Aliases for NR2C2AP Gene

Aliases for NR2C2AP Gene

  • Nuclear Receptor 2C2 Associated Protein 2 3 5
  • TR4 Orphan Receptor-Associated 16 KDa Protein 3 4
  • TR4 Orphan Receptor Associated Protein TRA16 2 3
  • Nuclear Receptor 2C2-Associated Protein 3 4
  • TRA16 3 4
  • Repressor For TR4 Transactivation 3

External Ids for NR2C2AP Gene

Previous GeneCards Identifiers for NR2C2AP Gene

  • GC19M019174
  • GC19M019312
  • GC19M018875

Summaries for NR2C2AP Gene

GeneCards Summary for NR2C2AP Gene

NR2C2AP (Nuclear Receptor 2C2 Associated Protein) is a Protein Coding gene. Among its related pathways are Gene Expression and Nuclear Receptor transcription pathway.

UniProtKB/Swiss-Prot Summary for NR2C2AP Gene

  • May act as a repressor of NR2C2-mediated transactivation by suppressing the binding between NR2C2/TR4 and the TR4-response element in target genes.

Additional gene information for NR2C2AP Gene

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for NR2C2AP Gene

Genomics for NR2C2AP Gene

GeneHancer (GH) Regulatory Elements for NR2C2AP Gene

Promoters and enhancers for NR2C2AP Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around NR2C2AP on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the NR2C2AP gene promoter:
  • AREB6
  • c-Ets-1
  • c-Myc
  • Max1
  • NRSF form 1
  • NRSF form 2
  • Pax-4a
  • POU3F2
  • Roaz
  • SRF

Genomic Locations for NR2C2AP Gene

Genomic Locations for NR2C2AP Gene
chr19:19,201,409-19,203,435
(GRCh38/hg38)
Size:
2,027 bases
Orientation:
Minus strand
chr19:19,312,224-19,314,238
(GRCh37/hg19)
Size:
2,015 bases
Orientation:
Minus strand

Genomic View for NR2C2AP Gene

Genes around NR2C2AP on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
NR2C2AP Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for NR2C2AP Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NR2C2AP Gene

Proteins for NR2C2AP Gene

  • Protein details for NR2C2AP Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q86WQ0-NR2CA_HUMAN
    Recommended name:
    Nuclear receptor 2C2-associated protein
    Protein Accession:
    Q86WQ0
    Secondary Accessions:
    • A6NGP7
    • B4DW92

    Protein attributes for NR2C2AP Gene

    Size:
    139 amino acids
    Molecular mass:
    15876 Da
    Quaternary structure:
    • Interacts with NR2C2/TR4.

    Alternative splice isoforms for NR2C2AP Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for NR2C2AP Gene

Post-translational modifications for NR2C2AP Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for NR2C2AP Gene

No data available for DME Specific Peptides for NR2C2AP Gene

Domains & Families for NR2C2AP Gene

Gene Families for NR2C2AP Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for NR2C2AP Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for NR2C2AP Gene

GenScript: Design optimal peptide antigens:
  • cDNA FLJ60181, highly similar to Homo sapiens TR4 orphan receptor associated protein TRA16, mRNA (B4DW92_HUMAN)
  • TR4 orphan receptor-associated 16 kDa protein (NR2CA_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q86WQ0

UniProtKB/Swiss-Prot:

NR2CA_HUMAN :
  • Belongs to the NR2C2AP family.
Family:
  • Belongs to the NR2C2AP family.
genes like me logo Genes that share domains with NR2C2AP: view

Function for NR2C2AP Gene

Molecular function for NR2C2AP Gene

UniProtKB/Swiss-Prot Function:
May act as a repressor of NR2C2-mediated transactivation by suppressing the binding between NR2C2/TR4 and the TR4-response element in target genes.

Phenotypes From GWAS Catalog for NR2C2AP Gene

Gene Ontology (GO) - Molecular Function for NR2C2AP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 12486131
genes like me logo Genes that share ontologies with NR2C2AP: view
genes like me logo Genes that share phenotypes with NR2C2AP: view

Animal Model Products

CRISPR Products

miRNA for NR2C2AP Gene

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for NR2C2AP Gene

Localization for NR2C2AP Gene

Subcellular locations from UniProtKB/Swiss-Prot for NR2C2AP Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for NR2C2AP gene
Compartment Confidence
nucleus 4
mitochondrion 1
peroxisome 1
cytosol 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for NR2C2AP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005654 nucleoplasm IDA,TAS --
genes like me logo Genes that share ontologies with NR2C2AP: view

Pathways & Interactions for NR2C2AP Gene

genes like me logo Genes that share pathways with NR2C2AP: view

Pathways by source for NR2C2AP Gene

Gene Ontology (GO) - Biological Process for NR2C2AP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006367 transcription initiation from RNA polymerase II promoter TAS --
genes like me logo Genes that share ontologies with NR2C2AP: view

No data available for SIGNOR curated interactions for NR2C2AP Gene

Drugs & Compounds for NR2C2AP Gene

No Compound Related Data Available

Transcripts for NR2C2AP Gene

mRNA/cDNA for NR2C2AP Gene

CRISPR Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for NR2C2AP Gene

ExUns: 1 ^ 2a · 2b ^ 3a · 3b ^ 4a · 4b · 4c
SP1: -
SP2:
SP3: -
SP4: -

Relevant External Links for NR2C2AP Gene

GeneLoc Exon Structure for
NR2C2AP
ECgene alternative splicing isoforms for
NR2C2AP

Expression for NR2C2AP Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for NR2C2AP Gene

Protein differential expression in normal tissues from HIPED for NR2C2AP Gene

This gene is overexpressed in Peripheral blood mononuclear cells (12.5) and Ovary (6.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for NR2C2AP Gene



Protein tissue co-expression partners for NR2C2AP Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of NR2C2AP Gene:

NR2C2AP

SOURCE GeneReport for Unigene cluster for NR2C2AP Gene:

Hs.708153

mRNA Expression by UniProt/SwissProt for NR2C2AP Gene:

Q86WQ0-NR2CA_HUMAN
Tissue specificity: Expressed in all tissues examined, with highest expression in heart, skeletal muscle and pancreas.

Evidence on tissue expression from TISSUES for NR2C2AP Gene

  • Lung(2.7)
  • Nervous system(2.7)
  • Intestine(2.1)
genes like me logo Genes that share expression patterns with NR2C2AP: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for NR2C2AP Gene

Orthologs for NR2C2AP Gene

This gene was present in the common ancestor of animals.

Orthologs for NR2C2AP Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia NR2C2AP 33 32
  • 99.52 (n)
OneToOne
dog
(Canis familiaris)
Mammalia NR2C2AP 33 32
  • 89.21 (n)
OneToOne
cow
(Bos Taurus)
Mammalia NR2C2AP 33 32
  • 87.92 (n)
OneToOne
mouse
(Mus musculus)
Mammalia Nr2c2ap 17 33 32
  • 83.21 (n)
rat
(Rattus norvegicus)
Mammalia Nr2c2ap 32
  • 81.85 (n)
oppossum
(Monodelphis domestica)
Mammalia NR2C2AP 33
  • 70 (a)
OneToOne
chicken
(Gallus gallus)
Aves NR2C2AP 33 32
  • 66.67 (n)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii nr2c2ap 33 32
  • 61.35 (n)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CG34213 33 32
  • 51.37 (n)
OneToOne
Species where no ortholog for NR2C2AP was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for NR2C2AP Gene

ENSEMBL:
Gene Tree for NR2C2AP (if available)
TreeFam:
Gene Tree for NR2C2AP (if available)
Aminode:
Evolutionary constrained regions (ECRs) for NR2C2AP: view image

Paralogs for NR2C2AP Gene

No data available for Paralogs for NR2C2AP Gene

Variants for NR2C2AP Gene

Sequence variations from dbSNP and Humsavar for NR2C2AP Gene

SNP ID Clin Chr 19 pos Variation AA Info Type
rs10413280 uncertain-significance, MHC Class II Deficiency 19,201,731(-) C/T 3_prime_UTR_variant, intron_variant
rs113406972 uncertain-significance, benign, MHC Class II Deficiency, Bare lymphocyte syndrome 2 19,201,701(-) G/A 3_prime_UTR_variant, intron_variant
rs1802498 likely-benign, benign, MHC Class II Deficiency, Bare lymphocyte syndrome 2 19,201,687(-) C/G/T 3_prime_UTR_variant, intron_variant
rs200043123 uncertain-significance, Bare lymphocyte syndrome 2 19,201,662(-) C/G/T 3_prime_UTR_variant, intron_variant
rs73922832 likely-benign, MHC Class II Deficiency 19,201,728(-) T/C 3_prime_UTR_variant, intron_variant

Structural Variations from Database of Genomic Variants (DGV) for NR2C2AP Gene

Variant ID Type Subtype PubMed ID
nsv1151217 CNV deletion 26484159
nsv833779 CNV loss 17160897

Variation tolerance for NR2C2AP Gene

Residual Variation Intolerance Score: 37.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.33; 7.27% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for NR2C2AP Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
NR2C2AP

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NR2C2AP Gene

Disorders for NR2C2AP Gene

Additional Disease Information for NR2C2AP

No disorders were found for NR2C2AP Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for NR2C2AP Gene

Publications for NR2C2AP Gene

  1. Identification of a novel testicular orphan receptor-4 (TR4)-associated protein as repressor for the selective suppression of TR4-mediated transactivation. (PMID: 12486131) Yang Y … Chang C (The Journal of biological chemistry 2003) 2 3 4 23 56
  2. Panorama of ancient metazoan macromolecular complexes. (PMID: 26344197) Wan C … Emili A (Nature 2015) 3 56
  3. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T … Vidal M (Cell 2014) 3 56
  4. Proteomic analysis of podocyte exosome-enriched fraction from normal human urine. (PMID: 23376485) Prunotto M … Moll S (Journal of proteomics 2013) 3 56
  5. Bcl2-associated athanogene 3 interactome analysis reveals a new role in modulating proteasome activity. (PMID: 23824909) Chen Y … Ge F (Molecular & cellular proteomics : MCP 2013) 3 56

Products for NR2C2AP Gene

  • Biorbyt antibodies for NR2C2AP

Sources for NR2C2AP Gene