NR2F2 Gene (Protein Coding)

Nuclear Receptor Subfamily 2 Group F Member 2

GC15P096325
GIFtS:
49
This gene encodes a member of the steroid thyroid hormone superfamily of nuclear receptors. The encoded protein is a ligand inducible transcription factor that is involved in the regulation of many different genes. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Mar 2010] See more...

Aliases for NR2F2 Gene

Aliases for NR2F2 Gene

  • Nuclear Receptor Subfamily 2 Group F Member 2 2 3 4 5
  • Apolipoprotein A-I Regulatory Protein 1 3 4
  • COUP Transcription Factor II 3 4
  • COUP Transcription Factor 2 3 4
  • TFCOUP2 3 4
  • ARP-1 3 4
  • ARP1 3 4
  • Chicken Ovalbumin Upstream Promoter Transcription Factor 2 3
  • Chicken Ovalbumin Upstream Promoter-Transcription Factor I 3
  • Nuclear Receptor Subfamily 2, Group F, Member 2 2
  • ADP-Ribosylation Factor Related Protein 1 3
  • Apolipoprotein AI Regulatory Protein 1 3
  • COUP-TF II 4
  • COUPTFII 3
  • COUP-TF2 4
  • COUPTF2 3
  • COUPTFB 3
  • CHTD4 3
  • NF-E3 3
  • SVP40 3

External Ids for NR2F2 Gene

Previous HGNC Symbols for NR2F2 Gene

  • ARP1
  • TFCOUP2

Previous GeneCards Identifiers for NR2F2 Gene

  • GC15P093321
  • GC15P090625
  • GC15P094456
  • GC15P094603
  • GC15P094674
  • GC15P096869
  • GC15P072999

Summaries for NR2F2 Gene

Entrez Gene Summary for NR2F2 Gene

  • This gene encodes a member of the steroid thyroid hormone superfamily of nuclear receptors. The encoded protein is a ligand inducible transcription factor that is involved in the regulation of many different genes. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Mar 2010]

CIViC Summary for NR2F2 Gene

GeneCards Summary for NR2F2 Gene

NR2F2 (Nuclear Receptor Subfamily 2 Group F Member 2) is a Protein Coding gene. Diseases associated with NR2F2 include Congenital Heart Defects, Multiple Types, 4 and Complete Atrioventricular Canal-Left Heart Obstruction Syndrome. Among its related pathways are Developmental Biology and Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha). Gene Ontology (GO) annotations related to this gene include DNA-binding transcription factor activity and sequence-specific DNA binding. An important paralog of this gene is NR2F1.

UniProtKB/Swiss-Prot Summary for NR2F2 Gene

  • Ligand-activated transcription factor. Activated by high concentrations of 9-cis-retinoic acid and all-trans-retinoic acid, but not by dexamethasone, cortisol or progesterone (in vitro). Regulation of the apolipoprotein A-I gene transcription. Binds to DNA site A.

Gene Wiki entry for NR2F2 Gene

Additional gene information for NR2F2 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for NR2F2 Gene

Genomics for NR2F2 Gene

GeneHancer (GH) Regulatory Elements for NR2F2 Gene


GeneHancers around NR2F2 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the NR2F2 gene promoter:
  • MyoD
  • NF-kappaB1
  • RSRFC4

Genomic Locations for NR2F2 Gene

Genomic Locations for NR2F2 Gene
chr15:96,325,928-96,340,263
(GRCh38/hg38)
Size:
14,336 bases
Orientation:
Plus strand
chr15:96,869,157-96,883,492
(GRCh37/hg19)
Size:
14,336 bases
Orientation:
Plus strand

Genomic View for NR2F2 Gene

Genes around NR2F2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
NR2F2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for NR2F2 Gene
GeneLoc Logo Genomic Neighborhood • Exon Structure • Gene Density

RefSeq DNA sequence for NR2F2 Gene

Proteins for NR2F2 Gene

Products:

  1. Antibody
  2. Protein
  3. Assay

  • Protein details for NR2F2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P24468-COT2_HUMAN
    Recommended name:
    COUP transcription factor 2
    Protein Accession:
    P24468
    Secondary Accessions:
    • B4DQJ2
    • B6ZGU1
    • Q03754
    • Q3KQR7

    Protein attributes for NR2F2 Gene

    Size:
    414 amino acids
    Molecular mass:
    45571 Da
    Quaternary structure:
    • Interacts with SQSTM1 (By similarity). Binds DNA as a dimer; homodimer or heterodimer with NR2F6. Interacts with NCOA1, NCOA2, NCOA3 and PPARGC1A. Interacts with ZFPM2 (By similarity).

    Three dimensional structures from OCA and Proteopedia for NR2F2 Gene

    Alternative splice isoforms for NR2F2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for NR2F2 Gene

Protein Expression for NR2F2 Gene

See protein expression from ProteomicsDB, MOPED, PaxDb, and MaxQB

Post-translational modifications for NR2F2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for NR2F2 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • Abcam antibodies for NR2F2

No data available for DME Specific Peptides for NR2F2 Gene

Domains & Families for NR2F2 Gene

Gene Families for NR2F2 Gene

HGNC:
IUPHAR :
Human Protein Atlas (HPA):
  • Disease related genes
  • Nuclear receptors
  • Predicted intracellular proteins
  • Transcription factors

Protein Domains for NR2F2 Gene

Blocks:
InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for NR2F2 Gene

GenScript: Design optimal peptide antigens:
  • cDNA, FLJ78985, highly similar to COUP transcription factor 2 (B4DQJ2_HUMAN)
  • Nuclear receptor subfamily 2 group F member 2 (COT2_HUMAN)
  • Ovalbumin upstream promoter-transcription factor II variant 1 (F1D8R0_HUMAN)
  • cDNA FLJ50900, highly similar to COUP transcription factor 2 (Q3KQR7_HUMAN)

Graphical View of Domain Structure for InterPro Entry

P24468

UniProtKB/Swiss-Prot:

COT2_HUMAN :
  • Belongs to the nuclear hormone receptor family. NR2 subfamily.
Family:
  • Belongs to the nuclear hormone receptor family. NR2 subfamily.
genes like me logo Genes that share domains with NR2F2: view

Function for NR2F2 Gene

Products:

  1. Animal Model
  2. CRISPR
  3. miRNA
  4. Inhibitory RNA
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  6. Cell Line

Molecular function for NR2F2 Gene

UniProtKB/Swiss-Prot Function:
Ligand-activated transcription factor. Activated by high concentrations of 9-cis-retinoic acid and all-trans-retinoic acid, but not by dexamethasone, cortisol or progesterone (in vitro). Regulation of the apolipoprotein A-I gene transcription. Binds to DNA site A.
GENATLAS Biochemistry:
nuclear receptor subfamily 2,group F,member 2,negative post transcriptional regulator of MYOD1 function,may be required for angiogenesis and heart developpment, steroid/thyroid hormone receptor superfamily

Phenotypes From GWAS Catalog for NR2F2 Gene

Gene Ontology (GO) - Molecular Function for NR2F2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000977 RNA polymerase II regulatory region sequence-specific DNA binding IBA 21873635
GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific NAS 19274049
GO:0001972 retinoic acid binding IDA 18798693
GO:0003677 DNA binding IEA --
GO:0003700 DNA-binding transcription factor activity IDA 9343308
genes like me logo Genes that share ontologies with NR2F2: view
genes like me logo Genes that share phenotypes with NR2F2: view

Human Phenotype Ontology for NR2F2 Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Models for NR2F2 Gene

MGI Knock Outs for NR2F2:

Animal Model Products

CRISPR Products

miRNA for NR2F2 Gene

miRTarBase miRNAs that target NR2F2

Transcription Factor Targets for NR2F2 Gene

Selected GeneGlobe predicted Target genes for NR2F2
Targeted motifs for NR2F2 Gene
HOMER Transcription Factor Regulatory Elements motif NR2F2
  • Consensus sequence: AGRGGTCA Submotif: canonical Cell Type: Artia GEO ID: GSE46497

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for NR2F2

Clone Products

  • Addgene plasmids for NR2F2

No data available for Enzyme Numbers (IUBMB) for NR2F2 Gene

Localization for NR2F2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for NR2F2 Gene

Nucleus.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for NR2F2 gene
Compartment Confidence
nucleus 5
cytosol 4
extracellular 1
mitochondrion 1
peroxisome 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (2)
  • Nucleoplasm (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for NR2F2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA 19210544
GO:0005654 nucleoplasm IDA --
GO:0005829 cytosol IDA --
genes like me logo Genes that share ontologies with NR2F2: view

Pathways & Interactions for NR2F2 Gene

genes like me logo Genes that share pathways with NR2F2: view

Pathways by source for NR2F2 Gene

1 Qiagen pathway for NR2F2 Gene
  • Oct4 in Mammalian ESC Pluripotency

SIGNOR curated interactions for NR2F2 Gene

Activates:
Inactivates:
Is activated by:

Gene Ontology (GO) - Biological Process for NR2F2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000122 negative regulation of transcription by RNA polymerase II IDA 9343308
GO:0001701 in utero embryonic development IEA --
GO:0001764 neuron migration IEA --
GO:0001893 maternal placenta development IEA --
GO:0001937 negative regulation of endothelial cell proliferation IMP 19210544
genes like me logo Genes that share ontologies with NR2F2: view

Drugs & Compounds for NR2F2 Gene

Products:

  1. Drug

(5) Drugs for NR2F2 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(4) Additional Compounds for NR2F2 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with NR2F2: view

Transcripts for NR2F2 Gene

Products:

  1. CRISPR
  2. miRNA
  3. Inhibitory RNA
  4. Clone

mRNA/cDNA for NR2F2 Gene

(4) REFSEQ mRNAs :
(17) Additional mRNA sequences :
(292) Selected AceView cDNA sequences:
(5) Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for NR2F2

Clone Products

  • Addgene plasmids for NR2F2

Alternative Splicing Database (ASD) splice patterns (SP) for NR2F2 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3a · 3b ^ 4
SP1: - -
SP2:
SP3: -

Relevant External Links for NR2F2 Gene

GeneLoc Exon Structure for
NR2F2
ECgene alternative splicing isoforms for
NR2F2

Expression for NR2F2 Gene

Products:

  1. Primer
  2. Gene Expression Assay

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for NR2F2 Gene

mRNA expression in normal human tissues for NR2F2 Gene
mRNA expression by BioGPS for NR2F2 GenemRNA expression by GTEx for NR2F2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for NR2F2 Gene

This gene is overexpressed in Ovary (x4.7).

Protein differential expression in normal tissues from HIPED for NR2F2 Gene

This gene is overexpressed in Ovary (36.1), Bone (18.9), and Fetal ovary (6.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for NR2F2 Gene



Protein tissue co-expression partners for NR2F2 Gene

NURSA nuclear receptor signaling pathways regulating expression of NR2F2 Gene:

NR2F2

SOURCE GeneReport for Unigene cluster for NR2F2 Gene:

Hs.347991

mRNA Expression by UniProt/SwissProt for NR2F2 Gene:

P24468-COT2_HUMAN
Tissue specificity: Ubiquitous.

Evidence on tissue expression from TISSUES for NR2F2 Gene

  • Nervous system(4.9)
  • Kidney(4.5)
  • Liver(4.5)
  • Spleen(4.3)
  • Lung(2.5)
  • Heart(2.4)
  • Muscle(2.2)
  • Stomach(2.1)

Phenotype-based relationships between genes and organs from Gene ORGANizer for NR2F2 Gene

Germ Layers:
  • endoderm
  • mesoderm
Systems:
  • cardiovascular
  • respiratory
Regions:
Head and neck:
  • ear
Thorax:
  • aorta
  • heart
  • heart valve
  • lung
General:
  • blood
  • blood vessel
genes like me logo Genes that share expression patterns with NR2F2: view

Orthologs for NR2F2 Gene

This gene was present in the common ancestor of animals.

Orthologs for NR2F2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
 Mammalia NR2F2 33 32
  • 100 (n)
 OneToOne
cow
(Bos Taurus)
 Mammalia NR2F2 33 32
  • 96.38 (n)
 OneToOne
dog
(Canis familiaris)
 Mammalia NR2F2 33 32
  • 96.22 (n)
 OneToOne
mouse
(Mus musculus)
 Mammalia Nr2f2 17 33 32
  • 95.33 (n)
rat
(Rattus norvegicus)
 Mammalia Nr2f2 32
  • 95.01 (n)
platypus
(Ornithorhynchus anatinus)
 Mammalia NR2F2 33
  • 92 (a)
 OneToOne
oppossum
(Monodelphis domestica)
 Mammalia NR2F2 33
  • 89 (a)
 OneToOne
chicken
(Gallus gallus)
 Aves NR2F2 33 32
  • 84.88 (n)
 OneToOne
lizard
(Anolis carolinensis)
 Reptilia NR2F2 33
  • 74 (a)
 OneToOne
tropical clawed frog
(Silurana tropicalis)
 Amphibia nr2f2 32
  • 80.15 (n)
Str.11156 32
African clawed frog
(Xenopus laevis)
 Amphibia nr2f2-prov 32
zebrafish
(Danio rerio)
 Actinopterygii nr2f2 33 32 32
  • 77.32 (n)
 OneToOne
African malaria mosquito
(Anopheles gambiae)
 Insecta AgaP_AGAP002544 32
  • 76.92 (n)
fruit fly
(Drosophila melanogaster)
 Insecta svp 34 32
  • 73.72 (n)
dsf 34
  • 41 (a)
Hr51 33
  • 25 (a)
 ManyToMany
worm
(Caenorhabditis elegans)
 Secernentea unc-55 34
  • 34 (a)
sea squirt
(Ciona savignyi)
 Ascidiacea Cin.9339 32
sea squirt
(Ciona intestinalis)
 Ascidiacea Cin.9339 32
Species where no ortholog for NR2F2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for NR2F2 Gene

ENSEMBL:
Gene Tree for NR2F2 (if available)
TreeFam:
Gene Tree for NR2F2 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for NR2F2: view image

Paralogs for NR2F2 Gene

Paralogs for NR2F2 Gene

(26) SIMAP similar genes for NR2F2 Gene using alignment to 3 proteins:

  • COT2_HUMAN
  • F1D8R0_HUMAN
  • H3BTC2_HUMAN
genes like me logo Genes that share paralogs with NR2F2: view

Variants for NR2F2 Gene

Products:

  1. SNP Genotyping and Copy Number Assay

Sequence variations from dbSNP and Humsavar for NR2F2 Gene

SNP ID Clin Chr 15 pos Variation AA Info Type
rs143951395 benign, Congenital heart defects, multiple types, 4 96,334,170(+) C/T coding_sequence_variant, synonymous_variant
rs1555446980 pathogenic, Inborn genetic diseases 96,332,169(+) C/T coding_sequence_variant, genic_upstream_transcript_variant, intron_variant, stop_gained, upstream_transcript_variant
rs1555446983 likely-pathogenic, Congenital heart defects, multiple types, 4 96,332,187(+) CCC/CCCCC coding_sequence_variant, frameshift, genic_upstream_transcript_variant, intron_variant, upstream_transcript_variant
rs1555447012 pathogenic, Congenital heart defects, multiple types, 4 96,332,352(+) G/T coding_sequence_variant, genic_upstream_transcript_variant, intron_variant, stop_gained, upstream_transcript_variant
rs1555447237 likely-pathogenic, Inborn genetic diseases 96,334,573(+) T/C coding_sequence_variant, missense_variant

Structural Variations from Database of Genomic Variants (DGV) for NR2F2 Gene

Variant ID Type Subtype PubMed ID
dgv448n67 CNV gain 20364138
esv21861 CNV loss 19812545
nsv1126408 CNV deletion 24896259
nsv1141674 CNV deletion 24896259
nsv570580 CNV loss 21841781
nsv570581 CNV loss 21841781
nsv570582 CNV loss 21841781
nsv827449 CNV gain 20364138
nsv827450 CNV gain 20364138

Variation tolerance for NR2F2 Gene

Residual Variation Intolerance Score: 15.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.17; 3.81% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for NR2F2 Gene

Human Gene Mutation Database (HGMD)
NR2F2
SNPedia medical, phenotypic, and genealogical associations of SNPs for
NR2F2

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NR2F2 Gene

Disorders for NR2F2 Gene

MalaCards: The human disease database

(15) MalaCards diseases for NR2F2 Gene - From: HGMD, OMIM, ClinVar, GTR, Orphanet, DISEASES, and GeneCards

- elite association - COSMIC cancer census association via MalaCards
Search NR2F2 in MalaCards View complete list of genes associated with diseases

UniProtKB/Swiss-Prot

COT2_HUMAN
  • Congenital heart defects, multiple types, 4 (CHTD4) [MIM:615779]: A disorder characterized by congenital developmental abnormalities involving structures of the heart. Common defects include transposition of the great arteries, aortic stenosis, atrial septal defect, ventricular septal defect, pulmonic stenosis, and patent ductus arteriosus. Some patients also have cardiac arrhythmias, which may be due to the anatomic defect itself or to surgical interventions. {ECO:0000269 PubMed:24702954}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Additional Disease Information for NR2F2

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with NR2F2: view

No data available for Genatlas for NR2F2 Gene

Publications for NR2F2 Gene

  1. Identification of COUP-TFII orphan nuclear receptor as a retinoic acid-activated receptor. (PMID: 18798693) Kruse SW … Xu HE (PLoS biology 2008) 3 4 23 56
  2. Cooperation and competition between the binding of COUP-TFII and NF-Y on human epsilon- and gamma-globin gene promoters. (PMID: 11544252) Liberati C … Ronchi A (The Journal of biological chemistry 2001) 2 3 23 56
  3. The nuclear orphan receptors COUP-TFII and Ear-2 act as silencers of the human oxytocin gene promoter. (PMID: 9343308) Chu K … Zingg HH (Journal of molecular endocrinology 1997) 3 4 23 56
  4. Isolation, characterization, and chromosomal localization of mouse and human COUP-TF I and II genes. (PMID: 8530078) Qiu Y … Tsai SY (Genomics 1995) 2 3 23 56
  5. Regulation of the apolipoprotein AI gene by ARP-1, a novel member of the steroid receptor superfamily. (PMID: 1899293) Ladias JA … Karathanasis SK (Science (New York, N.Y.) 1991) 3 4 23 56

ExternalLinks

View latest publications for NR2F2 gene in Mastermind

Products for NR2F2 Gene

  • Addgene plasmids for NR2F2

Sources for NR2F2 Gene