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Aliases for NR0B2 Gene

Aliases for NR0B2 Gene

  • Nuclear Receptor Subfamily 0 Group B Member 2 2 3 3 5
  • Orphan Nuclear Receptor SHP 3 4
  • Small Heterodimer Partner 3 4
  • SHP 3 4
  • Nuclear Receptor Subfamily 0, Group B, Member 2 2
  • Nuclear Receptor SHP 3
  • SHP1 3

External Ids for NR0B2 Gene

Previous GeneCards Identifiers for NR0B2 Gene

  • GC01P028351
  • GC01M026270
  • GC01M026471
  • GC01M026842
  • GC01M027110
  • GC01M027237
  • GC01M025491

Summaries for NR0B2 Gene

Entrez Gene Summary for NR0B2 Gene

  • The protein encoded by this gene is an unusual orphan receptor that contains a putative ligand-binding domain but lacks a conventional DNA-binding domain. The gene product is a member of the nuclear hormone receptor family, a group of transcription factors regulated by small hydrophobic hormones, a subset of which do not have known ligands and are referred to as orphan nuclear receptors. The protein has been shown to interact with retinoid and thyroid hormone receptors, inhibiting their ligand-dependent transcriptional activation. In addition, interaction with estrogen receptors has been demonstrated, leading to inhibition of function. Studies suggest that the protein represses nuclear hormone receptor-mediated transactivation via two separate steps: competition with coactivators and the direct effects of its transcriptional repressor function. [provided by RefSeq, Jul 2008]

GeneCards Summary for NR0B2 Gene

NR0B2 (Nuclear Receptor Subfamily 0 Group B Member 2) is a Protein Coding gene. Diseases associated with NR0B2 include Body Mass Index Quantitative Trait Locus 11 and Hemopneumothorax. Among its related pathways are Gene Expression and Farnesoid X Receptor Pathway. Gene Ontology (GO) annotations related to this gene include DNA binding transcription factor activity and transcription factor binding. An important paralog of this gene is NR0B1.

UniProtKB/Swiss-Prot for NR0B2 Gene

  • Acts as a transcriptional regulator. Acts as a negative regulator of receptor-dependent signaling pathways. Specifically inhibits transactivation of the nuclear receptor with whom it interacts. Inhibits transcriptional activity of NEUROD1 on E-box-containing promoter by interfering with the coactivation function of the p300/CBP-mediated transcription complex for NEUROD1.

Gene Wiki entry for NR0B2 Gene

Additional gene information for NR0B2 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NR0B2 Gene

Genomics for NR0B2 Gene

GeneHancer (GH) Regulatory Elements for NR0B2 Gene

Promoters and enhancers for NR0B2 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH01J026909 Promoter/Enhancer 2 EPDnew Ensembl ENCODE dbSUPER 654.9 +1.1 1113 7 FOXA2 MLX ZFP64 ARID4B FEZF1 DMAP1 YY1 SLC30A9 ZNF766 PAF1 NR0B2 LOC101928324 PIGV ZDHHC18 ENSG00000226698 LIN28A LOC101928728 TRNP1 ARID1A KDF1
GH01J026990 Promoter/Enhancer 2.7 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 11.5 -82.7 -82717 13.3 PKNOX1 FOXA2 MLX ZFP64 ARID4B SIN3A DMAP1 SLC30A9 ZNF143 FOS TRNP1 ARID1A LOC101928324 PIGV RPL17P9 HMGN2 NR0B2 NUDC RPA2 NPM1P39
GH01J026958 Promoter/Enhancer 2.4 EPDnew FANTOM5 Ensembl ENCODE 12.2 -46.8 -46766 3.9 FOXA2 MLX ARID4B SIN3A DMAP1 ZNF48 ETS1 ZNF121 GLIS2 ELK1 GC01P026960 KDF1 TRNP1 PIGV NR0B2 NUDC TENT5B GPATCH3 ENSG00000226698 SFN
GH01J026856 Promoter/Enhancer 2.6 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 4.7 +52.3 52333 9.6 HDGF PKNOX1 SMAD1 ARNT ARID4B SIN3A ZNF2 YY1 POLR2B ZNF213 SFN ARID1A HMGN2 LOC101928324 GPATCH3 LOC101928728 ACTG1P20 ENSG00000231344 NPM1P39 PIGV
GH01J026966 Enhancer 0.9 ENCODE 11.8 -53.2 -53235 0.7 ELF3 HDGF RB1 ARID4B SIN3A DMAP1 RAD21 RARA RFX5 ZNF614 NR0B2 NUDC TENT5B GPATCH3 SFN WDTC1 LOC105376890 RNU6-48P ACTG1P20 TMEM222
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around NR0B2 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the NR0B2 gene promoter:
  • STAT3
  • PPAR-gamma2
  • PPAR-gamma1
  • C/EBPalpha
  • CHOP-10
  • Lmo2
  • Arnt
  • AhR

Genomic Locations for NR0B2 Gene

Genomic Locations for NR0B2 Gene
2,593 bases
Minus strand
2,593 bases
Minus strand

Genomic View for NR0B2 Gene

Genes around NR0B2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
NR0B2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for NR0B2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NR0B2 Gene

Proteins for NR0B2 Gene

  • Protein details for NR0B2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Nuclear receptor subfamily 0 group B member 2
    Protein Accession:
    Secondary Accessions:
    • F1D8P5
    • Q5QP36

    Protein attributes for NR0B2 Gene

    257 amino acids
    Molecular mass:
    28058 Da
    Quaternary structure:
    • Interacts with RARA, RXRA, THRB, NR5A1, NR5A2, NR1I3, PPARA, PPARG and EID1. May also interact with HNF4A (By similarity). Heterodimer; efficient DNA binding requires dimerization with another bHLH protein. Interacts (via N-terminus) with NEUROD1 (via N-terminus an C-terminus). Interacts with ID2.

    Three dimensional structures from OCA and Proteopedia for NR0B2 Gene

neXtProt entry for NR0B2 Gene

Post-translational modifications for NR0B2 Gene

  • Arginine methylation by PRMT5 enhances repression activity of metabolic genes in liver in response to bile acid signaling, by increasing interaction with cofactors.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for NR0B2 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for NR0B2 Gene

Domains & Families for NR0B2 Gene

Gene Families for NR0B2 Gene

Human Protein Atlas (HPA):
  • Disease related genes
  • Nuclear receptors
  • Predicted intracellular proteins
  • Transcription factors

Protein Domains for NR0B2 Gene

Suggested Antigen Peptide Sequences for NR0B2 Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the nuclear hormone receptor family. NR0 subfamily.
  • Belongs to the nuclear hormone receptor family. NR0 subfamily.
genes like me logo Genes that share domains with NR0B2: view

Function for NR0B2 Gene

Molecular function for NR0B2 Gene

UniProtKB/Swiss-Prot Function:
Acts as a transcriptional regulator. Acts as a negative regulator of receptor-dependent signaling pathways. Specifically inhibits transactivation of the nuclear receptor with whom it interacts. Inhibits transcriptional activity of NEUROD1 on E-box-containing promoter by interfering with the coactivation function of the p300/CBP-mediated transcription complex for NEUROD1.
GENATLAS Biochemistry:
orphan nuclear (steroid/thyroid/retinoid) receptor,subfamily 0,group B,member 2,orphan specifically expressed in fetal liver and adrenal gland,adult spleen and small intestine,heterodimerizing with many members of receptor superfamily including RARs,RRXs,small heterodimer partner interacting with PPARx,potential negative regulator of receptor dependent signaling pathways

Phenotypes From GWAS Catalog for NR0B2 Gene

Gene Ontology (GO) - Molecular Function for NR0B2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding ISA --
GO:0003677 DNA binding IEA --
GO:0003707 steroid hormone receptor activity IEA --
GO:0003714 transcription corepressor activity IDA,TAS 14752053
GO:0005515 protein binding IPI 14752053
genes like me logo Genes that share ontologies with NR0B2: view
genes like me logo Genes that share phenotypes with NR0B2: view

Human Phenotype Ontology for NR0B2 Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Models for NR0B2 Gene

MGI Knock Outs for NR0B2:

Animal Model Products

  • Taconic Biosciences Mouse Models for NR0B2

miRNA for NR0B2 Gene

miRTarBase miRNAs that target NR0B2

Clone Products

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targets and HOMER Transcription for NR0B2 Gene

Localization for NR0B2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for NR0B2 Gene

Nucleus. Cytoplasm. Note=Colocalizes with NEUROD1 in the nucleus.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for NR0B2 gene
Compartment Confidence
nucleus 5
extracellular 3
plasma membrane 2
mitochondrion 2
peroxisome 2
cytosol 2
endoplasmic reticulum 1

Gene Ontology (GO) - Cellular Components for NR0B2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA 14752053
GO:0005654 nucleoplasm TAS --
GO:0005737 cytoplasm IEA,IDA 14752053
GO:0032991 protein-containing complex IEA --
genes like me logo Genes that share ontologies with NR0B2: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for NR0B2 Gene

Pathways & Interactions for NR0B2 Gene

genes like me logo Genes that share pathways with NR0B2: view

Pathways by source for NR0B2 Gene

1 KEGG pathway for NR0B2 Gene
1 GeneGo (Thomson Reuters) pathway for NR0B2 Gene

SIGNOR curated interactions for NR0B2 Gene

Is activated by:
Is inactivated by:

Gene Ontology (GO) - Biological Process for NR0B2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000122 negative regulation of transcription by RNA polymerase II IEA --
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0006367 transcription initiation from RNA polymerase II promoter TAS --
GO:0007219 Notch signaling pathway IEA --
genes like me logo Genes that share ontologies with NR0B2: view

Drugs & Compounds for NR0B2 Gene

(9) Drugs for NR0B2 Gene - From: DrugBank and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
D-serine Approved, Experimental, Investigational Pharma Agonist, Target 0

(5) Additional Compounds for NR0B2 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with NR0B2: view

Transcripts for NR0B2 Gene

mRNA/cDNA for NR0B2 Gene

(2) REFSEQ mRNAs :
(3) Additional mRNA sequences :
(39) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for NR0B2 Gene

Nuclear receptor subfamily 0, group B, member 2:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for NR0B2 Gene

No ASD Table

Relevant External Links for NR0B2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for NR0B2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for NR0B2 Gene

mRNA differential expression in normal tissues according to GTEx for NR0B2 Gene

This gene is overexpressed in Liver (x26.1), Pancreas (x6.0), Stomach (x5.1), and Adrenal Gland (x4.3).

NURSA nuclear receptor signaling pathways regulating expression of NR0B2 Gene:


SOURCE GeneReport for Unigene cluster for NR0B2 Gene:


mRNA Expression by UniProt/SwissProt for NR0B2 Gene:

Tissue specificity: Liver. Low levels of expression were detected in heart and pancreas.

Evidence on tissue expression from TISSUES for NR0B2 Gene

  • Kidney(4.4)
  • Pancreas(4.4)
  • Spleen(4.3)
  • Liver(3.5)
  • Intestine(2.9)
genes like me logo Genes that share expression patterns with NR0B2: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for NR0B2 Gene

Orthologs for NR0B2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for NR0B2 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia NR0B2 34 33
  • 99.09 (n)
(Canis familiaris)
Mammalia NR0B2 34 33
  • 85.55 (n)
(Bos Taurus)
Mammalia NR0B2 34 33
  • 84.64 (n)
(Mus musculus)
Mammalia Nr0b2 16 34 33
  • 80.93 (n)
(Rattus norvegicus)
Mammalia Nr0b2 33
  • 80.8 (n)
(Ornithorhynchus anatinus)
Mammalia NR0B2 34
  • 54 (a)
(Monodelphis domestica)
Mammalia NR0B2 34
  • 51 (a)
(Gallus gallus)
Aves NR0B2 34 33
  • 65.7 (n)
(Anolis carolinensis)
Reptilia NR0B2 34
  • 35 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia nr0b2 33
  • 49.53 (n)
(Danio rerio)
Actinopterygii nr0b2a 34 33
  • 57.28 (n)
nr0b2b 34
  • 38 (a)
Dr.11590 33
Species where no ortholog for NR0B2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for NR0B2 Gene

Gene Tree for NR0B2 (if available)
Gene Tree for NR0B2 (if available)
Evolutionary constrained regions (ECRs) for NR0B2: view image

Paralogs for NR0B2 Gene

Paralogs for NR0B2 Gene

(1) SIMAP similar genes for NR0B2 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with NR0B2: view

Variants for NR0B2 Gene

Sequence variations from dbSNP and Humsavar for NR0B2 Gene

SNP ID Clin Chr 01 pos Variation AA Info Type
rs74315349 pathogenic, Obesity, mild, early-onset 26,913,841(-) G/A/C coding_sequence_variant, missense_variant, stop_gained
rs74315350 pathogenic, Obesity, mild, early-onset 26,912,036(-) C/A coding_sequence_variant, downstream_transcript_variant, genic_downstream_transcript_variant, missense_variant
rs201991593 likely-benign, not specified 26,913,409(-) C/G/T coding_sequence_variant, missense_variant
rs113654931 uncertain-significance, not specified 26,913,781(-) G/A coding_sequence_variant, missense_variant
rs768288444 uncertain-significance, not specified 26,913,819(-) C/T coding_sequence_variant, missense_variant

Structural Variations from Database of Genomic Variants (DGV) for NR0B2 Gene

Variant ID Type Subtype PubMed ID
nsv1000012 CNV gain 25217958
nsv508689 CNV deletion 20534489
nsv834524 CNV gain+loss 17160897

Variation tolerance for NR0B2 Gene

Residual Variation Intolerance Score: 84.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.19; 61.89% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for NR0B2 Gene

Human Gene Mutation Database (HGMD)
SNPedia medical, phenotypic, and genealogical associations of SNPs for

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NR0B2 Gene

Disorders for NR0B2 Gene

MalaCards: The human disease database

(7) MalaCards diseases for NR0B2 Gene - From: HGMD, OMIM, ClinVar, GTR, DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
body mass index quantitative trait locus 11
  • bmiq11
fibrolamellar carcinoma
  • fibrolamellar hepatocellular carcinoma
hepatopulmonary syndrome
  • bile occlusion
- elite association - COSMIC cancer census association via MalaCards
Search NR0B2 in MalaCards View complete list of genes associated with diseases


  • Obesity (OBESITY) [MIM:601665]: A condition characterized by an increase of body weight beyond the limitation of skeletal and physical requirements, as the result of excessive accumulation of body fat. {ECO:0000269 PubMed:11136233}. Note=Disease susceptibility is associated with variations affecting the gene represented in this entry.

Additional Disease Information for NR0B2

Genetic Association Database
Human Genome Epidemiology Navigator
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with NR0B2: view

No data available for Genatlas for NR0B2 Gene

Publications for NR0B2 Gene

  1. Mutations in the small heterodimer partner gene are associated with mild obesity in Japanese subjects. (PMID: 11136233) Nishigori H … Takeda J (Proceedings of the National Academy of Sciences of the United States of America 2001) 3 4 22 44 58
  2. Structure and expression of the orphan nuclear receptor SHP gene. (PMID: 9603951) Lee HK … Choi HS (The Journal of biological chemistry 1998) 2 3 4 22 58
  3. Mutation analysis of NR0B2 among 1545 Danish men identifies a novel c.278G>A (p.G93D) variant with reduced functional activity. (PMID: 15459958) Echwald SM … Pedersen O (Human mutation 2004) 3 22 44 58
  4. Arginine methylation by PRMT5 at a naturally occurring mutation site is critical for liver metabolic regulation by small heterodimer partner. (PMID: 21262773) Kanamaluru D … Kemper JK (Molecular and cellular biology 2011) 3 4 58
  5. Genetic risk factors for hepatopulmonary syndrome in patients with advanced liver disease. (PMID: 20346360) Roberts KE … Pulmonary Vascular Complications of Liver Disease Study Group (Gastroenterology 2010) 3 44 58

Products for NR0B2 Gene

Sources for NR0B2 Gene

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