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Aliases for NQO2 Gene

Aliases for NQO2 Gene

  • N-Ribosyldihydronicotinamide:Quinone Reductase 2 2 3 5
  • NAD(P)H Quinone Dehydrogenase 2 2 3
  • NRH:Quinone Oxidoreductase 2 3 4
  • Quinone Reductase 2 3 4
  • NMOR2 3 4
  • QR2 3 4
  • NAD(P)H Menadione Oxidoreductase-1, Dioxin-Inducible-2 3
  • NAD(P)H Menadione Oxidoreductase 2, Dioxin-Inducible 2
  • Ribosyldihydronicotinamide Dehydrogenase [Quinone] 3
  • Ribosyldihydronicotinamide Dehydrogenase 3
  • NAD(P)H Dehydrogenase, Quinone 2 3
  • NRH Dehydrogenase [Quinone] 2 4
  • EC 1.10.5.1 4
  • DHQV 3
  • DIA6 3

External Ids for NQO2 Gene

Previous HGNC Symbols for NQO2 Gene

  • NMOR2

Previous GeneCards Identifiers for NQO2 Gene

  • GC06P002985
  • GC06P002945
  • GC06P002873
  • GC06P003000

Summaries for NQO2 Gene

Entrez Gene Summary for NQO2 Gene

  • This gene encodes a member of the thioredoxin family of enzymes. It is a cytosolic and ubiquitously expressed flavoprotein that catalyzes the two-electron reduction of quinone substrates and uses dihydronicotinamide riboside as a reducing coenzyme. Mutations in this gene have been associated with neurodegenerative diseases and several cancers. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2014]

GeneCards Summary for NQO2 Gene

NQO2 (N-Ribosyldihydronicotinamide:Quinone Reductase 2) is a Protein Coding gene. Diseases associated with NQO2 include Marburg Hemorrhagic Fever and Breast Cancer. Among its related pathways are Metabolism and Photodynamic therapy-induced NFE2L2 (NRF2) survival signaling. Gene Ontology (GO) annotations related to this gene include oxidoreductase activity and NADPH dehydrogenase (quinone) activity. An important paralog of this gene is NQO1.

UniProtKB/Swiss-Prot for NQO2 Gene

  • The enzyme apparently serves as a quinone reductase in connection with conjugation reactions of hydroquinones involved in detoxification pathways as well as in biosynthetic processes such as the vitamin K-dependent gamma-carboxylation of glutamate residues in prothrombin synthesis.

Gene Wiki entry for NQO2 Gene

Additional gene information for NQO2 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NQO2 Gene

Genomics for NQO2 Gene

GeneHancer (GH) Regulatory Elements for NQO2 Gene

Promoters and enhancers for NQO2 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH06J002979 Promoter/Enhancer 2.8 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 668.9 -1.9 -1867 13.6 CLOCK FEZF1 DMAP1 YY1 SLC30A9 ZNF213 E2F8 ZNF143 ZNF548 ZNF263 NQO2 LINC01011 RIPK1 PSMG4 ENSG00000228170 WRNIP1 ENSG00000272320 LOC105374888 SERPINB9 SERPINB6
GH06J002998 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 678.6 +12.6 12584 4.1 MLX DMAP1 YY1 SLC30A9 ZNF143 SP3 NFYC MEF2D SSRP1 GLIS1 LOC105374888 NQO2 SERPINB6 GC06P002980 HTATSF1P2
GH06J003021 Promoter/Enhancer 1.8 Ensembl ENCODE dbSUPER 39.8 +36.8 36817 5.8 HDGF HNRNPUL1 PKNOX1 SMAD1 ARNT ARID4B SIN3A IRF4 SLC30A9 POLR2B HTATSF1P2 LOC101927759 PRPF4B NQO2 RIPK1 LINC01011 BPHL ENSG00000272277 GC06P002980
GH06J002957 Promoter/Enhancer 1.8 EPDnew Ensembl ENCODE dbSUPER 17.8 -27.2 -27172 5.9 PKNOX1 FOXA2 TCF12 POLR2B ATF7 FOS CREM CEBPB NCOA1 GATAD2B SERPINB6 NQO2 LINC01011 ENSG00000232999 SERPINB9 MYLK4 GC06P002970 GC06M002954 PIR46440
GH06J002836 Promoter/Enhancer 2.5 EPDnew Ensembl ENCODE dbSUPER 12.6 -147.8 -147762 6.7 MLX ZFP64 FEZF1 DMAP1 SLC30A9 E2F8 ZNF143 SP3 MEF2D SSRP1 SERPINB1 SERPINB9 SERPINB9P1 LINC01011 NQO2 ENSG00000232999 SERPINB6 WRNIP1 MYLK4 GC06P002818
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around NQO2 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the NQO2 gene promoter:
  • AP-1
  • Sp1
  • C/EBPalpha
  • ATF-2
  • c-Jun

Genomic Locations for NQO2 Gene

Genomic Locations for NQO2 Gene
chr6:2,987,987-3,028,869
(GRCh38/hg38)
Size:
40,883 bases
Orientation:
Plus strand
chr6:2,988,221-3,019,996
(GRCh37/hg19)
Size:
31,776 bases
Orientation:
Plus strand

Genomic View for NQO2 Gene

Genes around NQO2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
NQO2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for NQO2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NQO2 Gene

Proteins for NQO2 Gene

  • Protein details for NQO2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P16083-NQO2_HUMAN
    Recommended name:
    Ribosyldihydronicotinamide dehydrogenase [quinone]
    Protein Accession:
    P16083
    Secondary Accessions:
    • B2R492
    • Q5TD04

    Protein attributes for NQO2 Gene

    Size:
    231 amino acids
    Molecular mass:
    25919 Da
    Cofactor:
    Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
    Cofactor:
    Name=FAD; Xref=ChEBI:CHEBI:57692;
    Quaternary structure:
    • Homodimer.
    Miscellaneous:
    • Uses dihydronicotinamide riboside (NRH) rather than NAD(P)H as an electron donor.

    Three dimensional structures from OCA and Proteopedia for NQO2 Gene

neXtProt entry for NQO2 Gene

Post-translational modifications for NQO2 Gene

  • Ubiquitination at Lys16
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for NQO2 Gene

Domains & Families for NQO2 Gene

Gene Families for NQO2 Gene

Human Protein Atlas (HPA):
  • Enzymes
  • Plasma proteins
  • Predicted intracellular proteins
  • Predicted secreted proteins

Protein Domains for NQO2 Gene

Suggested Antigen Peptide Sequences for NQO2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P16083

UniProtKB/Swiss-Prot:

NQO2_HUMAN :
  • Belongs to the NAD(P)H dehydrogenase (quinone) family.
Family:
  • Belongs to the NAD(P)H dehydrogenase (quinone) family.
genes like me logo Genes that share domains with NQO2: view

Function for NQO2 Gene

Molecular function for NQO2 Gene

UniProtKB/Swiss-Prot Function:
The enzyme apparently serves as a quinone reductase in connection with conjugation reactions of hydroquinones involved in detoxification pathways as well as in biosynthetic processes such as the vitamin K-dependent gamma-carboxylation of glutamate residues in prothrombin synthesis.
UniProtKB/Swiss-Prot CatalyticActivity:
1-(beta-D-ribofuranosyl)-1,4-dihydronicotinamide + a quinone = 1-(beta-D-ribofuranosyl)nicotinamide + a quinol.
UniProtKB/Swiss-Prot EnzymeRegulation:
Inhibited by melatonin, resveratrol and 5-hydroxytryptamine.
UniProtKB/Swiss-Prot BiophysicochemicalProperties:
Kinetic parameters: KM=28 uM for NRH {ECO:0000269 PubMed:15078100, ECO:0000269 PubMed:9367528}; KM=11.6 uM for menadione {ECO:0000269 PubMed:15078100, ECO:0000269 PubMed:9367528}; KM=252 uM for NADH {ECO:0000269 PubMed:15078100, ECO:0000269 PubMed:9367528};

Enzyme Numbers (IUBMB) for NQO2 Gene

Phenotypes From GWAS Catalog for NQO2 Gene

Gene Ontology (GO) - Molecular Function for NQO2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001512 dihydronicotinamide riboside quinone reductase activity TAS --
GO:0003955 NAD(P)H dehydrogenase (quinone) activity IBA --
GO:0005515 protein binding IPI 16189514
GO:0008270 zinc ion binding IDA 18254726
GO:0009055 electron transfer activity IDA 10945627
genes like me logo Genes that share ontologies with NQO2: view
genes like me logo Genes that share phenotypes with NQO2: view

Animal Models for NQO2 Gene

MGI Knock Outs for NQO2:

Animal Model Products

CRISPR Products

miRNA for NQO2 Gene

miRTarBase miRNAs that target NQO2

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for NQO2

Clone Products

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for NQO2 Gene

Localization for NQO2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for NQO2 Gene

Cytoplasm.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for NQO2 gene
Compartment Confidence
extracellular 5
nucleus 5
cytosol 5

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (3)
  • Nucleoplasm (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for NQO2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005654 nucleoplasm IDA --
GO:0005737 cytoplasm IEA --
GO:0005829 cytosol TAS --
GO:0070062 extracellular exosome HDA 19056867
genes like me logo Genes that share ontologies with NQO2: view

Pathways & Interactions for NQO2 Gene

genes like me logo Genes that share pathways with NQO2: view

Pathways by source for NQO2 Gene

Gene Ontology (GO) - Biological Process for NQO2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006805 xenobiotic metabolic process TAS --
GO:0022900 electron transport chain IEA --
GO:0055114 oxidation-reduction process IDA 18254726
genes like me logo Genes that share ontologies with NQO2: view

No data available for SIGNOR curated interactions for NQO2 Gene

Drugs & Compounds for NQO2 Gene

(25) Drugs for NQO2 Gene - From: DrugBank, PharmGKB, DGIdb, HMDB, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Menadione Approved Nutra inhibitor, Target 257
Melatonin Approved, Vet_approved Nutra Antagonist, Full agonist, Agonist, Target Melatonin receptors MT inhibitor, Endogenous hormone; agonist at MT1 and MT2 292
FAD Approved Pharma Target 0
Primaquine Approved Pharma Target, inhibitor 80
Resveratrol Approved, Experimental, Investigational Pharma Target Cyclooxygenase inhibitor 126

(13) Additional Compounds for NQO2 Gene - From: HMDB and Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
Quinone
  • 1,4-Benzochinon
  • 2,5-Cyclohexadiene-1,4-dione
  • benzo-1,4-Quinone
  • Benzoquinone
  • P-Benzoquinone
106-51-4
1-(beta-D-Ribofuranosyl)-1,4-dihydronicotinamide
  • Reduced nicotinamide riboside
  • 1-(b-D-Ribofuranosyl)-1,4-dihydronicotinamide
  • 1-(β-D-ribofuranosyl)-1,4-dihydronicotinamide
Nicotinamide riboside
  • 1-(beta-D-Ribofuranosyl)nicotinamide
  • beta-Nicotinamide D-riboside
  • Nicotinamide ribonucleoside
  • Nicotinamide ribose
  • Nicotinamide-beta-riboside
1341-23-7
genes like me logo Genes that share compounds with NQO2: view

Transcripts for NQO2 Gene

Unigene Clusters for NQO2 Gene

NAD(P)H dehydrogenase, quinone 2:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for NQO2

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for NQO2 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7a · 7b ^ 8a · 8b ^ 9a · 9b ^ 10 ^ 11a · 11b
SP1: - -
SP2: - - - - -
SP3: - - - - - - -
SP4: - - - -
SP5: - - - - - - -
SP6: - - - -
SP7: - -
SP8: - -

Relevant External Links for NQO2 Gene

GeneLoc Exon Structure for
NQO2
ECgene alternative splicing isoforms for
NQO2

Expression for NQO2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for NQO2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for NQO2 Gene

This gene is overexpressed in Whole Blood (x8.6).

Protein differential expression in normal tissues from HIPED for NQO2 Gene

This gene is overexpressed in Liver, secretome (8.1) and Kidney (7.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for NQO2 Gene



Protein tissue co-expression partners for NQO2 Gene

NURSA nuclear receptor signaling pathways regulating expression of NQO2 Gene:

NQO2

SOURCE GeneReport for Unigene cluster for NQO2 Gene:

Hs.145597

Evidence on tissue expression from TISSUES for NQO2 Gene

  • Nervous system(4.6)
  • Liver(4.4)
  • Kidney(2)
genes like me logo Genes that share expression patterns with NQO2: view

No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for NQO2 Gene

Orthologs for NQO2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for NQO2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia NQO2 34 33
  • 98.85 (n)
OneToOne
dog
(Canis familiaris)
Mammalia NQO2 34 33
  • 82.97 (n)
OneToOne
mouse
(Mus musculus)
Mammalia Nqo2 16 34 33
  • 82.68 (n)
rat
(Rattus norvegicus)
Mammalia Nqo2 33
  • 82.68 (n)
cow
(Bos Taurus)
Mammalia NQO2 34 33
  • 81.53 (n)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia NQO2 34
  • 71 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia -- 34
  • 68 (a)
OneToMany
-- 34
  • 49 (a)
OneToMany
chicken
(Gallus gallus)
Aves NQO2 34 33
  • 71.62 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia NQO2 34
  • 64 (a)
OneToOne
Species where no ortholog for NQO2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for NQO2 Gene

ENSEMBL:
Gene Tree for NQO2 (if available)
TreeFam:
Gene Tree for NQO2 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for NQO2: view image

Paralogs for NQO2 Gene

Paralogs for NQO2 Gene

(1) SIMAP similar genes for NQO2 Gene using alignment to 5 proteins:

  • NQO2_HUMAN
  • A2A2U4_HUMAN
  • Q5TD05_HUMAN
  • Q5TD07_HUMAN
  • U3KQG7_HUMAN

Pseudogenes.org Pseudogenes for NQO2 Gene

genes like me logo Genes that share paralogs with NQO2: view

Variants for NQO2 Gene

Sequence variations from dbSNP and Humsavar for NQO2 Gene

SNP ID Clin Chr 06 pos Variation AA Info Type
rs1000146700 -- 3,014,974(+) A/G intron_variant
rs1000386937 -- 3,000,839(+) C/G intron_variant
rs1000520002 -- 3,014,716(+) A/G intron_variant
rs1000538816 -- 3,006,270(+) AAAAAA/AAAAA intron_variant
rs1000602487 -- 3,011,408(+) G/A intron_variant

Structural Variations from Database of Genomic Variants (DGV) for NQO2 Gene

Variant ID Type Subtype PubMed ID
esv2759404 CNV gain 17122850
esv3426962 CNV duplication 20981092
esv3607919 CNV loss 21293372
nsv1029300 CNV loss 25217958
nsv1073952 CNV deletion 25765185
nsv470795 CNV gain 18288195
nsv5177 CNV insertion 18451855
nsv523441 CNV loss 19592680
nsv600833 CNV loss 21841781
nsv830575 CNV loss 17160897
nsv981099 CNV duplication 23825009

Variation tolerance for NQO2 Gene

Residual Variation Intolerance Score: 87.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.73; 57.65% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for NQO2 Gene

Human Gene Mutation Database (HGMD)
NQO2
SNPedia medical, phenotypic, and genealogical associations of SNPs for
NQO2

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NQO2 Gene

Disorders for NQO2 Gene

MalaCards: The human disease database

(4) MalaCards diseases for NQO2 Gene - From: HGMD, OMIM, GTR, DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
marburg hemorrhagic fever
  • marburg disease
breast cancer
  • breast cancer, familial
alcoholic pancreatitis
  • pancreatitis alcoholic
parkinson disease, late-onset
  • pd
- elite association - COSMIC cancer census association via MalaCards
Search NQO2 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for NQO2

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with NQO2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for NQO2 Gene

Publications for NQO2 Gene

  1. Kinetic mechanism of quinone oxidoreductase 2 and its inhibition by the antimalarial quinolines. (PMID: 15078100) Kwiek JJ … Rudolph J (Biochemistry 2004) 3 4 22 25 58
  2. Crystal structure of human quinone reductase type 2, a metalloflavoprotein. (PMID: 10433694) Foster CE … Amzel LM (Biochemistry 1999) 3 4 22 25 58
  3. Nucleotide and deduced amino acid sequence of a human cDNA (NQO2) corresponding to a second member of the NAD(P)H:quinone oxidoreductase gene family. Extensive polymorphism at the NQO2 gene locus on chromosome 6. (PMID: 1691923) Jaiswal AK … McBride OW (Biochemistry 1990) 2 3 4 22 58
  4. Investigation of a functional quinine oxidoreductase (NQO2) polymorphism and cognitive decline. (PMID: 18538895) Payton A … Horan M (Neurobiology of aging 2010) 3 22 44 58
  5. The structure of the leukemia drug imatinib bound to human quinone reductase 2 (NQO2). (PMID: 19236722) Winger JA … Kuriyan J (BMC structural biology 2009) 3 4 22 58

Products for NQO2 Gene

Sources for NQO2 Gene

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