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NR2F6 (Nuclear Receptor Subfamily 2 Group F Member 6) is a Protein Coding gene. Diseases associated with NR2F6 include Patulous Eustachian Tube and Chronic Purulent Otitis Media. Among its related pathways are Gene Expression and Nuclear Receptor transcription pathway. Gene Ontology (GO) annotations related to this gene include DNA-binding transcription factor activity and RNA polymerase II distal enhancer sequence-specific DNA binding. An important paralog of this gene is NR2F1.
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0000977 | RNA polymerase II regulatory region sequence-specific DNA binding | IBA | 21873635 |
GO:0000978 | RNA polymerase II proximal promoter sequence-specific DNA binding | IEA | -- |
GO:0000981 | DNA-binding transcription factor activity, RNA polymerase II-specific | ISM | 19274049 |
GO:0001227 | DNA-binding transcription repressor activity, RNA polymerase II-specific | IEA | -- |
GO:0003677 | DNA binding | IEA,TAS | 2905047 |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0000790 | nuclear chromatin | ISA | -- |
GO:0005634 | nucleus | IEA,IDA | 10644740 |
GO:0005654 | nucleoplasm | TAS | -- |
GO:0042025 | host cell nucleus | IEA | -- |
SuperPathway | Contained pathways | ||
---|---|---|---|
1 | Gene Expression |
.48
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2 | Nuclear Receptor transcription pathway | ||
3 | Circadian rythm related genes | ||
4 | IL-6 signaling pathway |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0000122 | negative regulation of transcription by RNA polymerase II | IEA,IDA | 10644740 |
GO:0006355 | regulation of transcription, DNA-templated | IEA | -- |
GO:0006357 | regulation of transcription by RNA polymerase II | IBA | 21873635 |
GO:0006367 | transcription initiation from RNA polymerase II promoter | TAS | -- |
GO:0007165 | signal transduction | TAS | 2905047 |
This gene was present in the common ancestor of animals.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
Chimpanzee (Pan troglodytes) |
Mammalia | NR2F6 30 31 |
|
OneToOne | |
Dog (Canis familiaris) |
Mammalia | NR2F6 30 31 |
|
OneToOne | |
Cow (Bos Taurus) |
Mammalia | NR2F6 30 31 |
|
OneToOne | |
Mouse (Mus musculus) |
Mammalia | Nr2f6 30 17 31 |
|
OneToOne | |
Rat (Rattus norvegicus) |
Mammalia | Nr2f6 30 |
|
||
Platypus (Ornithorhynchus anatinus) |
Mammalia | NR2F6 31 |
|
OneToOne | |
Oppossum (Monodelphis domestica) |
Mammalia | NR2F6 31 |
|
OneToOne | |
Chicken (Gallus gallus) |
Aves | NR2F6 31 |
|
OneToOne | |
Lizard (Anolis carolinensis) |
Reptilia | -- 31 |
|
ManyToMany | |
Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | nr2f6 30 |
|
||
African clawed frog (Xenopus laevis) |
Amphibia | nr2f6-prov 30 |
|
||
Zebrafish (Danio rerio) |
Actinopterygii | nr2f6b 31 |
|
OneToMany | |
nr2f6a 30 31 |
|
OneToMany | |||
Fruit Fly (Drosophila melanogaster) |
Insecta | dsf 32 |
|
|
|
Worm (Caenorhabditis elegans) |
Secernentea | unc-55 31 32 |
|
OneToOne |
Variant ID | Type | Subtype | PubMed ID |
---|---|---|---|
esv29611 | CNV | loss | 19812545 |
nsv1071513 | CNV | deletion | 25765185 |
nsv1118819 | CNV | deletion | 24896259 |
nsv1118820 | CNV | deletion | 24896259 |
nsv470129 | CNV | loss | 18288195 |
Disorder | Aliases | PubMed IDs |
---|---|---|
patulous eustachian tube |
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chronic purulent otitis media |
|
|
eustachian tube disease |
|
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suppurative otitis media |
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