Aliases for NR2C1 Gene
Aliases for NR2C1 Gene
External Ids for NR2C1 Gene
- HGNC: 7971
- Entrez Gene: 7181
- Ensembl: ENSG00000120798
- OMIM: 601529
- UniProtKB: P13056
Previous HGNC Symbols for NR2C1 Gene
- TR2
Previous GeneCards Identifiers for NR2C1 Gene
- GC12P094483
- GC12P9G0092
- GC12M095348
- GC12M093918
- GC12M095414
- GC12M092481
Summaries for NR2C1 Gene
-
This gene encodes a nuclear hormone receptor characterized by a highly conserved DNA binding domain (DBD), a variable hinge region, and a carboxy-terminal ligand binding domain (LBD) that is typical for all members of the steroid/thyroid hormone receptor superfamily. This protein also belongs to a large family of ligand-inducible transcription factors that regulate gene expression by binding to specific DNA sequences within promoters of target genes. Multiple alternatively spliced transcript variants have been described, but the full-length nature of some of these variants has not been determined. [provided by RefSeq, Jul 2008]
GeneCards Summary for NR2C1 Gene
NR2C1 (Nuclear Receptor Subfamily 2 Group C Member 1) is a Protein Coding gene. Among its related pathways are Gene Expression and Signaling events mediated by HDAC Class I. Gene Ontology (GO) annotations related to this gene include DNA binding transcription factor activity and sequence-specific DNA binding. An important paralog of this gene is NR2C2.
UniProtKB/Swiss-Prot for NR2C1 Gene
-
Orphan nuclear receptor. Binds the IR7 element in the promoter of its own gene in an autoregulatory negative feedback mechanism. Primarily repressor of a broad range of genes. Binds to hormone response elements (HREs) consisting of two 5-AGGTCA-3 half site direct repeat consensus sequences. Together with NR2C2, forms the core of the DRED (direct repeat erythroid-definitive) complex that represses embryonic and fetal globin transcription. Also activator of OCT4 gene expression. May be involved in stem cell proliferation and differentiation. Mediator of retinoic acid-regulated preadipocyte proliferation.
Additional gene information for NR2C1 Gene
- Monarch Initiative
- Search for NR2C1 at DataMed
- Search for NR2C1 at HumanCyc
No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NR2C1 Gene
Genomics for NR2C1 Gene
GeneHancer (GH) Regulatory Elements for NR2C1 Gene
Promoters and enhancers for NR2C1 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)
GeneHancers around NR2C1 on UCSC Golden Path with GeneCards custom track
- Top Transcription factor binding sites by QIAGEN in the NR2C1 gene promoter:
-
- p53
- Egr-1
- RORalpha2
- Pax-2b
- Pax-2a
- Pax-2
- SRF
- SRF (504 AA)
- PPAR-alpha
Regulatory Element Products
Genomic Locations for NR2C1 Gene
Genomic Locations for NR2C1 Gene
- chr12:95,020,229-95,073,703
- (GRCh38/hg38)
- Size:
- 53,475 bases
- Orientation:
- Minus strand
- chr12:95,414,005-95,467,479
- (GRCh37/hg19)
- Size:
- 53,475 bases
- Orientation:
- Minus strand
Genomic View for NR2C1 Gene
Genes around NR2C1 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 12q22 by Entrez Gene
- 12q22 by HGNC
- 12q22 by Ensembl
NR2C1 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for NR2C1 Gene
Proteins for NR2C1 Gene
-
Protein details for NR2C1 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- P13056-NR2C1_HUMAN
- Recommended name:
- Nuclear receptor subfamily 2 group C member 1
- Protein Accession:
- P13056
- A8K5K4
- Q15625
- Q15626
Protein attributes for NR2C1 Gene
- Size:
- 603 amino acids
- Molecular mass:
- 67315 Da
- Quaternary structure:
-
- Homodimer (By similarity). Heterodimer; binds DNA as a heterodimer with NR2C2 required for chromatin remodeling and for binding to promoter regions such as globin DR1 repeats (By similarity). Interacts with NRIP1 (via its LXXLL motifs); the interaction provides corepressor activity. Interacts with HDAC3 (via the DNA-binding domain). Interacts with HDAC4 (via the DNA-binding domain). Interacts with PIAS1; the interaction is required for sumoylation of NR2C1. Interacts with UBE2I; the interaction is required for sumoylation of NR2C1. Interacts with KAT2B; the interaction acts as a corepressor of gene expression (By similarity). Interacts with ESR1; the interaction prevents homodimerization of ESR1 and suppresses its transcriptional activity and cell growth.
Protein Expression for NR2C1 Gene
Post-translational modifications for NR2C1 Gene
- Sumoylation requires both PIAS1 and UBE2I. Sumoylation appears to dissociate NR2C1 from the PML nuclear bodies. Enhances the interaction with NRIP1 but inhibits interaction with KAT2B. In proliferating cells, stimulation by all-trans retinoic acid, activation of MAPK1-mediated phosphorylation and recruitment to PML bodies with subsequent sumoylation, suppresses OCT4 expression (By similarity).
- Phosphorylated on several serine and threonine residues. Phosphorylation on Thr-222, stimulated by all-trans retinoic acid (atRA) mediates PML location and sumoylation in proliferating cells which then modulates its association with effector molecules, KAT2B and NRIP1. Phosphorylation on Ser-581 by PKC is important for protein stability and function as activator of RARB (By similarity).
- Modification sites at PhosphoSitePlus
- Modification sites at neXtProt
Other Protein References for NR2C1 Gene
Antibody Products
- R&D Systems Antibodies for NR2C1 (TR2/NR2C1)
- Novus Biologicals Antibodies for NR2C1
-
Abcam antibodies for NR2C1
- Invitrogen Antibodies for NR2C1 (AFLGC-NR2C1)
- GeneTex NR2C1 Antibody for NR2C1
-
Boster Bio Antibodies for NR2C1
-
Santa Cruz Biotechnology (SCBT) Antibodies for NR2C1
Protein Products
-
OriGene Purified Proteins for NR2C1
- Search Origene for MassSpec and Protein Over-expression Lysates for NR2C1
- Origene Custom Protein Services for NR2C1
- Search GeneTex for Proteins for NR2C1
-
Abcam proteins for NR2C1
Assay Products
No data available for DME Specific Peptides for NR2C1 Gene
Domains & Families for NR2C1 Gene
Gene Families for NR2C1 Gene
- HGNC:
- IUPHAR :
- Human Protein Atlas (HPA):
-
- Nuclear receptors
- Plasma proteins
- Predicted intracellular proteins
- Transcription factors
Protein Domains for NR2C1 Gene
- InterPro:
- ProtoNet:
Suggested Antigen Peptide Sequences for NR2C1 Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
P13056- Family:
-
- Belongs to the nuclear hormone receptor family. NR2 subfamily.
Function for NR2C1 Gene
Molecular function for NR2C1 Gene
- UniProtKB/Swiss-Prot Function:
- Orphan nuclear receptor. Binds the IR7 element in the promoter of its own gene in an autoregulatory negative feedback mechanism. Primarily repressor of a broad range of genes. Binds to hormone response elements (HREs) consisting of two 5-AGGTCA-3 half site direct repeat consensus sequences. Together with NR2C2, forms the core of the DRED (direct repeat erythroid-definitive) complex that represses embryonic and fetal globin transcription. Also activator of OCT4 gene expression. May be involved in stem cell proliferation and differentiation. Mediator of retinoic acid-regulated preadipocyte proliferation.
- GENATLAS Biochemistry:
- nuclear receptor subfamily 2,group C,member 1,expressed in testis and prostate,steroid/thyroid hormone receptor superfamily,with several alternative isoforms
Phenotypes From GWAS Catalog for NR2C1 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000978 | RNA polymerase II proximal promoter sequence-specific DNA binding | IEA | -- |
| GO:0000981 | RNA polymerase II transcription factor activity, sequence-specific DNA binding | NAS | 19274049 |
| GO:0001078 | transcriptional repressor activity, RNA polymerase II proximal promoter sequence-specific DNA binding | IEA | -- |
| GO:0003677 | DNA binding | IEA,TAS | 3421977 |
| GO:0003700 | DNA binding transcription factor activity | IEA | -- |
Phenotypes for NR2C1 Gene
- MGI mutant phenotypes for NR2C1:
- inferred from 1 alleles
- GenomeRNAi human phenotypes for NR2C1:
Animal Models for NR2C1 Gene
- MGI Knock Outs for NR2C1:
-
- Nr2c1 Nr2c1<tm1Chc>
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
- Cyagen custom Knockout/knockin (KOKI) mouse models for NR2C1
-
CRISPR Products
-
OriGene CRISPR knockouts for NR2C1
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for NR2C1
- genomics-online: gRNA clones - Search results for 109 available NR2C1 gene related products
- Overview of 109 available NR2C1 gene related products
- Applied Biological Materials CRISPR for NR2C1
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for NR2C1
- GenScript: Design CRISPR guide RNA sequences for NR2C1
miRNA for NR2C1 Gene
- miRTarBase miRNAs that target NR2C1
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for NR2C1
- Browse OriGene Inhibitory RNA Products For NR2C1
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for NR2C1
- genomics-online: shRNA clones - Search results for 109 available NR2C1 gene related products
- Overview of 109 available NR2C1 gene related products
Clone Products
-
OriGene ORF clones in human for NR2C1
- RC208060
- RC208060L1
- RC208060L2
- RC208060L3
- RC208060L4
- RC218582
- RC218582L1
- RC218582L2
- RC218582L3
- RC218582L4
- RC225822
- RC225822L1
- RC225822L2
- RC225822L3
- RC225822L4
- RG208060
- RG218582
- RG225822
- RC208060L1V
- RC208060L2V
- RC208060L3V
- RC208060L4V
- RC218582L1V
- RC218582L2V
- RC218582L3V
- RC218582L4V
- RC225822L1V
- RC225822L2V
- RC225822L3V
- RC225822L4V
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Sino Biological Human cDNA Clone for NR2C1
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for NR2C1
- Applied Biological Materials Clones for NR2C1
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
Cell Line Products
-
Horizon Cell Lines for NR2C1
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for NR2C1 Gene
Localization for NR2C1 Gene
Subcellular locations from UniProtKB/Swiss-Prot for NR2C1 Gene
- Nucleus. Nucleus, PML body. Note=Recruited by HDAC3, after all-trans retinoic acid stimulated MAPK1-mediated Thr-223 phosphorylation, to PML bodies for subsequent sumoylation. {ECO:0000250}.
| Compartment | Confidence |
|---|---|
| nucleus | 5 |
| cytosol | 3 |
| plasma membrane | 2 |
- Nucleus (3)
- Cell Junctions (2)
- Cytosol (2)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005634 | nucleus | IEA | -- |
| GO:0005654 | nucleoplasm | TAS | -- |
| GO:0016605 | PML body | IEA | -- |
Pathways & Interactions for NR2C1 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Gene Expression |
.48
|
|
| 2 | Nuclear Receptor transcription pathway | ||
| 3 | Regulation of Androgen receptor activity | ||
| 4 | Signaling events mediated by HDAC Class I | ||
Pathways by source for NR2C1 Gene
2 BioSystems pathways for NR2C1 Gene
3 Reactome pathways for NR2C1 Gene
Interacting Proteins for NR2C1 Gene
Selected Interacting proteins:
ENSP00000333275
P13056-NR2C1_HUMAN
for NR2C1 Gene via
STRING
MINT
IID
GPS-Prot Interaction Network for NR2C1
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000122 | negative regulation of transcription by RNA polymerase II | IEA | -- |
| GO:0006351 | transcription, DNA-templated | IEA | -- |
| GO:0006355 | regulation of transcription, DNA-templated | IEA | -- |
| GO:0006367 | transcription initiation from RNA polymerase II promoter | TAS | -- |
| GO:0043401 | steroid hormone mediated signaling pathway | IEA | -- |
No data available for SIGNOR curated interactions for NR2C1 Gene
Transcripts for NR2C1 Gene
mRNA/cDNA for NR2C1 Gene
- (8) REFSEQ mRNAs :
- (9) Additional mRNA sequences :
- (147) Selected AceView cDNA sequences:
- (19) Ensembl transcripts including schematic representations, and UCSC links where relevant :
-
- ENST00000333003 4143 bps (uc001tdm.6)
- ENST00000551647 740 bps (uc058rvo.1)
- ENST00000552861 2499 bps (uc058rvp.1)
- ENST00000549617 683 bps (uc058rvq.1)
- ENST00000546416 864 bps (uc058rvr.1)
Unigene Clusters for NR2C1 Gene
CRISPR Products
-
OriGene CRISPR knockouts for NR2C1
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for NR2C1
- genomics-online: gRNA clones - Search results for 109 available NR2C1 gene related products
- Overview of 109 available NR2C1 gene related products
- Applied Biological Materials CRISPR for NR2C1
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for NR2C1
- GenScript: Design CRISPR guide RNA sequences for NR2C1
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for NR2C1
- Browse OriGene Inhibitory RNA Products For NR2C1
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for NR2C1
- genomics-online: shRNA clones - Search results for 109 available NR2C1 gene related products
- Overview of 109 available NR2C1 gene related products
Clone Products
-
OriGene ORF clones in human for NR2C1
- RC208060
- RC208060L1
- RC208060L2
- RC208060L3
- RC208060L4
- RC218582
- RC218582L1
- RC218582L2
- RC218582L3
- RC218582L4
- RC225822
- RC225822L1
- RC225822L2
- RC225822L3
- RC225822L4
- RG208060
- RG218582
- RG225822
- RC208060L1V
- RC208060L2V
- RC208060L3V
- RC208060L4V
- RC218582L1V
- RC218582L2V
- RC218582L3V
- RC218582L4V
- RC225822L1V
- RC225822L2V
- RC225822L3V
- RC225822L4V
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Sino Biological Human cDNA Clone for NR2C1
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for NR2C1
- Applied Biological Materials Clones for NR2C1
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
| ExUns: | 1a | · | 1b | · | 1c | · | 1d | · | 1e | · | 1f | · | 1g | · | 1h | ^ | 2a | · | 2b | ^ | 3 | ^ | 4a | · | 4b | · | 4c | ^ | 5a | · | 5b | · | 5c | ^ | 6a | · | 6b | ^ | 7a | · | 7b | · | 7c | · | 7d | ^ | 8 | ^ | 9 | ^ | 10 | ^ |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||||||
| SP2: | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||
| SP3: | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||||||
| SP4: | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||||||
| SP5: | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||||
| SP6: | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||||
| SP7: | - | |||||||||||||||||||||||||||||||||||||||||||||||||||
| SP8: | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||||||
| SP9: | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||
| SP10: | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||
| SP11: | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||||
| SP12: | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||||||
| SP13: | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||||||
| SP14: | - | |||||||||||||||||||||||||||||||||||||||||||||||||||
| SP15: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP16: |
| ExUns: | 11a | · | 11b | ^ | 12 | ^ | 13a | · | 13b | ^ | 14a | · | 14b | · | 14c | ^ | 15a | · | 15b | · | 15c | ^ | 16a | · | 16b | ^ | 17a | · | 17b |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | - | - | - | - | ||||||||||||||||||||||||
| SP2: | - | ||||||||||||||||||||||||||||
| SP3: | - | - | - | - | - | - | - | - | - | ||||||||||||||||||||
| SP4: | |||||||||||||||||||||||||||||
| SP5: | |||||||||||||||||||||||||||||
| SP6: | |||||||||||||||||||||||||||||
| SP7: | |||||||||||||||||||||||||||||
| SP8: | |||||||||||||||||||||||||||||
| SP9: | |||||||||||||||||||||||||||||
| SP10: | |||||||||||||||||||||||||||||
| SP11: | |||||||||||||||||||||||||||||
| SP12: | |||||||||||||||||||||||||||||
| SP13: | |||||||||||||||||||||||||||||
| SP14: | |||||||||||||||||||||||||||||
| SP15: | - | - | - | ||||||||||||||||||||||||||
| SP16: |
Expression for NR2C1 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
This gene is overexpressed in Fetal ovary (32.3) and Platelet (24.8).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for NR2C1 Gene
NURSA nuclear receptor signaling pathways regulating expression of NR2C1 Gene:
NR2C1SOURCE GeneReport for Unigene cluster for NR2C1 Gene:
Hs.108301Evidence on tissue expression from TISSUES for NR2C1 Gene
- Intestine(4.2)
- Nervous system(3.5)
Primer Products
-
OriGene qPCR primer pairs for NR2C1
- genomics-online: primer clones - Search results for 109 available NR2C1 gene related products
- Overview of 109 available NR2C1 gene related products
Gene Expression Assay Products
No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for NR2C1 Gene
Orthologs for NR2C1 Gene
This gene was present in the common ancestor of animals.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | NR2C1 34 33 |
|
OneToOne | |
| dog (Canis familiaris) |
Mammalia | NR2C1 34 33 |
|
OneToOne | |
| cow (Bos Taurus) |
Mammalia | NR2C1 34 33 |
|
OneToOne | |
| oppossum (Monodelphis domestica) |
Mammalia | NR2C1 34 |
|
OneToOne | |
| mouse (Mus musculus) |
Mammalia | Nr2c1 16 34 33 |
|
||
| rat (Rattus norvegicus) |
Mammalia | Nr2c1 33 |
|
||
| platypus (Ornithorhynchus anatinus) |
Mammalia | NR2C1 34 |
|
OneToOne | |
| chicken (Gallus gallus) |
Aves | NR2C1 34 33 |
|
OneToOne | |
| lizard (Anolis carolinensis) |
Reptilia | NR2C1 34 |
|
OneToOne | |
| tropical clawed frog (Silurana tropicalis) |
Amphibia | nr2c1 33 |
|
||
| Str.15706 33 |
|
||||
| African clawed frog (Xenopus laevis) |
Amphibia | Xl.21534 33 |
|
||
| zebrafish (Danio rerio) |
Actinopterygii | nr2c1 34 33 |
|
OneToOne | |
| fruit fly (Drosophila melanogaster) |
Insecta | Hr78 34 35 |
|
OneToMany | |
| worm (Caenorhabditis elegans) |
Secernentea | nhr-41 34 |
|
OneToMany | |
| sea squirt (Ciona savignyi) |
Ascidiacea | CSA.9698 34 |
|
OneToMany |
- Species where no ortholog for NR2C1 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
Evolution for NR2C1 Gene
- ENSEMBL:
- Gene Tree for NR2C1 (if available)
- TreeFam:
- Gene Tree for NR2C1 (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for NR2C1: view image
Paralogs for NR2C1 Gene
Paralogs for NR2C1 Gene
(11) SIMAP similar genes for NR2C1 Gene using alignment to 6 proteins:
- NR2C1_HUMAN
- B6ZGT7_HUMAN
- F8W1Q1_HUMAN
- H0YHC6_HUMAN
- H0YIV1_HUMAN
- H9NIM2_HUMAN
Variants for NR2C1 Gene
| SNP ID | Clin | Chr 12 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| rs1000043150 | -- | 95,051,983(-) | C/T | intron_variant | |
| rs1000052195 | -- | 95,030,799(-) | T/C | 3_prime_UTR_variant, intron_variant | |
| rs1000071948 | -- | 95,045,320(-) | G/A/T | intron_variant | |
| rs1000109595 | -- | 95,043,290(-) | A/C | intron_variant | |
| rs1000119195 | -- | 95,035,590(-) | G/A | intron_variant |
Residual Variation Intolerance Score:
32.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
1.60;
30.82% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for NR2C1 Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- NR2C1
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NR2C1 Gene
Disorders for NR2C1 Gene
Additional Disease Information for NR2C1
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
No disorders were found for NR2C1 Gene.
No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for NR2C1 Gene
Publications for NR2C1 Gene
- Transcriptional regulation of the human TR2 orphan receptor gene by nuclear factor 1-A. (PMID: 17010934) Lin YL … Lee HJ (Biochemical and biophysical research communications 2006) 3 4 22 58
- Suppression of estrogen receptor-mediated transcription and cell growth by interaction with TR2 orphan receptor. (PMID: 12093804) Hu YC … Chang C (The Journal of biological chemistry 2002) 3 4 22 58
- Molecular cloning of new human TR2 receptors: a class of steroid receptor with multiple ligand-binding domains. (PMID: 2597158) Chang C … Chang Y (Biochemical and biophysical research communications 1989) 2 3 4 58
- Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 44 58
- HDAC3 as a molecular chaperone for shuttling phosphorylated TR2 to PML: a novel deacetylase activity-independent function of HDAC3. (PMID: 19204783) Gupta P … Wei LN (PloS one 2009) 3 22 58
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Sources for NR2C1 Gene
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