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This gene is a member of the NAD(P)H dehydrogenase (quinone) family and encodes a cytoplasmic 2-electron reductase. This FAD-binding protein forms homodimers and reduces quinones to hydroquinones. This protein's enzymatic activity prevents the one electron reduction of quinones that results in the production of radical species. Mutations in this gene have been associated with t... See more...
Aliases for NQO1 Gene
Aliases for NQO1 Gene
- NAD(P)H Quinone Dehydrogenase 1 2 3 5
- DTD 2 3 4
- QR1 2 3 4
- Diaphorase (NADH/NADPH) (Cytochrome B-5 Reductase) 2 3
- NAD(P)H Dehydrogenase [Quinone] 1 3 4
- NAD(P)H Dehydrogenase, Quinone 1 2 3
- NAD(P)H:Quinone Oxidoreductase 1 3 4
- Phylloquinone Reductase 3 4
- Menadione Reductase 3 4
- Quinone Reductase 1 3 4
- DT-Diaphorase 3 4
External Ids for NQO1 Gene
- HGNC: 2874
- Entrez Gene: 1728
- Ensembl: ENSG00000181019
- OMIM: 125860
- UniProtKB: P15559
Previous HGNC Symbols for NQO1 Gene
- NMOR1
- DIA4
Previous GeneCards Identifiers for NQO1 Gene
- GC16M060424
- GC16M070163
- GC16M069478
- GC16M069519
- GC16M068300
- GC16M069744
- GC16M055621
Summaries for NQO1 Gene
-
This gene is a member of the NAD(P)H dehydrogenase (quinone) family and encodes a cytoplasmic 2-electron reductase. This FAD-binding protein forms homodimers and reduces quinones to hydroquinones. This protein's enzymatic activity prevents the one electron reduction of quinones that results in the production of radical species. Mutations in this gene have been associated with tardive dyskinesia (TD), an increased risk of hematotoxicity after exposure to benzene, and susceptibility to various forms of cancer. Altered expression of this protein has been seen in many tumors and is also associated with Alzheimer's disease (AD). Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008]
GeneCards Summary for NQO1 Gene
NQO1 (NAD(P)H Quinone Dehydrogenase 1) is a Protein Coding gene. Diseases associated with NQO1 include Tardive Dyskinesia and Lung Cancer. Among its related pathways are Simplified Interaction Map Between LOXL4 and Oxidative Stress Pathway and Photodynamic therapy-induced NFE2L2 (NRF2) survival signaling. Gene Ontology (GO) annotations related to this gene include oxidoreductase activity. An important paralog of this gene is NQO2.
UniProtKB/Swiss-Prot Summary for NQO1 Gene
-
The enzyme apparently serves as a quinone reductase in connection with conjugation reactions of hydroquinons involved in detoxification pathways as well as in biosynthetic processes such as the vitamin K-dependent gamma-carboxylation of glutamate residues in prothrombin synthesis.
Additional gene information for NQO1 Gene
- HGNC(2874)
- Entrez Gene(1728)
- Ensembl(ENSG00000181019)
- OMIM(125860)
- UniProtKB(P15559)
- Open Targets Platform(ENSG00000181019)
- Monarch Initiative
- Search for NQO1 at DataMed
- Search for NQO1 at HumanCyc
No data available for Tocris Summary , Rfam classification and piRNA Summary for NQO1 Gene
Genomics for NQO1 Gene
GeneHancer (GH) Regulatory Elements Pubs
Promoters and enhancers for NQO1 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication |
Request up-to-date GeneHancer data (full dataset)
GeneHancers around NQO1 on the GeneHancer Hub at the UCSC Golden Path
Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for NQO1
- Top Transcription factor binding sites by QIAGEN in the NQO1 gene promoter:
-
- AP-1
- ATF-2
- c-Jun
- p53
Genomic Locations for NQO1 Gene
Genomic Locations for NQO1 Gene
- chr16:69,706,996-69,726,668
- (GRCh38/hg38)
- Size:
- 19,673 bases
- Orientation:
- Minus strand
- chr16:69,740,899-69,760,854
- (GRCh37/hg19)
- Size:
- 19,956 bases
- Orientation:
- Minus strand
Genomic View for NQO1 Gene
Genes around NQO1 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 16q22.1 by HGNC
- 16q22.1 by Entrez Gene
- 16q22.1 by Ensembl
NQO1 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for NQO1 Gene
Proteins for NQO1 Gene
-
Protein details for NQO1 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- P15559-NQO1_HUMAN
- Recommended name:
- NAD(P)H dehydrogenase [quinone] 1
- Protein Accession:
- P15559
- B2R5Y9
- B4DNM7
- B7ZAD1
- Q86UK1
Protein attributes for NQO1 Gene
- Size:
- 274 amino acids
- Molecular mass:
- 30868 Da
- Cofactor:
- Name=FAD; Xref=ChEBI:CHEBI:57692;
- Quaternary structure:
-
- Homodimer (PubMed:10543876, PubMed:10706635, PubMed:11735396, PubMed:11587640, PubMed:16700548). Interacts with PDLIM4 isoform 2; this interaction stabilizes PDLIM4 isoform 2 in response to oxidative stress and protects it from ubiquitin-independent degradation by the core 20S proteasome (PubMed:21636573).
- Miscellaneous:
-
- Quinone reductase accepts electrons from both NADH and NADPH with equal efficiency.
Three dimensional structures from OCA and Proteopedia for NQO1 Gene
Protein Expression for NQO1 Gene
Selected DME Specific Peptides for NQO1 Gene
- P15559:
-
- PLYFAPSSLFDLNFQAGFL
- FCGFQVLEPQL
- WFGVPAILKGWFERV
- GLSVGHHLGK
Post-translational modifications for NQO1 Gene
Other Protein References for NQO1 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- G Biosciences Immunotag™ NQO1 Antibody
- NSJ Bioreagents NQO1 Antibody
-
Custom Antibody ServicesOriGene Antibodies for NQO1
- Novus Biologicals Antibodies for NQO1
-
Abcam antibodies for NQO1
- Invitrogen Antibodies for NQO1 (AFLGC-NQO1)
-
Santa Cruz Biotechnology (SCBT) Antibodies for NQO1
- Sino Biological Antibodies for NQO1
Protein Products
- Search Origene for MassSpec and Protein Over-expression Lysates for NQO1
- Origene Custom Protein Services for NQO1
- Sino Biological Recombinant Proteins for NQO1
- Browse Sino Biological Cell Lysates
- ProSpec Recombinant Proteins for NQO1
-
Signalway Proteins for NQO1
-
Abcam proteins for NQO1
Assay Products
- RayBiotech Custom Human NQO-1 ELISA
- antibodies-online: Show 33 available NQO1 Elisa Kits ranked by validation data
- Compare Top NQO1 Elisa Kits
-
Quality Products:
Domains & Families for NQO1 Gene
Gene Families for NQO1 Gene
- Human Protein Atlas (HPA):
-
- Cancer-related genes
- Enzymes
- Predicted intracellular proteins
Protein Domains for NQO1 Gene
- InterPro:
- Blocks:
-
- NAD(P)H dehydrogenase (quinone)
- ProtoNet:
Suggested Antigen Peptide Sequences for NQO1 Gene
- GenScript: Design optimal peptide antigens:
-
- cDNA FLJ50573, highly similar to Homo sapiens NAD(P)H dehydrogenase, quinone 1 (NQO1), transcript variant 3, mRNA (B4DLR8_HUMAN)
- cDNA, FLJ79145, highly similar to Homo sapiens NAD(P)H dehydrogenase, quinone 1 (NQO1) (B7ZAD1_HUMAN)
- Quinone reductase 1 (NQO1_HUMAN)
- NQO1 protein (Q3B792_HUMAN)
Graphical View of Domain Structure for InterPro Entry
P15559- Family:
-
- Belongs to the NAD(P)H dehydrogenase (quinone) family.
Function for NQO1 Gene
Molecular function for NQO1 Gene
- UniProtKB/Swiss-Prot Function:
- The enzyme apparently serves as a quinone reductase in connection with conjugation reactions of hydroquinons involved in detoxification pathways as well as in biosynthetic processes such as the vitamin K-dependent gamma-carboxylation of glutamate residues in prothrombin synthesis.
- UniProtKB/Swiss-Prot CatalyticActivity:
- Reaction=a quinone + H(+) + NADH = a quinol + NAD(+); Xref=Rhea:RHEA:46160, ChEBI:CHEBI:15378, ChEBI:CHEBI:24646, ChEBI:CHEBI:57540, ChEBI:CHEBI:57945, ChEBI:CHEBI:132124; EC=1.6.5.2;.
- UniProtKB/Swiss-Prot CatalyticActivity:
- Reaction=a quinone + H(+) + NADPH = a quinol + NADP(+); Xref=Rhea:RHEA:46164, ChEBI:CHEBI:15378, ChEBI:CHEBI:24646, ChEBI:CHEBI:57783, ChEBI:CHEBI:58349, ChEBI:CHEBI:132124; EC=1.6.5.2;.
- UniProtKB/Swiss-Prot Induction:
- By dioxin (PubMed:1657151). By oxidative stress (PubMed:21636573).
- UniProtKB/Swiss-Prot EnzymeRegulation:
- Inhibited by dicoumarol.
Enzyme Numbers (IUBMB) for NQO1 Gene
Phenotypes From GWAS Catalog for NQO1 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0003723 | RNA binding | HDA | 22658674 |
| GO:0003955 | NAD(P)H dehydrogenase (quinone) activity | IBA | 21873635 |
| GO:0004128 | cytochrome-b5 reductase activity, acting on NAD(P)H | TAS | 9579781 |
| GO:0004784 | superoxide dismutase activity | IEA | -- |
| GO:0005515 | protein binding | IPI | 18388957 |
Phenotypes for NQO1 Gene
- MGI mutant phenotypes for NQO1:
- inferred from 2 alleles
- GenomeRNAi human phenotypes for NQO1:
Animal Model Products
-
Taconic Biosciences Mouse Models for NQO1
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for NQO1 - Select products 50% OFF >
- * NQO1 CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for NQO1
-
Santa Cruz Biotechnology (SCBT) CRISPR for NQO1
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for NQO1
- Browse OriGene Inhibitory RNA Products For NQO1
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Clone Products
- Applied Biological Materials (abm): Clones for NQO1 - Select products 50% OFF >
- * NQO1 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
- MG227333
- MR227333
- MR227333L3
- MR227333L4
- RC200620
- RC200620L1
- RC200620L2
- RC200620L3
- RC200620L4
- RC222529
- RC222529L3
- RC222529L4
- RC223447
- RC223447L3
- RC223447L4
- RC236529
- RG200620
- RG222529
- RG223447
- RR201654
- RR201654L3
- RR201654L4
- MR227333L3V
- MR227333L4V
- RC200620L1V
- RC200620L2V
- RC200620L3V
- RC200620L4V
- RC222529L3V
- RC222529L4V
- RC223447L3V
- RC223447L4V
- RR201654L3V
- RR201654L4V
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Sino Biological Human cDNA Clone for NQO1
- Addgene plasmids for NQO1
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for NQO1
Cell Line Products
-
Horizon Cell Lines for NQO1
No data available for Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for NQO1 Gene
Localization for NQO1 Gene
Subcellular locations from UniProtKB/Swiss-Prot for NQO1 Gene
- Cytoplasm.
| Compartment | Confidence |
|---|---|
| cytosol | 5 |
| mitochondrion | 3 |
| nucleus | 3 |
| plasma membrane | 2 |
| extracellular | 2 |
| cytoskeleton | 2 |
| peroxisome | 2 |
| endoplasmic reticulum | 2 |
| lysosome | 2 |
| endosome | 1 |
| golgi apparatus | 1 |
- Cytosol (4)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005737 | cytoplasm | TAS | 2843525 |
| GO:0005829 | cytosol | IDA,TAS | -- |
| GO:0030425 | dendrite | IEA | -- |
| GO:0043025 | neuronal cell body | IEA | -- |
| GO:0045202 | synapse | IEA | -- |
Pathways & Interactions for NQO1 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Metabolism |
.40
|
|
| 2 | Doxorubicin Pathway, Pharmacokinetics | ||
| 3 | Regulation of activated PAK-2p34 by proteasome mediated degradation | ||
| 4 | Apoptosis and Autophagy | ||
| 5 | Glucose / Energy Metabolism | ||
Pathways by source for NQO1 Gene
11 BioSystems pathways for NQO1 Gene
4 Reactome pathways for NQO1 Gene
5 KEGG pathways for NQO1 Gene
1 GeneGo (Thomson Reuters) pathway for NQO1 Gene
- Acetaminophen metabolism
3 Cell Signaling Technology pathways for NQO1 Gene
Interacting Proteins for NQO1 Gene
Selected Interacting proteins:
P15559-NQO1_HUMAN
ENSP00000319788
for NQO1 Gene via
UniProtKB
MINT
STRING
IID
GPS-Prot Interaction Network for NQO1
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0006521 | regulation of cellular amino acid metabolic process | TAS | -- |
| GO:0006801 | superoxide metabolic process | IEA | -- |
| GO:0006805 | xenobiotic metabolic process | TAS | 10393963 |
| GO:0006809 | nitric oxide biosynthetic process | TAS | 9579781 |
| GO:0006979 | response to oxidative stress | IEP | 21636573 |
Drugs & Compounds for NQO1 Gene
| Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
|---|---|---|---|---|---|---|
| Dicumarol | Approved | Pharma | Target, inhibitor | 0 | ||
| Menadione | Approved | Nutra | Target, inhibitor | 327 | ||
| FAD | Approved | Pharma | Target | 0 | ||
| Vitamin E | Approved, Vet_approved | Nutra | Enzyme, inducer | 526,534 | ||
| Cisplatin | Approved | Pharma | Enzyme, substrate | Inhibits DNA synthesis,chemotherapy drug, Potent pro-apoptotic anticancer agent; activates caspase-3, Platinum | 3412 |
| Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs | |
|---|---|---|---|---|---|---|
| Quinone |
|
106-51-4 | ||||
| Hydrogen Ion |
|
|
||||
| Menaquinol |
|
|
||||
| Phylloquinol |
|
572-96-3 |
|
(4) ApexBio Compounds for NQO1 Gene
| Compound | Action | Cas Number |
|---|---|---|
| Dicoumarol | 66-76-2 | |
| DMXAA (Vadimezan) | Tumnor vascular disrupting agent, apoptosis inducer | 117570-53-3 |
| ES 936 | 192820-78-3 | |
| Oltipraz | An antischistosomal agent | 64224-21-1 |
Transcripts for NQO1 Gene
mRNA/cDNA for NQO1 Gene
- 4 REFSEQ mRNAs :
- 21 NCBI additional mRNA sequence :
- 7 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
-
- ENST00000320623 2521 nts (view in UCSC)
- ENST00000379046 1105 nts (view in UCSC)
- ENST00000379047 2527 nts (view in UCSC)
- ENST00000439109 924 nts (view in UCSC)
- ENST00000561500 891 nts (view in UCSC)
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for NQO1 - Select products 50% OFF >
- * NQO1 CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for NQO1
-
Santa Cruz Biotechnology (SCBT) CRISPR for NQO1
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for NQO1
- Browse OriGene Inhibitory RNA Products For NQO1
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for NQO1
Clone Products
- Applied Biological Materials (abm): Clones for NQO1 - Select products 50% OFF >
- * NQO1 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
- MG227333
- MR227333
- MR227333L3
- MR227333L4
- RC200620
- RC200620L1
- RC200620L2
- RC200620L3
- RC200620L4
- RC222529
- RC222529L3
- RC222529L4
- RC223447
- RC223447L3
- RC223447L4
- RC236529
- RG200620
- RG222529
- RG223447
- RR201654
- RR201654L3
- RR201654L4
- MR227333L3V
- MR227333L4V
- RC200620L1V
- RC200620L2V
- RC200620L3V
- RC200620L4V
- RC222529L3V
- RC222529L4V
- RC223447L3V
- RC223447L4V
- RR201654L3V
- RR201654L4V
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Sino Biological Human cDNA Clone for NQO1
- Addgene plasmids for NQO1
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for NQO1
| ExUns: | 1a | · | 1b | · | 1c | · | 1d | ^ | 2a | · | 2b | ^ | 3a | · | 3b | ^ | 4a | · | 4b | · | 4c | ^ | 5a | · | 5b | ^ | 6a | · | 6b | · | 6c | · | 6d | · | 6e | ^ | 7 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | |||||||||||||||||||||||||||||||||||||
| SP2: | - | - | - | - | |||||||||||||||||||||||||||||||||
| SP3: | - | - | |||||||||||||||||||||||||||||||||||
| SP4: | - | - | - | ||||||||||||||||||||||||||||||||||
| SP5: | - | ||||||||||||||||||||||||||||||||||||
| SP6: | - | - | |||||||||||||||||||||||||||||||||||
| SP7: | |||||||||||||||||||||||||||||||||||||
| SP8: | - | - | - | - | - | ||||||||||||||||||||||||||||||||
| SP9: | - | - | - | - | - |
Relevant External Links for NQO1 Gene
- GeneLoc Exon Structure for
- NQO1
Expression for NQO1 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
- Brain (Nervous System)
- Inner Cell Mass (Early Embryonic Tissues)
- Tooth (Integumentary System)
-
Testis (Reproductive System)
- Leydig Cells Testis Interstitium
- Intestine (Gastrointestinal Tract)
- Ovary (Reproductive System)
- Eye (Sensory Organs)
-
Colon (Gastrointestinal Tract)
-
Smooth Muscle (Muscoskeletal System)
-
Thyroid (Endocrine System)
-
Gall Bladder (Hepatobiliary System)
-
Esophagus (Gastrointestinal Tract)
-
Stomach (Gastrointestinal Tract)
-
Adipose (Muscoskeletal System)
mRNA differential expression in normal tissues according to GTEx for NQO1 Gene
This gene is overexpressed in Stomach (x5.2).
This gene is overexpressed in Nasopharynx (13.6), Skin (8.6), and Nasal epithelium (7.2).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for NQO1 Gene
Transcriptomic regulation report from SPP (The Signaling Pathways Project) for NQO1
SOURCE GeneReport for Unigene cluster for NQO1 Gene:
Hs.406515Evidence on tissue expression from TISSUES for NQO1 Gene
- Liver(4.9)
- Intestine(4.9)
- Nervous system(4.9)
- Lung(4.6)
- Skin(4.5)
- Kidney(4.2)
- Eye(3.9)
- Stomach(3.7)
- Pancreas(3)
- Heart(2.9)
- Thyroid gland(2.8)
- Muscle(2.8)
- Blood(2.8)
- Adrenal gland(2.7)
- Gall bladder(2.7)
- Spleen(2.5)
- Lymph node(2.1)
- Bone marrow(2)
- Urine(2)
Primer Products
-
OriGene qPCR primer pairs for NQO1
-
OriGene qPCR primer pairs and template standards for NQO1
Gene Expression Assay Products
No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for NQO1 Gene
Orthologs for NQO1 Gene
This gene was present in the common ancestor of chordates.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| Chimpanzee (Pan troglodytes) |
Mammalia | NQO1 30 31 |
|
OneToOne | |
| Cow (Bos Taurus) |
Mammalia | NQO1 30 31 |
|
OneToOne | |
| Mouse (Mus musculus) |
Mammalia | Nqo1 30 17 31 |
|
OneToOne | |
| Dog (Canis familiaris) |
Mammalia | NQO1 30 31 |
|
OneToOne | |
| Rat (Rattus norvegicus) |
Mammalia | Nqo1 30 |
|
||
| Platypus (Ornithorhynchus anatinus) |
Mammalia | NQO1 31 |
|
OneToOne | |
| Oppossum (Monodelphis domestica) |
Mammalia | NQO1 31 |
|
OneToOne | |
| Chicken (Gallus gallus) |
Aves | NQO1 30 31 |
|
OneToOne | |
| Lizard (Anolis carolinensis) |
Reptilia | NQO1 31 |
|
OneToOne | |
| Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | nqo1 30 |
|
||
| Zebrafish (Danio rerio) |
Actinopterygii | nqo1 30 31 |
|
OneToOne | |
| Rainbow Trout (Oncorhynchus mykiss) |
Actinopterygii | Omy.8645 30 |
|
- Species where no ortholog for NQO1 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Eremothecium gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- Alpha proteobacteria (Wolbachia pipientis)
- Amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- Baker's yeast (Saccharomyces cerevisiae)
- Barley (Hordeum vulgare)
- Beta proteobacteria (Neisseria meningitidis)
- Bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- Common water flea (Daphnia pulex)
- Corn (Zea mays)
- E. coli (Escherichia coli)
- Filamentous fungi (Aspergillus nidulans)
- Firmicute Bacteria (Streptococcus pneumoniae)
- Fission Yeast (Schizosaccharomyces pombe)
- Fruit Fly (Drosophila melanogaster)
- Green Algae (Chlamydomonas reinhardtii)
- Honey Bee (Apis mellifera)
- K. Lactis Yeast (Kluyveromyces lactis)
- Loblloly Pine (Pinus taeda)
- Malaria Parasite (Plasmodium falciparum)
- Medicago Trunc (Medicago Truncatula)
- Moss (Physcomitrella patens)
- Orangutan (Pongo pygmaeus)
- Pig (Sus scrofa)
- Rice (Oryza sativa)
- Rice Blast Fungus (Magnaporthe grisea)
- Schistosome Parasite (Schistosoma mansoni)
- Sea Anemone (Nematostella vectensis)
- Sea Vase (Ciona intestinalis)
- Sea Squirt (Ciona savignyi)
- Sea Urchin (Strongylocentrotus purpuratus)
- Sorghum (Sorghum bicolor)
- Soybean (Glycine max)
- Stem Rust Fungus (Puccinia graminis)
- Sugarcane (Saccharum officinarum)
- Thale Cress (Arabidopsis thaliana)
- Tomato (Lycopersicon esculentum)
- Toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- Wheat (Triticum aestivum)
- Worm (Caenorhabditis elegans)
Evolution for NQO1 Gene
- ENSEMBL:
- Gene Tree for NQO1 (if available)
- TreeFam:
- Gene Tree for NQO1 (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for NQO1: view image
Paralogs for NQO1 Gene
Variants for NQO1 Gene
Polymorphic Variants from UniProtKB/Swiss-Prot for NQO1 Gene
- NQO1_HUMAN-P15559
- The Ser-187 polymorphism may be linked to susceptibility to forms of cancers.
Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for NQO1 Gene
| SNP ID | Clinical significance and condition | Chr 16 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| 741777 | Likely Benign: not provided | 69,711,216(-) | G/A | SYNONYMOUS_VARIANT | |
| 780185 | Benign: not provided | 69,710,994(-) | C/G | MISSENSE_VARIANT | |
| rs1555537451 | Likely Pathogenic: not provided | 69,711,254(-) | G/A | NONSENSE | |
| rs1800566 | Drug Response: Lung cancer; Benzene toxicity, susceptibility to; Leukemia, post-chemotherapy, susceptibility to; Breast cancer, post-chemotherapy poor survival in; Alkylating Agents, anthracyclines and related substances, fluorouracil, and Platinum compounds response - Efficacy. - | 69,711,242(-) | G/Ap.Pro187Ser | MISSENSE_VARIANT | |
| rs1131341 | - | p.Arg139Trp |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| esv3638928 | CNV | gain | 21293372 |
| esv3638929 | CNV | gain | 21293372 |
| esv3892878 | CNV | gain | 25118596 |
| nsv517207 | CNV | loss | 19592680 |
| nsv524364 | CNV | loss | 19592680 |
Residual Variation Intolerance Score:
78.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
11.04;
92.13% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for NQO1 Gene
SNP Genotyping and Copy Number Assay Products
Disorders for NQO1 Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| tardive dyskinesia |
|
|
| lung cancer |
|
|
| colon adenocarcinoma |
|
|
| colorectal cancer |
|
|
| alcoholic pancreatitis |
|
|
Search NQO1 in MalaCards
View complete list of genes associated with diseases
Additional Disease Information for NQO1
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
- Open Targets Platform
No data available for UniProtKB/Swiss-Prot and Genatlas for NQO1 Gene
Publications for NQO1 Gene
- Role of the CYP2D6, EPHX1, MPO, and NQO1 genes in the susceptibility to acute lymphoblastic leukemia in Brazilian children. (PMID: 19593802) Silveira Vda S … Tone LG (Environmental and molecular mutagenesis 2010) 3 23 41
- [Role of polymorphic markers of antioxidants (NQO1, GSTP1, GPX1) genes in adaptive response to hazardous work conditions in workers]. (PMID: 20480816) Kochetova OV … Viktorova TV (Meditsina truda i promyshlennaia ekologiia 2010) 3 23 41
- Dietary glucosinolate intake, polymorphisms in selected biotransformation enzymes, and risk of prostate cancer. (PMID: 20056632) Steinbrecher A … Linseisen J (Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology 2010) 3 23 41
- Genotype polymorphisms of GGCX, NQO1, and VKORC1 genes associated with risk susceptibility in patients with large-artery atherosclerotic stroke. (PMID: 20193673) Shyu HY … Cheng CW (Clinica chimica acta; international journal of clinical chemistry 2010) 3 23 41
- Association analyses of genetic polymorphisms of GSTM1, GSTT1, NQO1, NAT2, LPL, PRSS1, PSTI, and CFTR with chronic alcoholic pancreatitis in Japan. (PMID: 18986377) Maruyama K … Otsuki M (Alcoholism, clinical and experimental research 2010) 3 23 41
ExternalLinks
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Sources for NQO1 Gene
- (1) GeneCards
- (2) HGNC
- (3) NCBI Entrez Gene
- (4) UniProtKB/Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) Cell Signaling Technology
- (12) GO
- (13) UniProtKB/TrEMBL
- (14) InterPro
- (15) ProtoNet
- (16) Blocks
- (17) MGI
- (18) IUBMB
- (19) KEGG
- (20) MINT
- (21) STRING
- (22) IntAct
- (23) Novoseek
- (24) PharmGKB
- (25) DrugBank
- (26) HMDB
- (27) ASD
- (28) SAGE
- (29) SOURCE
- (30) HomoloGene
- (31) PanEnsembl
- (32) euGenes
- (33) SGD
- (34) FlyBase
- (35) WormBase
- (36) Pseudogene
- (37) DGV
- (38) dbSNP
- (39) GenAtlas
- (40) HGMD
- (41)