Aliases for NR2F2 Gene
Aliases for NR2F2 Gene
- Nuclear Receptor Subfamily 2 Group F Member 2 2 3 4 5
- Apolipoprotein A-I Regulatory Protein 1 3 4
- COUP Transcription Factor II 3 4
- TFCOUP2 3 4
- ARP1 3 4
- Chicken Ovalbumin Upstream Promoter Transcription Factor 2 3
- Chicken Ovalbumin Upstream Promoter-Transcription Factor I 3
- Nuclear Receptor Subfamily 2, Group F, Member 2 2
- ADP-Ribosylation Factor Related Protein 1 3
- Apolipoprotein AI Regulatory Protein 1 3
- COUP Transcription Factor 2 3
External Ids for NR2F2 Gene
- HGNC: 7976
- Entrez Gene: 7026
- Ensembl: ENSG00000185551
- OMIM: 107773
- UniProtKB: P24468
Previous HGNC Symbols for NR2F2 Gene
- ARP1
- TFCOUP2
Previous GeneCards Identifiers for NR2F2 Gene
- GC15P093321
- GC15P090625
- GC15P094456
- GC15P094603
- GC15P094674
- GC15P096869
- GC15P072999
Summaries for NR2F2 Gene
-
This gene encodes a member of the steroid thyroid hormone superfamily of nuclear receptors. The encoded protein is a ligand inducible transcription factor that is involved in the regulation of many different genes. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Mar 2010]
GeneCards Summary for NR2F2 Gene
NR2F2 (Nuclear Receptor Subfamily 2 Group F Member 2) is a Protein Coding gene. Diseases associated with NR2F2 include Congenital Heart Defects, Multiple Types, 4 and Complete Atrioventricular Canal-Left Heart Obstruction Syndrome. Among its related pathways are Oct4 in Mammalian ESC Pluripotency and Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha). Gene Ontology (GO) annotations related to this gene include DNA binding transcription factor activity and sequence-specific DNA binding. An important paralog of this gene is NR2F1.
UniProtKB/Swiss-Prot for NR2F2 Gene
-
Ligand-activated transcription factor. Activated by high concentrations of 9-cis-retinoic acid and all-trans-retinoic acid, but not by dexamethasone, cortisol or progesterone (in vitro). Regulation of the apolipoprotein A-I gene transcription. Binds to DNA site A.
Additional gene information for NR2F2 Gene
- Monarch Initiative
- Search for NR2F2 at DataMed
- Search for NR2F2 at HumanCyc
No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NR2F2 Gene
Genomics for NR2F2 Gene
GeneHancer (GH) Regulatory Elements for NR2F2 Gene
Promoters and enhancers for NR2F2 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data dump
GeneHancers around NR2F2 on UCSC Golden Path with GeneCards custom track
- Top Transcription factor binding sites by QIAGEN in the NR2F2 gene promoter:
-
- NF-kappaB1
- MyoD
- RSRFC4
Regulatory Element Products
Genomic Locations for NR2F2 Gene
Genomic Locations for NR2F2 Gene
- chr15:96,325,928-96,340,263
- (GRCh38/hg38)
- Size:
- 14,336 bases
- Orientation:
- Plus strand
- chr15:96,869,157-96,883,492
- (GRCh37/hg19)
- Size:
- 14,336 bases
- Orientation:
- Plus strand
Genomic View for NR2F2 Gene
Genes around NR2F2 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 15q26.2 by Entrez Gene
- 15q26.2 by HGNC
- 15q26.2 by Ensembl
NR2F2 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for NR2F2 Gene
Proteins for NR2F2 Gene
-
Protein details for NR2F2 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- P24468-COT2_HUMAN
- Recommended name:
- COUP transcription factor 2
- Protein Accession:
- P24468
- B4DQJ2
- B6ZGU1
- Q03754
- Q3KQR7
Protein attributes for NR2F2 Gene
- Size:
- 414 amino acids
- Molecular mass:
- 45571 Da
- Quaternary structure:
-
- Interacts with SQSTM1 (By similarity). Binds DNA as a dimer; homodimer or heterodimer with NR2F6. Interacts with NCOA1, NCOA2, NCOA3 and PPARGC1A. Interacts with ZFPM2 (By similarity).
Protein Expression for NR2F2 Gene
Post-translational modifications for NR2F2 Gene
Other Protein References for NR2F2 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- R&D Systems Antibodies for NR2F2 (COUP-TF II/NR2F2)
- Novus Biologicals Antibodies for NR2F2
- Invitrogen Antibodies for NR2F2
- GeneTex NR2F2 Antibody for NR2F2
-
Santa Cruz Biotechnology (SCBT) Antibodies for NR2F2
- Sino Biological Antibodies for NR2F2
Protein Products
-
OriGene Purified Proteins for NR2F2
- Search Origene for MassSpec and Protein Over-expression Lysates for NR2F2
- Origene Custom Protein Services for NR2F2
- Search GeneTex for Proteins for NR2F2
Assay Products
No data available for DME Specific Peptides for NR2F2 Gene
Domains & Families for NR2F2 Gene
Gene Families for NR2F2 Gene
- HGNC:
- IUPHAR :
- Human Protein Atlas (HPA):
-
- Disease related genes
- Nuclear receptors
- Predicted intracellular proteins
- Transcription factors
Protein Domains for NR2F2 Gene
Suggested Antigen Peptide Sequences for NR2F2 Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
P24468- Family:
-
- Belongs to the nuclear hormone receptor family. NR2 subfamily.
Function for NR2F2 Gene
Molecular function for NR2F2 Gene
- UniProtKB/Swiss-Prot Function:
- Ligand-activated transcription factor. Activated by high concentrations of 9-cis-retinoic acid and all-trans-retinoic acid, but not by dexamethasone, cortisol or progesterone (in vitro). Regulation of the apolipoprotein A-I gene transcription. Binds to DNA site A.
- GENATLAS Biochemistry:
- nuclear receptor subfamily 2,group F,member 2,negative post transcriptional regulator of MYOD1 function,may be required for angiogenesis and heart developpment, steroid/thyroid hormone receptor superfamily
Phenotypes From GWAS Catalog for NR2F2 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000981 | RNA polymerase II transcription factor activity, sequence-specific DNA binding | NAS | 19274049 |
| GO:0001972 | retinoic acid binding | IDA | 18798693 |
| GO:0003677 | DNA binding | IEA | -- |
| GO:0003700 | DNA binding transcription factor activity | IDA | 9343308 |
| GO:0003707 | steroid hormone receptor activity | IEA | -- |
Phenotypes for NR2F2 Gene
- MGI mutant phenotypes for NR2F2:
-
inferred from 4 alleles
- cardiovascular system phenotype
- pigmentation phenotype
- vision/eye phenotype
- digestive/alimentary phenotype
- homeostasis/metabolism phenotype
- nervous system phenotype
- no phenotypic analysis
- endocrine/exocrine gland phenotype
- mortality/aging
- muscle phenotype
- reproductive system phenotype
- embryo phenotype
- immune system phenotype
- growth/size/body region phenotype
- GenomeRNAi human phenotypes for NR2F2:
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
- Cyagen custom Knockout/knockin (KOKI) mouse models for NR2F2
-
CRISPR Products
-
OriGene CRISPR knockouts for NR2F2
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for NR2F2
- genomics-online: gRNA clones - Search results for 120 available NR2F2 gene related products
- Overview of 120 available NR2F2 gene related products
- Applied Biological Materials CRISPR for NR2F2
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for NR2F2
- GenScript: Design CRISPR guide RNA sequences for NR2F2
miRNA for NR2F2 Gene
- miRTarBase miRNAs that target NR2F2
-
- hsa-mir-302a-3p (MIRT006555)
- hsa-mir-101-3p (MIRT027270)
- hsa-mir-935 (MIRT036667)
- hsa-mir-877-5p (MIRT037296)
- hsa-mir-129-5p (MIRT073558)
- hsa-mir-4709-5p (MIRT073561)
- hsa-let-7f-2-3p (MIRT073563)
- hsa-mir-144-3p (MIRT073564)
- hsa-mir-409-3p (MIRT073565)
- hsa-mir-1185-2-3p (MIRT073566)
- hsa-mir-1185-1-3p (MIRT073567)
- hsa-mir-4325 (MIRT073568)
- hsa-mir-5680 (MIRT073569)
- hsa-mir-7703 (MIRT073570)
- hsa-mir-582-5p (MIRT471982)
- hsa-mir-4684-3p (MIRT471983)
- hsa-mir-548z (MIRT471984)
- hsa-mir-548h-3p (MIRT471985)
- hsa-mir-548d-3p (MIRT471986)
- hsa-mir-548bb-3p (MIRT471987)
- hsa-mir-548ac (MIRT471988)
- hsa-mir-203a-3p (MIRT547307)
- hsa-mir-5189-3p (MIRT574560)
- hsa-mir-519c-3p (MIRT574561)
- hsa-mir-519b-3p (MIRT574562)
- hsa-mir-519a-3p (MIRT574563)
- hsa-mir-520c-3p (MIRT574564)
- hsa-mir-520b (MIRT574565)
- hsa-mir-302b-3p (MIRT574566)
- hsa-mir-302c-3p (MIRT574567)
- hsa-mir-302e (MIRT574568)
- hsa-mir-372-3p (MIRT574569)
- hsa-mir-520a-3p (MIRT574570)
- hsa-mir-373-3p (MIRT574571)
- hsa-mir-520d-3p (MIRT574572)
- hsa-mir-302d-3p (MIRT574573)
- hsa-mir-520e (MIRT574574)
- hsa-mir-6793-3p (MIRT612716)
- hsa-mir-362-3p (MIRT612717)
- hsa-mir-329-3p (MIRT612718)
- hsa-mir-8485 (MIRT612719)
- hsa-mir-510-3p (MIRT641995)
- hsa-mir-513a-5p (MIRT641996)
- hsa-mir-4645-3p (MIRT641997)
- hsa-mir-27a-3p (MIRT641998)
- hsa-mir-27b-3p (MIRT641999)
- hsa-mir-216a-3p (MIRT642000)
- hsa-mir-3681-3p (MIRT642001)
- hsa-mir-128-3p (MIRT642002)
- hsa-mir-6818-3p (MIRT655741)
- hsa-mir-4713-5p (MIRT655742)
- hsa-mir-2116-3p (MIRT655743)
- hsa-mir-532-3p (MIRT655744)
- hsa-mir-150-5p (MIRT655745)
- hsa-mir-6749-3p (MIRT716947)
Transcription Factor Targets for NR2F2 Gene
Targeted motifs for NR2F2 Gene
HOMER Transcription Factor Regulatory Elements motif NR2F2
- Consensus sequence: AGRGGTCA Submotif: canonical Cell Type: Artia GEO ID: GSE46497
miRNA Products
Inhibitory RNA Products
- Origene sirna, shrna, and RNAi products in human, mouse, rat for NR2F2
- Browse OriGene Inhibitory RNA Products For NR2F2
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for NR2F2
- genomics-online: shRNA clones - Search results for 120 available NR2F2 gene related products
- Overview of 120 available NR2F2 gene related products
Clone Products
- Sino Biological Human cDNA Clone for NR2F2
- VectorBuilder custom plasmid, inducible vectors for NR2F2
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for NR2F2
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Addgene plasmids for NR2F2
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for NR2F2
- Applied Biological Materials Clones for NR2F2
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
Cell Line Products
-
Horizon Cell Lines for NR2F2
No data available for Enzyme Numbers (IUBMB) for NR2F2 Gene
Localization for NR2F2 Gene
Subcellular locations from UniProtKB/Swiss-Prot for NR2F2 Gene
- Nucleus.
| Compartment | Confidence |
|---|---|
| nucleus | 5 |
| peroxisome | 1 |
| cytosol | 1 |
- Cytosol (2)
- Nucleoplasm (2)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005634 | nucleus | IDA | 19210544 |
| GO:0005654 | nucleoplasm | IDA | -- |
| GO:0005829 | cytosol | IDA | -- |
Pathways & Interactions for NR2F2 Gene
Pathways by source for NR2F2 Gene
4 BioSystems pathways for NR2F2 Gene
2 Reactome pathways for NR2F2 Gene
1 Qiagen pathway for NR2F2 Gene
Interacting Proteins for NR2F2 Gene
Selected Interacting proteins:
P24468-COT2_HUMAN
ENSP00000377721
for NR2F2 Gene via
IID
MINT
STRING
UniProtKB
GPS-Prot Interaction Network for NR2F2
SIGNOR curated interactions for NR2F2 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000122 | negative regulation of transcription by RNA polymerase II | IDA | 9343308 |
| GO:0001701 | in utero embryonic development | IEA | -- |
| GO:0001764 | neuron migration | IEA | -- |
| GO:0001893 | maternal placenta development | IEA | -- |
| GO:0001937 | negative regulation of endothelial cell proliferation | IMP | 19210544 |
Transcripts for NR2F2 Gene
mRNA/cDNA for NR2F2 Gene
- (4) REFSEQ mRNAs :
- (26) Additional mRNA sequences :
- (292) Selected AceView cDNA sequences:
- (5) Ensembl transcripts including schematic representations, and UCSC links where relevant :
-
- ENST00000394166 5275 bps (uc010uri.3)
- ENST00000394171 3501 bps (uc010urj.2)
- ENST00000421109 2214 bps (uc002btp.4)
- ENST00000453270 1712 bps (uc010urk.3)
- ENST00000559679 382 bps (uc059nqg.1)
Unigene Clusters for NR2F2 Gene
CRISPR Products
-
OriGene CRISPR knockouts for NR2F2
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for NR2F2
- genomics-online: gRNA clones - Search results for 120 available NR2F2 gene related products
- Overview of 120 available NR2F2 gene related products
- Applied Biological Materials CRISPR for NR2F2
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for NR2F2
- GenScript: Design CRISPR guide RNA sequences for NR2F2
miRNA Products
Inhibitory RNA Products
- Origene sirna, shrna, and RNAi products in human, mouse, rat for NR2F2
- Browse OriGene Inhibitory RNA Products For NR2F2
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for NR2F2
- genomics-online: shRNA clones - Search results for 120 available NR2F2 gene related products
- Overview of 120 available NR2F2 gene related products
Clone Products
- Sino Biological Human cDNA Clone for NR2F2
- VectorBuilder custom plasmid, inducible vectors for NR2F2
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for NR2F2
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Addgene plasmids for NR2F2
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for NR2F2
- Applied Biological Materials Clones for NR2F2
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
| ExUns: | 1a | · | 1b | · | 1c | ^ | 2 | ^ | 3a | · | 3b | ^ | 4 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | - | |||||||||||
| SP2: | |||||||||||||
| SP3: | - |
Expression for NR2F2 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
-
Heart (Cardiovascular System)
- Cardiomyocytes Left Atrium
- Venous Endothelial Cells Cardinal Veins
- Cardiomyocytes Right Atrium
-
Endothelium (Cardiovascular System)
- Lymphatic Endothelial Cells Lymphatic Vessels
- Venous Endothelial Cells Cardinal Veins
-
Lymph (Hematopoietic System)
- Lymphatic Endothelial Cells Lymphatic Vessels
- Eye (Sensory Organs)
mRNA differential expression in normal tissues according to GTEx for NR2F2 Gene
This gene is overexpressed in Ovary (x4.7).
This gene is overexpressed in Ovary (36.1), Bone (18.9), and Fetal ovary (6.5).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for NR2F2 Gene
NURSA nuclear receptor signaling pathways regulating expression of NR2F2 Gene:
NR2F2SOURCE GeneReport for Unigene cluster for NR2F2 Gene:
Hs.347991mRNA Expression by UniProt/SwissProt for NR2F2 Gene:
P24468-COT2_HUMAN
Tissue specificity:
Ubiquitous.
Evidence on tissue expression from TISSUES for NR2F2 Gene
- Nervous system(4.9)
- Kidney(4.5)
- Liver(4.5)
- Spleen(4.3)
- Lung(2.5)
- Heart(2.4)
- Muscle(2.2)
- Stomach(2.1)
Phenotype-based relationships between genes and organs from Gene ORGANizer for NR2F2 Gene
Germ Layers:
- endoderm
- mesoderm
Systems:
- cardiovascular
- respiratory
Regions:
Head and neck:
- ear
Thorax:
- aorta
- heart
- heart valve
- lung
General:
- blood
- blood vessel
Primer Products
-
OriGene qPCR primer pairs and template standards for NR2F2
-
OriGene qPCR primer pairs for NR2F2
- genomics-online: primer clones - Search results for 120 available NR2F2 gene related products
- Overview of 120 available NR2F2 gene related products
Gene Expression Assay Products
Orthologs for NR2F2 Gene
This gene was present in the common ancestor of animals.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | NR2F2 34 33 |
|
OneToOne | |
| cow (Bos Taurus) |
Mammalia | NR2F2 34 33 |
|
OneToOne | |
| dog (Canis familiaris) |
Mammalia | NR2F2 34 33 |
|
OneToOne | |
| mouse (Mus musculus) |
Mammalia | Nr2f2 16 34 33 |
|
||
| rat (Rattus norvegicus) |
Mammalia | Nr2f2 33 |
|
||
| platypus (Ornithorhynchus anatinus) |
Mammalia | NR2F2 34 |
|
OneToOne | |
| oppossum (Monodelphis domestica) |
Mammalia | NR2F2 34 |
|
OneToOne | |
| chicken (Gallus gallus) |
Aves | NR2F2 34 33 |
|
OneToOne | |
| lizard (Anolis carolinensis) |
Reptilia | NR2F2 34 |
|
OneToOne | |
| tropical clawed frog (Silurana tropicalis) |
Amphibia | nr2f2 33 |
|
||
| Str.11156 33 |
|
||||
| African clawed frog (Xenopus laevis) |
Amphibia | nr2f2-prov 33 |
|
||
| zebrafish (Danio rerio) |
Actinopterygii | nr2f2 34 33 33 |
|
OneToOne | |
| African malaria mosquito (Anopheles gambiae) |
Insecta | AgaP_AGAP002544 33 |
|
||
| fruit fly (Drosophila melanogaster) |
Insecta | svp 35 33 |
|
||
| dsf 35 |
|
|
|||
| Hr51 34 |
|
ManyToMany | |||
| worm (Caenorhabditis elegans) |
Secernentea | unc-55 35 |
|
|
|
| sea squirt (Ciona savignyi) |
Ascidiacea | Cin.9339 33 |
|
||
| sea squirt (Ciona intestinalis) |
Ascidiacea | Cin.9339 33 |
|
- Species where no ortholog for NR2F2 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
Evolution for NR2F2 Gene
- ENSEMBL:
- Gene Tree for NR2F2 (if available)
- TreeFam:
- Gene Tree for NR2F2 (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for NR2F2: view image
Paralogs for NR2F2 Gene
Paralogs for NR2F2 Gene
(26) SIMAP similar genes for NR2F2 Gene using alignment to 3 proteins:
- COT2_HUMAN
- F1D8R0_HUMAN
- H3BTC2_HUMAN
Variants for NR2F2 Gene
| SNP ID | Clin | Chr 15 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| rs143951395 | benign, Congenital heart defects, multiple types, 4 | 96,334,170(+) | C/T | coding_sequence_variant, synonymous_variant | |
| rs199886454 | benign, Congenital heart defects, multiple types, 4 | 96,334,467(+) | G/A | coding_sequence_variant, synonymous_variant | |
| rs201527820 | Congenital heart defects, multiple types, 4 (CHTD4) [MIM:615779] | 96,337,611(+) | G/A/C/T | coding_sequence_variant, missense_variant | |
| rs551936462 | likely-benign, Congenital heart defects, multiple types, 4 | 96,332,234(+) | C/A/G/T | coding_sequence_variant, genic_upstream_transcript_variant, intron_variant, synonymous_variant, upstream_transcript_variant | |
| rs587777371 | pathogenic, Congenital heart defects, multiple types, 4, not provided, Congenital heart defects, multiple types, 4 (CHTD4) [MIM:615779] | 96,337,399(+) | C/A | coding_sequence_variant, missense_variant |
Residual Variation Intolerance Score:
15.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
0.17;
3.81% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for NR2F2 Gene
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NR2F2 Gene
Disorders for NR2F2 Gene
(13) MalaCards diseases for NR2F2 Gene - From: HGMD, OMIM, ClinVar, GTR, Orphanet, Swiss-Prot, DISEASES, and GeneCards
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| congenital heart defects, multiple types, 4 |
|
|
| complete atrioventricular canal-tetralogy of fallot syndrome |
|
|
| complete atrioventricular canal-left heart obstruction syndrome |
|
|
| complete atrioventricular canal-ventricle hypoplasia syndrome |
|
|
| bosch-boonstra-schaaf optic atrophy syndrome |
|
|
Search NR2F2 in MalaCards
View complete list of genes associated with diseases
UniProtKB/Swiss-Prot
COT2_HUMAN- Congenital heart defects, multiple types, 4 (CHTD4) [MIM:615779]: A disorder characterized by congenital developmental abnormalities involving structures of the heart. Common defects include transposition of the great arteries, aortic stenosis, atrial septal defect, ventricular septal defect, pulmonic stenosis, and patent ductus arteriosus. Some patients also have cardiac arrhythmias, which may be due to the anatomic defect itself or to surgical interventions. {ECO:0000269 PubMed:24702954}. Note=The disease is caused by mutations affecting the gene represented in this entry.
Additional Disease Information for NR2F2
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
No data available for Genatlas for NR2F2 Gene
Publications for NR2F2 Gene
- Identification of COUP-TFII orphan nuclear receptor as a retinoic acid-activated receptor. (PMID: 18798693) Kruse SW … Xu HE (PLoS biology 2008) 3 4 22 58
- Cooperation and competition between the binding of COUP-TFII and NF-Y on human epsilon- and gamma-globin gene promoters. (PMID: 11544252) Liberati C … Ronchi A (The Journal of biological chemistry 2001) 2 3 22 58
- The nuclear orphan receptors COUP-TFII and Ear-2 act as silencers of the human oxytocin gene promoter. (PMID: 9343308) Chu K … Zingg HH (Journal of molecular endocrinology 1997) 3 4 22 58
- Isolation, characterization, and chromosomal localization of mouse and human COUP-TF I and II genes. (PMID: 8530078) Qiu Y … Tsai SY (Genomics 1995) 2 3 22 58
- Regulation of the apolipoprotein AI gene by ARP-1, a novel member of the steroid receptor superfamily. (PMID: 1899293) Ladias JA … Karathanasis SK (Science (New York, N.Y.) 1991) 3 4 22 58
Products for NR2F2 Gene
- R&D Systems Antibodies for NR2F2 (COUP-TF II/NR2F2)
- Browse R&D Systems for Human Recombinant Proteins
- Browse R&D Systems for biochemical assays
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- Custom Antibody Services
- Browse OriGene ELISA Kits
- Custom Assay Services
- OriGene Purified Proteins for NR2F2
- Search Origene for MassSpec and Protein Over-expression Lysates for NR2F2
- Origene Custom Protein Services for NR2F2
- Origene sirna, shrna, and RNAi products in human, mouse, rat for NR2F2
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- OriGene qPCR primer pairs and template standards for NR2F2
- OriGene qPCR primer pairs for NR2F2
- OriGene CRISPR knockouts for NR2F2
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Browse OriGene miRNA Products For NR2F2
- GenScript: Next-day shipping of latest version cDNA ORF clones for NR2F2 in any vector
- GenScript Custom Purified and Recombinant Proteins Services for NR2F2
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- GenScript Custom overexpressing Cell Line Services for NR2F2
- GenScript: Design CRISPR guide RNA sequences for NR2F2
- Design optimal peptide antigens
- CloneReady with Over 120,000 Genes
- Gene Synthesis: Any Gene in Any Vector
- Vector-based siRNA and miRNA, Ready for Transfection
- Gene Mutant Library, Variants up to 10^11
- Plasmid Preparation
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- Sino Biological Human cDNA Clone for NR2F2
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- Sino Biological Antibodies for NR2F2
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- High-throughput Antibody Production Service
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- Epitope Tag Antibodies & Reporter Protein Antibodies
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- Novus Biologicals Antibodies for NR2F2
- Novus Biologicals proteins and lysates for NR2F2
- Novus Biologicals
- Novus Biologicals Tissue Microarrays
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- VectorBuilder custom plasmid, inducible vectors for NR2F2
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for NR2F2
- VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
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- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Addgene plasmids for NR2F2
- antibodies-online: Search results for 73 available NR2F2 Antibodies ranked by validation data
- Compare Top NR2F2 Antibodies
- antibodies-online: Search results for available NR2F2 related products ranked by validation data
- antibodies-online: Search results for 8 available NR2F2 Proteins ranked by validation data
- Compare Top NR2F2 Proteins
- GeneTex NR2F2 Antibody for NR2F2
- Search GeneTex for Proteins for NR2F2
- Santa Cruz Biotechnology (SCBT) Antibodies for NR2F2
- Search Santa Cruz Biotechnology (SCBT) for NR2F2 siRNA/shRNA
- Santa Cruz Biotechnology (SCBT) CRISPR for NR2F2
- Horizon Cell Lines for NR2F2
- genomics-online: cdna clones - Search results for 120 available NR2F2 gene related products
- Overview of 120 available NR2F2 gene related products
- orf clones - Search results for 120 available NR2F2 gene related products
- Overview of 120 available NR2F2 gene related products
- genomics-online: gRNA clones - Search results for 120 available NR2F2 gene related products
- Overview of 120 available NR2F2 gene related products
- genomics-online: primer clones - Search results for 120 available NR2F2 gene related products
- Overview of 120 available NR2F2 gene related products
- genomics-online: shRNA clones - Search results for 120 available NR2F2 gene related products
- Overview of 120 available NR2F2 gene related products
- Browse GeneCopoeia Cell Lines
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for NR2F2
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for NR2F2
- GeneCopoeia miRNA 3'UTR Target clone products for NR2F2
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for NR2F2
Sources for NR2F2 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) ASD
- (29) ECgene
- (30) GeneAnnot
- (31) CGAP SAGE
- (32) SOURCE
- (33) HomoloGene
- (34) PanEnsembl
- (35) euGenes
- (36) SGD
- (37) FlyBase
- (38) WormBase
- (39) Pseudogene
- (40) DGV
- (41) dbSNP
- (42) GenAtlas
- (43) HGMD
- (44) GAD
- (45) BGMUT
- (46) HuGE
- (47) Atlas
- (48) Cell Signaling Technology
- (49) GenBank
- (50) H-invDB
- (51) HORDE
- (52) HUGE
- (53) IMGT
- (54) Leiden
- (55) miRBase
- (56) DME
- (57) OriGene
- (58) PubMed
- (59) R&D Systems
- (60) TGDB
- (61) Tocris
- (62) Abcam
- (63) Novus Biologicals
- (64) ProSpec
- (65) Sino Biological
- (66) GenScript
- (67) Qiagen
- (68) Cloud-Clone Corp.
- (69) OCA
- (70) Proteopedia
- (71) MOPED
- (72) neXtProt
- (73) Reactome
- (74) GeneGo (Thomson Reuters)
- (75) fRNAdb
- (76) DISEASES
- (77) SIMAP
- (78) GenomeRNAi
- (79) LifeMap
- (80) miRTarBase
- (81) MalaCards
- (82) Invitrogen
- (83) BitterDB
- (84) Vector BioLabs
- (85) ESI-BIO
- (86) RefSeq
- (87) BioSystems
- (88) MaxQB
- (89) IUPHAR
- (90) BioGPS
- (91) Illumina
- (92) COMPARTMENTS
- (93) HOMER
- (94) PaxDb
- (95) ApexBio
- (96) Addgene
- (97) antibodies-online
- (98) CYP
- (99) NONCODE
- (100) SwitchGear Genomics
- (101) TreeFam
- (102) PathCards
- (103) GeneReviews
- (104) GeneTex
- (105) Taconic Biosciences
- (106) GTEx
- (107) ProteomicsDB
- (108) SCBT
- (109) DGIdb
- (110) ClinicalTrials
- (111) FDA Approved Drugs
- (112) RVIS
- (113) SIGNOR
- (114) diseasecard
- (115) NIH Rare Diseases
- (116) Orphanet
- (117) UMLS
- (118) GTR
- (119) Disease Ontology
- (120) Genetics Home Reference
- (121) MeSH
- (122) MedlinePlus
- (123) CDC
- (124) NINDS
- (125) NCBI Bookshelf
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- (128) ViGene Biosciences
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- (132) FANTOM5
- (133) ENCODE
- (134) ProSci
- (135) Horizon
- (136) NURSA
- (137) IID
- (138) Cyagen
- (139) VectorBuilder
- (140) SNPedia
- (141) BRCA Exchange
- (142) St John's Lab
- (143) CIViC
- (144) ProteoGenix
- (145) dbSUPER
- (146) TISSUES
- (147) Gene ORGANizer
- (148) abm
- (149) CrownBio
- (150) Human Protein Atlas
- (151) GWAS Catalog
- (152) Monarch Initiative
- (153) DataMed
- (154) HumanCyc
- (155) genomics-online
- (156) UCNEbase
- (157) EPDnew
- (158) Applied Biosystems
- (159) GlyConnect
- (160) Aminode
- (161) GeneCopoeia
- (162) GPS-Prot
- (163) RNACentral
- (164) LncRNADisease
- (165) LOVD
- (166) miR2Disease
- (167) DiseaseEnhancer
- (168) Boster Bio
- (169) Biorbyt