This gene encodes a member of the thioredoxin family of enzymes. It is a cytosolic and ubiquitously expressed flavoprotein that catalyzes the two-electron reduction of quinone substrates and uses dihydronicotinamide riboside as a reducing coenzyme. Mutations in this gene have been associated with neurodegenerative diseases and several cancers. Alternative splicing results in mu... See more...

Aliases for NQO2 Gene

Aliases for NQO2 Gene

  • N-Ribosyldihydronicotinamide:Quinone Reductase 2 2 3 5
  • Ribosyldihydronicotinamide Dehydrogenase [Quinone] 3 4
  • NAD(P)H Quinone Dehydrogenase 2 2 3
  • NRH:Quinone Oxidoreductase 2 3 4
  • Quinone Reductase 2 3 4
  • NMOR2 3 4
  • QR2 3 4
  • NAD(P)H Menadione Oxidoreductase-1, Dioxin-Inducible-2 3
  • NAD(P)H Menadione Oxidoreductase 2, Dioxin-Inducible 2
  • Ribosyldihydronicotinamide Dehydrogenase 3
  • NAD(P)H Dehydrogenase, Quinone 2 3
  • NRH Dehydrogenase [Quinone] 2 4
  • EC 1.10.5.1 4
  • DHQV 3
  • DIA6 3

External Ids for NQO2 Gene

Previous HGNC Symbols for NQO2 Gene

  • NMOR2

Previous GeneCards Identifiers for NQO2 Gene

  • GC06P002985
  • GC06P002945
  • GC06P002873
  • GC06P003000
  • GC06P003006
  • GC06P003002

Summaries for NQO2 Gene

Entrez Gene Summary for NQO2 Gene

  • This gene encodes a member of the thioredoxin family of enzymes. It is a cytosolic and ubiquitously expressed flavoprotein that catalyzes the two-electron reduction of quinone substrates and uses dihydronicotinamide riboside as a reducing coenzyme. Mutations in this gene have been associated with neurodegenerative diseases and several cancers. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2014]

GeneCards Summary for NQO2 Gene

NQO2 (N-Ribosyldihydronicotinamide:Quinone Reductase 2) is a Protein Coding gene. Diseases associated with NQO2 include Breast Cancer and Alcoholic Pancreatitis. Among its related pathways are Cytochrome P450 - arranged by substrate type and Photodynamic therapy-induced NFE2L2 (NRF2) survival signaling. Gene Ontology (GO) annotations related to this gene include oxidoreductase activity and NADPH dehydrogenase (quinone) activity. An important paralog of this gene is NQO1.

UniProtKB/Swiss-Prot Summary for NQO2 Gene

  • The enzyme apparently serves as a quinone reductase in connection with conjugation reactions of hydroquinones involved in detoxification pathways as well as in biosynthetic processes such as the vitamin K-dependent gamma-carboxylation of glutamate residues in prothrombin synthesis.

Gene Wiki entry for NQO2 Gene

Additional gene information for NQO2 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for NQO2 Gene

Genomics for NQO2 Gene

GeneHancer (GH) Regulatory Elements for NQO2 Gene

Promoters and enhancers for NQO2 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around NQO2 on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for NQO2

Top Transcription factor binding sites by QIAGEN in the NQO2 gene promoter:
  • AP-1
  • ATF-2
  • c-Jun
  • C/EBPalpha
  • Sp1

Genomic Locations for NQO2 Gene

Genomic Locations for NQO2 Gene
chr6:2,987,987-3,028,869
(GRCh38/hg38)
Size:
40,883 bases
Orientation:
Plus strand
chr6:2,988,221-3,019,996
(GRCh37/hg19)
Size:
31,776 bases
Orientation:
Plus strand

Genomic View for NQO2 Gene

Genes around NQO2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
NQO2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for NQO2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NQO2 Gene

Proteins for NQO2 Gene

  • Protein details for NQO2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P16083-NQO2_HUMAN
    Recommended name:
    Ribosyldihydronicotinamide dehydrogenase [quinone]
    Protein Accession:
    P16083
    Secondary Accessions:
    • B2R492
    • Q5TD04

    Protein attributes for NQO2 Gene

    Size:
    231 amino acids
    Molecular mass:
    25919 Da
    Cofactor:
    Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
    Cofactor:
    Name=FAD; Xref=ChEBI:CHEBI:57692;
    Quaternary structure:
    • Homodimer.
    Miscellaneous:
    • Uses dihydronicotinamide riboside (NRH) rather than NAD(P)H as an electron donor.

    Three dimensional structures from OCA and Proteopedia for NQO2 Gene

neXtProt entry for NQO2 Gene

Post-translational modifications for NQO2 Gene

  • Ubiquitination at Lys16
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for NQO2 Gene

Domains & Families for NQO2 Gene

Gene Families for NQO2 Gene

Human Protein Atlas (HPA):
  • Enzymes
  • Plasma proteins
  • Predicted intracellular proteins

Protein Domains for NQO2 Gene

Blocks:
  • NAD(P)H dehydrogenase (quinone)
InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for NQO2 Gene

GenScript: Design optimal peptide antigens:
  • Quinone reductase 2 (NQO2_HUMAN)

Graphical View of Domain Structure for InterPro Entry

P16083

UniProtKB/Swiss-Prot:

NQO2_HUMAN :
  • Belongs to the NAD(P)H dehydrogenase (quinone) family.
Family:
  • Belongs to the NAD(P)H dehydrogenase (quinone) family.
genes like me logo Genes that share domains with NQO2: view

Function for NQO2 Gene

Molecular function for NQO2 Gene

UniProtKB/Swiss-Prot Function:
The enzyme apparently serves as a quinone reductase in connection with conjugation reactions of hydroquinones involved in detoxification pathways as well as in biosynthetic processes such as the vitamin K-dependent gamma-carboxylation of glutamate residues in prothrombin synthesis.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=1-(beta-D-ribofuranosyl)-1,4-dihydronicotinamide + a quinone + H(+) = a quinol + beta-nicotinamide D-riboside; Xref=Rhea:RHEA:12364, ChEBI:CHEBI:15378, ChEBI:CHEBI:15927, ChEBI:CHEBI:24646, ChEBI:CHEBI:55458, ChEBI:CHEBI:132124; EC=1.10.5.1; Evidence=. ;.
UniProtKB/Swiss-Prot EnzymeRegulation:
Inhibited by melatonin, resveratrol and 5-hydroxytryptamine.
UniProtKB/Swiss-Prot BiophysicochemicalProperties:
Kinetic parameters: KM=28 uM for NRH {ECO:0000269 PubMed:15078100, ECO:0000269 PubMed:9367528}; KM=11.6 uM for menadione {ECO:0000269 PubMed:15078100, ECO:0000269 PubMed:9367528}; KM=252 uM for NADH {ECO:0000269 PubMed:15078100, ECO:0000269 PubMed:9367528};

Enzyme Numbers (IUBMB) for NQO2 Gene

Phenotypes From GWAS Catalog for NQO2 Gene

Gene Ontology (GO) - Molecular Function for NQO2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001512 dihydronicotinamide riboside quinone reductase activity IDA 18254726
GO:0003955 NAD(P)H dehydrogenase (quinone) activity IBA 21873635
GO:0005515 protein binding IPI 16189514
GO:0008270 zinc ion binding IDA 18254726
GO:0009055 electron transfer activity IDA 10945627
genes like me logo Genes that share ontologies with NQO2: view
genes like me logo Genes that share phenotypes with NQO2: view

Human Phenotype Ontology for NQO2 Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Models for NQO2 Gene

MGI Knock Outs for NQO2:

Animal Model Products

CRISPR Products

miRNA for NQO2 Gene

miRTarBase miRNAs that target NQO2

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for NQO2

Clone Products

No data available for Transcription Factor Targets and HOMER Transcription for NQO2 Gene

Localization for NQO2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for NQO2 Gene

Cytoplasm.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for NQO2 gene
Compartment Confidence
nucleus 5
cytosol 5
plasma membrane 2
cytoskeleton 2
mitochondrion 2
extracellular 1
peroxisome 1
endoplasmic reticulum 1
endosome 1
lysosome 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (3)
  • Nucleoplasm (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for NQO2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005654 nucleoplasm IDA --
GO:0005737 cytoplasm IEA --
GO:0005829 cytosol TAS --
GO:0070062 extracellular exosome HDA 19056867
genes like me logo Genes that share ontologies with NQO2: view

Pathways & Interactions for NQO2 Gene

genes like me logo Genes that share pathways with NQO2: view

Pathways by source for NQO2 Gene

Gene Ontology (GO) - Biological Process for NQO2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006805 xenobiotic metabolic process TAS --
GO:0007613 memory IEA --
GO:0022900 electron transport chain IEA --
GO:0043525 positive regulation of neuron apoptotic process IEA --
GO:0055114 oxidation-reduction process IDA 18254726
genes like me logo Genes that share ontologies with NQO2: view

No data available for SIGNOR curated interactions for NQO2 Gene

Drugs & Compounds for NQO2 Gene

(27) Drugs for NQO2 Gene - From: DrugBank, PharmGKB, ApexBio, DGIdb, HMDB, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Menadione Approved Nutra inhibitor, Target 306
Melatonin Approved, Vet_approved Nutra Antagonist, Full agonist, Agonist, Target Melatonin receptors MT inhibitor, Endogenous hormone; agonist at MT1 and MT2 374
FAD Approved Pharma Target 0
Primaquine Approved Pharma Target, inhibitor 91
Resveratrol Approved, Experimental, Investigational Pharma Target Cyclooxygenase inhibitor 150

(11) Additional Compounds for NQO2 Gene - From: Novoseek and HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
Quinone
  • 1,4-Benzochinon
  • 2,5-Cyclohexadiene-1,4-dione
  • benzo-1,4-Quinone
  • Benzoquinone
  • P-Benzoquinone
106-51-4
1-(beta-D-Ribofuranosyl)-1,4-dihydronicotinamide
  • Reduced nicotinamide riboside
  • 1-(b-D-Ribofuranosyl)-1,4-dihydronicotinamide
  • 1-(β-D-ribofuranosyl)-1,4-dihydronicotinamide

(1) ApexBio Compounds for NQO2 Gene

Compound Action Cas Number
DMXAA (Vadimezan) Tumnor vascular disrupting agent, apoptosis inducer 117570-53-3
genes like me logo Genes that share compounds with NQO2: view

Drug Products

Transcripts for NQO2 Gene

mRNA/cDNA for NQO2 Gene

4 REFSEQ mRNAs :
7 NCBI additional mRNA sequence :
9 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for NQO2

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for NQO2 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7a · 7b ^ 8a · 8b ^ 9a · 9b ^ 10 ^ 11a · 11b
SP1: - -
SP2: - - - - -
SP3: - - - - - - -
SP4: - - - -
SP5: - - - - - - -
SP6: - - - -
SP7: - -
SP8: - -

Relevant External Links for NQO2 Gene

GeneLoc Exon Structure for
NQO2

Expression for NQO2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for NQO2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for NQO2 Gene

This gene is overexpressed in Whole Blood (x8.6).

Protein differential expression in normal tissues from HIPED for NQO2 Gene

This gene is overexpressed in Liver, secretome (8.1) and Kidney (7.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for NQO2 Gene



Protein tissue co-expression partners for NQO2 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for NQO2

SOURCE GeneReport for Unigene cluster for NQO2 Gene:

Hs.145597

Evidence on tissue expression from TISSUES for NQO2 Gene

  • Nervous system(4.6)
  • Liver(4.4)
  • Kidney(2)
genes like me logo Genes that share expression patterns with NQO2: view

No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for NQO2 Gene

Orthologs for NQO2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for NQO2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia NQO2 31 30
  • 98.85 (n)
OneToOne
dog
(Canis familiaris)
Mammalia NQO2 31 30
  • 82.97 (n)
OneToOne
mouse
(Mus musculus)
Mammalia Nqo2 17 31 30
  • 82.68 (n)
rat
(Rattus norvegicus)
Mammalia Nqo2 30
  • 82.68 (n)
cow
(Bos Taurus)
Mammalia NQO2 31 30
  • 81.53 (n)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia NQO2 31
  • 71 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia -- 31
  • 68 (a)
OneToMany
-- 31
  • 49 (a)
OneToMany
chicken
(Gallus gallus)
Aves NQO2 31 30
  • 71.62 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia NQO2 31
  • 64 (a)
OneToOne
Species where no ortholog for NQO2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for NQO2 Gene

ENSEMBL:
Gene Tree for NQO2 (if available)
TreeFam:
Gene Tree for NQO2 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for NQO2: view image

Paralogs for NQO2 Gene

Paralogs for NQO2 Gene

(1) SIMAP similar genes for NQO2 Gene using alignment to 5 proteins:

  • NQO2_HUMAN
  • A2A2U4_HUMAN
  • Q5TD05_HUMAN
  • Q5TD07_HUMAN
  • U3KQG7_HUMAN

Pseudogenes.org Pseudogenes for NQO2 Gene

genes like me logo Genes that share paralogs with NQO2: view

Variants for NQO2 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for NQO2 Gene

SNP ID Clinical significance and condition Chr 06 pos Variation AA Info Type
rs1143684 - p.Leu47Phe
rs17136117 - p.Glu29Gly
rs17300141 - p.Gly58Asp
rs28383623 - p.Lys16Arg
rs28383651 - p.Val184Ala

Additional dbSNP identifiers (rs#s) for NQO2 Gene

Structural Variations from Database of Genomic Variants (DGV) for NQO2 Gene

Variant ID Type Subtype PubMed ID
esv2759404 CNV gain 17122850
esv3426962 CNV duplication 20981092
esv3607919 CNV loss 21293372
nsv1029300 CNV loss 25217958
nsv1073952 CNV deletion 25765185
nsv470795 CNV gain 18288195
nsv5177 CNV insertion 18451855
nsv523441 CNV loss 19592680
nsv600833 CNV loss 21841781
nsv830575 CNV loss 17160897
nsv981099 CNV duplication 23825009

Variation tolerance for NQO2 Gene

Residual Variation Intolerance Score: 87.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.73; 57.65% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for NQO2 Gene

Human Gene Mutation Database (HGMD)
NQO2
SNPedia medical, phenotypic, and genealogical associations of SNPs for
NQO2

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NQO2 Gene

Disorders for NQO2 Gene

MalaCards: The human disease database

(7) MalaCards diseases for NQO2 Gene - From: OMIM, GTR, DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
breast cancer
  • breast cancer, familial
alcoholic pancreatitis
  • pancreatitis alcoholic
marburg hemorrhagic fever
  • marburg disease
substance dependence
granulocytopenia
  • agranulocytosis
- elite association - COSMIC cancer census association via MalaCards
Search NQO2 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for NQO2

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with NQO2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for NQO2 Gene

Publications for NQO2 Gene

  1. Kinetic mechanism of quinone oxidoreductase 2 and its inhibition by the antimalarial quinolines. (PMID: 15078100) Kwiek JJ … Rudolph J (Biochemistry 2004) 3 4 23 26 54
  2. Crystal structure of human quinone reductase type 2, a metalloflavoprotein. (PMID: 10433694) Foster CE … Amzel LM (Biochemistry 1999) 3 4 23 26 54
  3. Nucleotide and deduced amino acid sequence of a human cDNA (NQO2) corresponding to a second member of the NAD(P)H:quinone oxidoreductase gene family. Extensive polymorphism at the NQO2 gene locus on chromosome 6. (PMID: 1691923) Jaiswal AK … McBride OW (Biochemistry 1990) 2 3 4 23 54
  4. Investigation of a functional quinine oxidoreductase (NQO2) polymorphism and cognitive decline. (PMID: 18538895) Payton A … Horan M (Neurobiology of aging 2010) 3 23 41 54
  5. The structure of the leukemia drug imatinib bound to human quinone reductase 2 (NQO2). (PMID: 19236722) Winger JA … Kuriyan J (BMC structural biology 2009) 3 4 23 54

Products for NQO2 Gene

Sources for NQO2 Gene