Aliases for NR2F6 Gene
External Ids for NR2F6 Gene
Previous HGNC Symbols for NR2F6 Gene
Previous GeneCards Identifiers for NR2F6 Gene
GeneCards Summary for NR2F6 Gene
NR2F6 (Nuclear Receptor Subfamily 2 Group F Member 6) is a Protein Coding gene. Diseases associated with NR2F6 include Patulous Eustachian Tube and Chronic Purulent Otitis Media. Among its related pathways are Gene Expression and Nuclear Receptor transcription pathway. Gene Ontology (GO) annotations related to this gene include DNA-binding transcription factor activity and RNA polymerase II distal enhancer sequence-specific DNA binding. An important paralog of this gene is NR2F1.
UniProtKB/Swiss-Prot Summary for NR2F6 Gene
Transcription factor predominantly involved in transcriptional repression. Binds to promoter/enhancer response elements that contain the imperfect 5'-AGGTCA-3' direct or inverted repeats with various spacings which are also recognized by other nuclear hormone receptors. Involved in modulation of hormonal responses. Represses transcriptional activity of the lutropin-choriogonadotropic hormone receptor/LHCGR gene, the renin/REN gene and the oxytocin-neurophysin/OXT gene. Represses the triiodothyronine-dependent and -independent transcriptional activity of the thyroid hormone receptor gene in a cell type-specific manner. The corepressing function towards thyroid hormone receptor beta/THRB involves at least in part the inhibition of THRB binding to triiodothyronine response elements (TREs) by NR2F6. Inhibits NFATC transcription factor DNA binding and subsequently its transcriptional activity. Acts as transcriptional repressor of IL-17 expression in Th-17 differentiated CD4(+) T cells and may be involved in induction and/or maintenance of peripheral immunological tolerance and autoimmunity. Involved in development of forebrain circadian clock; is required early in the development of the locus coeruleus (LC).