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Aliases for NR1D1 Gene

Aliases for NR1D1 Gene

  • Nuclear Receptor Subfamily 1 Group D Member 1 2 3 3 5
  • V-ErbA-Related Protein 1 3 4
  • Rev-ErbA-Alpha 3 4
  • THRAL 3 4
  • EAR1 3 4
  • Nuclear Receptor Subfamily 1, Group D, Member 1 2
  • Nuclear Receptor Rev-ErbA-Alpha 3
  • Rev-ErbAalpha 3
  • REVERBalpha 3
  • REVERBA 3
  • THRA1 3
  • Ear-1 3
  • EAR-1 4
  • HRev 3
  • HREV 4

External Ids for NR1D1 Gene

Previous HGNC Symbols for NR1D1 Gene

  • THRAL

Previous GeneCards Identifiers for NR1D1 Gene

  • GC17M037844
  • GC17P040302
  • GC17M038159
  • GC17M038624
  • GC17M035502
  • GC17M038249
  • GC17M034042

Summaries for NR1D1 Gene

Entrez Gene Summary for NR1D1 Gene

  • This gene encodes a transcription factor that is a member of the nuclear receptor subfamily 1. The encoded protein is a ligand-sensitive transcription factor that negatively regulates the expression of core clock proteins. In particular this protein represses the circadian clock transcription factor aryl hydrocarbon receptor nuclear translocator-like protein 1 (ARNTL). This protein may also be involved in regulating genes that function in metabolic, inflammatory and cardiovascular processes. [provided by RefSeq, Jan 2013]

GeneCards Summary for NR1D1 Gene

NR1D1 (Nuclear Receptor Subfamily 1 Group D Member 1) is a Protein Coding gene. Diseases associated with NR1D1 include Cauda Equina Syndrome and Hypothyroidism, Congenital, Nongoitrous, 6. Among its related pathways are Gene Expression and Circadian rhythm pathway. Gene Ontology (GO) annotations related to this gene include DNA binding transcription factor activity and RNA polymerase II proximal promoter sequence-specific DNA binding. An important paralog of this gene is NR1D2.

UniProtKB/Swiss-Prot for NR1D1 Gene

  • Transcriptional repressor which coordinates circadian rhythm and metabolic pathways in a heme-dependent manner. Integral component of the complex transcription machinery that governs circadian rhythmicity and forms a critical negative limb of the circadian clock by directly repressing the expression of core clock components ARTNL/BMAL1, CLOCK and CRY1. Also regulates genes involved in metabolic functions, including lipid and bile acid metabolism, adipogenesis, gluconeogenesis and the macrophage inflammatory response. Acts as a receptor for heme which stimulates its interaction with the NCOR1/HDAC3 corepressor complex, enhancing transcriptional repression. Recognizes two classes of DNA response elements within the promoter of its target genes and can bind to DNA as either monomers or homodimers, depending on the nature of the response element. Binds as a monomer to a response element composed of the consensus half-site motif 5-[A/G]GGTCA-3 preceded by an A/T-rich 5 sequence (RevRE), or as a homodimer to a direct repeat of the core motif spaced by two nucleotides (RevDR-2). Acts as a potent competitive repressor of ROR alpha (RORA) function and regulates the levels of its ligand heme by repressing the expression of PPARGC1A, a potent inducer of heme synthesis. Regulates lipid metabolism by repressing the expression of APOC3 and by influencing the activity of sterol response element binding proteins (SREBPs); represses INSIG2 which interferes with the proteolytic activation of SREBPs which in turn govern the rhythmic expression of enzymes with key functions in sterol and fatty acid synthesis. Regulates gluconeogenesis via repression of G6PC and PEPCK and adipocyte differentiation via repression of PPARG. Regulates glucagon release in pancreatic alpha-cells via the AMPK-NAMPT-SIRT1 pathway and the proliferation, glucose-induced insulin secretion and expression of key lipogenic genes in pancreatic-beta cells. Positively regulates bile acid synthesis by increasing hepatic expression of CYP7A1 via repression of NR0B2 and NFIL3 which are negative regulators of CYP7A1. Modulates skeletal muscle oxidative capacity by regulating mitochondrial biogenesis and autophagy; controls mitochondrial biogenesis and respiration by interfering with the STK11-PRKAA1/2-SIRT1-PPARGC1A signaling pathway. Represses the expression of SERPINE1/PAI1, an important modulator of cardiovascular disease and the expression of inflammatory cytokines and chemokines in macrophages. Represses gene expression at a distance in macrophages by inhibiting the transcription of enhancer-derived RNAs (eRNAs). Plays a role in the circadian regulation of body temperature and negatively regulates thermogenic transcriptional programs in brown adipose tissue (BAT); imposes a circadian oscillation in BAT activity, increasing body temperature when awake and depressing thermogenesis during sleep. In concert with NR2E3, regulates transcriptional networks critical for photoreceptor development and function. In addition to its activity as a repressor, can also act as a transcriptional activator. In the ovarian granulosa cells acts as a transcriptional activator of STAR which plays a role in steroid biosynthesis. In collaboration with SP1, activates GJA1 transcription in a heme-independent manner.

Tocris Summary for NR1D1 Gene

  • Rev-Erb receptors are orphan nuclear receptors belonging to the NR1D receptor family. There are two types, Rev-Erbalpha and Rev-Erbbeta. They are important in the regulation of circadian rhythm, as well as lipid homeostasis and lipid metabolism.

Gene Wiki entry for NR1D1 Gene

Additional gene information for NR1D1 Gene

No data available for CIViC summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NR1D1 Gene

Genomics for NR1D1 Gene

GeneHancer (GH) Regulatory Elements for NR1D1 Gene

Promoters and enhancers for NR1D1 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH17J040088 Promoter/Enhancer 2.8 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 652.1 +5.4 5378 14.4 CLOCK MLX ZFP64 FEZF1 DMAP1 YBX1 IRF4 YY1 SLC30A9 ZNF213 NR1D1 CDK12 MED1 SMARCE1 MSL1 RARA RPL19 MED24 GSDMA CCR7
GH17J040102 Promoter/Enhancer 2.3 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 652.1 -8.7 -8741 13.3 CLOCK MLX ZFP64 FEZF1 DMAP1 YY1 SLC30A9 ZNF213 E2F8 ZNF143 NR1D1 CDK12 MED1 MSL1 SMARCE1 RARA RPL19 MED24 SNORD124 STARD3
GH17J040061 Promoter/Enhancer 3 VISTA EPDnew FANTOM5 Ensembl ENCODE dbSUPER 3.2 +31.4 31430 14.8 CLOCK MLX ZFP64 FEZF1 YY1 SLC30A9 ZNF143 SP3 PPARGC1A MEF2D THRA GC17P040067 MED1 SMARCE1 CDK12 MED24 MSL1 GSDMA RPL19 RARA
GH17J040217 Promoter/Enhancer 2.3 EPDnew FANTOM5 Ensembl ENCODE 1.5 -118.4 -118434 2.9 HDGF FOXA2 PKNOX1 SMAD1 MLX ARNT ARID4B SIN3A DMAP1 ZNF2 WIPF2 MED1 CDK12 SMARCE1 RAPGEFL1 LOC105371776 PGAP3 MSL1 STARD3 IGFBP4
GH17J040086 Enhancer 1 ENCODE dbSUPER 0.4 +14.1 14112 0.2 CTCF RB1 ARID4B KDM3A THRB ZNF48 RBPJ RAD21 CC2D1A PATZ1 MED24 THRA MSL1 PSMD3 GSDMA LRRC3C ORMDL3 CDC6 GC17P040082 NR1D1
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around NR1D1 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the NR1D1 gene promoter:
  • Nkx3-1 v1
  • Arnt
  • YY1
  • Ik-2
  • LCR-F1
  • Nkx3-1
  • Nkx3-1 v2
  • Nkx3-1 v3
  • Nkx3-1 v4
  • PPAR-gamma1

Genomic Locations for NR1D1 Gene

Genomic Locations for NR1D1 Gene
chr17:40,092,784-40,100,725
(GRCh38/hg38)
Size:
7,942 bases
Orientation:
Minus strand
chr17:38,249,037-38,256,978
(GRCh37/hg19)
Size:
7,942 bases
Orientation:
Minus strand

Genomic View for NR1D1 Gene

Genes around NR1D1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
NR1D1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for NR1D1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NR1D1 Gene

Proteins for NR1D1 Gene

  • Protein details for NR1D1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P20393-NR1D1_HUMAN
    Recommended name:
    Nuclear receptor subfamily 1 group D member 1
    Protein Accession:
    P20393
    Secondary Accessions:
    • Q0P5Z4
    • Q15304

    Protein attributes for NR1D1 Gene

    Size:
    614 amino acids
    Molecular mass:
    66805 Da
    Quaternary structure:
    • Binds DNA as a monomer or a homodimer. Interacts with C1D, NR2E3 and SP1. Interacts with OPHN1 (via C-terminus). Interacts with ZNHIT1. Interacts with PER2; the interaction associates PER2 to ARNTL promoter region. Interacts with CRY1. Interacts with CCAR2.

    Three dimensional structures from OCA and Proteopedia for NR1D1 Gene

neXtProt entry for NR1D1 Gene

Post-translational modifications for NR1D1 Gene

Other Protein References for NR1D1 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • R&D Systems Antibodies for NR1D1 (Rev-erb A alpha/NR1D1)
  • Abcam antibodies for NR1D1

No data available for DME Specific Peptides for NR1D1 Gene

Domains & Families for NR1D1 Gene

Gene Families for NR1D1 Gene

HGNC:
IUPHAR :
Human Protein Atlas (HPA):
  • Nuclear receptors
  • Predicted intracellular proteins
  • Transcription factors

Suggested Antigen Peptide Sequences for NR1D1 Gene

Graphical View of Domain Structure for InterPro Entry

P20393

UniProtKB/Swiss-Prot:

NR1D1_HUMAN :
  • Composed of three domains: a modulating N-terminal domain, a DNA-binding domain and a C-terminal ligand-binding domain.
  • Belongs to the nuclear hormone receptor family. NR1 subfamily.
Domain:
  • Composed of three domains: a modulating N-terminal domain, a DNA-binding domain and a C-terminal ligand-binding domain.
Family:
  • Belongs to the nuclear hormone receptor family. NR1 subfamily.
genes like me logo Genes that share domains with NR1D1: view

Function for NR1D1 Gene

Molecular function for NR1D1 Gene

UniProtKB/Swiss-Prot Function:
Transcriptional repressor which coordinates circadian rhythm and metabolic pathways in a heme-dependent manner. Integral component of the complex transcription machinery that governs circadian rhythmicity and forms a critical negative limb of the circadian clock by directly repressing the expression of core clock components ARTNL/BMAL1, CLOCK and CRY1. Also regulates genes involved in metabolic functions, including lipid and bile acid metabolism, adipogenesis, gluconeogenesis and the macrophage inflammatory response. Acts as a receptor for heme which stimulates its interaction with the NCOR1/HDAC3 corepressor complex, enhancing transcriptional repression. Recognizes two classes of DNA response elements within the promoter of its target genes and can bind to DNA as either monomers or homodimers, depending on the nature of the response element. Binds as a monomer to a response element composed of the consensus half-site motif 5-[A/G]GGTCA-3 preceded by an A/T-rich 5 sequence (RevRE), or as a homodimer to a direct repeat of the core motif spaced by two nucleotides (RevDR-2). Acts as a potent competitive repressor of ROR alpha (RORA) function and regulates the levels of its ligand heme by repressing the expression of PPARGC1A, a potent inducer of heme synthesis. Regulates lipid metabolism by repressing the expression of APOC3 and by influencing the activity of sterol response element binding proteins (SREBPs); represses INSIG2 which interferes with the proteolytic activation of SREBPs which in turn govern the rhythmic expression of enzymes with key functions in sterol and fatty acid synthesis. Regulates gluconeogenesis via repression of G6PC and PEPCK and adipocyte differentiation via repression of PPARG. Regulates glucagon release in pancreatic alpha-cells via the AMPK-NAMPT-SIRT1 pathway and the proliferation, glucose-induced insulin secretion and expression of key lipogenic genes in pancreatic-beta cells. Positively regulates bile acid synthesis by increasing hepatic expression of CYP7A1 via repression of NR0B2 and NFIL3 which are negative regulators of CYP7A1. Modulates skeletal muscle oxidative capacity by regulating mitochondrial biogenesis and autophagy; controls mitochondrial biogenesis and respiration by interfering with the STK11-PRKAA1/2-SIRT1-PPARGC1A signaling pathway. Represses the expression of SERPINE1/PAI1, an important modulator of cardiovascular disease and the expression of inflammatory cytokines and chemokines in macrophages. Represses gene expression at a distance in macrophages by inhibiting the transcription of enhancer-derived RNAs (eRNAs). Plays a role in the circadian regulation of body temperature and negatively regulates thermogenic transcriptional programs in brown adipose tissue (BAT); imposes a circadian oscillation in BAT activity, increasing body temperature when awake and depressing thermogenesis during sleep. In concert with NR2E3, regulates transcriptional networks critical for photoreceptor development and function. In addition to its activity as a repressor, can also act as a transcriptional activator. In the ovarian granulosa cells acts as a transcriptional activator of STAR which plays a role in steroid biosynthesis. In collaboration with SP1, activates GJA1 transcription in a heme-independent manner.
GENATLAS Biochemistry:
nuclear receptor subfamily 1,group D,member 1,partially overlapping THRA (exon for THRA2) on the opposite strand

Gene Ontology (GO) - Molecular Function for NR1D1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000976 transcription regulatory region sequence-specific DNA binding IBA --
GO:0000977 RNA polymerase II regulatory region sequence-specific DNA binding IDA 19955433
GO:0000978 RNA polymerase II proximal promoter sequence-specific DNA binding IMP 8622974
GO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding NAS 19274049
GO:0001046 core promoter sequence-specific DNA binding IDA 15761026
genes like me logo Genes that share ontologies with NR1D1: view
genes like me logo Genes that share phenotypes with NR1D1: view

Animal Models for NR1D1 Gene

MGI Knock Outs for NR1D1:

Animal Model Products

miRNA for NR1D1 Gene

miRTarBase miRNAs that target NR1D1
Targeted motifs for NR1D1 Gene
HOMER Transcription Factor Regulatory Elements motif NR1D1
  • Consensus sequence: GTAGGTCACTGGGTCA Submotif: DR2 Cell Type: RAW GEO ID: GSE45914

Clone Products

  • Addgene plasmids for NR1D1

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology and Transcription Factor Targets for NR1D1 Gene

Localization for NR1D1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for NR1D1 Gene

Nucleus. Cytoplasm. Cell projection, dendrite. Cell projection, dendritic spine. Note=Localizes to the cytoplasm, dendrites and dendritic spine in the presence of OPHN1. {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for NR1D1 gene
Compartment Confidence
nucleus 5

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nuclear bodies (3)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for NR1D1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000790 nuclear chromatin IDA 18511497
GO:0005634 nucleus ISS,TAS --
GO:0005654 nucleoplasm TAS --
GO:0005737 cytoplasm ISS --
GO:0016604 nuclear body IDA --
genes like me logo Genes that share ontologies with NR1D1: view

Pathways & Interactions for NR1D1 Gene

genes like me logo Genes that share pathways with NR1D1: view

Pathways by source for NR1D1 Gene

SIGNOR curated interactions for NR1D1 Gene

Activates:
Is activated by:

Gene Ontology (GO) - Biological Process for NR1D1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000122 negative regulation of transcription by RNA polymerase II IMP 18511497
GO:0005978 glycogen biosynthetic process ISS --
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0006367 transcription initiation from RNA polymerase II promoter TAS --
genes like me logo Genes that share ontologies with NR1D1: view

Drugs & Compounds for NR1D1 Gene

(8) Drugs for NR1D1 Gene - From: DrugBank, PharmGKB, ApexBio, DGIdb, and IUPHAR

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Lithium Approved Pharma 0
SR-9009 Experimental Pharma Target, agonist 0
SR-9011 Experimental Pharma Target, agonist 0
GSK4112 Pharma Agonist 0
heme Pharma Agonist 0
genes like me logo Genes that share compounds with NR1D1: view

Transcripts for NR1D1 Gene

mRNA/cDNA for NR1D1 Gene

(1) REFSEQ mRNAs :
(8) Additional mRNA sequences :
(146) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for NR1D1 Gene

Nuclear receptor subfamily 1, group D, member 1:
Representative Sequences:

Clone Products

  • Addgene plasmids for NR1D1

Alternative Splicing Database (ASD) splice patterns (SP) for NR1D1 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b ^ 5a · 5b ^ 6a · 6b ^ 7 ^ 8 ^ 9
SP1:
SP2: -
SP3:
SP4: - - -
SP5:
SP6:

Relevant External Links for NR1D1 Gene

GeneLoc Exon Structure for
NR1D1
ECgene alternative splicing isoforms for
NR1D1

Expression for NR1D1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for NR1D1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for NR1D1 Gene

This gene is overexpressed in Skin - Sun Exposed (Lower leg) (x6.2) and Skin - Not Sun Exposed (Suprapubic) (x6.1).

Protein differential expression in normal tissues from HIPED for NR1D1 Gene

This gene is overexpressed in Heart (49.6), Urine (9.7), and Stomach (8.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for NR1D1 Gene



Protein tissue co-expression partners for NR1D1 Gene

NURSA nuclear receptor signaling pathways regulating expression of NR1D1 Gene:

NR1D1

SOURCE GeneReport for Unigene cluster for NR1D1 Gene:

Hs.592130

mRNA Expression by UniProt/SwissProt for NR1D1 Gene:

P20393-NR1D1_HUMAN
Tissue specificity: Widely expressed. Expressed at high levels in the liver, adipose tissue, skeletal muscle and brain. Also expressed in endothelial cells (ECs), vascular smooth muscle cells (VSMCs) and macrophages. Expression oscillates diurnally in the suprachiasmatic nucleus (SCN) of the hypothalamus as well as in peripheral tissues. Expression increases during the differentiation of pre-adipocytes into mature adipocytes. Expressed at high levels in some squamous carcinoma cell lines.

Evidence on tissue expression from TISSUES for NR1D1 Gene

  • Nervous system(4.7)
  • Muscle(4.6)
  • Liver(4.4)
  • Eye(2.2)
  • Thyroid gland(2.2)
genes like me logo Genes that share expression patterns with NR1D1: view

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for NR1D1 Gene

Orthologs for NR1D1 Gene

This gene was present in the common ancestor of animals.

Orthologs for NR1D1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia NR1D1 34 33
  • 99.84 (n)
OneToOne
cow
(Bos Taurus)
Mammalia NR1D1 34 33
  • 92.59 (n)
OneToOne
dog
(Canis familiaris)
Mammalia NR1D1 34 33
  • 91.72 (n)
OneToOne
rat
(Rattus norvegicus)
Mammalia Nr1d1 33
  • 90.07 (n)
mouse
(Mus musculus)
Mammalia Nr1d1 16 34 33
  • 90.01 (n)
oppossum
(Monodelphis domestica)
Mammalia NR1D1 34
  • 85 (a)
OneToOne
chicken
(Gallus gallus)
Aves -- 34
  • 30 (a)
ManyToMany
lizard
(Anolis carolinensis)
Reptilia NR1D1 34
  • 71 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia nr1d1 33
  • 69.79 (n)
Str.16697 33
African clawed frog
(Xenopus laevis)
Amphibia Xl.9778 33
zebrafish
(Danio rerio)
Actinopterygii nr1d1 34 33
  • 62.27 (n)
OneToOne
Dr.27124 33
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.8023 33
fruit fly
(Drosophila melanogaster)
Insecta Eip78C 35
  • 71 (a)
Eip75B 34 35
  • 14 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea sex-1 34
  • 24 (a)
ManyToMany
nhr-85 34
  • 24 (a)
ManyToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 19 (a)
OneToMany
Species where no ortholog for NR1D1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for NR1D1 Gene

ENSEMBL:
Gene Tree for NR1D1 (if available)
TreeFam:
Gene Tree for NR1D1 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for NR1D1: view image

Paralogs for NR1D1 Gene

Paralogs for NR1D1 Gene

(2) SIMAP similar genes for NR1D1 Gene using alignment to 2 proteins:

  • NR1D1_HUMAN
  • F1D8S3_HUMAN

Pseudogenes.org Pseudogenes for NR1D1 Gene

genes like me logo Genes that share paralogs with NR1D1: view

Variants for NR1D1 Gene

Sequence variations from dbSNP and Humsavar for NR1D1 Gene

SNP ID Clin Chr 17 pos Variation AA Info Type
rs201037953 uncertain-significance, Hypothyroidism, congenital, nongoitrous, 6 40,093,275(-) C/T coding_sequence_variant, synonymous_variant
rs1000270585 -- 40,096,936(-) T/C intron_variant
rs1000446914 -- 40,098,124(-) T/C intron_variant
rs1000548258 -- 40,097,856(-) G/C intron_variant
rs1000737935 -- 40,093,882(-) T/C intron_variant

Structural Variations from Database of Genomic Variants (DGV) for NR1D1 Gene

Variant ID Type Subtype PubMed ID
nsv1146669 OTHER inversion 26484159
nsv520636 CNV loss 19592680
nsv528369 CNV loss 19592680
nsv833444 CNV loss 17160897

Variation tolerance for NR1D1 Gene

Residual Variation Intolerance Score: 10.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.87; 35.04% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for NR1D1 Gene

Human Gene Mutation Database (HGMD)
NR1D1
SNPedia medical, phenotypic, and genealogical associations of SNPs for
NR1D1

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NR1D1 Gene

Disorders for NR1D1 Gene

MalaCards: The human disease database

(4) MalaCards diseases for NR1D1 Gene - From: HGMD, DISEASES, and GeneCards

- elite association - COSMIC cancer census association via MalaCards
Search NR1D1 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for NR1D1

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with NR1D1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for NR1D1 Gene

Publications for NR1D1 Gene

  1. Association study in a Sardinian sample between bipolar disorder and the nuclear receptor REV-ERBalpha gene, a critical component of the circadian clock system. (PMID: 19267705) Severino G … Del Zompo M (Bipolar disorders 2009) 3 22 44 58
  2. Association analysis of nuclear receptor Rev-erb alpha gene (NR1D1) with mood disorders in the Japanese population. (PMID: 18804497) Kishi T … Iwata N (Neuroscience research 2008) 3 22 44 58
  3. Isolation of a cDNA encoding human Rev-ErbA alpha: transcription from the noncoding DNA strand of a thyroid hormone receptor gene results in a related protein that does not bind thyroid hormone. (PMID: 1971514) Lazar MA … Chin WW (DNA and cell biology 1990) 2 3 4 58
  4. DBC1 (Deleted in Breast Cancer 1) modulates the stability and function of the nuclear receptor Rev-erbα. (PMID: 23398316) Chini CC … Chini EN (The Biochemical journal 2013) 3 4 58
  5. Direct regulation of CLOCK expression by REV-ERB. (PMID: 21479263) Crumbley C … Burris TP (PloS one 2011) 3 4 58

Products for NR1D1 Gene

  • Addgene plasmids for NR1D1