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This gene encodes a member of the steroid thyroid hormone superfamily of nuclear receptors. The encoded protein is a ligand inducible transcription factor that is involved in the regulation of many different genes. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Mar 2010] See more...
Aliases for NR2F2 Gene
Aliases for NR2F2 Gene
- Chicken Ovalbumin Upstream Promoter Transcription Factor 2 3
- Chicken Ovalbumin Upstream Promoter-Transcription Factor I 3
- Nuclear Receptor Subfamily 2, Group F, Member 2 2
- ADP-Ribosylation Factor Related Protein 1 3
- Apolipoprotein AI Regulatory Protein 1 3
- COUP-TF II 4
- COUP-TFII 2
- COUPTFII 3
- COUP-TF2 4
- CHTD4 3
- SRXX5 3
- NR2F2 5
External Ids for NR2F2 Gene
- HGNC: 7976
- NCBI Entrez Gene: 7026
- Ensembl: ENSG00000185551
- OMIM®: 107773
- UniProtKB/Swiss-Prot: P24468
Previous HGNC Symbols for NR2F2 Gene
- ARP1
- TFCOUP2
Previous GeneCards Identifiers for NR2F2 Gene
- GC15P093321
- GC15P090625
- GC15P094456
- GC15P094603
- GC15P094674
- GC15P096869
- GC15P072999
Summaries for NR2F2 Gene
-
This gene encodes a member of the steroid thyroid hormone superfamily of nuclear receptors. The encoded protein is a ligand inducible transcription factor that is involved in the regulation of many different genes. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Mar 2010]
GeneCards Summary for NR2F2 Gene
NR2F2 (Nuclear Receptor Subfamily 2 Group F Member 2) is a Protein Coding gene. Diseases associated with NR2F2 include Congenital Heart Defects, Multiple Types, 4 and 46,Xx Sex Reversal 5. Among its related pathways are Nuclear Receptor transcription pathway and Ectoderm Differentiation. Gene Ontology (GO) annotations related to this gene include DNA-binding transcription factor activity and sequence-specific DNA binding. An important paralog of this gene is NR2F1.
UniProtKB/Swiss-Prot Summary for NR2F2 Gene
-
Ligand-activated transcription factor. Activated by high concentrations of 9-cis-retinoic acid and all-trans-retinoic acid, but not by dexamethasone, cortisol or progesterone (in vitro). Regulation of the apolipoprotein A-I gene transcription. Binds to DNA site A.
Additional gene information for NR2F2 Gene
No data available for Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for NR2F2 Gene
Genomics for NR2F2 Gene
GeneHancer (GH) Regulatory Elements Pubs
Promoters and enhancers for NR2F2 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication |
Request up-to-date GeneHancer data (full dataset)
GeneHancers around NR2F2 on the GeneHancer Hub at the UCSC Golden Path
Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for NR2F2
- Top Transcription factor binding sites by QIAGEN in the NR2F2 gene promoter:
-
- MyoD
- NF-kappaB1
- RSRFC4
Genomic Locations for NR2F2 Gene
Latest Assembly
- chr15:96,325,938-96,340,263
- (GRCh38/hg38)
- Size:
- 14,326 bases
- Orientation:
- Plus strand
Previous Assembly
- chr15:96,869,275-96,883,492
- (GRCh37/hg19 by Entrez Gene)
- Size:
- 14,218 bases
- Orientation:
- Plus strand
Genomic View for NR2F2 Gene
Genes around NR2F2 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 15q26.2 by HGNC
- 15q26.2 by Entrez Gene
- 15q26.2 by Ensembl
NR2F2 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for NR2F2 Gene
Proteins for NR2F2 Gene
-
Protein details for NR2F2 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- P24468-COT2_HUMAN
- Recommended name:
- COUP transcription factor 2
- Protein Accession:
- P24468
- B4DQJ2
- B6ZGU1
- Q03754
- Q3KQR7
Protein attributes for NR2F2 Gene
- Size:
- 414 amino acids
- Molecular mass:
- 45571 Da
- Quaternary structure:
-
- Interacts with SQSTM1 (By similarity). Binds DNA as a dimer; homodimer or heterodimer with NR2F6. Interacts with NCOA1, NCOA2, NCOA3 and PPARGC1A. Interacts with ZFPM2 (By similarity).
Protein Expression for NR2F2 Gene
Post-translational modifications for NR2F2 Gene
Other Protein References for NR2F2 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibodies for research
- LifeSpan BioSciences COUP-TFII / NR2F2 Antibody
- G Biosciences Immunotag™ ARP-1 Antibody
- Novus Biologicals Antibodies for NR2F2
-
Abcam antibodies for NR2F2
- Invitrogen Antibodies for NR2F2 (AFLGC-NR2F2)
- antibodies-online: Show 43 available NR2F2 Antibodies ranked by validation data
- Compare Top NR2F2 Antibodies
-
Recommended
-
Santa Cruz Biotechnology (SCBT) Antibodies for NR2F2
- Sino Biological Antibodies for NR2F2
Protein products for research
-
OriGene Purified Proteins for NR2F2
- Search Origene for MassSpec and Protein Over-expression Lysates for NR2F2
- Origene Custom Protein Services for NR2F2
-
Abcam proteins for NR2F2
Assay products for research
No data available for DME Specific Peptides for NR2F2 Gene
Domains & Families for NR2F2 Gene
Gene Families for NR2F2 Gene
- HGNC:
- IUPHAR :
- Human Protein Atlas (HPA):
-
- Disease related genes
- Nuclear receptors
- Predicted intracellular proteins
- Transcription factors
Protein Domains for NR2F2 Gene
- InterPro:
- Blocks:
-
- Steroid hormone receptor signature
- COUP transcription factor (2F nuclear receptor) family signature
- Zinc finger, C4-type, C-terminal
Suggested Antigen Peptide Sequences for NR2F2 Gene
- GenScript: Design optimal peptide antigens:
-
- cDNA, FLJ78985, highly similar to COUP transcription factor 2 (B4DQJ2_HUMAN)
- Nuclear receptor subfamily 2 group F member 2 (COT2_HUMAN)
- Ovalbumin upstream promoter-transcription factor II variant 1 (F1D8R0_HUMAN)
- cDNA FLJ50900, highly similar to COUP transcription factor 2 (Q3KQR7_HUMAN)
Graphical View of Domain Structure for InterPro Entry
P24468- Family:
-
- Belongs to the nuclear hormone receptor family. NR2 subfamily.
Function for NR2F2 Gene
Molecular function for NR2F2 Gene
- UniProtKB/Swiss-Prot Function:
- Ligand-activated transcription factor. Activated by high concentrations of 9-cis-retinoic acid and all-trans-retinoic acid, but not by dexamethasone, cortisol or progesterone (in vitro). Regulation of the apolipoprotein A-I gene transcription. Binds to DNA site A.
- GENATLAS Biochemistry:
- nuclear receptor subfamily 2,group F,member 2,negative post transcriptional regulator of MYOD1 function,may be required for angiogenesis and heart developpment, steroid/thyroid hormone receptor superfamily
Phenotypes From GWAS Catalog for NR2F2 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000978 | RNA polymerase II proximal promoter sequence-specific DNA binding | IBA | 21873635 |
| GO:0001972 | retinoic acid binding | IBA,IDA | 18798693 |
| GO:0003677 | DNA binding | IEA | -- |
| GO:0003700 | DNA-binding transcription factor activity | IDA | 9343308 |
| GO:0004879 | nuclear receptor activity | TAS,IDA | 18798693 |
Phenotypes for NR2F2 Gene
- MGI mutant phenotypes for NR2F2:
-
inferred from 4 alleles
- nervous system phenotype
- muscle phenotype
- homeostasis/metabolism phenotype
- growth/size/body region phenotype
- cardiovascular system phenotype
- immune system phenotype
- mortality/aging
- digestive/alimentary phenotype
- endocrine/exocrine gland phenotype
- reproductive system phenotype
- vision/eye phenotype
- embryo phenotype
- pigmentation phenotype
- no phenotypic analysis
- GenomeRNAi human phenotypes for NR2F2:
Animal Models for research
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
CRISPR products for research
- Applied Biological Materials (abm): CRISPR Clones for NR2F2 - Starting at $85 >
- * NR2F2 CRISPR as ready-to-use vector or virus: Non-viral | Lenti- | Adeno- | AAV- | siRNA - Browse All
- * Cas9 Nucleases, Nickases, Null Mutants, and GFP tag also available.
-
OriGene CRISPR knockouts for NR2F2
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for NR2F2
-
Santa Cruz Biotechnology (SCBT) CRISPR for NR2F2
miRNA for NR2F2 Gene
- miRTarBase miRNAs that target NR2F2
-
- hsa-miR-302a-3p (MIRT006555)
- mmu-miR-15a-5p (MIRT011533)
- mmu-miR-297a-5p (MIRT012938)
- hsa-miR-101-3p (MIRT027270)
- hsa-miR-935 (MIRT036667)
- hsa-miR-877-5p (MIRT037296)
- hsa-miR-129-5p (MIRT073558)
- hsa-miR-4709-5p (MIRT073561)
- hsa-let-7f-2-3p (MIRT073563)
- hsa-miR-144-3p (MIRT073564)
- hsa-miR-409-3p (MIRT073565)
- hsa-miR-1185-2-3p (MIRT073566)
- hsa-miR-1185-1-3p (MIRT073567)
- hsa-miR-4325 (MIRT073568)
- hsa-miR-5680 (MIRT073569)
- hsa-miR-7703 (MIRT073570)
- hsa-miR-582-5p (MIRT471982)
- hsa-miR-4684-3p (MIRT471983)
- hsa-miR-548z (MIRT471984)
- hsa-miR-548h-3p (MIRT471985)
- hsa-miR-548d-3p (MIRT471986)
- hsa-miR-548bb-3p (MIRT471987)
- hsa-miR-548ac (MIRT471988)
- hsa-miR-203a-3p (MIRT547307)
- hsa-miR-5189-3p (MIRT574560)
- hsa-miR-519c-3p (MIRT574561)
- hsa-miR-519b-3p (MIRT574562)
- hsa-miR-519a-3p (MIRT574563)
- hsa-miR-520c-3p (MIRT574564)
- hsa-miR-520b (MIRT574565)
- hsa-miR-302b-3p (MIRT574566)
- hsa-miR-302c-3p (MIRT574567)
- hsa-miR-302e (MIRT574568)
- hsa-miR-372-3p (MIRT574569)
- hsa-miR-520a-3p (MIRT574570)
- hsa-miR-373-3p (MIRT574571)
- hsa-miR-520d-3p (MIRT574572)
- hsa-miR-302d-3p (MIRT574573)
- hsa-miR-520e (MIRT574574)
- mmu-miR-3473c (MIRT577063)
- mmu-miR-343 (MIRT577064)
- mmu-miR-698-3p (MIRT582122)
- mmu-miR-3086-3p (MIRT582123)
- mmu-miR-1952 (MIRT600577)
- hsa-miR-6793-3p (MIRT612716)
- hsa-miR-362-3p (MIRT612717)
- hsa-miR-329-3p (MIRT612718)
- hsa-miR-8485 (MIRT612719)
- hsa-miR-510-3p (MIRT641995)
- hsa-miR-513a-5p (MIRT641996)
- hsa-miR-4645-3p (MIRT641997)
- hsa-miR-27a-3p (MIRT641998)
- hsa-miR-27b-3p (MIRT641999)
- hsa-miR-216a-3p (MIRT642000)
- hsa-miR-3681-3p (MIRT642001)
- hsa-miR-128-3p (MIRT642002)
- hsa-miR-6818-3p (MIRT655741)
- hsa-miR-4713-5p (MIRT655742)
- hsa-miR-2116-3p (MIRT655743)
- hsa-miR-532-3p (MIRT655744)
- hsa-miR-150-5p (MIRT655745)
- hsa-miR-6749-3p (MIRT716947)
- mmu-miR-302a-3p (MIRT731069)
Transcription Factor Targets for NR2F2 Gene
Targeted motifs for NR2F2 Gene
HOMER Transcription Factor Regulatory Elements motif NR2F2
- Consensus sequence: AGRGGTCA Submotif: canonical Cell Type: Artia GEO ID: GSE46497
miRNA products for research
Inhibitory RNAs for research
- Origene shrna, sirna, and RNAi products in human, mouse, rat for NR2F2
- Browse OriGene Inhibitory RNA Products For NR2F2
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for NR2F2
Clone products for research
- Applied Biological Materials (abm): Clones for NR2F2 - Starting at $45 >
- * NR2F2 as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Retro- | Protein Vector - Browse All
- * Viral Packaging Services and High Titer Production Services also available.
-
- MG206541
- MG225381
- MR206541
- MR206541L3
- MR206541L4
- MR225381
- MR225381L3
- MR225381L4
- RC206753
- RC206753L1
- RC206753L2
- RC206753L3
- RC206753L4
- RC226609
- RC226609L1
- RC226609L2
- RC226609L3
- RC226609L4
- RC226714
- RC226714L3
- RC226714L4
- RC226862
- RC226862L3
- RC226862L4
- RG206753
- RG226609
- RG226714
- RG226862
- RR213536
- RR213536L3
- RR213536L4
- MR206541L3V
- MR206541L4V
- MR225381L3V
- MR225381L4V
- RC206753L1V
- RC206753L2V
- RC206753L3V
- RC206753L4V
- RC226609L1V
- RC226609L2V
- RC226609L3V
- RC226609L4V
- RC226714L3V
- RC226714L4V
- RC226862L3V
- RC226862L4V
- RR213536L3V
- RR213536L4V
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Sino Biological Human cDNA Clone for NR2F2
- Addgene plasmids for NR2F2
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for NR2F2
Cell Lines for research
-
Horizon Cell Lines for NR2F2
No data available for Enzyme Numbers (IUBMB) for NR2F2 Gene
Localization for NR2F2 Gene
Subcellular locations from UniProtKB/Swiss-Prot for NR2F2 Gene
- Nucleus.
| Compartment | Confidence |
|---|---|
| nucleus | 5 |
| cytosol | 4 |
| plasma membrane | 2 |
| extracellular | 2 |
| cytoskeleton | 2 |
| mitochondrion | 2 |
| peroxisome | 1 |
| endoplasmic reticulum | 1 |
| endosome | 1 |
| lysosome | 1 |
| golgi apparatus | 1 |
- Cytosol (2)
- Nucleoplasm (2)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000785 | chromatin | IBA | -- |
| GO:0005634 | nucleus | IEA,IDA | 19210544 |
| GO:0005654 | nucleoplasm | IDA | -- |
| GO:0005829 | cytosol | IDA | -- |
Pathways & Interactions for NR2F2 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Oct4 in Mammalian ESC Pluripotency |
Oct4 in Mammalian ESC Pluripotency
-
|
|
| 2 | Developmental Biology | ||
| 3 | Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha) | ||
| 4 | Ectoderm Differentiation | ||
| 5 | FOXA1 transcription factor network | ||
Pathways by source for NR2F2 Gene
4 BioSystems pathways for NR2F2 Gene
2 Reactome pathways for NR2F2 Gene
1 Qiagen pathway for NR2F2 Gene
- Oct4 in Mammalian ESC Pluripotency
Interacting Proteins for NR2F2 Gene
Selected Interacting proteins:
P24468-COT2_HUMAN
ENSP00000377721
for NR2F2 Gene via
UniProtKB
MINT
STRING
IID
GPS-Prot Interaction Network for NR2F2
SIGNOR curated interactions for NR2F2 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000122 | negative regulation of transcription by RNA polymerase II | IDA | 9343308 |
| GO:0001701 | in utero embryonic development | IEA | -- |
| GO:0001764 | neuron migration | IEA | -- |
| GO:0001893 | maternal placenta development | IEA | -- |
| GO:0001937 | negative regulation of endothelial cell proliferation | IMP | 19210544 |
Transcripts for NR2F2 Gene
mRNA/cDNA for NR2F2 Gene
- 4 REFSEQ mRNAs :
- 17 NCBI additional mRNA sequence :
- 5 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
-
- ENST00000394166 5287 nts (view in UCSC)
- ENST00000394171 3501 nts (view in UCSC)
- ENST00000421109 2214 nts (view in UCSC)
- ENST00000453270 1712 nts (view in UCSC)
- ENST00000559679 382 nts (view in UCSC)
CRISPR products for research
- Applied Biological Materials (abm): CRISPR Clones for NR2F2 - Starting at $85 >
- * NR2F2 CRISPR as ready-to-use vector or virus: Non-viral | Lenti- | Adeno- | AAV- | siRNA - Browse All
- * Cas9 Nucleases, Nickases, Null Mutants, and GFP tag also available.
-
OriGene CRISPR knockouts for NR2F2
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for NR2F2
-
Santa Cruz Biotechnology (SCBT) CRISPR for NR2F2
miRNA products for research
Inhibitory RNAs for research
- Origene shrna, sirna, and RNAi products in human, mouse, rat for NR2F2
- Browse OriGene Inhibitory RNA Products For NR2F2
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for NR2F2
Clone products for research
- Applied Biological Materials (abm): Clones for NR2F2 - Starting at $45 >
- * NR2F2 as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Retro- | Protein Vector - Browse All
- * Viral Packaging Services and High Titer Production Services also available.
-
- MG206541
- MG225381
- MR206541
- MR206541L3
- MR206541L4
- MR225381
- MR225381L3
- MR225381L4
- RC206753
- RC206753L1
- RC206753L2
- RC206753L3
- RC206753L4
- RC226609
- RC226609L1
- RC226609L2
- RC226609L3
- RC226609L4
- RC226714
- RC226714L3
- RC226714L4
- RC226862
- RC226862L3
- RC226862L4
- RG206753
- RG226609
- RG226714
- RG226862
- RR213536
- RR213536L3
- RR213536L4
- MR206541L3V
- MR206541L4V
- MR225381L3V
- MR225381L4V
- RC206753L1V
- RC206753L2V
- RC206753L3V
- RC206753L4V
- RC226609L1V
- RC226609L2V
- RC226609L3V
- RC226609L4V
- RC226714L3V
- RC226714L4V
- RC226862L3V
- RC226862L4V
- RR213536L3V
- RR213536L4V
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Sino Biological Human cDNA Clone for NR2F2
- Addgene plasmids for NR2F2
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for NR2F2
| ExUns: | 1a | · | 1b | · | 1c | ^ | 2 | ^ | 3a | · | 3b | ^ | 4 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | - | |||||||||||
| SP2: | |||||||||||||
| SP3: | - |
Relevant External Links for NR2F2 Gene
- GeneLoc Exon Structure for
- NR2F2
Expression for NR2F2 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
-
Heart (Cardiovascular System)
- Cardiomyocytes Left Atrium
- Venous Endothelial Cells Cardinal Veins
- Cardiomyocytes Right Atrium
-
Endothelium (Cardiovascular System)
- Lymphatic Endothelial Cells Lymphatic Vessels
- Venous Endothelial Cells Cardinal Veins
-
Lymph (Hematopoietic System)
- Lymphatic Endothelial Cells Lymphatic Vessels
- Eye (Sensory Organs)
mRNA differential expression in normal tissues according to GTEx for NR2F2 Gene
This gene is overexpressed in Ovary (x4.7).
This gene is overexpressed in Ovary (36.1), Bone (18.9), and Fetal ovary (6.5).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for NR2F2 Gene
Transcriptomic regulation report from SPP (The Signaling Pathways Project) for NR2F2
SOURCE GeneReport for Unigene cluster for NR2F2 Gene:
Hs.347991mRNA Expression by UniProt/SwissProt for NR2F2 Gene:
P24468-COT2_HUMAN
Tissue specificity:
Ubiquitous.
Evidence on tissue expression from TISSUES for NR2F2 Gene
- Nervous system(4.9)
- Kidney(4.6)
- Liver(4.6)
- Spleen(4.5)
- Lung(3.1)
- Stomach(2.8)
- Heart(2.8)
- Muscle(2.6)
- Eye(2.6)
- Adrenal gland(2.3)
- Thyroid gland(2.3)
- Skin(2.2)
- Lymph node(2.2)
- Blood(2.2)
- Intestine(2.2)
- Pancreas(2)
Phenotype-based relationships between genes and organs from Gene ORGANizer for NR2F2 Gene
Germ Layers:
- endoderm
- mesoderm
Systems:
- cardiovascular
- respiratory
Regions:
Head and neck:
- ear
Thorax:
- aorta
- heart
- heart valve
- lung
General:
- blood
- blood vessel
Primer products for research
-
OriGene qPCR primer pairs for NR2F2
-
OriGene qPCR primer pairs and template standards for NR2F2
Gene Expression Assays for research
Orthologs for NR2F2 Gene
This gene was present in the common ancestor of animals.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| Chimpanzee (Pan troglodytes) |
Mammalia | NR2F2 29 30 |
|
OneToOne | |
| Cow (Bos Taurus) |
Mammalia | NR2F2 29 30 |
|
OneToOne | |
| Dog (Canis familiaris) |
Mammalia | NR2F2 29 30 |
|
OneToOne | |
| Mouse (Mus musculus) |
Mammalia | Nr2f2 29 16 30 |
|
OneToOne | |
| Rat (Rattus norvegicus) |
Mammalia | Nr2f2 29 |
|
||
| Platypus (Ornithorhynchus anatinus) |
Mammalia | NR2F2 30 |
|
OneToOne | |
| Oppossum (Monodelphis domestica) |
Mammalia | NR2F2 30 |
|
OneToOne | |
| Chicken (Gallus gallus) |
Aves | NR2F2 29 30 |
|
OneToOne | |
| Lizard (Anolis carolinensis) |
Reptilia | NR2F2 30 |
|
OneToOne | |
| Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | nr2f2 29 |
|
||
| Str.11156 29 |
|
||||
| African clawed frog (Xenopus laevis) |
Amphibia | nr2f2-prov 29 |
|
||
| Zebrafish (Danio rerio) |
Actinopterygii | nr2f2 29 30 |
|
OneToOne | |
| African malaria mosquito (Anopheles gambiae) |
Insecta | AgaP_AGAP002544 29 |
|
||
| Fruit Fly (Drosophila melanogaster) |
Insecta | svp 29 31 |
|
||
| dsf 31 |
|
|
|||
| Hr51 30 |
|
ManyToMany | |||
| Worm (Caenorhabditis elegans) |
Secernentea | unc-55 31 |
|
|
|
| Sea Vase (Ciona intestinalis) |
Ascidiacea | Cin.9339 29 |
|
- Species where no ortholog for NR2F2 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Eremothecium gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- Alicante grape (Vitis vinifera)
- Alpha proteobacteria (Wolbachia pipientis)
- Amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- Baker's yeast (Saccharomyces cerevisiae)
- Barley (Hordeum vulgare)
- Beta proteobacteria (Neisseria meningitidis)
- Bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- Common water flea (Daphnia pulex)
- Corn (Zea mays)
- E. coli (Escherichia coli)
- Filamentous fungi (Aspergillus nidulans)
- Firmicute Bacteria (Streptococcus pneumoniae)
- Fission Yeast (Schizosaccharomyces pombe)
- Green Algae (Chlamydomonas reinhardtii)
- Honey Bee (Apis mellifera)
- K. Lactis Yeast (Kluyveromyces lactis)
- Loblloly Pine (Pinus taeda)
- Malaria Parasite (Plasmodium falciparum)
- Medicago Trunc (Medicago Truncatula)
- Moss (Physcomitrella patens)
- Orangutan (Pongo pygmaeus)
- Pig (Sus scrofa)
- Rainbow Trout (Oncorhynchus mykiss)
- Rice (Oryza sativa)
- Rice Blast Fungus (Magnaporthe grisea)
- Schistosome Parasite (Schistosoma mansoni)
- Sea Anemone (Nematostella vectensis)
- Sea Squirt (Ciona savignyi)
- Sea Urchin (Strongylocentrotus purpuratus)
- Sorghum (Sorghum bicolor)
- Soybean (Glycine max)
- Stem Rust Fungus (Puccinia graminis)
- Sugarcane (Saccharum officinarum)
- Thale Cress (Arabidopsis thaliana)
- Tomato (Lycopersicon esculentum)
- Toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- Wheat (Triticum aestivum)
Evolution for NR2F2 Gene
- ENSEMBL:
- Gene Tree for NR2F2 (if available)
- TreeFam:
- Gene Tree for NR2F2 (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for NR2F2: view image
- Alliance of Genome Resources:
- Additional Orthologs for NR2F2
Paralogs for NR2F2 Gene
Paralogs for NR2F2 Gene
(26) SIMAP similar genes for NR2F2 Gene using alignment to 3 proteins:
- COT2_HUMAN
- F1D8R0_HUMAN
- H3BTC2_HUMAN
Variants for NR2F2 Gene
Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for NR2F2 Gene
| SNP ID | Clinical significance and condition | Chr 15 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| 1012381 | Uncertain Significance: not provided | 96,337,458(+) |
G/C NM_021005.4(NR2F2):c.1081G>C (p.Gly361Arg) |
MISSENSE | |
| 1014312 | Uncertain Significance: Congenital heart defects, multiple types, 4 | 96,332,414(+) |
C/G NM_021005.4(NR2F2):c.309C>G (p.Phe103Leu) |
MISSENSE_VARIANT,INTRON | |
| 1016890 | Uncertain Significance: Congenital heart defects, multiple types, 4 | 96,332,124(+) |
A/G NM_021005.4(NR2F2):c.19A>G (p.Thr7Ala) |
MISSENSE_VARIANT,INTRON | |
| 1038040 | Uncertain Significance: Congenital heart defects, multiple types, 4 | 96,334,315(+) |
C/T NM_021005.4(NR2F2):c.682C>T (p.Arg228Trp) |
MISSENSE | |
| 848589 | Pathogenic: Congenital heart defects, multiple types, 4 | 96,332,322(+) |
C/T NM_021005.4(NR2F2):c.217C>T (p.Gln73Ter) |
NONSENSE,INTRON |
All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).
Residual Variation Intolerance Score:
15.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
0.17;
3.81% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for NR2F2 Gene
SNP Genotyping and Copy Number Assays for research
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NR2F2 Gene
Disorders for NR2F2 Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| congenital heart defects, multiple types, 4 |
|
|
| 46,xx sex reversal 5 |
|
|
| partial atrioventricular canal |
|
|
| bosch-boonstra-schaaf optic atrophy syndrome |
|
|
| ring chromosome 15 |
|
|
Search NR2F2 in MalaCards
View complete list of genes associated with diseases
UniProtKB/Swiss-Prot
COT2_HUMAN- Congenital heart defects, multiple types, 4 (CHTD4) [MIM:615779]: A disorder characterized by congenital developmental abnormalities involving structures of the heart. Common defects include transposition of the great arteries, aortic stenosis, atrial septal defect, ventricular septal defect, pulmonic stenosis, and patent ductus arteriosus. Some patients also have cardiac arrhythmias, which may be due to the anatomic defect itself or to surgical interventions. {ECO:0000269 PubMed:24702954}. Note=The disease is caused by variants affecting the gene represented in this entry.
Additional Disease Information for NR2F2
- Human Genome Epidemiology Navigator
- (HuGE)
- Atlas
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
- Open Targets Platform
- Open Targets Platform
No data available for Genatlas for NR2F2 Gene
Publications for NR2F2 Gene
- Rare variants in NR2F2 cause congenital heart defects in humans. (PMID: 24702954) Al Turki S … Hurles ME (American journal of human genetics 2014) 3 4 72
- Identification of COUP-TFII orphan nuclear receptor as a retinoic acid-activated receptor. (PMID: 18798693) Kruse SW … Xu HE (PLoS biology 2008) 3 4 22
- Cooperation and competition between the binding of COUP-TFII and NF-Y on human epsilon- and gamma-globin gene promoters. (PMID: 11544252) Liberati C … Ronchi A (The Journal of biological chemistry 2001) 2 3 22
- The nuclear orphan receptors COUP-TFII and Ear-2 act as silencers of the human oxytocin gene promoter. (PMID: 9343308) Chu K … Zingg HH (Journal of molecular endocrinology 1997) 3 4 22
- Isolation, characterization, and chromosomal localization of mouse and human COUP-TF I and II genes. (PMID: 8530078) Qiu Y … Tsai SY (Genomics 1995) 2 3 22
ExternalLinks
Products for NR2F2 Gene
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Sources for NR2F2 Gene
- (1) GeneCards
- (2) HGNC
- (3) NCBI Entrez Gene
- (4) UniProtKB/Swiss-Prot
- (5) Ensembl
- (6) OMIM® (Updated: 05-Apr-2021)
- (7) GeneLoc
- (8) Gene Wiki
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- (65) Reactome
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