NQO1 Gene (Protein Coding)

NAD(P)H Quinone Dehydrogenase 1

GC16M069706
GIFtS:
50
This gene is a member of the NAD(P)H dehydrogenase (quinone) family and encodes a cytoplasmic 2-electron reductase. This FAD-binding protein forms homodimers and reduces quinones to hydroquinones. This protein's enzymatic activity prevents the one electron reduction of quinones that results in the production of radical species. Mutations in this gene have been associated with t... See more...

Aliases for NQO1 Gene

Aliases for NQO1 Gene

  • NAD(P)H Quinone Dehydrogenase 1 2 3 5
  • DTD 2 3 4
  • QR1 2 3 4
  • Diaphorase (NADH/NADPH) (Cytochrome B-5 Reductase) 2 3
  • NAD(P)H Dehydrogenase [Quinone] 1 3 4
  • NAD(P)H Dehydrogenase, Quinone 1 2 3
  • NAD(P)H:Quinone Oxidoreductase 1 3 4
  • Phylloquinone Reductase 3 4
  • Menadione Reductase 3 4
  • Quinone Reductase 1 3 4
  • DT-Diaphorase 3 4
  • Azoreductase 3 4
  • EC 1.6.5.2 4 50
  • NMOR1 3 4
  • DHQU 2 3
  • DIA4 3 4
  • NAD(P)H:Quinone Acceptor Oxidoreductase Type 1 3
  • NAD(P)H:Menadione Oxidoreductase 1 3
  • NAD(P)H:Quinone Oxireductase 3
  • Dioxin-Inducible 1 3
  • Diaphorase-4 3
  • NMORI 3
  • NQO1 5

External Ids for NQO1 Gene

Previous HGNC Symbols for NQO1 Gene

  • NMOR1
  • DIA4

Previous GeneCards Identifiers for NQO1 Gene

  • GC16M060424
  • GC16M070163
  • GC16M069478
  • GC16M069519
  • GC16M068300
  • GC16M069744
  • GC16M055621

Summaries for NQO1 Gene

Entrez Gene Summary for NQO1 Gene

  • This gene is a member of the NAD(P)H dehydrogenase (quinone) family and encodes a cytoplasmic 2-electron reductase. This FAD-binding protein forms homodimers and reduces quinones to hydroquinones. This protein's enzymatic activity prevents the one electron reduction of quinones that results in the production of radical species. Mutations in this gene have been associated with tardive dyskinesia (TD), an increased risk of hematotoxicity after exposure to benzene, and susceptibility to various forms of cancer. Altered expression of this protein has been seen in many tumors and is also associated with Alzheimer's disease (AD). Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008]

CIViC Summary for NQO1 Gene

GeneCards Summary for NQO1 Gene

NQO1 (NAD(P)H Quinone Dehydrogenase 1) is a Protein Coding gene. Diseases associated with NQO1 include Tardive Dyskinesia and Colon Adenocarcinoma. Among its related pathways are Gastric cancer and Simplified Interaction Map Between LOXL4 and Oxidative Stress Pathway. Gene Ontology (GO) annotations related to this gene include oxidoreductase activity. An important paralog of this gene is NQO2.

UniProtKB/Swiss-Prot Summary for NQO1 Gene

  • The enzyme apparently serves as a quinone reductase in connection with conjugation reactions of hydroquinons involved in detoxification pathways as well as in biosynthetic processes such as the vitamin K-dependent gamma-carboxylation of glutamate residues in prothrombin synthesis.

Gene Wiki entry for NQO1 Gene

PharmGKB "VIP" Summary for NQO1 Gene

Additional gene information for NQO1 Gene

No data available for Tocris Summary , Rfam classification and piRNA Summary for NQO1 Gene

Genomics for NQO1 Gene

GeneHancer (GH) Regulatory Elements Pubs

Download GeneHancer 2017 data
Promoters and enhancers for NQO1 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around NQO1 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for NQO1

Top Transcription factor binding sites by QIAGEN in the NQO1 gene promoter:
  • AP-1
  • ATF-2
  • c-Jun
  • p53

Genomic Locations for NQO1 Gene

Latest Assembly
chr16:69,706,996-69,726,668
(GRCh38/hg38)
Size:
19,673 bases
Orientation:
Minus strand

Previous Assembly
chr16:69,743,304-69,760,463
(GRCh37/hg19 by Entrez Gene)
Size:
17,160 bases
Orientation:
Minus strand

chr16:69,740,899-69,760,854
(GRCh37/hg19 by Ensembl)
Size:
19,956 bases
Orientation:
Minus strand

Genomic View for NQO1 Gene

Genes around NQO1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
NQO1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for NQO1 Gene
GeneLoc Logo Genomic Neighborhood • Exon Structure • Gene Density

RefSeq DNA sequence for NQO1 Gene

Proteins for NQO1 Gene

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  • Protein details for NQO1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P15559-NQO1_HUMAN
    Recommended name:
    NAD(P)H dehydrogenase [quinone] 1
    Protein Accession:
    P15559
    Secondary Accessions:
    • B2R5Y9
    • B4DNM7
    • B7ZAD1
    • Q86UK1

    Protein attributes for NQO1 Gene

    Size:
    274 amino acids
    Molecular mass:
    30868 Da
    Cofactor:
    Name=FAD; Xref=ChEBI:CHEBI:57692;
    Quaternary structure:
    • Homodimer (PubMed:10543876, PubMed:10706635, PubMed:11735396, PubMed:11587640, PubMed:16700548). Interacts with PDLIM4 isoform 2; this interaction stabilizes PDLIM4 isoform 2 in response to oxidative stress and protects it from ubiquitin-independent degradation by the core 20S proteasome (PubMed:21636573).
    Miscellaneous:
    • Quinone reductase accepts electrons from both NADH and NADPH with equal efficiency.

    Three dimensional structures from OCA and Proteopedia for NQO1 Gene

    Alternative splice isoforms for NQO1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for NQO1 Gene

Protein Expression for NQO1 Gene

See protein expression from ProteomicsDB, MOPED, PaxDb, and MaxQB

Selected DME Specific Peptides for NQO1 Gene

P15559:
  • PLYFAPSSLFDLNFQAGFL
  • FCGFQVLEPQL
  • WFGVPAILKGWFERV
  • GLSVGHHLGK

Post-translational modifications for NQO1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for NQO1 Gene

ENSEMBL proteins:
REFSEQ proteins:

Domains & Families for NQO1 Gene

Gene Families for NQO1 Gene

Human Protein Atlas (HPA):
  • Cancer-related genes
  • Enzymes
  • Predicted intracellular proteins

Protein Domains for NQO1 Gene

InterPro:
Blocks:
  • NAD(P)H dehydrogenase (quinone)

Suggested Antigen Peptide Sequences for NQO1 Gene

GenScript: Design optimal peptide antigens:
  • cDNA FLJ50573, highly similar to Homo sapiens NAD(P)H dehydrogenase, quinone 1 (NQO1), transcript variant 3, mRNA (B4DLR8_HUMAN)
  • cDNA, FLJ79145, highly similar to Homo sapiens NAD(P)H dehydrogenase, quinone 1 (NQO1) (B7ZAD1_HUMAN)
  • Quinone reductase 1 (NQO1_HUMAN)
  • NQO1 protein (Q3B792_HUMAN)

Graphical View of Domain Structure for InterPro Entry

P15559

UniProtKB/Swiss-Prot:

NQO1_HUMAN :
  • Belongs to the NAD(P)H dehydrogenase (quinone) family.
Family:
  • Belongs to the NAD(P)H dehydrogenase (quinone) family.
genes like me logo Genes that share domains with NQO1: view

Function for NQO1 Gene

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Molecular function for NQO1 Gene

UniProtKB/Swiss-Prot Function:
The enzyme apparently serves as a quinone reductase in connection with conjugation reactions of hydroquinons involved in detoxification pathways as well as in biosynthetic processes such as the vitamin K-dependent gamma-carboxylation of glutamate residues in prothrombin synthesis.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=a quinone + H(+) + NADH = a quinol + NAD(+); Xref=Rhea:RHEA:46160, ChEBI:CHEBI:15378, ChEBI:CHEBI:24646, ChEBI:CHEBI:57540, ChEBI:CHEBI:57945, ChEBI:CHEBI:132124; EC=1.6.5.2;.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=a quinone + H(+) + NADPH = a quinol + NADP(+); Xref=Rhea:RHEA:46164, ChEBI:CHEBI:15378, ChEBI:CHEBI:24646, ChEBI:CHEBI:57783, ChEBI:CHEBI:58349, ChEBI:CHEBI:132124; EC=1.6.5.2;.
UniProtKB/Swiss-Prot Induction:
By dioxin (PubMed:1657151). By oxidative stress (PubMed:21636573).
UniProtKB/Swiss-Prot EnzymeRegulation:
Inhibited by dicoumarol.

Enzyme Numbers (IUBMB) for NQO1 Gene

Phenotypes From GWAS Catalog for NQO1 Gene

Gene Ontology (GO) - Molecular Function for NQO1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003723 RNA binding HDA 22658674
GO:0003955 NAD(P)H dehydrogenase (quinone) activity IBA 21873635
GO:0004128 cytochrome-b5 reductase activity, acting on NAD(P)H TAS 9579781
GO:0004784 superoxide dismutase activity IEA --
GO:0005515 protein binding IPI 18388957
genes like me logo Genes that share ontologies with NQO1: view
genes like me logo Genes that share phenotypes with NQO1: view

Animal Models for NQO1 Gene

MGI Knock Outs for NQO1:

Animal Models for research

  • Taconic Biosciences Mouse Models for NQO1

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for NQO1

Clone products for research

  • Addgene plasmids for NQO1

No data available for Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for NQO1 Gene

Localization for NQO1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for NQO1 Gene

Cytoplasm.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for NQO1 gene
Compartment Confidence
cytosol 5
mitochondrion 3
nucleus 3
plasma membrane 2
extracellular 2
cytoskeleton 2
peroxisome 2
endoplasmic reticulum 2
lysosome 2
endosome 1
golgi apparatus 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (3)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for NQO1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm TAS 2843525
GO:0005829 cytosol IDA,TAS --
GO:0030425 dendrite IEA --
GO:0043025 neuronal cell body IEA --
GO:0045202 synapse IEA --
genes like me logo Genes that share ontologies with NQO1: view

Pathways & Interactions for NQO1 Gene

genes like me logo Genes that share pathways with NQO1: view

SIGNOR curated interactions for NQO1 Gene

Is activated by:
Is inactivated by:

Gene Ontology (GO) - Biological Process for NQO1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002931 response to ischemia IEA --
GO:0006116 NADH oxidation IEA --
GO:0006521 regulation of cellular amino acid metabolic process TAS --
GO:0006801 superoxide metabolic process IEA --
GO:0006805 xenobiotic metabolic process TAS 10393963
genes like me logo Genes that share ontologies with NQO1: view

Drugs & Compounds for NQO1 Gene

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(96) Drugs for NQO1 Gene - From: DrugBank, PharmGKB, ApexBio, DGIdb, HMDB, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Dicumarol Approved Pharma Target, inhibitor 0
Menadione Approved Nutra Target, inhibitor 346
Oxaliplatin Approved, Investigational Pharma Enzyme, substrate Antitumor agent, Platinum 2071
FAD Approved Pharma Target 0
Vitamin E Approved, Vet_approved Nutra Enzyme, inducer 553,561

(61) Additional Compounds for NQO1 Gene - From: Novoseek and HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
Quinone
  • 1,4-Benzochinon
  • 2,5-Cyclohexadiene-1,4-dione
  • Benzo-1,4-quinone
  • Benzoquinone
  • p-Benzoquinone
 106-51-4
Hydrogen Ion
  • H+
  • H(+)
  • Hydron
  • Hydrogen cation
  • Proton
Menaquinol
  • Reduced menaquinone
  • Vitamin K2 hydroquinone
  • Reduced vitamin K2
Phylloquinol
  • Phytonadiol
  • Vitamin K hydroquinone
  • Vitamin K1 hydroquinone
  • Reduced vitamin K1
  • Dihydrovitamin K1
 572-96-3

(4) ApexBio Compounds for NQO1 Gene

Compound Action Cas Number
Dicoumarol 66-76-2
DMXAA (Vadimezan) Tumnor vascular disrupting agent, apoptosis inducer 117570-53-3
ES 936 192820-78-3
Oltipraz An antischistosomal agent 64224-21-1
genes like me logo Genes that share compounds with NQO1: view

Drug products for research

Transcripts for NQO1 Gene

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mRNA/cDNA for NQO1 Gene

4 REFSEQ mRNAs :
21 NCBI additional mRNA sequence :
7 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for NQO1

Clone products for research

  • Addgene plasmids for NQO1

Alternative Splicing Database (ASD) splice patterns (SP) for NQO1 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2a · 2b ^ 3a · 3b ^ 4a · 4b · 4c ^ 5a · 5b ^ 6a · 6b · 6c · 6d · 6e ^ 7
SP1:
SP2: - - - -
SP3: - -
SP4: - - -
SP5: -
SP6: - -
SP7:
SP8: - - - - -
SP9: - - - - -

Relevant External Links for NQO1 Gene

GeneLoc Exon Structure for
NQO1

Expression for NQO1 Gene

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mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for NQO1 Gene

mRNA expression in normal human tissues for NQO1 Gene
mRNA expression by BioGPS for NQO1 GenemRNA expression by GTEx for NQO1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for NQO1 Gene

This gene is overexpressed in Stomach (x5.2).

Protein differential expression in normal tissues from HIPED for NQO1 Gene

This gene is overexpressed in Nasopharynx (13.6), Skin (8.6), and Nasal epithelium (7.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for NQO1 Gene



Protein tissue co-expression partners for NQO1 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for NQO1

SOURCE GeneReport for Unigene cluster for NQO1 Gene:

Hs.406515

Evidence on tissue expression from TISSUES for NQO1 Gene

  • Liver(4.9)
  • Intestine(4.8)
  • Nervous system(4.8)
  • Lung(4.5)
  • Skin(4.5)
  • Kidney(4.1)
  • Eye(3.8)
  • Stomach(3.6)
  • Pancreas(2.8)
  • Gall bladder(2.7)
  • Heart(2.7)
  • Thyroid gland(2.7)
  • Adrenal gland(2.5)
  • Muscle(2.5)
  • Blood(2.5)
  • Spleen(2.3)
genes like me logo Genes that share expression patterns with NQO1: view

Primer products for research

No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for NQO1 Gene

Orthologs for NQO1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for NQO1 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
 Mammalia NQO1 29 30
  • 99.58 (n)
 OneToOne
Cow
(Bos Taurus)
 Mammalia NQO1 29 30
  • 91.24 (n)
 OneToOne
Mouse
(Mus musculus)
 Mammalia Nqo1 29 16 30
  • 85.89 (n)
 OneToOne
Dog
(Canis familiaris)
 Mammalia NQO1 29 30
  • 85.59 (n)
 OneToOne
Rat
(Rattus norvegicus)
 Mammalia Nqo1 29
  • 85.04 (n)
Platypus
(Ornithorhynchus anatinus)
 Mammalia NQO1 30
  • 85 (a)
 OneToOne
Oppossum
(Monodelphis domestica)
 Mammalia NQO1 30
  • 80 (a)
 OneToOne
Chicken
(Gallus gallus)
 Aves NQO1 29 30
  • 61.68 (n)
 OneToOne
Lizard
(Anolis carolinensis)
 Reptilia NQO1 30
  • 65 (a)
 OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
 Amphibia nqo1 29
  • 66.79 (n)
Zebrafish
(Danio rerio)
 Actinopterygii nqo1 29 30
  • 58.27 (n)
 OneToOne
Rainbow Trout
(Oncorhynchus mykiss)
 Actinopterygii Omy.8645 29
Species where no ortholog for NQO1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)

Evolution for NQO1 Gene

ENSEMBL:
Gene Tree for NQO1 (if available)
TreeFam:
Gene Tree for NQO1 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for NQO1: view image
Alliance of Genome Resources:
Additional Orthologs for NQO1

Paralogs for NQO1 Gene

Paralogs for NQO1 Gene

(1) SIMAP similar genes for NQO1 Gene using alignment to 7 proteins:

  • NQO1_HUMAN
  • B4DLR8_HUMAN
  • H3BNV2_HUMAN
  • H3BRK3_HUMAN
  • L8E9G5_HUMAN
  • L8EC59_HUMAN
  • Q3B792_HUMAN
genes like me logo Genes that share paralogs with NQO1: view

Variants for NQO1 Gene

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Polymorphic Variants from UniProtKB/Swiss-Prot for NQO1 Gene

NQO1_HUMAN-P15559
The Ser-187 polymorphism may be linked to susceptibility to forms of cancers.

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for NQO1 Gene

SNP ID Clinical significance and condition Chr 16 pos Variation AA Info Type
988341 Likely Pathogenic: not provided 69,711,266(-) A/T
NM_000903.3(NQO1):c.535T>A (p.Phe179Ile) 		MISSENSE
rs1555537451 Likely Pathogenic: not provided 69,711,254(-) G/A
NM_000903.3(NQO1):c.547C>T (p.Gln183Ter) 		NONSENSE
rs1800566 Drug Response: Lung carcinoma; Benzene toxicity, susceptibility to; Leukemia, post-chemotherapy, susceptibility to; Breast cancer, post-chemotherapy poor survival in; Alkylating Agents, anthracyclines and related substances, fluorouracil, and Platinum compounds response - Efficacy 69,711,242(-) G/Ap.Pro187Ser
NM_000903.3(NQO1):c.559C>T (p.Pro187Ser) 		MISSENSE
rs199904938 Likely Benign: not provided 69,711,216(-) G/A
NM_000903.3(NQO1):c.585C>T (p.His195=) 		SYNONYMOUS
rs34447156 Benign: not provided 69,710,994(-) C/Gp.Gln269His
NM_000903.3(NQO1):c.807G>C (p.Gln269His) 		MISSENSE

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for NQO1 Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for NQO1 Gene

Variant ID Type Subtype PubMed ID
esv3638928 CNV gain 21293372
esv3638929 CNV gain 21293372
esv3892878 CNV gain 25118596
nsv517207 CNV loss 19592680
nsv524364 CNV loss 19592680

Variation tolerance for NQO1 Gene

Residual Variation Intolerance Score: 78.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 11.04; 92.13% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for NQO1 Gene

Human Gene Mutation Database (HGMD)
NQO1
SNPedia medical, phenotypic, and genealogical associations of SNPs for
NQO1
Leiden Open Variation Database (LOVD)
NQO1

SNP Genotyping and Copy Number Assays for research

Disorders for NQO1 Gene

MalaCards: The human disease database

(30) MalaCards diseases for NQO1 Gene - From: COP and GCD

Disorder Aliases PubMed IDs
tardive dyskinesia
  • linguofacial dyskinesia
colon adenocarcinoma
  • adenocarcinoma of colon
childhood leukemia
colorectal cancer
  • crc
aplastic anemia
  • aplastic anemia, susceptibility to
- elite association - COSMIC cancer census association via MalaCards
Search NQO1 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for NQO1

Human Genome Epidemiology Navigator
(HuGE)
Atlas
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
Open Targets Platform
genes like me logo Genes that share disorders with NQO1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for NQO1 Gene

Publications for NQO1 Gene

  1. Genotype polymorphisms of GGCX, NQO1, and VKORC1 genes associated with risk susceptibility in patients with large-artery atherosclerotic stroke. (PMID: 20193673) Shyu HY ā€¦ Cheng CW (Clinica chimica acta; international journal of clinical chemistry 2010) 3 22 40
  2. Dietary glucosinolate intake, polymorphisms in selected biotransformation enzymes, and risk of prostate cancer. (PMID: 20056632) Steinbrecher A ā€¦ Linseisen J (Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology 2010) 3 22 40
  3. Investigation of NQO1 genetic polymorphism, NQO1 gene expression and PAH-DNA adducts in ESCC. A case-control study from Iran. (PMID: 20198579) Marjani HA ā€¦ Malekzadeh R (Genetics and molecular research : GMR 2010) 3 22 40
  4. Increase in markers of airway inflammation after ozone exposure can be observed also in stable treated asthmatics with minimal functional response to ozone. (PMID: 20085630) Vagaggini B ā€¦ Paggiaro P (Respiratory research 2010) 3 22 40
  5. [Role of polymorphic markers of antioxidants (NQO1, GSTP1, GPX1) genes in adaptive response to hazardous work conditions in workers]. (PMID: 20480816) Kochetova OV ā€¦ Viktorova TV (Meditsina truda i promyshlennaia ekologiia 2010) 3 22 40

ExternalLinks

View latest publications for NQO1 gene in Mastermind

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Sources for NQO1 Gene