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Aliases for NR2F6 Gene
Aliases for NR2F6 Gene
External Ids for NR2F6 Gene
- HGNC: 7977
- Entrez Gene: 2063
- Ensembl: ENSG00000160113
- OMIM: 132880
- UniProtKB: P10588
Previous HGNC Symbols for NR2F6 Gene
- ERBAL2
Previous GeneCards Identifiers for NR2F6 Gene
- GC19M017836
- GC19M017734
- GC19M017187
- GC19M017203
- GC19M017342
- GC19M016910
Summaries for NR2F6 Gene
GeneCards Summary for NR2F6 Gene
NR2F6 (Nuclear Receptor Subfamily 2 Group F Member 6) is a Protein Coding gene. Diseases associated with NR2F6 include Patulous Eustachian Tube and Chronic Purulent Otitis Media. Among its related pathways are Gene Expression and Nuclear Receptor transcription pathway. Gene Ontology (GO) annotations related to this gene include DNA-binding transcription factor activity and RNA polymerase II distal enhancer sequence-specific DNA binding. An important paralog of this gene is NR2F1.
UniProtKB/Swiss-Prot Summary for NR2F6 Gene
-
Transcription factor predominantly involved in transcriptional repression. Binds to promoter/enhancer response elements that contain the imperfect 5'-AGGTCA-3' direct or inverted repeats with various spacings which are also recognized by other nuclear hormone receptors. Involved in modulation of hormonal responses. Represses transcriptional activity of the lutropin-choriogonadotropic hormone receptor/LHCGR gene, the renin/REN gene and the oxytocin-neurophysin/OXT gene. Represses the triiodothyronine-dependent and -independent transcriptional activity of the thyroid hormone receptor gene in a cell type-specific manner. The corepressing function towards thyroid hormone receptor beta/THRB involves at least in part the inhibition of THRB binding to triiodothyronine response elements (TREs) by NR2F6. Inhibits NFATC transcription factor DNA binding and subsequently its transcriptional activity. Acts as transcriptional repressor of IL-17 expression in Th-17 differentiated CD4(+) T cells and may be involved in induction and/or maintenance of peripheral immunological tolerance and autoimmunity. Involved in development of forebrain circadian clock; is required early in the development of the locus coeruleus (LC).
Additional gene information for NR2F6 Gene
- HGNC(7977)
- Entrez Gene(2063)
- Ensembl(ENSG00000160113)
- OMIM(132880)
- UniProtKB(P10588)
- Open Targets Platform(ENSG00000160113)
- Monarch Initiative
- Search for NR2F6 at DataMed
- Search for NR2F6 at HumanCyc
No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for NR2F6 Gene
Genomics for NR2F6 Gene
GeneHancer (GH) Regulatory Elements Pubs
Promoters and enhancers for NR2F6 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication |
Request up-to-date GeneHancer data (full dataset)
GeneHancers around NR2F6 on the GeneHancer Hub at the UCSC Golden Path
Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for NR2F6
- Top Transcription factor binding sites by QIAGEN in the NR2F6 gene promoter:
-
- C/EBPalpha
- CREB
- deltaCREB
- NF-kappaB
- NF-kappaB1
- TBP
Genomic Locations for NR2F6 Gene
Genomic Locations for NR2F6 Gene
- chr19:17,231,883-17,245,940
- (GRCh38/hg38)
- Size:
- 14,058 bases
- Orientation:
- Minus strand
- chr19:17,342,692-17,356,749
- (GRCh37/hg19)
- Size:
- 14,058 bases
- Orientation:
- Minus strand
Genomic View for NR2F6 Gene
Genes around NR2F6 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 19p13.11 by HGNC
- 19p13.11 by Entrez Gene
- 19p13.11 by Ensembl
NR2F6 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for NR2F6 Gene
Proteins for NR2F6 Gene
-
Protein details for NR2F6 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- P10588-NR2F6_HUMAN
- Recommended name:
- Nuclear receptor subfamily 2 group F member 6
- Protein Accession:
- P10588
- B2RC68
- Q5XGA0
- Q6P586
- Q9BUE8
Protein attributes for NR2F6 Gene
- Size:
- 404 amino acids
- Molecular mass:
- 42979 Da
- Quaternary structure:
-
- Binds DNA as dimer; homodimer and heterodimer with NR2F2 and probably NR2F1 (By similarity). Interacts with THRB.
Protein Expression for NR2F6 Gene
Post-translational modifications for NR2F6 Gene
Other Protein References for NR2F6 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- G Biosciences Immunotag™ NR2F6 Antibody
- GeneTex Anti-NR2F6 antibody
-
Custom Antibody ServicesOriGene Antibodies for NR2F6
- Novus Biologicals Antibodies for NR2F6
- Invitrogen Antibodies for NR2F6 (AFLGC-NR2F6)
-
Santa Cruz Biotechnology (SCBT) Antibodies for NR2F6
Protein Products
- Search Origene for MassSpec and Protein Over-expression Lysates for NR2F6
- Origene Custom Protein Services for NR2F6
-
Signalway Proteins for NR2F6
-
Abcam proteins for NR2F6
Assay Products
- antibodies-online: Show 8 available NR2F6 Elisa Kits ranked by validation data
- Compare Top NR2F6 Elisa Kits
-
Quality Products:
-
Boster Bio ELISA Kits for NR2F6
No data available for DME Specific Peptides for NR2F6 Gene
Domains & Families for NR2F6 Gene
Gene Families for NR2F6 Gene
- HGNC:
- IUPHAR :
- Human Protein Atlas (HPA):
-
- Nuclear receptors
- Predicted intracellular proteins
- Transcription factors
Protein Domains for NR2F6 Gene
- InterPro:
- Blocks:
-
- Steroid hormone receptor signature
- COUP transcription factor (2F nuclear receptor) family signature
- Zinc finger, C4-type, C-terminal
- ProtoNet:
Suggested Antigen Peptide Sequences for NR2F6 Gene
- GenScript: Design optimal peptide antigens:
-
- cDNA FLJ51763, highly similar to Orphan nuclear receptor EAR-2 (B4DQE4_HUMAN)
- Nuclear receptor subfamily 2, group F, member 6 (B6ZGU2_HUMAN)
- Nuclear receptor V-erbA-related (F1D8R3_HUMAN)
- V-erbA-related protein 2 (NR2F6_HUMAN)
Graphical View of Domain Structure for InterPro Entry
P10588- Family:
-
- Belongs to the nuclear hormone receptor family. NR2 subfamily.
Function for NR2F6 Gene
Molecular function for NR2F6 Gene
- UniProtKB/Swiss-Prot Function:
- Transcription factor predominantly involved in transcriptional repression. Binds to promoter/enhancer response elements that contain the imperfect 5'-AGGTCA-3' direct or inverted repeats with various spacings which are also recognized by other nuclear hormone receptors. Involved in modulation of hormonal responses. Represses transcriptional activity of the lutropin-choriogonadotropic hormone receptor/LHCGR gene, the renin/REN gene and the oxytocin-neurophysin/OXT gene. Represses the triiodothyronine-dependent and -independent transcriptional activity of the thyroid hormone receptor gene in a cell type-specific manner. The corepressing function towards thyroid hormone receptor beta/THRB involves at least in part the inhibition of THRB binding to triiodothyronine response elements (TREs) by NR2F6. Inhibits NFATC transcription factor DNA binding and subsequently its transcriptional activity. Acts as transcriptional repressor of IL-17 expression in Th-17 differentiated CD4(+) T cells and may be involved in induction and/or maintenance of peripheral immunological tolerance and autoimmunity. Involved in development of forebrain circadian clock; is required early in the development of the locus coeruleus (LC).
- UniProtKB/Swiss-Prot Induction:
- Inhibited by gonadotropin in granulosa cells.
- GENATLAS Biochemistry:
- nuclear receptor subfamily 2,group F,member 6,steroid/thyroid receptor superfamily
Phenotypes From GWAS Catalog for NR2F6 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000977 | RNA polymerase II regulatory region sequence-specific DNA binding | IBA | 21873635 |
| GO:0000978 | RNA polymerase II proximal promoter sequence-specific DNA binding | IEA | -- |
| GO:0000981 | DNA-binding transcription factor activity, RNA polymerase II-specific | ISM | 19274049 |
| GO:0001227 | DNA-binding transcription repressor activity, RNA polymerase II-specific | IEA | -- |
| GO:0003677 | DNA binding | IEA,TAS | 2905047 |
Phenotypes for NR2F6 Gene
- MGI mutant phenotypes for NR2F6:
- inferred from 2 alleles
- GenomeRNAi human phenotypes for NR2F6:
-
- Increased vaccinia virus (VACV) infection
- no effect
- shRNA abundance <= 50%
- Negative genetic interaction between BLM-/- and BLM+/+
- Strongly decreased CFP-tsO45G cell surface transport
- Decreased shRNA abundance (Z-score < -2)
- Increased shRNA abundance (Z-score > 2)
- Negative genetic interaction between PTTG1-/- and PTTG1+/+
- Negative genetic interaction between PTEN-/- and PTEN+/+
- Decreased caspase 3/7 activity
Animal Models for NR2F6 Gene
- MGI Knock Outs for NR2F6:
-
- Nr2f6 Nr2f6<tm1Ge>
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for NR2F6 - Select products 50% OFF >
- * NR2F6 CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
OriGene CRISPR knockouts for NR2F6
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for NR2F6
-
Santa Cruz Biotechnology (SCBT) CRISPR for NR2F6
miRNA for NR2F6 Gene
- miRTarBase miRNAs that target NR2F6
-
- hsa-miR-346 (MIRT004232)
- hsa-miR-335-5p (MIRT018838)
- hsa-miR-98-5p (MIRT027803)
- hsa-miR-30d-5p (MIRT047809)
- hsa-miR-196a-5p (MIRT048210)
- hsa-miR-30a-5p (MIRT049946)
- hsa-miR-6780a-3p (MIRT150615)
- hsa-miR-142-3p (MIRT440094)
- hsa-miR-6855-5p (MIRT522144)
- hsa-miR-3170 (MIRT522145)
- hsa-miR-6807-5p (MIRT522146)
- hsa-miR-5095 (MIRT522147)
- hsa-miR-7151-3p (MIRT522148)
- hsa-miR-193b-5p (MIRT522149)
- hsa-miR-5589-5p (MIRT522150)
- hsa-miR-4731-5p (MIRT522151)
- hsa-miR-7155-5p (MIRT522152)
- hsa-miR-519d-5p (MIRT522153)
- hsa-miR-4438 (MIRT522154)
- hsa-miR-512-3p (MIRT522155)
- hsa-miR-520e (MIRT522156)
- hsa-miR-520d-3p (MIRT522157)
- hsa-miR-520c-3p (MIRT522158)
- hsa-miR-520b (MIRT522159)
- hsa-miR-520a-3p (MIRT522160)
- hsa-miR-373-3p (MIRT522161)
- hsa-miR-372-3p (MIRT522162)
- hsa-miR-302e (MIRT522163)
- hsa-miR-302d-3p (MIRT522164)
- hsa-miR-302c-3p (MIRT522165)
- hsa-miR-302b-3p (MIRT522166)
- hsa-miR-302a-3p (MIRT522167)
- hsa-miR-93-5p (MIRT522168)
- hsa-miR-526b-3p (MIRT522169)
- hsa-miR-519d-3p (MIRT522170)
- hsa-miR-20b-5p (MIRT522171)
- hsa-miR-20a-5p (MIRT522172)
- hsa-miR-17-5p (MIRT522173)
- hsa-miR-106b-5p (MIRT522174)
- hsa-miR-106a-5p (MIRT522175)
- hsa-miR-548t-5p (MIRT522176)
- hsa-miR-548az-5p (MIRT522177)
- hsa-miR-335-3p (MIRT612710)
- hsa-miR-30e-3p (MIRT612711)
- hsa-miR-30d-3p (MIRT612712)
- hsa-miR-30a-3p (MIRT612713)
- hsa-miR-3942-3p (MIRT612714)
- hsa-miR-1324 (MIRT612715)
- hsa-miR-665 (MIRT667171)
- hsa-miR-6763-5p (MIRT667172)
- hsa-miR-3150a-3p (MIRT667173)
- hsa-miR-6825-5p (MIRT667174)
- hsa-miR-939-5p (MIRT667175)
- hsa-miR-1343-5p (MIRT667176)
- hsa-miR-3175 (MIRT667177)
- hsa-miR-7160-5p (MIRT667178)
- hsa-miR-4722-5p (MIRT667179)
- hsa-miR-6884-5p (MIRT667180)
- hsa-miR-485-5p (MIRT667181)
- hsa-miR-1827 (MIRT667182)
- hsa-miR-4649-3p (MIRT667183)
- hsa-miR-4478 (MIRT667184)
- hsa-miR-4419b (MIRT667185)
- hsa-miR-3929 (MIRT667186)
- hsa-miR-940 (MIRT667187)
- hsa-miR-6893-5p (MIRT667188)
- hsa-miR-6808-5p (MIRT667189)
- hsa-miR-6720-5p (MIRT701366)
- hsa-miR-6512-3p (MIRT701367)
- hsa-miR-8089 (MIRT701368)
- hsa-miR-4700-5p (MIRT701369)
- hsa-miR-4667-5p (MIRT701370)
- hsa-miR-4267 (MIRT701371)
- hsa-miR-5690 (MIRT701372)
- hsa-miR-649 (MIRT701373)
- hsa-miR-744-3p (MIRT719126)
- hsa-miR-6881-3p (MIRT719127)
- hsa-miR-7111-3p (MIRT719128)
- hsa-miR-4423-5p (MIRT719129)
- hsa-miR-6501-5p (MIRT719130)
- hsa-miR-367-5p (MIRT719131)
- hsa-miR-1267 (MIRT719132)
- hsa-miR-101-3p (MIRT761075)
- hsa-miR-1262 (MIRT761707)
- hsa-miR-1273g-3p (MIRT761968)
- hsa-miR-1294 (MIRT762342)
- hsa-miR-1910-3p (MIRT763315)
- hsa-miR-2467-3p (MIRT764111)
- hsa-miR-4252 (MIRT768023)
- hsa-miR-4257 (MIRT768148)
- hsa-miR-4316 (MIRT768588)
- hsa-miR-4677-3p (MIRT770911)
- hsa-miR-4701-3p (MIRT771317)
- hsa-miR-4793-3p (MIRT772412)
- hsa-miR-508-5p (MIRT773174)
- hsa-miR-582-5p (MIRT775326)
- hsa-miR-6511a-5p (MIRT776814)
- hsa-miR-655-5p (MIRT777308)
- hsa-miR-661 (MIRT777444)
- hsa-miR-6736-5p (MIRT778068)
- hsa-miR-6742-3p (MIRT778145)
- hsa-miR-6776-5p (MIRT778754)
- hsa-miR-6849-3p (MIRT780311)
- hsa-miR-766-3p (MIRT781881)
- hsa-miR-7703 (MIRT782033)
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for NR2F6
- Browse OriGene Inhibitory RNA Products For NR2F6
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for NR2F6
Clone Products
- Applied Biological Materials (abm): Clones for NR2F6 - Select products 50% OFF >
- * NR2F6 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
- Sino Biological Human cDNA Clone for NR2F6
- Addgene plasmids for NR2F6
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for NR2F6
Cell Line Products
-
Horizon Cell Lines for NR2F6
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for NR2F6 Gene
Localization for NR2F6 Gene
Subcellular locations from UniProtKB/Swiss-Prot for NR2F6 Gene
- Nucleus.
| Compartment | Confidence |
|---|---|
| nucleus | 5 |
| plasma membrane | 1 |
| extracellular | 1 |
| cytoskeleton | 1 |
| mitochondrion | 1 |
| peroxisome | 1 |
| cytosol | 1 |
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000790 | nuclear chromatin | ISA | -- |
| GO:0005634 | nucleus | IEA,IDA | 10644740 |
| GO:0005654 | nucleoplasm | TAS | -- |
| GO:0042025 | host cell nucleus | IEA | -- |
No data available for Subcellular locations from the Human Protein Atlas (HPA) for NR2F6 Gene
Pathways & Interactions for NR2F6 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Gene Expression |
.48
|
|
| 2 | Nuclear Receptor transcription pathway | ||
| 3 | Circadian rythm related genes | ||
| 4 | IL-6 signaling pathway | ||
Pathways by source for NR2F6 Gene
3 BioSystems pathways for NR2F6 Gene
3 Reactome pathways for NR2F6 Gene
Interacting Proteins for NR2F6 Gene
Selected Interacting proteins:
P10588-NR2F6_HUMAN
ENSP00000291442
for NR2F6 Gene via
UniProtKB
MINT
STRING
IID
GPS-Prot Interaction Network for NR2F6
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000122 | negative regulation of transcription by RNA polymerase II | IEA,IDA | 10644740 |
| GO:0006355 | regulation of transcription, DNA-templated | IEA | -- |
| GO:0006357 | regulation of transcription by RNA polymerase II | IBA | 21873635 |
| GO:0006367 | transcription initiation from RNA polymerase II promoter | TAS | -- |
| GO:0007165 | signal transduction | TAS | 2905047 |
Transcripts for NR2F6 Gene
mRNA/cDNA for NR2F6 Gene
- 1 REFSEQ mRNAs :
- 7 NCBI additional mRNA sequence :
- 2 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
-
- ENST00000291442 2404 nts (view in UCSC)
- ENST00000596878 731 nts (view in UCSC)
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for NR2F6 - Select products 50% OFF >
- * NR2F6 CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
OriGene CRISPR knockouts for NR2F6
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for NR2F6
-
Santa Cruz Biotechnology (SCBT) CRISPR for NR2F6
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for NR2F6
- Browse OriGene Inhibitory RNA Products For NR2F6
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for NR2F6
Clone Products
- Applied Biological Materials (abm): Clones for NR2F6 - Select products 50% OFF >
- * NR2F6 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
- Sino Biological Human cDNA Clone for NR2F6
- Addgene plasmids for NR2F6
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for NR2F6
Relevant External Links for NR2F6 Gene
- GeneLoc Exon Structure for
- NR2F6
Expression for NR2F6 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
-
Trophoblast (Extraembryonic Tissues)
- Mural Trophectoderm Cells Mural Trophectoderm
- Brain (Nervous System)
- Kidney (Urinary System)
- Thymus (Hematopoietic System)
- Eye (Sensory Organs)
-
Placenta (Extraembryonic Tissues)
mRNA differential expression in normal tissues according to GTEx for NR2F6 Gene
This gene is overexpressed in Liver (x4.3).
This gene is overexpressed in Breast (51.5) and Retina (7.4).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for NR2F6 Gene
Transcriptomic regulation report from SPP (The Signaling Pathways Project) for NR2F6
SOURCE GeneReport for Unigene cluster for NR2F6 Gene:
Hs.466148mRNA Expression by UniProt/SwissProt for NR2F6 Gene:
P10588-NR2F6_HUMAN
Tissue specificity:
Expressed in heart, placenta, liver, skeletal muscle, kidney and pancreas.
Evidence on tissue expression from TISSUES for NR2F6 Gene
- Lung(4.5)
- Liver(4.5)
- Kidney(4.4)
- Pancreas(4.3)
- Nervous system(3.4)
- Eye(2.4)
- Heart(2)
Primer Products
-
OriGene qPCR primer pairs for NR2F6
-
OriGene qPCR primer pairs and template standards for NR2F6
Gene Expression Assay Products
No data available for Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for NR2F6 Gene
Orthologs for NR2F6 Gene
This gene was present in the common ancestor of animals.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| Chimpanzee (Pan troglodytes) |
Mammalia | NR2F6 30 31 |
|
OneToOne | |
| Dog (Canis familiaris) |
Mammalia | NR2F6 30 31 |
|
OneToOne | |
| Cow (Bos Taurus) |
Mammalia | NR2F6 30 31 |
|
OneToOne | |
| Mouse (Mus musculus) |
Mammalia | Nr2f6 30 17 31 |
|
OneToOne | |
| Rat (Rattus norvegicus) |
Mammalia | Nr2f6 30 |
|
||
| Platypus (Ornithorhynchus anatinus) |
Mammalia | NR2F6 31 |
|
OneToOne | |
| Oppossum (Monodelphis domestica) |
Mammalia | NR2F6 31 |
|
OneToOne | |
| Chicken (Gallus gallus) |
Aves | NR2F6 31 |
|
OneToOne | |
| Lizard (Anolis carolinensis) |
Reptilia | -- 31 |
|
ManyToMany | |
| Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | nr2f6 30 |
|
||
| African clawed frog (Xenopus laevis) |
Amphibia | nr2f6-prov 30 |
|
||
| Zebrafish (Danio rerio) |
Actinopterygii | nr2f6b 31 |
|
OneToMany | |
| nr2f6a 30 31 |
|
OneToMany | |||
| Fruit Fly (Drosophila melanogaster) |
Insecta | dsf 32 |
|
|
|
| Worm (Caenorhabditis elegans) |
Secernentea | unc-55 31 32 |
|
OneToOne |
- Species where no ortholog for NR2F6 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Eremothecium gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- Alpha proteobacteria (Wolbachia pipientis)
- Amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- Baker's yeast (Saccharomyces cerevisiae)
- Barley (Hordeum vulgare)
- Beta proteobacteria (Neisseria meningitidis)
- Bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- Common water flea (Daphnia pulex)
- Corn (Zea mays)
- E. coli (Escherichia coli)
- Filamentous fungi (Aspergillus nidulans)
- Firmicute Bacteria (Streptococcus pneumoniae)
- Fission Yeast (Schizosaccharomyces pombe)
- Green Algae (Chlamydomonas reinhardtii)
- Honey Bee (Apis mellifera)
- K. Lactis Yeast (Kluyveromyces lactis)
- Loblloly Pine (Pinus taeda)
- Malaria Parasite (Plasmodium falciparum)
- Medicago Trunc (Medicago Truncatula)
- Moss (Physcomitrella patens)
- Orangutan (Pongo pygmaeus)
- Pig (Sus scrofa)
- Rainbow Trout (Oncorhynchus mykiss)
- Rice (Oryza sativa)
- Rice Blast Fungus (Magnaporthe grisea)
- Schistosome Parasite (Schistosoma mansoni)
- Sea Anemone (Nematostella vectensis)
- Sea Vase (Ciona intestinalis)
- Sea Squirt (Ciona savignyi)
- Sea Urchin (Strongylocentrotus purpuratus)
- Sorghum (Sorghum bicolor)
- Soybean (Glycine max)
- Stem Rust Fungus (Puccinia graminis)
- Sugarcane (Saccharum officinarum)
- Thale Cress (Arabidopsis thaliana)
- Tomato (Lycopersicon esculentum)
- Toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- Wheat (Triticum aestivum)
Evolution for NR2F6 Gene
- ENSEMBL:
- Gene Tree for NR2F6 (if available)
- TreeFam:
- Gene Tree for NR2F6 (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for NR2F6: view image
Paralogs for NR2F6 Gene
Paralogs for NR2F6 Gene
(29) SIMAP similar genes for NR2F6 Gene using alignment to 4 proteins:
- NR2F6_HUMAN
- B6ZGU2_HUMAN
- F1D8R3_HUMAN
- M0R175_HUMAN
Variants for NR2F6 Gene
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| esv29611 | CNV | loss | 19812545 |
| nsv1071513 | CNV | deletion | 25765185 |
| nsv1118819 | CNV | deletion | 24896259 |
| nsv1118820 | CNV | deletion | 24896259 |
| nsv470129 | CNV | loss | 18288195 |
Gene Damage Index Score:
2.23;
40.22% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for NR2F6 Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- NR2F6
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for NR2F6 Gene
Disorders for NR2F6 Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| patulous eustachian tube |
|
|
| chronic purulent otitis media |
|
|
| eustachian tube disease |
|
|
| suppurative otitis media |
|
|
Search NR2F6 in MalaCards
View complete list of genes associated with diseases
Additional Disease Information for NR2F6
No data available for UniProtKB/Swiss-Prot and Genatlas for NR2F6 Gene
Publications for NR2F6 Gene
- The orphan nuclear receptor Ear-2 is a negative coregulator for thyroid hormone nuclear receptor function. (PMID: 10713182) Zhu XG … Cheng SY (Molecular and cellular biology 2000) 3 4 23
- Identification of two novel members of erbA superfamily by molecular cloning: the gene products of the two are highly related to each other. (PMID: 2905047) Miyajima N … Yamamoto T (Nucleic acids research 1988) 2 3 4
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4
- EAR2 and EAR3/COUP-TFI regulate transcription of the rat LH receptor. (PMID: 11682620) Zhang Y … Dufau ML (Molecular endocrinology (Baltimore, Md.) 2001) 4 23
- Nuclear orphan receptors regulate transcription of the gene for the human luteinizing hormone receptor. (PMID: 10644740) Zhang Y … Dufau ML (The Journal of biological chemistry 2000) 3 4
ExternalLinks
Products for NR2F6 Gene
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Sources for NR2F6 Gene
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