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NR2F6 (Nuclear Receptor Subfamily 2 Group F Member 6) is a Protein Coding gene. Among its related pathways are Gene Expression and Circadian rythm related genes. Gene Ontology (GO) annotations related to this gene include DNA-binding transcription factor activity and RNA polymerase II distal enhancer sequence-specific DNA binding. An important paralog of this gene is NR2F1.
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0000977 | RNA polymerase II regulatory region sequence-specific DNA binding | IBA | 21873635 |
GO:0000980 | RNA polymerase II distal enhancer sequence-specific DNA binding | IEA | -- |
GO:0000981 | DNA-binding transcription factor activity, RNA polymerase II-specific | NAS | 19274049 |
GO:0001227 | DNA-binding transcription repressor activity, RNA polymerase II-specific | IEA | -- |
GO:0003677 | DNA binding | TAS,IEA | 2905047 |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005634 | nucleus | IEA,IDA | 10644740 |
GO:0005654 | nucleoplasm | TAS | -- |
SuperPathway | Contained pathways | ||
---|---|---|---|
1 | Gene Expression |
.48
|
|
2 | Nuclear Receptor transcription pathway | ||
3 | Circadian rythm related genes | ||
4 | IL-6 signaling pathway |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0000122 | negative regulation of transcription by RNA polymerase II | IDA | 10644740 |
GO:0006355 | regulation of transcription, DNA-templated | IEA | -- |
GO:0006357 | regulation of transcription by RNA polymerase II | IBA | 21873635 |
GO:0006367 | transcription initiation from RNA polymerase II promoter | TAS | -- |
GO:0007165 | signal transduction | TAS | 2905047 |
This gene was present in the common ancestor of animals.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
chimpanzee (Pan troglodytes) |
Mammalia | NR2F6 33 32 |
|
OneToOne | |
dog (Canis familiaris) |
Mammalia | NR2F6 33 32 |
|
OneToOne | |
cow (Bos Taurus) |
Mammalia | NR2F6 33 32 |
|
OneToOne | |
mouse (Mus musculus) |
Mammalia | Nr2f6 17 33 32 |
|
||
rat (Rattus norvegicus) |
Mammalia | Nr2f6 32 |
|
||
platypus (Ornithorhynchus anatinus) |
Mammalia | NR2F6 33 |
|
OneToOne | |
oppossum (Monodelphis domestica) |
Mammalia | NR2F6 33 |
|
OneToOne | |
chicken (Gallus gallus) |
Aves | NR2F6 33 |
|
OneToOne | |
lizard (Anolis carolinensis) |
Reptilia | -- 33 |
|
ManyToMany | |
tropical clawed frog (Silurana tropicalis) |
Amphibia | nr2f6 32 |
|
||
African clawed frog (Xenopus laevis) |
Amphibia | nr2f6-prov 32 |
|
||
zebrafish (Danio rerio) |
Actinopterygii | nr2f6b 33 |
|
OneToMany | |
nr2f6a 33 32 |
|
OneToMany | |||
fruit fly (Drosophila melanogaster) |
Insecta | dsf 34 |
|
|
|
worm (Caenorhabditis elegans) |
Secernentea | unc-55 33 34 |
|
OneToOne |
SNP ID | Clin | Chr 19 pos | Variation | AA Info | Type |
---|---|---|---|---|---|
rs1000144965 | -- | 17,246,105(-) | G/A/C | upstream_transcript_variant | |
rs1000229357 | -- | 17,232,278(-) | T/A | 3_prime_UTR_variant | |
rs1000298473 | -- | 17,237,414(-) | T/C/G | intron_variant | |
rs1000412418 | -- | 17,237,569(-) | G/A | intron_variant | |
rs1000622758 | -- | 17,236,324(-) | G/A | intron_variant |
Variant ID | Type | Subtype | PubMed ID |
---|---|---|---|
esv29611 | CNV | loss | 19812545 |
nsv1071513 | CNV | deletion | 25765185 |
nsv1118819 | CNV | deletion | 24896259 |
nsv1118820 | CNV | deletion | 24896259 |
nsv470129 | CNV | loss | 18288195 |
No disorders were found for NR2F6 Gene.