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Aliases for NR2C2AP Gene

Aliases for NR2C2AP Gene

  • Nuclear Receptor 2C2 Associated Protein 2 3 5
  • TR4 Orphan Receptor-Associated 16 KDa Protein 3 4
  • TR4 Orphan Receptor Associated Protein TRA16 2 3
  • TRA16 3 4
  • Nuclear Receptor 2C2-Associated Protein 3
  • Repressor For TR4 Transactivation 3

External Ids for NR2C2AP Gene

Previous GeneCards Identifiers for NR2C2AP Gene

  • GC19M019174
  • GC19M019312
  • GC19M018875

Summaries for NR2C2AP Gene

GeneCards Summary for NR2C2AP Gene

NR2C2AP (Nuclear Receptor 2C2 Associated Protein) is a Protein Coding gene. Among its related pathways are Gene Expression and Nuclear Receptor transcription pathway.

UniProtKB/Swiss-Prot for NR2C2AP Gene

  • May act as a repressor of NR2C2-mediated transactivation by suppressing the binding between NR2C2/TR4 and the TR4-response element in target genes.

Additional gene information for NR2C2AP Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NR2C2AP Gene

Genomics for NR2C2AP Gene

GeneHancer (GH) Regulatory Elements for NR2C2AP Gene

Promoters and enhancers for NR2C2AP Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH19I019201 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 561.3 +0.5 468 2.1 HDGF ATF1 ARID4B SIN3A DMAP1 ZNF2 YY1 GTF3C2 E2F8 ATF7 NR2C2AP ENSG00000267481 MAU2 ATP13A1 UPF1 ENSG00000268938 ENSG00000269191 ZNF90 ZNF14 ENSG00000268030
GH19I018372 Promoter/Enhancer 2.9 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 82.6 +822.3 822335 18 CLOCK MLX ZFP64 FEZF1 DMAP1 IRF4 YY1 SLC30A9 E2F8 ZNF143 GDF15 NR2C2AP ENSG00000268030 UPF1 ENSG00000268938 MEF2B COLGALT1 SUGP2 MVB12A IQCN
GH19I018587 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 64.3 +614.0 613995 3.6 CLOCK MLX DMAP1 SLC30A9 ZNF213 E2F8 ZNF143 SP3 SSRP1 ZNF610 REX1BD ENSG00000268030 UPF1 ENSG00000268938 NR2C2AP ENSG00000269191 MAU2 IQCN MEF2B ELL
GH19I018289 Enhancer 1.9 FANTOM5 Ensembl ENCODE dbSUPER 74.1 +911.2 911199 6.1 YBX1 DMAP1 IRF4 YY1 ZNF213 E2F8 ZNF143 ZNF548 SP3 MEF2D NR2C2AP ENSG00000268030 IQCN SUGP2 UPF1 COLGALT1 ENSG00000268938 MVB12A MEF2B ENSG00000269191
GH19I018401 Enhancer 1.6 FANTOM5 Ensembl ENCODE dbSUPER 87.6 +800.7 800739 2.8 HDGF ZNF493 ZFP64 ARID4B ZNF213 ZNF207 ZNF143 ZNF202 ZC3H11A REST NR2C2AP ENSG00000268030 UPF1 IQCN MAU2 ENSG00000268938 SUGP2 ENSG00000269191 MVB12A TMEM161A
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around NR2C2AP on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the NR2C2AP gene promoter:

Genomic Locations for NR2C2AP Gene

Genomic Locations for NR2C2AP Gene
chr19:19,201,409-19,203,435
(GRCh38/hg38)
Size:
2,027 bases
Orientation:
Minus strand
chr19:19,312,224-19,314,238
(GRCh37/hg19)

Genomic View for NR2C2AP Gene

Genes around NR2C2AP on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
NR2C2AP Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for NR2C2AP Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NR2C2AP Gene

Proteins for NR2C2AP Gene

  • Protein details for NR2C2AP Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q86WQ0-NR2CA_HUMAN
    Recommended name:
    Nuclear receptor 2C2-associated protein
    Protein Accession:
    Q86WQ0
    Secondary Accessions:
    • A6NGP7
    • B4DW92

    Protein attributes for NR2C2AP Gene

    Size:
    139 amino acids
    Molecular mass:
    15876 Da
    Quaternary structure:
    • Interacts with NR2C2/TR4.

    Alternative splice isoforms for NR2C2AP Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for NR2C2AP Gene

Post-translational modifications for NR2C2AP Gene

No Post-translational modifications

Other Protein References for NR2C2AP Gene

No data available for DME Specific Peptides for NR2C2AP Gene

Domains & Families for NR2C2AP Gene

Gene Families for NR2C2AP Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for NR2C2AP Gene

Graphical View of Domain Structure for InterPro Entry

Q86WQ0

UniProtKB/Swiss-Prot:

NR2CA_HUMAN :
  • Belongs to the NR2C2AP family.
Family:
  • Belongs to the NR2C2AP family.
genes like me logo Genes that share domains with NR2C2AP: view

Function for NR2C2AP Gene

Molecular function for NR2C2AP Gene

UniProtKB/Swiss-Prot Function:
May act as a repressor of NR2C2-mediated transactivation by suppressing the binding between NR2C2/TR4 and the TR4-response element in target genes.

Phenotypes From GWAS Catalog for NR2C2AP Gene

Gene Ontology (GO) - Molecular Function for NR2C2AP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 12486131
genes like me logo Genes that share ontologies with NR2C2AP: view
genes like me logo Genes that share phenotypes with NR2C2AP: view

Animal Model Products

miRNA for NR2C2AP Gene

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for NR2C2AP Gene

Localization for NR2C2AP Gene

Subcellular locations from UniProtKB/Swiss-Prot for NR2C2AP Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for NR2C2AP gene
Compartment Confidence
extracellular 5
nucleus 5
mitochondrion 2
peroxisome 1
cytosol 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for NR2C2AP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005654 nucleoplasm TAS,IDA --
GO:0070062 extracellular exosome IDA,HDA 23376485
genes like me logo Genes that share ontologies with NR2C2AP: view

Pathways & Interactions for NR2C2AP Gene

genes like me logo Genes that share pathways with NR2C2AP: view

Pathways by source for NR2C2AP Gene

Gene Ontology (GO) - Biological Process for NR2C2AP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006367 transcription initiation from RNA polymerase II promoter TAS --
genes like me logo Genes that share ontologies with NR2C2AP: view

No data available for SIGNOR curated interactions for NR2C2AP Gene

Drugs & Compounds for NR2C2AP Gene

No Compound Related Data Available

Transcripts for NR2C2AP Gene

Unigene Clusters for NR2C2AP Gene

Nuclear receptor 2C2-associated protein:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for NR2C2AP Gene

ExUns: 1 ^ 2a · 2b ^ 3a · 3b ^ 4a · 4b · 4c
SP1: -
SP2:
SP3: -
SP4: -

Relevant External Links for NR2C2AP Gene

GeneLoc Exon Structure for
NR2C2AP
ECgene alternative splicing isoforms for
NR2C2AP

Expression for NR2C2AP Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for NR2C2AP Gene

Protein differential expression in normal tissues from HIPED for NR2C2AP Gene

This gene is overexpressed in Peripheral blood mononuclear cells (12.5) and Ovary (6.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for NR2C2AP Gene



Protein tissue co-expression partners for NR2C2AP Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of NR2C2AP Gene:

NR2C2AP

SOURCE GeneReport for Unigene cluster for NR2C2AP Gene:

Hs.708153

mRNA Expression by UniProt/SwissProt for NR2C2AP Gene:

Q86WQ0-NR2CA_HUMAN
Tissue specificity: Expressed in all tissues examined, with highest expression in heart, skeletal muscle and pancreas.

Evidence on tissue expression from TISSUES for NR2C2AP Gene

  • Lung(2.7)
  • Nervous system(2.7)
  • Intestine(2.1)
genes like me logo Genes that share expression patterns with NR2C2AP: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for NR2C2AP Gene

Orthologs for NR2C2AP Gene

This gene was present in the common ancestor of animals.

Orthologs for NR2C2AP Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia NR2C2AP 33 34
  • 99.52 (n)
dog
(Canis familiaris)
Mammalia NR2C2AP 33 34
  • 89.21 (n)
cow
(Bos Taurus)
Mammalia NR2C2AP 33 34
  • 87.92 (n)
mouse
(Mus musculus)
Mammalia Nr2c2ap 33 16 34
  • 83.21 (n)
rat
(Rattus norvegicus)
Mammalia Nr2c2ap 33
  • 81.85 (n)
oppossum
(Monodelphis domestica)
Mammalia NR2C2AP 34
  • 70 (a)
OneToOne
chicken
(Gallus gallus)
Aves NR2C2AP 33 34
  • 66.67 (n)
zebrafish
(Danio rerio)
Actinopterygii nr2c2ap 33 34
  • 61.35 (n)
fruit fly
(Drosophila melanogaster)
Insecta CG34213 33 34
  • 51.37 (n)
Species where no ortholog for NR2C2AP was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for NR2C2AP Gene

ENSEMBL:
Gene Tree for NR2C2AP (if available)
TreeFam:
Gene Tree for NR2C2AP (if available)

Paralogs for NR2C2AP Gene

No data available for Paralogs for NR2C2AP Gene

Variants for NR2C2AP Gene

Sequence variations from dbSNP and Humsavar for NR2C2AP Gene

SNP ID Clin Chr 19 pos Variation AA Info Type
rs10413280 uncertain-significance, MHC Class II Deficiency 19,201,731(-) C/T 3_prime_UTR_variant, intron_variant
rs113406972 uncertain-significance, MHC Class II Deficiency 19,201,701(-) G/A 3_prime_UTR_variant, intron_variant
rs1802498 likely-benign, benign, MHC Class II Deficiency, Bare lymphocyte syndrome 2 19,201,687(-) C/G/T 3_prime_UTR_variant, intron_variant
rs73922832 likely-benign, MHC Class II Deficiency 19,201,728(-) T/C 3_prime_UTR_variant, intron_variant
rs1001368041 -- 19,201,045(-) C/T downstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for NR2C2AP Gene

Variant ID Type Subtype PubMed ID
nsv1151217 CNV deletion 26484159
nsv833779 CNV loss 17160897

Variation tolerance for NR2C2AP Gene

Residual Variation Intolerance Score: 37.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.33; 7.27% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for NR2C2AP Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
NR2C2AP

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NR2C2AP Gene

Disorders for NR2C2AP Gene

Additional Disease Information for NR2C2AP

No disorders were found for NR2C2AP Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for NR2C2AP Gene

Publications for NR2C2AP Gene

  1. Identification of a novel testicular orphan receptor-4 (TR4)-associated protein as repressor for the selective suppression of TR4-mediated transactivation. (PMID: 12486131) Yang Y … Chang C (The Journal of biological chemistry 2003) 2 3 4 22 58
  2. Panorama of ancient metazoan macromolecular complexes. (PMID: 26344197) Wan C … Emili A (Nature 2015) 3 58
  3. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T … Vidal M (Cell 2014) 3 58
  4. Proteomic analysis of podocyte exosome-enriched fraction from normal human urine. (PMID: 23376485) Prunotto M … Moll S (Journal of proteomics 2013) 3 58
  5. Bcl2-associated athanogene 3 interactome analysis reveals a new role in modulating proteasome activity. (PMID: 23824909) Chen Y … Ge F (Molecular & cellular proteomics : MCP 2013) 3 58

Products for NR2C2AP Gene

Sources for NR2C2AP Gene

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