Aliases for NR2F6 Gene
Aliases for NR2F6 Gene
External Ids for NR2F6 Gene
- HGNC: 7977
- Entrez Gene: 2063
- Ensembl: ENSG00000160113
- OMIM: 132880
- UniProtKB: P10588
Previous HGNC Symbols for NR2F6 Gene
- ERBAL2
Previous GeneCards Identifiers for NR2F6 Gene
- GC19M017836
- GC19M017734
- GC19M017187
- GC19M017203
- GC19M017342
- GC19M016910
Summaries for NR2F6 Gene
GeneCards Summary for NR2F6 Gene
NR2F6 (Nuclear Receptor Subfamily 2 Group F Member 6) is a Protein Coding gene. Among its related pathways are Gene Expression and IL6-mediated signaling events. Gene Ontology (GO) annotations related to this gene include DNA binding transcription factor activity and RNA polymerase II distal enhancer sequence-specific DNA binding. An important paralog of this gene is NR2F2.
UniProtKB/Swiss-Prot for NR2F6 Gene
-
Transcription factor predominantly involved in transcriptional repression. Binds to promoter/enhancer response elements that contain the imperfect 5-AGGTCA-3 direct or inverted repeats with various spacings which are also recognized by other nuclear hormone receptors. Involved in modulation of hormonal responses. Represses transcriptional activity of the lutropin-choriogonadotropic hormone receptor/LHCGR gene, the renin/REN gene and the oxytocin-neurophysin/OXT gene. Represses the triiodothyronine-dependent and -independent transcriptional activity of the thyroid hormone receptor gene in a cell type-specific manner. The corepressing function towards thyroid hormone receptor beta/THRB involves at least in part the inhibition of THRB binding to triiodothyronine response elements (TREs) by NR2F6. Inhibits NFATC transcription factor DNA binding and subsequently its transcriptional activity. Acts as transcriptional repressor of IL-17 expression in Th-17 differentiated CD4(+) T cells and may be involved in induction and/or maintenance of peripheral immunological tolerance and autoimmunity. Involved in development of forebrain circadian clock; is required early in the development of the locus coeruleus (LC).
Additional gene information for NR2F6 Gene
- Monarch Initiative
- Search for NR2F6 at DataMed
- Search for NR2F6 at HumanCyc
No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NR2F6 Gene
Genomics for NR2F6 Gene
GeneHancer (GH) Regulatory Elements for NR2F6 Gene
Promoters and enhancers for NR2F6 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data dump
GeneHancers around NR2F6 on UCSC Golden Path with GeneCards custom track
- Top Transcription factor binding sites by QIAGEN in the NR2F6 gene promoter:
-
- CREB
- deltaCREB
- NF-kappaB
- NF-kappaB1
- C/EBPalpha
- TBP
Regulatory Element Products
Genomic Locations for NR2F6 Gene
Genomic Locations for NR2F6 Gene
- chr19:17,231,883-17,245,940
- (GRCh38/hg38)
- Size:
- 14,058 bases
- Orientation:
- Minus strand
- chr19:17,342,692-17,356,749
- (GRCh37/hg19)
- Size:
- 14,058 bases
- Orientation:
- Minus strand
Genomic View for NR2F6 Gene
Genes around NR2F6 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 19p13.11 by Entrez Gene
- 19p13.11 by HGNC
- 19p13.11 by Ensembl
NR2F6 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for NR2F6 Gene
Proteins for NR2F6 Gene
-
Protein details for NR2F6 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- P10588-NR2F6_HUMAN
- Recommended name:
- Nuclear receptor subfamily 2 group F member 6
- Protein Accession:
- P10588
- B2RC68
- Q5XGA0
- Q6P586
- Q9BUE8
Protein attributes for NR2F6 Gene
- Size:
- 404 amino acids
- Molecular mass:
- 42979 Da
- Quaternary structure:
-
- Binds DNA as dimer; homodimer and heterodimer with NR2F2 and probably NR2F1 (By similarity). Interacts with THRB.
Protein Expression for NR2F6 Gene
Post-translational modifications for NR2F6 Gene
Other Protein References for NR2F6 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- R&D Systems Antibodies for NR2F6 (EAR2/NR2F6)
-
Custom Antibody ServicesOriGene Antibodies for NR2F6
- Novus Biologicals Antibodies for NR2F6
- Invitrogen Antibodies for NR2F6
- GeneTex NR2F6 Antibody for NR2F6
-
Santa Cruz Biotechnology (SCBT) Antibodies for NR2F6
Protein Products
-
OriGene Purified Proteins for NR2F6
- Search Origene for MassSpec and Protein Over-expression Lysates for NR2F6
- Origene Custom Protein Services for NR2F6
- Search GeneTex for Proteins for NR2F6
Assay Products
No data available for DME Specific Peptides for NR2F6 Gene
Domains & Families for NR2F6 Gene
Gene Families for NR2F6 Gene
- HGNC:
- IUPHAR :
- Human Protein Atlas (HPA):
-
- Nuclear receptors
- Predicted intracellular proteins
- Transcription factors
Protein Domains for NR2F6 Gene
Suggested Antigen Peptide Sequences for NR2F6 Gene
Graphical View of Domain Structure for InterPro Entry
P10588- Family:
-
- Belongs to the nuclear hormone receptor family. NR2 subfamily.
Function for NR2F6 Gene
Molecular function for NR2F6 Gene
- UniProtKB/Swiss-Prot Function:
- Transcription factor predominantly involved in transcriptional repression. Binds to promoter/enhancer response elements that contain the imperfect 5-AGGTCA-3 direct or inverted repeats with various spacings which are also recognized by other nuclear hormone receptors. Involved in modulation of hormonal responses. Represses transcriptional activity of the lutropin-choriogonadotropic hormone receptor/LHCGR gene, the renin/REN gene and the oxytocin-neurophysin/OXT gene. Represses the triiodothyronine-dependent and -independent transcriptional activity of the thyroid hormone receptor gene in a cell type-specific manner. The corepressing function towards thyroid hormone receptor beta/THRB involves at least in part the inhibition of THRB binding to triiodothyronine response elements (TREs) by NR2F6. Inhibits NFATC transcription factor DNA binding and subsequently its transcriptional activity. Acts as transcriptional repressor of IL-17 expression in Th-17 differentiated CD4(+) T cells and may be involved in induction and/or maintenance of peripheral immunological tolerance and autoimmunity. Involved in development of forebrain circadian clock; is required early in the development of the locus coeruleus (LC).
- UniProtKB/Swiss-Prot Induction:
- Inhibited by gonadotropin in granulosa cells.
- GENATLAS Biochemistry:
- nuclear receptor subfamily 2,group F,member 6,steroid/thyroid receptor superfamily
Phenotypes From GWAS Catalog for NR2F6 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000980 | RNA polymerase II distal enhancer sequence-specific DNA binding | IEA | -- |
| GO:0000981 | RNA polymerase II transcription factor activity, sequence-specific DNA binding | NAS | 19274049 |
| GO:0001227 | transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding | IEA | -- |
| GO:0003677 | DNA binding | TAS,IEA | 2905047 |
| GO:0003700 | DNA binding transcription factor activity | IDA | 10644740 |
Phenotypes for NR2F6 Gene
- MGI mutant phenotypes for NR2F6:
- inferred from 1 alleles
- GenomeRNAi human phenotypes for NR2F6:
-
- Decreased shRNA abundance (Z-score < -2)
- Increased shRNA abundance (Z-score > 2)
- Negative genetic interaction between PTTG1-/- and PTTG1+/+
- Negative genetic interaction between BLM-/- and BLM+/+
- Negative genetic interaction between PTEN-/- and PTEN+/+
- Decreased viability
- no effect
- Increased vaccinia virus (VACV) infection
- Mildly decreased CFP-tsO45G cell surface transport
- Strongly decreased CFP-tsO45G cell surface transport
- Decreased caspase 3/7 activity
- shRNA abundance <= 50%
Animal Models for NR2F6 Gene
- MGI Knock Outs for NR2F6:
-
- Nr2f6 Nr2f6<tm1Ge>
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
- Cyagen custom Knockout/knockin (KOKI) mouse models for NR2F6
-
CRISPR Products
-
OriGene CRISPR knockouts for NR2F6
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for NR2F6
- genomics-online: gRNA clones - Search results for available NR2F6 gene related products
- Applied Biological Materials CRISPR for NR2F6
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for NR2F6
- GenScript: Design CRISPR guide RNA sequences for NR2F6
miRNA for NR2F6 Gene
- miRTarBase miRNAs that target NR2F6
-
- hsa-mir-346 (MIRT004232)
- hsa-mir-335-5p (MIRT018838)
- hsa-mir-98-5p (MIRT027803)
- hsa-mir-30d-5p (MIRT047809)
- hsa-mir-196a-5p (MIRT048210)
- hsa-mir-30a-5p (MIRT049946)
- hsa-mir-6780a-3p (MIRT150615)
- hsa-mir-142-3p (MIRT440094)
- hsa-mir-6855-5p (MIRT522144)
- hsa-mir-3170 (MIRT522145)
- hsa-mir-6807-5p (MIRT522146)
- hsa-mir-5095 (MIRT522147)
- hsa-mir-7151-3p (MIRT522148)
- hsa-mir-193b-5p (MIRT522149)
- hsa-mir-5589-5p (MIRT522150)
- hsa-mir-4731-5p (MIRT522151)
- hsa-mir-7155-5p (MIRT522152)
- hsa-mir-519d-5p (MIRT522153)
- hsa-mir-4438 (MIRT522154)
- hsa-mir-512-3p (MIRT522155)
- hsa-mir-520e (MIRT522156)
- hsa-mir-520d-3p (MIRT522157)
- hsa-mir-520c-3p (MIRT522158)
- hsa-mir-520b (MIRT522159)
- hsa-mir-520a-3p (MIRT522160)
- hsa-mir-373-3p (MIRT522161)
- hsa-mir-372-3p (MIRT522162)
- hsa-mir-302e (MIRT522163)
- hsa-mir-302d-3p (MIRT522164)
- hsa-mir-302c-3p (MIRT522165)
- hsa-mir-302b-3p (MIRT522166)
- hsa-mir-302a-3p (MIRT522167)
- hsa-mir-93-5p (MIRT522168)
- hsa-mir-526b-3p (MIRT522169)
- hsa-mir-519d-3p (MIRT522170)
- hsa-mir-20b-5p (MIRT522171)
- hsa-mir-20a-5p (MIRT522172)
- hsa-mir-17-5p (MIRT522173)
- hsa-mir-106b-5p (MIRT522174)
- hsa-mir-106a-5p (MIRT522175)
- hsa-mir-548t-5p (MIRT522176)
- hsa-mir-548az-5p (MIRT522177)
- hsa-mir-335-3p (MIRT612710)
- hsa-mir-30e-3p (MIRT612711)
- hsa-mir-30d-3p (MIRT612712)
- hsa-mir-30a-3p (MIRT612713)
- hsa-mir-3942-3p (MIRT612714)
- hsa-mir-1324 (MIRT612715)
- hsa-mir-665 (MIRT667171)
- hsa-mir-6763-5p (MIRT667172)
- hsa-mir-3150a-3p (MIRT667173)
- hsa-mir-6825-5p (MIRT667174)
- hsa-mir-939-5p (MIRT667175)
- hsa-mir-1343-5p (MIRT667176)
- hsa-mir-3175 (MIRT667177)
- hsa-mir-7160-5p (MIRT667178)
- hsa-mir-4722-5p (MIRT667179)
- hsa-mir-6884-5p (MIRT667180)
- hsa-mir-485-5p (MIRT667181)
- hsa-mir-1827 (MIRT667182)
- hsa-mir-4649-3p (MIRT667183)
- hsa-mir-4478 (MIRT667184)
- hsa-mir-4419b (MIRT667185)
- hsa-mir-3929 (MIRT667186)
- hsa-mir-940 (MIRT667187)
- hsa-mir-6893-5p (MIRT667188)
- hsa-mir-6808-5p (MIRT667189)
- hsa-mir-6720-5p (MIRT701366)
- hsa-mir-6512-3p (MIRT701367)
- hsa-mir-8089 (MIRT701368)
- hsa-mir-4700-5p (MIRT701369)
- hsa-mir-4667-5p (MIRT701370)
- hsa-mir-4267 (MIRT701371)
- hsa-mir-5690 (MIRT701372)
- hsa-mir-649 (MIRT701373)
- hsa-mir-744-3p (MIRT719126)
- hsa-mir-6881-3p (MIRT719127)
- hsa-mir-7111-3p (MIRT719128)
- hsa-mir-4423-5p (MIRT719129)
- hsa-mir-6501-5p (MIRT719130)
- hsa-mir-367-5p (MIRT719131)
- hsa-mir-1267 (MIRT719132)
- hsa-mir-101-3p (MIRT761075)
- hsa-mir-1262 (MIRT761707)
- hsa-mir-1273g-3p (MIRT761968)
- hsa-mir-1294 (MIRT762342)
- hsa-mir-1910-3p (MIRT763315)
- hsa-mir-2467-3p (MIRT764111)
- hsa-mir-4252 (MIRT768023)
- hsa-mir-4257 (MIRT768148)
- hsa-mir-4316 (MIRT768588)
- hsa-mir-4677-3p (MIRT770911)
- hsa-mir-4701-3p (MIRT771317)
- hsa-mir-4793-3p (MIRT772412)
- hsa-mir-508-5p (MIRT773174)
- hsa-mir-582-5p (MIRT775326)
- hsa-mir-6511a-5p (MIRT776814)
- hsa-mir-655-5p (MIRT777308)
- hsa-mir-661 (MIRT777444)
- hsa-mir-6736-5p (MIRT778068)
- hsa-mir-6742-3p (MIRT778145)
- hsa-mir-6776-5p (MIRT778754)
- hsa-mir-6849-3p (MIRT780311)
- hsa-mir-766-3p (MIRT781881)
- hsa-mir-7703 (MIRT782033)
miRNA Products
Inhibitory RNA Products
- Origene sirna, shrna, and RNAi products in human, mouse, rat for NR2F6
- Browse OriGene Inhibitory RNA Products For NR2F6
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for NR2F6
- genomics-online: shRNA clones - Search results for available NR2F6 gene related products
Clone Products
- Sino Biological Human cDNA Clone for NR2F6
- VectorBuilder custom plasmid, inducible vectors for NR2F6
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for NR2F6
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Addgene plasmids for NR2F6
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for NR2F6
- genomics-online: cdna clones - Search results for available NR2F6 gene related products
- orf clones - Search results for available NR2F6 gene related products
- Applied Biological Materials Clones for NR2F6
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
Cell Line Products
-
Horizon Cell Lines for NR2F6
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for NR2F6 Gene
Localization for NR2F6 Gene
Subcellular locations from UniProtKB/Swiss-Prot for NR2F6 Gene
- Nucleus.
| Compartment | Confidence |
|---|---|
| nucleus | 5 |
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005634 | nucleus | IEA,IDA | 10644740 |
| GO:0005654 | nucleoplasm | TAS | -- |
No data available for Subcellular locations from the Human Protein Atlas (HPA) for NR2F6 Gene
Pathways & Interactions for NR2F6 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Gene Expression |
.48
|
|
| 2 | Nuclear Receptor transcription pathway | ||
| 3 | Circadian rythm related genes | ||
| 4 | IL6-mediated signaling events | ||
Pathways by source for NR2F6 Gene
3 BioSystems pathways for NR2F6 Gene
3 Reactome pathways for NR2F6 Gene
Interacting Proteins for NR2F6 Gene
Selected Interacting proteins:
P10588-NR2F6_HUMAN
ENSP00000291442
for NR2F6 Gene via
IID
UniProtKB
MINT
STRING
GPS-Prot Interaction Network for NR2F6
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000122 | negative regulation of transcription by RNA polymerase II | IDA | 10644740 |
| GO:0006351 | transcription, DNA-templated | IEA | -- |
| GO:0006355 | regulation of transcription, DNA-templated | IEA | -- |
| GO:0006367 | transcription initiation from RNA polymerase II promoter | TAS | -- |
| GO:0007165 | signal transduction | TAS | 2905047 |
Transcripts for NR2F6 Gene
mRNA/cDNA for NR2F6 Gene
- (1) REFSEQ mRNAs :
- (7) Additional mRNA sequences :
- (286) Selected AceView cDNA sequences:
- (2) Ensembl transcripts including schematic representations, and UCSC links where relevant :
-
- ENST00000291442 2404 bps (uc002nfq.4)
- ENST00000596878 731 bps (uc060vfg.1)
Unigene Clusters for NR2F6 Gene
CRISPR Products
-
OriGene CRISPR knockouts for NR2F6
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for NR2F6
- genomics-online: gRNA clones - Search results for available NR2F6 gene related products
- Applied Biological Materials CRISPR for NR2F6
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for NR2F6
- GenScript: Design CRISPR guide RNA sequences for NR2F6
miRNA Products
Inhibitory RNA Products
- Origene sirna, shrna, and RNAi products in human, mouse, rat for NR2F6
- Browse OriGene Inhibitory RNA Products For NR2F6
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for NR2F6
- genomics-online: shRNA clones - Search results for available NR2F6 gene related products
Clone Products
- Sino Biological Human cDNA Clone for NR2F6
- VectorBuilder custom plasmid, inducible vectors for NR2F6
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for NR2F6
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Addgene plasmids for NR2F6
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for NR2F6
- genomics-online: cdna clones - Search results for available NR2F6 gene related products
- orf clones - Search results for available NR2F6 gene related products
- Applied Biological Materials Clones for NR2F6
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
Expression for NR2F6 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
-
Trophoblast (Extraembryonic Tissues)
- Mural Trophectoderm Cells Mural Trophectoderm
- Brain (Nervous System)
- Kidney (Urinary System)
- Thymus (Hematopoietic System)
- Eye (Sensory Organs)
-
Placenta (Extraembryonic Tissues)
mRNA differential expression in normal tissues according to GTEx for NR2F6 Gene
This gene is overexpressed in Liver (x4.3).
This gene is overexpressed in Breast (51.5) and Retina (7.4).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for NR2F6 Gene
NURSA nuclear receptor signaling pathways regulating expression of NR2F6 Gene:
NR2F6SOURCE GeneReport for Unigene cluster for NR2F6 Gene:
Hs.466148mRNA Expression by UniProt/SwissProt for NR2F6 Gene:
P10588-NR2F6_HUMAN
Tissue specificity:
Expressed in heart, placenta, liver, skeletal muscle, kidney and pancreas.
Evidence on tissue expression from TISSUES for NR2F6 Gene
- Lung(4.5)
- Liver(4.4)
- Kidney(4.3)
- Pancreas(4.2)
- Nervous system(2.7)
Primer Products
-
OriGene qPCR primer pairs for NR2F6
-
OriGene qPCR primer pairs and template standards for NR2F6
- genomics-online: primer clones - Search results for available NR2F6 gene related products
Gene Expression Assay Products
No data available for Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for NR2F6 Gene
Orthologs for NR2F6 Gene
This gene was present in the common ancestor of animals.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | NR2F6 34 33 |
|
OneToOne | |
| dog (Canis familiaris) |
Mammalia | NR2F6 34 33 |
|
OneToOne | |
| cow (Bos Taurus) |
Mammalia | NR2F6 34 33 |
|
OneToOne | |
| mouse (Mus musculus) |
Mammalia | Nr2f6 16 34 33 |
|
||
| rat (Rattus norvegicus) |
Mammalia | Nr2f6 33 |
|
||
| platypus (Ornithorhynchus anatinus) |
Mammalia | NR2F6 34 |
|
OneToOne | |
| oppossum (Monodelphis domestica) |
Mammalia | NR2F6 34 |
|
OneToOne | |
| chicken (Gallus gallus) |
Aves | NR2F6 34 |
|
OneToOne | |
| lizard (Anolis carolinensis) |
Reptilia | -- 34 |
|
ManyToMany | |
| tropical clawed frog (Silurana tropicalis) |
Amphibia | nr2f6 33 |
|
||
| African clawed frog (Xenopus laevis) |
Amphibia | nr2f6-prov 33 |
|
||
| zebrafish (Danio rerio) |
Actinopterygii | nr2f6b 34 |
|
OneToMany | |
| nr2f6a 34 33 |
|
OneToMany | |||
| fruit fly (Drosophila melanogaster) |
Insecta | dsf 35 |
|
|
|
| worm (Caenorhabditis elegans) |
Secernentea | unc-55 34 35 |
|
OneToOne |
- Species where no ortholog for NR2F6 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea squirt (Ciona intestinalis)
- sea squirt (Ciona savignyi)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
Evolution for NR2F6 Gene
- ENSEMBL:
- Gene Tree for NR2F6 (if available)
- TreeFam:
- Gene Tree for NR2F6 (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for NR2F6: view image
Paralogs for NR2F6 Gene
Paralogs for NR2F6 Gene
(29) SIMAP similar genes for NR2F6 Gene using alignment to 4 proteins:
- NR2F6_HUMAN
- B6ZGU2_HUMAN
- F1D8R3_HUMAN
- M0R175_HUMAN
Variants for NR2F6 Gene
| SNP ID | Clin | Chr 19 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| rs1000144965 | -- | 17,246,105(-) | G/C | upstream_transcript_variant | |
| rs1000229357 | -- | 17,232,278(-) | T/A | 3_prime_UTR_variant | |
| rs1000298473 | -- | 17,237,414(-) | T/C | intron_variant | |
| rs1000412418 | -- | 17,237,569(-) | G/A | intron_variant | |
| rs1000622758 | -- | 17,236,324(-) | G/A | intron_variant |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| nsv470129 | CNV | loss | 18288195 |
| nsv1118820 | CNV | deletion | 24896259 |
| nsv1118819 | CNV | deletion | 24896259 |
| nsv1071513 | CNV | deletion | 25765185 |
| esv29611 | CNV | loss | 19812545 |
Gene Damage Index Score:
2.23;
40.22% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for NR2F6 Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- NR2F6
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NR2F6 Gene
Disorders for NR2F6 Gene
Additional Disease Information for NR2F6
No disorders were found for NR2F6 Gene.
No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for NR2F6 Gene
Publications for NR2F6 Gene
- The orphan nuclear receptor Ear-2 is a negative coregulator for thyroid hormone nuclear receptor function. (PMID: 10713182) Zhu XG … Cheng SY (Molecular and cellular biology 2000) 3 4 22 58
- Identification of two novel members of erbA superfamily by molecular cloning: the gene products of the two are highly related to each other. (PMID: 2905047) Miyajima N … Yamamoto T (Nucleic acids research 1988) 2 3 4 58
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
- EAR2 and EAR3/COUP-TFI regulate transcription of the rat LH receptor. (PMID: 11682620) Zhang Y … Dufau ML (Molecular endocrinology (Baltimore, Md.) 2001) 4 22 58
- Nuclear orphan receptors regulate transcription of the gene for the human luteinizing hormone receptor. (PMID: 10644740) Zhang Y … Dufau ML (The Journal of biological chemistry 2000) 3 4 58
Products for NR2F6 Gene
- R&D Systems Antibodies for NR2F6 (EAR2/NR2F6)
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- Custom Antibody ServicesOriGene Antibodies for NR2F6
- Browse OriGene ELISA Kits
- Custom Assay Services
- OriGene Purified Proteins for NR2F6
- Search Origene for MassSpec and Protein Over-expression Lysates for NR2F6
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- Origene sirna, shrna, and RNAi products in human, mouse, rat for NR2F6
- Browse OriGene Inhibitory RNA Products For NR2F6
- OriGene qPCR primer pairs for NR2F6
- OriGene qPCR primer pairs and template standards for NR2F6
- OriGene CRISPR knockouts for NR2F6
- OriGene ORF clones in human for NR2F6
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Browse OriGene miRNA Products For NR2F6
- GenScript: Next-day shipping of latest version cDNA ORF clones for NR2F6 in any vector
- GenScript Custom Purified and Recombinant Proteins Services for NR2F6
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- GenScript Custom overexpressing Cell Line Services for NR2F6
- GenScript: Design CRISPR guide RNA sequences for NR2F6
- Design optimal peptide antigens
- CloneReady with Over 120,000 Genes
- Gene Synthesis: Any Gene in Any Vector
- Vector-based siRNA and miRNA, Ready for Transfection
- Gene Mutant Library, Variants up to 10^11
- Plasmid Preparation
- GenScript Custom Peptide Services for NR2F6
- Sino Biological Human cDNA Clone for NR2F6
- Browse Sino Biological Recombinant Proteins
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- High-throughput Antibody Production Service
- Protein Production Service
- Epitope Tag Antibodies & Reporter Protein Antibodies
- Lentiviral ORF Clones
- Novus Biologicals Antibodies for NR2F6
- Novus Biologicals proteins and lysates for NR2F6
- Novus Biologicals
- Novus Biologicals Tissue Microarrays
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- VectorBuilder custom plasmid, inducible vectors for NR2F6
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for NR2F6
- VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Addgene plasmids for NR2F6
- antibodies-online: Search results for 94 available NR2F6 Antibodies ranked by validation data
- Compare Top NR2F6 Antibodies
- antibodies-online: Search results for 4 available NR2F6 Elisa Kits ranked by validation data
- Compare Top NR2F6 Elisa Kits
- antibodies-online: Search results for 6 available NR2F6 Proteins ranked by validation data
- Compare Top NR2F6 Proteins
- GeneTex NR2F6 Antibody for NR2F6
- Search GeneTex for Proteins for NR2F6
- Santa Cruz Biotechnology (SCBT) Antibodies for NR2F6
- Search Santa Cruz Biotechnology (SCBT) for NR2F6 siRNA/shRNA
- Santa Cruz Biotechnology (SCBT) CRISPR for NR2F6
- Horizon Cell Lines for NR2F6
- genomics-online: cdna clones - Search results for available NR2F6 gene related products
- orf clones - Search results for available NR2F6 gene related products
- genomics-online: gRNA clones - Search results for available NR2F6 gene related products
- genomics-online: primer clones - Search results for available NR2F6 gene related products
- genomics-online: shRNA clones - Search results for available NR2F6 gene related products
- Browse GeneCopoeia Cell Lines
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for NR2F6
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for NR2F6
- GeneCopoeia miRNA 3'UTR Target clone products for NR2F6
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for NR2F6
Sources for NR2F6 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) ASD
- (29) ECgene
- (30) GeneAnnot
- (31) CGAP SAGE
- (32) SOURCE
- (33) HomoloGene
- (34) PanEnsembl
- (35) euGenes
- (36) SGD
- (37) FlyBase
- (38) WormBase
- (39) Pseudogene
- (40) DGV
- (41) dbSNP
- (42) GenAtlas
- (43) HGMD
- (44) GAD
- (45) BGMUT
- (46) HuGE
- (47) Atlas
- (48) Cell Signaling Technology
- (49) GenBank
- (50) H-invDB
- (51) HORDE
- (52) HUGE
- (53) IMGT
- (54) Leiden
- (55) miRBase
- (56) DME
- (57) OriGene
- (58) PubMed
- (59) R&D Systems
- (60) TGDB
- (61) Tocris
- (62) Abcam
- (63) Novus Biologicals
- (64) ProSpec
- (65) Sino Biological
- (66) GenScript
- (67) Qiagen
- (68) Cloud-Clone Corp.
- (69) OCA
- (70) Proteopedia
- (71) MOPED
- (72) neXtProt
- (73) Reactome
- (74) GeneGo (Thomson Reuters)
- (75) fRNAdb
- (76) DISEASES
- (77) SIMAP
- (78) GenomeRNAi
- (79) LifeMap
- (80) miRTarBase
- (81) MalaCards
- (82) Invitrogen
- (83) BitterDB
- (84) Vector BioLabs
- (85) ESI-BIO
- (86) RefSeq
- (87) BioSystems
- (88) MaxQB
- (89) IUPHAR
- (90) BioGPS
- (91) Illumina
- (92) COMPARTMENTS
- (93) HOMER
- (94) PaxDb
- (95) ApexBio
- (96) Addgene
- (97) antibodies-online
- (98) CYP
- (99) NONCODE
- (100) SwitchGear Genomics
- (101) TreeFam
- (102) PathCards
- (103) GeneReviews
- (104) GeneTex
- (105) Taconic Biosciences
- (106) GTEx
- (107) ProteomicsDB
- (108) SCBT
- (109) DGIdb
- (110) ClinicalTrials
- (111) FDA Approved Drugs
- (112) RVIS
- (113) SIGNOR
- (114) diseasecard
- (115) NIH Rare Diseases
- (116) Orphanet
- (117) UMLS
- (118) GTR
- (119) Disease Ontology
- (120) Genetics Home Reference
- (121) MeSH
- (122) MedlinePlus
- (123) CDC
- (124) NINDS
- (125) NCBI Bookshelf
- (126) ClinVar
- (127) Gene Damage Index
- (128) ViGene Biosciences
- (129) HPO
- (130) UDN
- (131) VISTA
- (132) FANTOM5
- (133) ENCODE
- (134) ProSci
- (135) Horizon
- (136) NURSA
- (137) IID
- (138) Cyagen
- (139) VectorBuilder
- (140) SNPedia
- (141) BRCA Exchange
- (142) St John's Lab
- (143) CIViC
- (144) ProteoGenix
- (145) dbSUPER
- (146) TISSUES
- (147) Gene ORGANizer
- (148) abm
- (149) CrownBio
- (150) Human Protein Atlas
- (151) GWAS Catalog
- (152) Monarch Initiative
- (153) DataMed
- (154) HumanCyc
- (155) genomics-online
- (156) UCNEbase
- (157) EPDnew
- (158) Applied Biosystems
- (159) GlyConnect
- (160) Aminode
- (161) GeneCopoeia
- (162) GPS-Prot
- (163) RNACentral
- (164) LncRNADisease
- (165) LOVD
- (166) miR2Disease
- (167) DiseaseEnhancer
- (168) Boster Bio
- (169) Biorbyt