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Aliases for NR1H2 Gene

Aliases for NR1H2 Gene

  • Nuclear Receptor Subfamily 1 Group H Member 2 2 3 4 5
  • Ubiquitously-Expressed Nuclear Receptor 2 3 4
  • Nuclear Receptor NER 3 4
  • LXRB 3 4
  • UNR 3 4
  • NER 3 4
  • Nuclear Receptor Subfamily 1, Group H, Member 2 2
  • Steroid Hormone-Nuclear Receptor NER 3
  • Nuclear Orphan Receptor LXR-Beta 3
  • Liver X Nuclear Receptor Beta 3
  • Oxysterols Receptor LXR-Beta 3
  • Liver X Receptor Beta 4
  • Liver X Receptor-Beta 2
  • LX Receptor Beta 3
  • LXR-B 3
  • NER-I 3
  • RIP15 3

External Ids for NR1H2 Gene

Previous HGNC Symbols for NR1H2 Gene

  • UNR

Previous GeneCards Identifiers for NR1H2 Gene

  • GC19P051508
  • GC19P051241
  • GC19P055508
  • GC19P055571
  • GC19P050879
  • GC19P047217

Summaries for NR1H2 Gene

Entrez Gene Summary for NR1H2 Gene

  • The liver X receptors, LXRA (NR1H3; MIM 602423) and LXRB, form a subfamily of the nuclear receptor superfamily and are key regulators of macrophage function, controlling transcriptional programs involved in lipid homeostasis and inflammation. The inducible LXRA is highly expressed in liver, adrenal gland, intestine, adipose tissue, macrophages, lung, and kidney, whereas LXRB is ubiquitously expressed. Ligand-activated LXRs form obligate heterodimers with retinoid X receptors (RXRs; see MIM 180245) and regulate expression of target genes containing LXR response elements (summary by Korf et al., 2009 [PubMed 19436111]).[supplied by OMIM, Jan 2010]

GeneCards Summary for NR1H2 Gene

NR1H2 (Nuclear Receptor Subfamily 1 Group H Member 2) is a Protein Coding gene. Diseases associated with NR1H2 include Complete Androgen Insensitivity Syndrome and Vitamin D-Dependent Rickets, Type 2A. Among its related pathways are Gene Expression and Lipoprotein metabolism. Gene Ontology (GO) annotations related to this gene include DNA binding transcription factor activity and RNA polymerase II proximal promoter sequence-specific DNA binding. An important paralog of this gene is NR1H3.

UniProtKB/Swiss-Prot for NR1H2 Gene

  • Nuclear receptor that exhibits a ligand-dependent transcriptional activation activity (PubMed:25661920). Binds preferentially to double-stranded oligonucleotide direct repeats having the consensus half-site sequence 5-AGGTCA-3 and 4-nt spacing (DR-4). Regulates cholesterol uptake through MYLIP-dependent ubiquitination of LDLR, VLDLR and LRP8; DLDLR and LRP8. Interplays functionally with RORA for the regulation of genes involved in liver metabolism (By similarity). Plays an anti-inflammatory role during the hepatic acute phase response by acting as a corepressor: inhibits the hepatic acute phase response by preventing dissociation of the N-Cor corepressor complex (PubMed:20159957).

Tocris Summary for NR1H2 Gene

  • Liver X receptors (LXRs) and farnesoid X receptors (FXRs) are members of the steroid analog-activated nuclear receptor subfamily, which form heterodimers with members of the retinoid X receptor family. There are two closely related isoforms of each of these enzymes; alpha and beta.

Gene Wiki entry for NR1H2 Gene

Additional gene information for NR1H2 Gene

No data available for CIViC summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NR1H2 Gene

Genomics for NR1H2 Gene

GeneHancer (GH) Regulatory Elements for NR1H2 Gene

Promoters and enhancers for NR1H2 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH19J050328 Promoter/Enhancer 2.6 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 652.6 +2.0 1950 5.9 ZFP64 FEZF1 DMAP1 IRF4 YY1 SLC30A9 ZNF213 E2F8 ZNF143 SP3 KCNC3 NR1H2 LOC105372437 NUP62 PRR12 POLD1 ENSG00000268047 PTOV1-AS2 SNORD35A CTU1
GH19J050375 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 650.2 +47.2 47168 2.1 ZFP64 DMAP1 IRF4 YY1 E2F8 ZNF143 SP3 NFYC ZC3H11A ZNF610 NR1H2 NAPSB POLD1 NUP62 SNORD35B SNORD35A IRF3 PIH1D1 ALDH16A1 PNKP
GH19J050329 Enhancer 0.9 ENCODE dbSUPER 650.7 -1.3 -1314 0.2 CTCF SIN3A ZFHX2 MTA3 ZNF143 TRIM24 ATF7 EZH2 NCOA6 L3MBTL2 LOC105372437 NR1H2 GC19M050323 KCNC3
GH19J049486 Promoter/Enhancer 2.5 EPDnew Ensembl ENCODE dbSUPER 10.8 -839.4 -839413 7.5 ZFP64 DMAP1 IRF4 YY1 SLC30A9 E2F8 ZNF143 SP3 NFYC SSRP1 SNORD35A RPL13A GC19P049514 GC19P049531 GC19P049558 GC19P049559 GC19P049564 GC19P049569 PIR54526 SNORD34
GH19J050802 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 10.8 +474.6 474630 4.2 HDGF HNRNPUL1 PKNOX1 SMAD1 ARNT ARID4B NEUROD1 SIN3A FEZF1 DMAP1 C19orf48 GC19M050833 GC19M050843 SNORD88C POLD1 PTOV1-AS2 NUP62 PNKP ZNF175 CTU1
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around NR1H2 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the NR1H2 gene promoter:
  • NF-kappaB1
  • NF-kappaB
  • Elk-1
  • HOXA3

Genomic Locations for NR1H2 Gene

Genomic Locations for NR1H2 Gene
chr19:50,329,653-50,383,028
(GRCh38/hg38)
Size:
53,376 bases
Orientation:
Plus strand
chr19:50,832,910-50,886,267
(GRCh37/hg19)
Size:
53,358 bases
Orientation:
Plus strand

Genomic View for NR1H2 Gene

Genes around NR1H2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
NR1H2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for NR1H2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NR1H2 Gene

Proteins for NR1H2 Gene

  • Protein details for NR1H2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P55055-NR1H2_HUMAN
    Recommended name:
    Oxysterols receptor LXR-beta
    Protein Accession:
    P55055
    Secondary Accessions:
    • A8K490
    • B4DNM6
    • E7EWA6
    • Q12970
    • Q5I0Y1

    Protein attributes for NR1H2 Gene

    Size:
    460 amino acids
    Molecular mass:
    50974 Da
    Quaternary structure:
    • Forms a heterodimer with RXR. Interacts with CCAR2 (via N-terminus) in a ligand-independent manner (PubMed:25661920). Interacts (when sumoylated) with GPS2; interaction with GPS2 onto hepatic acute phase protein promoters prevents N-Cor corepressor complex dissociation (PubMed:20159957).

    Three dimensional structures from OCA and Proteopedia for NR1H2 Gene

    Alternative splice isoforms for NR1H2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for NR1H2 Gene

Post-translational modifications for NR1H2 Gene

  • Sumoylated by SUMO2 at Lys-409 and Lys-447 during the hepatic acute phase response, leading to promote interaction with GPS2 and prevent N-Cor corepressor complex dissociation.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for NR1H2 Gene

Domains & Families for NR1H2 Gene

Gene Families for NR1H2 Gene

HGNC:
IUPHAR :
Human Protein Atlas (HPA):
  • Cancer-related genes
  • Nuclear receptors
  • Predicted intracellular proteins
  • Transcription factors

Graphical View of Domain Structure for InterPro Entry

P55055

UniProtKB/Swiss-Prot:

NR1H2_HUMAN :
  • Belongs to the nuclear hormone receptor family. NR1 subfamily.
Family:
  • Belongs to the nuclear hormone receptor family. NR1 subfamily.
genes like me logo Genes that share domains with NR1H2: view

Function for NR1H2 Gene

Molecular function for NR1H2 Gene

UniProtKB/Swiss-Prot Function:
Nuclear receptor that exhibits a ligand-dependent transcriptional activation activity (PubMed:25661920). Binds preferentially to double-stranded oligonucleotide direct repeats having the consensus half-site sequence 5-AGGTCA-3 and 4-nt spacing (DR-4). Regulates cholesterol uptake through MYLIP-dependent ubiquitination of LDLR, VLDLR and LRP8; DLDLR and LRP8. Interplays functionally with RORA for the regulation of genes involved in liver metabolism (By similarity). Plays an anti-inflammatory role during the hepatic acute phase response by acting as a corepressor: inhibits the hepatic acute phase response by preventing dissociation of the N-Cor corepressor complex (PubMed:20159957).
GENATLAS Biochemistry:
nuclear receptor subfamily 1,group H,member2,modulating gene activation by retinoic acid and thyroid hormone receptors

Phenotypes From GWAS Catalog for NR1H2 Gene

Gene Ontology (GO) - Molecular Function for NR1H2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000976 transcription regulatory region sequence-specific DNA binding IBA --
GO:0000977 RNA polymerase II regulatory region sequence-specific DNA binding IBA --
GO:0000978 RNA polymerase II proximal promoter sequence-specific DNA binding IDA 9013544
GO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding NAS 19274049
GO:0001076 transcription factor activity, RNA polymerase II transcription factor binding IBA --
genes like me logo Genes that share ontologies with NR1H2: view
genes like me logo Genes that share phenotypes with NR1H2: view

Animal Models for NR1H2 Gene

MGI Knock Outs for NR1H2:

Animal Model Products

  • Taconic Biosciences Mouse Models for NR1H2

CRISPR Products

Targeted motifs for NR1H2 Gene
HOMER Transcription Factor Regulatory Elements motif NR1H2
  • Consensus sequence: GGGTTACTANAGGTCA Submotif: DR4 Cell Type: RAW GEO ID: GSE21512

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for NR1H2

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology and Transcription Factor Targets for NR1H2 Gene

Localization for NR1H2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for NR1H2 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for NR1H2 gene
Compartment Confidence
nucleus 5
cytosol 2
peroxisome 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for NR1H2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA,IEA 12393874
GO:0005654 nucleoplasm TAS --
GO:0005737 cytoplasm IDA 12393874
GO:0090575 RNA polymerase II transcription factor complex IBA --
genes like me logo Genes that share ontologies with NR1H2: view

Pathways & Interactions for NR1H2 Gene

genes like me logo Genes that share pathways with NR1H2: view

Pathways by source for NR1H2 Gene

1 KEGG pathway for NR1H2 Gene
1 Cell Signaling Technology pathway for NR1H2 Gene

SIGNOR curated interactions for NR1H2 Gene

Is activated by:
Is inactivated by:

Gene Ontology (GO) - Biological Process for NR1H2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000122 negative regulation of transcription by RNA polymerase II IEA --
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0006357 regulation of transcription by RNA polymerase II IEA --
GO:0006367 transcription initiation from RNA polymerase II promoter TAS --
genes like me logo Genes that share ontologies with NR1H2: view

Drugs & Compounds for NR1H2 Gene

(90) Drugs for NR1H2 Gene - From: DrugBank, ApexBio, DGIdb, IUPHAR, Tocris, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Diacerein Approved, Investigational Pharma Target, inhibitor 0
(3-{3-[[2-Chloro-3-(Trifluoromethyl)Benzyl](2,2-Diphenylethyl)Amino]Propoxy}Phenyl)Acetic Acid Experimental Pharma Target 0
1,1,1,3,3,3-HEXAFLUORO-2-{4-[(2,2,2-TRIFLUOROETHYL)AMINO]PHENYL}PROPAN-2-OL Experimental Pharma Target 0
Benzenesulfinic acid Experimental Pharma Target 0
N-(2,2,2-TRIFLUOROETHYL)-N-{4-[2,2,2-TRIFLUORO-1-HYDROXY-1-(TRIFLUOROMETHYL)ETHYL]PHENYL}BENZENESULFONAMIDE Experimental Pharma Target 0

(50) Additional Compounds for NR1H2 Gene - From: Novoseek and Tocris

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
GW 4064
278779-30-9

(3) Tocris Compounds for NR1H2 Gene

Compound Action Cas Number
27-Hydroxycholesterol LXR agonist; also ER partial agonist 20380-11-4
GW 4064 Selective farnesoid X receptor (FXR) agonist 278779-30-9
T 0901317 Potent liver X receptor (LXR) agonist; also CAR inverse agonist 293754-55-9

(6) ApexBio Compounds for NR1H2 Gene

Compound Action Cas Number
Fexaramine 574013-66-4
GW3965 HLXRα/hLXRβ agonist,potent and selective 405911-09-3
GW3965 HCl 405911-17-3
LXR-623 Liver X-receptor agonist 875787-07-8
SR-9243 inverse agonist of LXR 1613028-81-1
T0901317 Liver X receptor agonist,potent and selective 293754-55-9
genes like me logo Genes that share compounds with NR1H2: view

Drug Products

Transcripts for NR1H2 Gene

mRNA/cDNA for NR1H2 Gene

Unigene Clusters for NR1H2 Gene

Nuclear receptor subfamily 1, group H, member 2:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for NR1H2

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for NR1H2 Gene

ExUns: 1a · 1b · 1c · 1d · 1e ^ 2a · 2b ^ 3 ^ 4a · 4b · 4c ^ 5 ^ 6a · 6b · 6c ^ 7a · 7b · 7c · 7d · 7e ^ 8a · 8b · 8c ^ 9a · 9b ^ 10 ^
SP1: - - - - - - -
SP2: - - - -
SP3: - - - - - - - - -
SP4: - - - - - -
SP5: - - -
SP6: - - -
SP7: - - - - - - - - - - - - - - - - - -
SP8: - - - -
SP9: - - -
SP10: - - - -
SP11: -

ExUns: 11 ^ 12a · 12b ^ 13a · 13b
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:

Relevant External Links for NR1H2 Gene

GeneLoc Exon Structure for
NR1H2
ECgene alternative splicing isoforms for
NR1H2

Expression for NR1H2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for NR1H2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for NR1H2 Gene

This gene is overexpressed in Platelet (33.3), Placenta (22.5), and Peripheral blood mononuclear cells (6.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for NR1H2 Gene



Protein tissue co-expression partners for NR1H2 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of NR1H2 Gene:

NR1H2

SOURCE GeneReport for Unigene cluster for NR1H2 Gene:

Hs.432976

mRNA Expression by UniProt/SwissProt for NR1H2 Gene:

P55055-NR1H2_HUMAN
Tissue specificity: Ubiquitous.

Evidence on tissue expression from TISSUES for NR1H2 Gene

  • Nervous system(4.9)
  • Skin(4.7)
  • Blood(4.4)
  • Lung(2.9)
  • Liver(2.7)
  • Eye(2.2)
  • Intestine(2.2)
  • Muscle(2.2)
genes like me logo Genes that share expression patterns with NR1H2: view

No data available for mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for NR1H2 Gene

Orthologs for NR1H2 Gene

This gene was present in the common ancestor of animals.

Orthologs for NR1H2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia NR1H2 34 33
  • 98.63 (n)
OneToOne
dog
(Canis familiaris)
Mammalia NR1H2 34 33
  • 87.03 (n)
OneToOne
mouse
(Mus musculus)
Mammalia Nr1h2 16 34 33
  • 84.65 (n)
rat
(Rattus norvegicus)
Mammalia Nr1h2 33
  • 84.57 (n)
cow
(Bos Taurus)
Mammalia NR1H2 34 33
  • 83.84 (n)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia -- 34
  • 31 (a)
ManyToMany
lizard
(Anolis carolinensis)
Reptilia NR1H2 34
  • 73 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia nr1h2 33
  • 71.05 (n)
zebrafish
(Danio rerio)
Actinopterygii nr1h5 34
  • 24 (a)
ManyToMany
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP012211 33
  • 67.42 (n)
fruit fly
(Drosophila melanogaster)
Insecta EcR 34 35 33
  • 55.36 (n)
OneToMany
Species where no ortholog for NR1H2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for NR1H2 Gene

ENSEMBL:
Gene Tree for NR1H2 (if available)
TreeFam:
Gene Tree for NR1H2 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for NR1H2: view image

Paralogs for NR1H2 Gene

Paralogs for NR1H2 Gene

(34) SIMAP similar genes for NR1H2 Gene using alignment to 12 proteins:

  • NR1H2_HUMAN
  • B3KRG6_HUMAN
  • B6ZGS7_HUMAN
  • F1D8P7_HUMAN
  • M0QYE6_HUMAN
  • M0QZF5_HUMAN
  • M0R0K3_HUMAN
  • M0R1V8_HUMAN
  • M0R229_HUMAN
  • M0R2F9_HUMAN
  • M0R3A7_HUMAN
  • Q6IBU6_HUMAN
genes like me logo Genes that share paralogs with NR1H2: view

Variants for NR1H2 Gene

Sequence variations from dbSNP and Humsavar for NR1H2 Gene

SNP ID Clin Chr 19 pos Variation AA Info Type
rs1000022251 -- 50,380,396(+) G/A intron_variant
rs1000159721 -- 50,376,247(+) G/A upstream_transcript_variant
rs1000300894 -- 50,377,352(+) G/A intron_variant
rs1000609313 -- 50,380,209(+) A/C intron_variant
rs1001001507 -- 50,379,483(+) T/A intron_variant

Structural Variations from Database of Genomic Variants (DGV) for NR1H2 Gene

Variant ID Type Subtype PubMed ID
nsv1066389 CNV gain 25217958
nsv1071939 CNV deletion 25765185
nsv1133010 OTHER inversion 24896259
nsv1140251 OTHER inversion 24896259
nsv1152956 OTHER inversion 26484159

Variation tolerance for NR1H2 Gene

Residual Variation Intolerance Score: 12.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 10.99; 92.04% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for NR1H2 Gene

Human Gene Mutation Database (HGMD)
NR1H2
SNPedia medical, phenotypic, and genealogical associations of SNPs for
NR1H2

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NR1H2 Gene

Disorders for NR1H2 Gene

MalaCards: The human disease database

(7) MalaCards diseases for NR1H2 Gene - From: HGMD, DISEASES, Novoseek, and GeneCards

- elite association - COSMIC cancer census association via MalaCards
Search NR1H2 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for NR1H2

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with NR1H2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for NR1H2 Gene

Publications for NR1H2 Gene

  1. Functional and genetic analysis in type 2 diabetes of liver X receptor alleles--a cohort study. (PMID: 19292929) Dahlman I … Steffensen KR (BMC medical genetics 2009) 3 22 44 58
  2. The three-dimensional structure of the liver X receptor beta reveals a flexible ligand-binding pocket that can accommodate fundamentally different ligands. (PMID: 12819202) Färnegårdh M … Carlquist M (The Journal of biological chemistry 2003) 3 4 22 58
  3. CCAR2 negatively regulates nuclear receptor LXRα by competing with SIRT1 deacetylase. (PMID: 25661920) Sakurabashi A … Fujii T (The Journal of steroid biochemistry and molecular biology 2015) 3 4 58
  4. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PMID: 20628086) Bailey SD … DREAM investigators (Diabetes care 2010) 3 44 58
  5. Common genetic variation in multiple metabolic pathways influences susceptibility to low HDL-cholesterol and coronary heart disease. (PMID: 20855565) Peloso GM … Brousseau ME (Journal of lipid research 2010) 3 44 58

Products for NR1H2 Gene

Sources for NR1H2 Gene

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