| dgv2629n54 | CNV | loss | 21841781 |
| esv2656525 | CNV | deletion | 23128226 |
| esv3549214 | CNV | deletion | 23714750 |
| esv3629512 | CNV | loss | 21293372 |
| esv3629513 | CNV | loss | 21293372 |
| nsv1069668 | CNV | deletion | 25765185 |
| nsv469378 | CNV | loss | 19166990 |
| nsv518451 | CNV | loss | 19592680 |
| nsv558898 | CNV | loss | 21841781 |
| nsv832409 | CNV | loss | 17160897 |
Residual Variation Intolerance Score:
11.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
4.37;
63.44% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for NR4A1 Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- NR4A1
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NR4A1 Gene
Disorders for NR4A1 Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| pseudohypoaldosteronism |
|
|
| salivary gland carcinoma |
|
|
| salivary gland disease |
|
|
| pyomyositis |
|
|
| staphyloenterotoxemia |
|
|
Search NR4A1 in MalaCards
View complete list of genes associated with diseases
Additional Disease Information for NR4A1
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
- Open Targets Platform
No data available for UniProtKB/Swiss-Prot and Genatlas for NR4A1 Gene
Publications for NR4A1 Gene
- Association of the orphan nuclear receptor NR4A1 with tardive dyskinesia. (PMID: 20010315) Novak G … Le Foll B (Psychiatric genetics 2010) 3 23 41
- Orphan receptor TR3 attenuates the p300-induced acetylation of retinoid X receptor-alpha. (PMID: 17761950) Zhao WX … Wu Q (Molecular endocrinology (Baltimore, Md.) 2007) 3 4 23
- Negative cross-talk between the human orphan nuclear receptor Nur77/NAK-1/TR3 and nuclear factor-kappaB. (PMID: 15466594) Harant H … Lindley IJ (Nucleic acids research 2004) 3 4 23
- A human early response gene homologous to murine nur77 and rat NGFI-B, and related to the nuclear receptor superfamily. (PMID: 2283997) Nakai A … DeGroot LJ (Molecular endocrinology (Baltimore, Md.) 1990) 3 4 23
- Isolation and characterization of human TR3 receptor: a member of steroid receptor superfamily. (PMID: 2626032) Chang C … Chang Y (Journal of steroid biochemistry 1989) 2 3 4
ExternalLinks
Products for NR4A1 Gene
- Custom Antibody ServicesOriGene Antibodies for NR4A1
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- Custom Assay Services
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- MG209316
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- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Browse OriGene miRNA Products For NR4A1
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- Taconic Biosciences Mouse Models for NR4A1
- Find your next knockout model in the Taconic Knockout Repository
- Genetically Engineered Models Available Immediately
- Humanized Mice
- Invitrogen Antibodies for NR4A1 (AFLGC-NR4A1)
- VectorBuilder Custom and pre-made DNA vectors for NR4A1 (ie. gene expression, shRNA knockdown, CRISPR)
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- antibodies-online: Show 60 available NR4A1 Antibodies ranked by validation data
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- 1 EIA Antibody (anti-human)
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- 75 WB Antibodies (anti-mouse)
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- 1 IF Antibody (anti-mouse)
- 48 WB Antibodies (anti-rat)
- 12 IF (p) Antibodies (anti-rat)
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- 4 IHC (p) Antibodies (anti-rat)
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- antibodies-online: Show 7 available NR4A1 Proteins ranked by validation data
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- Santa Cruz Biotechnology (SCBT) Antibodies for NR4A1
- Search Santa Cruz Biotechnology (SCBT) for NR4A1 siRNA/shRNA
- Santa Cruz Biotechnology (SCBT) CRISPR for NR4A1
- Horizon Cell Lines for NR4A1
- Browse GeneCopoeia Cell Lines
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for NR4A1
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for NR4A1
- Search GeneCopoeia for miRNA 3'UTR Target clone products for NR4A1
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for NR4A1
Sources for NR4A1 Gene
- (1) GeneCards
- (2) HGNC
- (3) NCBI Entrez Gene
- (4) UniProtKB/Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) Cell Signaling Technology
- (12) GO
- (13) UniProtKB/TrEMBL
- (14) InterPro
- (15) ProtoNet
- (16) Blocks
- (17) MGI
- (18) IUBMB
- (19) KEGG
- (20) MINT
- (21) STRING
- (22) IntAct
- (23) Novoseek
- (24) PharmGKB
- (25) DrugBank
- (26) HMDB
- (27) ASD
- (28) SAGE
- (29) SOURCE
- (30) HomoloGene
- (31) PanEnsembl
- (32) euGenes
- (33) SGD
- (34) FlyBase
- (35) WormBase
- (36) Pseudogene
- (37) DGV
- (38) dbSNP
- (39) GenAtlas
- (40) HGMD
- (41) GAD
- (42) BGMUT
- (43) HuGE
- (44) Atlas
- (45) GenBank
- (46) HORDE
- (47) HUGE
- (48) IMGT
- (49) Leiden
- (50) miRBase
- (51) DME
- (52) OriGene
- (53) PubMed
- (54) R&D Systems
- (55) TGDB
- (56) Tocris
- (57) Abcam
- (58) Novus Biologicals
- (59) ProSpec
- (60) Sino Biological
- (61) GenScript
- (62) Qiagen
- (63) OCA
- (64) Proteopedia
- (65) MOPED
- (66) neXtProt
- (67) Reactome
- (68) GeneGo (Thomson Reuters)
- (69) DISEASES
- (70) SIMAP
- (71) GenomeRNAi
- (72) LifeMap
- (73) miRTarBase
- (74) MalaCards
- (75) Invitrogen
- (76) BitterDB
- (77) ESI-BIO
- (78) RefSeq
- (79) BioSystems
- (80) MaxQB
- (81) IUPHAR
- (82) BioGPS
- (83) Illumina
- (84) COMPARTMENTS
- (85) HOMER
- (86) PaxDb
- (87) ApexBio
- (88) Addgene
- (89) antibodies-online
- (90) CYP
- (91) NONCODE
- (92) TreeFam
- (93) PathCards
- (94) GeneReviews
- (95) GeneTex
- (96) Taconic Biosciences
- (97) GTEx
- (98) ProteomicsDB
- (99) SCBT
- (100) DGIdb
- (101) ClinicalTrials
- (102) RVIS
- (103) SIGNOR
- (104) diseasecard
- (105) NIH Rare Diseases
- (106) Orphanet
- (107) UMLS
- (108) GTR
- (109) Disease Ontology
- (110) Genetics Home Reference
- (111) MeSH
- (112) MedlinePlus
- (113) CDC
- (114) NINDS
- (115) NCBI Bookshelf
- (116) ClinVar
- (117) Gene Damage Index
- (118) HPO
- (119) UDN
- (120) VISTA
- (121) FANTOM5
- (122) ENCODE
- (123) ProSci
- (124) Horizon
- (125) The Signaling Pathways Project (SPP)
- (126) IID
- (127) VectorBuilder
- (128) SNPedia
- (129) BRCA Exchange
- (130) CIViC
- (131) ProteoGenix
- (132) dbSUPER
- (133) TISSUES
- (134) Gene ORGANizer
- (135) abm
- (136) Human Protein Atlas
- (137) GWAS Catalog
- (138) Monarch Initiative
- (139) DataMed
- (140) HumanCyc
- (141) UCNEbase
- (142) EPDnew
- (143) Applied Biosystems
- (144) GlyConnect
- (145) Aminode
- (146) GeneCopoeia
- (147) GPS-Prot
- (148) RNACentral
- (149) LncRNADisease
- (150) LOVD
- (151) miR2Disease
- (152) DiseaseEnhancer
- (153) Boster Bio
- (154) Biorbyt
- (155) Biocompare
- (156) Mastermind
- (157) CTD^2 Dashboard
- (158) CraniofacialAtlas
- (159) GeneImprint
- (160) Synthego
- (161) ENA
- (162) GtRNAdb
- (163) LncBase
- (164) LncBook
- (165) LNCipedia
- (166) Modomics
- (167) PDBe
- (168) Rfam
- (169) SILVA
- (170) snOPY
- (171) SRPDB
- (172) GENCODE
- (173) TarBase
- (174) Signalway Antibody
- (175) Open Targets Platform
- (176) 5SRRNADB
- (177) snoDB
- (178) MirGeneDB