This gene product belongs to the nuclear receptor superfamily, members of which are transcription factors characterized by a ligand-binding domain and a DNA-binding domain. The encoded protein is a transcriptional regulator of the cytochrome P450 gene CYP3A4, binding to the response element of the CYP3A4 promoter as a heterodimer with the 9-cis retinoic acid receptor RXR. It is... See more...

Aliases for NR1I2 Gene

Aliases for NR1I2 Gene

  • Nuclear Receptor Subfamily 1 Group I Member 2 2 3 4 5
  • Orphan Nuclear Receptor PXR 2 3 4
  • Pregnane X Receptor 2 3 4
  • Steroid And Xenobiotic Receptor 3 4
  • Orphan Nuclear Receptor PAR1 3 4
  • PXR 3 4
  • SXR 3 4
  • Nuclear Receptor Subfamily 1, Group I, Member 2 2
  • Pregnane X Nuclear Receptor Variant 2 3
  • ONR1 3
  • PAR1 3
  • PAR2 3
  • PARq 3
  • BXR 3
  • PAR 3
  • PRR 3
  • SAR 3

External Ids for NR1I2 Gene

Previous GeneCards Identifiers for NR1I2 Gene

  • GC03P116138
  • GC03P119128
  • GC03P120780
  • GC03P120820
  • GC03P120982
  • GC03P119499
  • GC03P116874

Summaries for NR1I2 Gene

Entrez Gene Summary for NR1I2 Gene

  • This gene product belongs to the nuclear receptor superfamily, members of which are transcription factors characterized by a ligand-binding domain and a DNA-binding domain. The encoded protein is a transcriptional regulator of the cytochrome P450 gene CYP3A4, binding to the response element of the CYP3A4 promoter as a heterodimer with the 9-cis retinoic acid receptor RXR. It is activated by a range of compounds that induce CYP3A4, including dexamethasone and rifampicin. Several alternatively spliced transcripts encoding different isoforms, some of which use non-AUG (CUG) translation initiation codon, have been described for this gene. Additional transcript variants exist, however, they have not been fully characterized. [provided by RefSeq, Jul 2008]

GeneCards Summary for NR1I2 Gene

NR1I2 (Nuclear Receptor Subfamily 1 Group I Member 2) is a Protein Coding gene. Diseases associated with NR1I2 include Cerebrotendinous Xanthomatosis and Biliary Tract Disease. Among its related pathways are Ponatinib Pathway, Pharmacokinetics/Pharmacodynamics and Gene Expression. Gene Ontology (GO) annotations related to this gene include DNA-binding transcription factor activity and transcription coactivator activity. An important paralog of this gene is VDR.

UniProtKB/Swiss-Prot Summary for NR1I2 Gene

  • Nuclear receptor that binds and is activated by variety of endogenous and xenobiotic compounds. Transcription factor that activates the transcription of multiple genes involved in the metabolism and secretion of potentially harmful xenobiotics, drugs and endogenous compounds. Activated by the antibiotic rifampicin and various plant metabolites, such as hyperforin, guggulipid, colupulone, and isoflavones. Response to specific ligands is species-specific. Activated by naturally occurring steroids, such as pregnenolone and progesterone. Binds to a response element in the promoters of the CYP3A4 and ABCB1/MDR1 genes.

Tocris Summary for NR1I2 Gene

  • Pregnane X receptors (PXRs) are nuclear receptors that regulate the expression of CYP3A genes, generating key enzymes involved in xenobiotic metabolism. PXRs also help regulate the induction of P-gp. PXRs are highly expressed in the liver, small intestine and colon.

Gene Wiki entry for NR1I2 Gene

PharmGKB "VIP" Summary for NR1I2 Gene

Additional gene information for NR1I2 Gene

No data available for CIViC Summary , Rfam classification and piRNA Summary for NR1I2 Gene

Genomics for NR1I2 Gene

GeneHancer (GH) Regulatory Elements for NR1I2 Gene

Promoters and enhancers for NR1I2 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH03J119779 Promoter/Enhancer 1.6 EPDnew Ensembl ENCODE dbSUPER 500.7 +1.4 1426 4 POLR2G ZNF510 SIN3A FOXA2 ZNF316 MAFF TRIM24 CEBPG MAFK NFE2 NR1I2 MAATS1 ENSG00000239994 PHBP8 ENSG00000285585
GH03J119778 Enhancer 0.5 ENCODE 500.7 -1.4 -1370 1.2 ZNF316 NFE2 MAFG ZEB2 ZNF766 EMSY NR1I2 piR-35282-004 ENSG00000285585
GH03J119794 Enhancer 1.3 FANTOM5 ENCODE dbSUPER 6.7 +15.6 15565 3.4 EP300 TCF12 POLR2G NCOR1 KDM6A TCF7 AFF1 TRIM28 MYC CTBP1 MAATS1 ENSG00000239994 NR1I2 ARHGAP31 PHBP8 HSALNG0028349 ENSG00000285585
GH03J119652 Enhancer 0.5 FANTOM5 dbSUPER 7.3 -129.3 -129262 0.3 ZNF623 ZMYM3 RPL10P7 ADPRH CD80 MAATS1 NR1I2 POPDC2
GH03J119715 Enhancer 1.1 FANTOM5 Ensembl ENCODE 2.7 -63.5 -63510 2.5 NCOR1 TEAD1 FOXA2 NR2F2 ZBTB33 SPI1 NFE2 JUND FOXP1 SMAD4 MAATS1 ENSG00000239994 RPL10P7 PLA1A LRRC58 NR1I2 ENSG00000285585
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around NR1I2 on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for NR1I2

Top Transcription factor binding sites by QIAGEN in the NR1I2 gene promoter:
  • AP-1
  • PPAR-gamma1

Genomic Locations for NR1I2 Gene

Genomic Locations for NR1I2 Gene
chr3:119,780,484-119,818,485
(GRCh38/hg38)
Size:
38,002 bases
Orientation:
Plus strand
chr3:119,499,331-119,537,332
(GRCh37/hg19)
Size:
38,002 bases
Orientation:
Plus strand

Genomic View for NR1I2 Gene

Genes around NR1I2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
NR1I2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for NR1I2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NR1I2 Gene

Proteins for NR1I2 Gene

  • Protein details for NR1I2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O75469-NR1I2_HUMAN
    Recommended name:
    Nuclear receptor subfamily 1 group I member 2
    Protein Accession:
    O75469
    Secondary Accessions:
    • Q006P5
    • Q008C8
    • Q96AC7
    • Q9UJ22
    • Q9UJ23
    • Q9UJ24
    • Q9UJ25
    • Q9UJ26
    • Q9UJ27
    • Q9UNW4

    Protein attributes for NR1I2 Gene

    Size:
    434 amino acids
    Molecular mass:
    49762 Da
    Quaternary structure:
    • Heterodimer with RXR. Interacts with NCOA1. Interacts (via domain NR LBD) with CRY1 and CRY2 in a ligand-dependent manner (By similarity).

    Three dimensional structures from OCA and Proteopedia for NR1I2 Gene

    Alternative splice isoforms for NR1I2 Gene

neXtProt entry for NR1I2 Gene

Post-translational modifications for NR1I2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for NR1I2 Gene

No data available for DME Specific Peptides for NR1I2 Gene

Domains & Families for NR1I2 Gene

Gene Families for NR1I2 Gene

HGNC:
IUPHAR :
Human Protein Atlas (HPA):
  • FDA approved drug targets
  • Nuclear receptors
  • Plasma proteins
  • Predicted intracellular proteins
  • Transcription factors

Protein Domains for NR1I2 Gene

Blocks:
  • Steroid hormone receptor signature
  • Vitamin D receptor signature
InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for NR1I2 Gene

GenScript: Design optimal peptide antigens:
  • Orphan nuclear receptor PXR (B6ZGT1_HUMAN)
  • Pregnane X nuclear receptor variant 2 (F1D8P9_HUMAN)
  • Pregnane X nuclear receptor (F1DAL3_HUMAN)
  • Steroid and xenobiotic receptor (NR1I2_HUMAN)
  • PAR2 (Q9H4M8_HUMAN)

Graphical View of Domain Structure for InterPro Entry

O75469

UniProtKB/Swiss-Prot:

NR1I2_HUMAN :
  • Belongs to the nuclear hormone receptor family. NR1 subfamily.
Family:
  • Belongs to the nuclear hormone receptor family. NR1 subfamily.
genes like me logo Genes that share domains with NR1I2: view

Function for NR1I2 Gene

Molecular function for NR1I2 Gene

UniProtKB/Swiss-Prot Function:
Nuclear receptor that binds and is activated by variety of endogenous and xenobiotic compounds. Transcription factor that activates the transcription of multiple genes involved in the metabolism and secretion of potentially harmful xenobiotics, drugs and endogenous compounds. Activated by the antibiotic rifampicin and various plant metabolites, such as hyperforin, guggulipid, colupulone, and isoflavones. Response to specific ligands is species-specific. Activated by naturally occurring steroids, such as pregnenolone and progesterone. Binds to a response element in the promoters of the CYP3A4 and ABCB1/MDR1 genes.

Phenotypes From GWAS Catalog for NR1I2 Gene

Gene Ontology (GO) - Molecular Function for NR1I2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000976 transcription regulatory region sequence-specific DNA binding IBA 21873635
GO:0000977 RNA polymerase II regulatory region sequence-specific DNA binding IDA 11114890
GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific NAS 19274049
GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific IDA 11114890
GO:0003677 DNA binding IEA --
genes like me logo Genes that share ontologies with NR1I2: view
genes like me logo Genes that share phenotypes with NR1I2: view

Animal Models for NR1I2 Gene

MGI Knock Outs for NR1I2:

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for NR1I2

Clone Products

  • Addgene plasmids for NR1I2

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for NR1I2 Gene

Localization for NR1I2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for NR1I2 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for NR1I2 gene
Compartment Confidence
nucleus 5
cytoskeleton 4
peroxisome 3
cytosol 3
plasma membrane 2
extracellular 2
mitochondrion 2
endoplasmic reticulum 2
lysosome 2
endosome 1
golgi apparatus 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for NR1I2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000790 nuclear chromatin ISA --
GO:0005634 nucleus IBA 21873635
GO:0005654 nucleoplasm TAS --
GO:0016604 nuclear body IDA --
GO:0045111 intermediate filament cytoskeleton IDA --
genes like me logo Genes that share ontologies with NR1I2: view

Pathways & Interactions for NR1I2 Gene

genes like me logo Genes that share pathways with NR1I2: view

SIGNOR curated interactions for NR1I2 Gene

Activates:
Is inactivated by:

Gene Ontology (GO) - Biological Process for NR1I2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000122 negative regulation of transcription by RNA polymerase II IBA 21873635
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0006367 transcription initiation from RNA polymerase II promoter TAS --
GO:0006629 lipid metabolic process IBA 21873635
GO:0006805 xenobiotic metabolic process IDA 12578355
genes like me logo Genes that share ontologies with NR1I2: view

Drugs & Compounds for NR1I2 Gene

(145) Drugs for NR1I2 Gene - From: DrugBank, PharmGKB, ApexBio, DGIdb, IUPHAR, HMDB, Tocris, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Rifampicin Approved Pharma Agonist, Inhibition, Inhibitor, Target, agonist, binder Pregnane X receptor agonist; antibiotic 454
Clotrimazole Approved, Vet_approved Pharma Inhibition, Pore Blocker, Antagonist, Agonist, Gating inhibitor, Channel blocker, Target, activator, inhibitor 39
Mifepristone Approved, Investigational Pharma Agonist, Antagonist, Mixed, Target, antagonist Progesterone receptor antagonist, Progesterone and glucocorticoid receptor antagonist 179
Nifedipine Approved Pharma Gating inhibitor, Channel blocker, Antagonist, Pore Blocker, Agonist, Activator, Target, blocker 137
Phenobarbital Approved, Investigational Pharma Agonist, Target, activator, antagonist 97

(50) Additional Compounds for NR1I2 Gene - From: Novoseek, IUPHAR, and Tocris

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
17beta-estradiol
Agonist, Activator
5beta-cholestane-3alpha,7alpha,12alpha-triol
Agonist
S20 (racemic mixture)
Agonist
taxol
Agonist 33069-62-4
Meclizine dihydrochloride
1104-22-9

(4) Tocris Compounds for NR1I2 Gene

Compound Action Cas Number
Meclizine dihydrochloride Human pregnane X receptor agonist; H1 antagonist 1104-22-9
Rifampicin Pregnane X receptor agonist; antibiotic 13292-46-1
Rifaximin Pregnane X receptor agonist; antibiotic 80621-81-4
SR 12813 Pregnane X receptor agonist 126411-39-0

(8) ApexBio Compounds for NR1I2 Gene

Compound Action Cas Number
Fexaramine 574013-66-4
GW3965 HLXRα/hLXRβ agonist,potent and selective 405911-09-3
Lithocholic Acid Activator of vitamin D receptor,PXR and FXR 434-13-9
LXR-623 Liver X-receptor agonist 875787-07-8
Rifaximin (Xifaxan) RNA synthesis inhibitor, PXR activator 80621-81-4
SR 12813 126411-39-0
SR-9243 inverse agonist of LXR 1613028-81-1
Z-Guggulsterone 39025-23-5
genes like me logo Genes that share compounds with NR1I2: view

Drug Products

Transcripts for NR1I2 Gene

mRNA/cDNA for NR1I2 Gene

3 REFSEQ mRNAs :
13 NCBI additional mRNA sequence :
7 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for NR1I2

Clone Products

  • Addgene plasmids for NR1I2

Alternative Splicing Database (ASD) splice patterns (SP) for NR1I2 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6a · 6b ^ 7 ^ 8 ^ 9 ^ 10a · 10b
SP1: - -
SP2: -
SP3: - -
SP4:

Relevant External Links for NR1I2 Gene

GeneLoc Exon Structure for
NR1I2

Expression for NR1I2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for NR1I2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for NR1I2 Gene

This gene is overexpressed in Liver (x29.6), Small Intestine - Terminal Ileum (x9.9), and Colon - Transverse (x9.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for NR1I2 Gene



Transcriptomic regulation report from SPP (The Signaling Pathways Project) for NR1I2

SOURCE GeneReport for Unigene cluster for NR1I2 Gene:

Hs.7303

mRNA Expression by UniProt/SwissProt for NR1I2 Gene:

O75469-NR1I2_HUMAN
Tissue specificity: Expressed in liver, colon and small intestine.

Evidence on tissue expression from TISSUES for NR1I2 Gene

  • Liver(4.8)
  • Intestine(2.8)
  • Blood(2)
genes like me logo Genes that share expression patterns with NR1I2: view

No data available for Protein differential expression in normal tissues , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for NR1I2 Gene

Orthologs for NR1I2 Gene

This gene was present in the common ancestor of animals.

Orthologs for NR1I2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia NR1I2 31 30
  • 99.15 (n)
OneToOne
cow
(Bos Taurus)
Mammalia NR1I2 31 30
  • 84.73 (n)
OneToOne
rat
(Rattus norvegicus)
Mammalia Nr1i2 30
  • 82.6 (n)
mouse
(Mus musculus)
Mammalia Nr1i2 17 31 30
  • 82.36 (n)
dog
(Canis familiaris)
Mammalia PXR 31
  • 80 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia NR1I2 31
  • 79 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 31
  • 20 (a)
ManyToMany
chicken
(Gallus gallus)
Aves -- 31
  • 20 (a)
ManyToMany
lizard
(Anolis carolinensis)
Reptilia -- 31
  • 21 (a)
ManyToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia nr1i2 30
  • 63.25 (n)
African clawed frog
(Xenopus laevis)
Amphibia MGC68499 30
zebrafish
(Danio rerio)
Actinopterygii nr1i2 31 30 30
  • 60.73 (n)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta Hr96 30
  • 48.69 (n)
EcR 31
  • 12 (a)
OneToMany
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP004224 30
  • 46.82 (n)
sea squirt
(Ciona savignyi)
Ascidiacea -- 31
  • 25 (a)
OneToMany
Species where no ortholog for NR1I2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for NR1I2 Gene

ENSEMBL:
Gene Tree for NR1I2 (if available)
TreeFam:
Gene Tree for NR1I2 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for NR1I2: view image

Paralogs for NR1I2 Gene

(18) SIMAP similar genes for NR1I2 Gene using alignment to 6 proteins:

  • NR1I2_HUMAN
  • B6ZGT1_HUMAN
  • F1DAL3_HUMAN
  • H0Y8E2_HUMAN
  • J3KPQ3_HUMAN
  • Q9H4M8_HUMAN
genes like me logo Genes that share paralogs with NR1I2: view

Variants for NR1I2 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for NR1I2 Gene

SNP ID Clinical significance and condition Chr 03 pos Variation AA Info Type
710422 Benign: not provided 119,811,576(+) C/T SYNONYMOUS_VARIANT
726853 Likely Benign: not provided 119,812,847(+) C/A SYNONYMOUS_VARIANT
734070 Likely Benign: not provided 119,812,958(+) C/T SYNONYMOUS_VARIANT
773133 Benign: not provided 119,810,178(+) C/T SYNONYMOUS_VARIANT
775899 Benign: not provided 119,811,699(+) T/C SYNONYMOUS_VARIANT

Additional dbSNP identifiers (rs#s) for NR1I2 Gene

Structural Variations from Database of Genomic Variants (DGV) for NR1I2 Gene

Variant ID Type Subtype PubMed ID
nsv965201 CNV duplication 23825009

Variation tolerance for NR1I2 Gene

Residual Variation Intolerance Score: 8.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.16; 39.17% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for NR1I2 Gene

Human Gene Mutation Database (HGMD)
NR1I2
SNPedia medical, phenotypic, and genealogical associations of SNPs for
NR1I2

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NR1I2 Gene

Disorders for NR1I2 Gene

MalaCards: The human disease database

(22) MalaCards diseases for NR1I2 Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
cerebrotendinous xanthomatosis
  • ctx
biliary tract disease
  • biliary tract abnormality
intrahepatic cholestasis of pregnancy
  • gravidic intrahepatic cholestasis
cholestasis
  • bile occlusion
osteomalacia
  • adult rickets
- elite association - COSMIC cancer census association via MalaCards
Search NR1I2 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for NR1I2

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with NR1I2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for NR1I2 Gene

Publications for NR1I2 Gene

  1. Explaining variability in ciclosporin exposure in adult kidney transplant recipients. (PMID: 20354687) Press RR … Guchelaar HJ (European journal of clinical pharmacology 2010) 3 23 41 54
  2. A role for the pregnane X receptor in flucloxacillin-induced liver injury. (PMID: 20222094) Andrews E … Daly AK (Hepatology (Baltimore, Md.) 2010) 3 23 41 54
  3. Long-term changes in cyclosporine pharmacokinetics after renal transplantation in children: evidence for saturable presystemic metabolism and effect of NR1I2 polymorphism. (PMID: 20107201) Fanta S … Backman JT (Journal of clinical pharmacology 2010) 3 23 41 54
  4. Rifampicin-activated human pregnane X receptor and CYP3A4 induction enhance acetaminophen-induced toxicity. (PMID: 19460945) Cheng J … Gonzalez FJ (Drug metabolism and disposition: the biological fate of chemicals 2009) 3 23 26 54
  5. Impact of the haplotypes of the human pregnane X receptor gene on the basal and St John's wort-induced activity of cytochrome P450 3A4 enzyme. (PMID: 19173680) Wang XD … Zhou SF (British journal of clinical pharmacology 2009) 3 23 41 54

Products for NR1I2 Gene

  • Addgene plasmids for NR1I2

Sources for NR1I2 Gene