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Aliases for NQO1 Gene

Aliases for NQO1 Gene

  • NAD(P)H Quinone Dehydrogenase 1 2 3 5
  • Diaphorase (NADH/NADPH) (Cytochrome B-5 Reductase) 2 3
  • NAD(P)H Dehydrogenase, Quinone 1 2 3
  • NAD(P)H:Quinone Oxidoreductase 1 3 4
  • Phylloquinone Reductase 3 4
  • Menadione Reductase 3 4
  • Quinone Reductase 1 3 4
  • DT-Diaphorase 3 4
  • Azoreductase 3 4
  • EC 4 56
  • NMOR1 3 4
  • DIA4 3 4
  • DTD 3 4
  • QR1 3 4
  • NAD(P)H:Quinone Acceptor Oxidoreductase Type 1 3
  • NAD(P)H:Menadione Oxidoreductase 1 3
  • NAD(P)H Dehydrogenase [Quinone] 1 3
  • NAD(P)H:Quinone Oxireductase 3
  • Dioxin-Inducible 1 3
  • Diaphorase-4 3
  • NMORI 3
  • DHQU 3

External Ids for NQO1 Gene

Previous HGNC Symbols for NQO1 Gene

  • NMOR1
  • DIA4

Previous GeneCards Identifiers for NQO1 Gene

  • GC16M060424
  • GC16M070163
  • GC16M069478
  • GC16M069519
  • GC16M068300
  • GC16M069744
  • GC16M055621

Summaries for NQO1 Gene

Entrez Gene Summary for NQO1 Gene

  • This gene is a member of the NAD(P)H dehydrogenase (quinone) family and encodes a cytoplasmic 2-electron reductase. This FAD-binding protein forms homodimers and reduces quinones to hydroquinones. This protein's enzymatic activity prevents the one electron reduction of quinones that results in the production of radical species. Mutations in this gene have been associated with tardive dyskinesia (TD), an increased risk of hematotoxicity after exposure to benzene, and susceptibility to various forms of cancer. Altered expression of this protein has been seen in many tumors and is also associated with Alzheimer's disease (AD). Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008]

CIViC summary for NQO1 Gene

GeneCards Summary for NQO1 Gene

NQO1 (NAD(P)H Quinone Dehydrogenase 1) is a Protein Coding gene. Diseases associated with NQO1 include Tardive Dyskinesia and North American Indian Childhood Cirrhosis. Among its related pathways are Aryl Hydrocarbon Receptor and Dopamine metabolism. Gene Ontology (GO) annotations related to this gene include oxidoreductase activity. An important paralog of this gene is NQO2.

UniProtKB/Swiss-Prot for NQO1 Gene

  • The enzyme apparently serves as a quinone reductase in connection with conjugation reactions of hydroquinons involved in detoxification pathways as well as in biosynthetic processes such as the vitamin K-dependent gamma-carboxylation of glutamate residues in prothrombin synthesis.

Gene Wiki entry for NQO1 Gene

PharmGKB "VIP" Summary for NQO1 Gene

Additional gene information for NQO1 Gene

No data available for Tocris Summary , fRNAdb sequence ontologies and piRNA Summary for NQO1 Gene

Genomics for NQO1 Gene

GeneHancer (GH) Regulatory Elements for NQO1 Gene

Promoters and enhancers for NQO1 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH16I069721 Promoter/Enhancer 2.5 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 555.4 +1.7 1699 7.2 CLOCK MLX DMAP1 SLC30A9 ZNF143 SP3 NFYC SSRP1 GLIS1 RCOR2 NQO1 ENSG00000262136 SNTB2 SF3B3 DDX19A NONOP1 CHTF8 NPIPB14P UTP4 PDPR
GH16I069829 Enhancer 1.6 FANTOM5 Ensembl ENCODE dbSUPER 17.9 -105.1 -105056 5.4 FOXA2 ARID4B ZNF48 SLC30A9 ATF7 FOS NFYC ZHX2 MXD4 MIER2 NQO1 ENSG00000252443 WWP2 NPIPB14P CLEC18A LOC100506083 GC16P069921
GH16I069837 Promoter/Enhancer 1.7 EPDnew Ensembl ENCODE dbSUPER 15.7 -112.6 -112630 3.8 ELF3 FOXA2 MLX ARID4B RAD21 ZNF48 ZSCAN9 RARA SLC30A9 MIXL1 WWP2 NPIPB14P NQO1 ENSG00000252443 CLEC18A GC16P069921
GH16I069753 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 12 -27.5 -27495 2.2 HDGF SMAD1 MLX ARID4B SIN3A DMAP1 ZNF2 IRF4 YY1 SLC30A9 NOB1 NPIPB14P NQO1 ENSG00000252443 WWP2 NONOP1 ENSG00000262136
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around NQO1 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the NQO1 gene promoter:

Genomic Locations for NQO1 Gene

Genomic Locations for NQO1 Gene
19,956 bases
Minus strand

Genomic View for NQO1 Gene

Genes around NQO1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
NQO1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for NQO1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NQO1 Gene

Proteins for NQO1 Gene

  • Protein details for NQO1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    NAD(P)H dehydrogenase [quinone] 1
    Protein Accession:
    Secondary Accessions:
    • B2R5Y9
    • B4DNM7
    • B7ZAD1
    • Q86UK1

    Protein attributes for NQO1 Gene

    274 amino acids
    Molecular mass:
    30868 Da
    Name=FAD; Xref=ChEBI:CHEBI:57692;
    Quaternary structure:
    • Homodimer (PubMed:10543876, PubMed:10706635, PubMed:11735396, PubMed:11587640, PubMed:16700548). Interacts with PDLIM4 isoform 2; this interaction stabilizes PDLIM4 isoform 2 in response to oxidative stress and protects it from ubiquitin-independent degradation by the core 20S proteasome (PubMed:21636573).
    • Quinone reductase accepts electrons from both NADH and NADPH with equal efficiency.

    Three dimensional structures from OCA and Proteopedia for NQO1 Gene

    Alternative splice isoforms for NQO1 Gene


neXtProt entry for NQO1 Gene

Selected DME Specific Peptides for NQO1 Gene


Post-translational modifications for NQO1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Domains & Families for NQO1 Gene

Gene Families for NQO1 Gene

Human Protein Atlas (HPA):
  • Cancer-related genes
  • Enzymes
  • Predicted intracellular proteins

Protein Domains for NQO1 Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the NAD(P)H dehydrogenase (quinone) family.
  • Belongs to the NAD(P)H dehydrogenase (quinone) family.
genes like me logo Genes that share domains with NQO1: view

Function for NQO1 Gene

Molecular function for NQO1 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
NAD(P)H + a quinone = NAD(P)(+) + a hydroquinone.
UniProtKB/Swiss-Prot EnzymeRegulation:
Inhibited by dicoumarol.
UniProtKB/Swiss-Prot Function:
The enzyme apparently serves as a quinone reductase in connection with conjugation reactions of hydroquinons involved in detoxification pathways as well as in biosynthetic processes such as the vitamin K-dependent gamma-carboxylation of glutamate residues in prothrombin synthesis.
UniProtKB/Swiss-Prot Induction:
By dioxin (PubMed:1657151). By oxidative stress (PubMed:21636573).

Enzyme Numbers (IUBMB) for NQO1 Gene

Gene Ontology (GO) - Molecular Function for NQO1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003723 RNA binding HDA 22658674
GO:0003955 NAD(P)H dehydrogenase (quinone) activity IEA,TAS --
GO:0004128 cytochrome-b5 reductase activity, acting on NAD(P)H TAS 9579781
GO:0004784 superoxide dismutase activity IEA --
GO:0005515 protein binding IPI 18388957
genes like me logo Genes that share ontologies with NQO1: view
genes like me logo Genes that share phenotypes with NQO1: view

Animal Models for NQO1 Gene

MGI Knock Outs for NQO1:

Animal Model Products

  • Taconic Biosciences Mouse Models for NQO1

Clone Products

  • Addgene plasmids for NQO1

No data available for Phenotypes From GWAS Catalog , Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for NQO1 Gene

Localization for NQO1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for NQO1 Gene


Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for NQO1 gene
Compartment Confidence
extracellular 5
cytosol 5
mitochondrion 3
nucleus 3
plasma membrane 1
cytoskeleton 1
endoplasmic reticulum 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for NQO1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm TAS 2843525
GO:0005829 cytosol TAS,IDA --
GO:0030425 dendrite IEA --
GO:0043025 neuronal cell body IEA --
GO:0070062 extracellular exosome IDA,HDA 23376485
genes like me logo Genes that share ontologies with NQO1: view

Pathways & Interactions for NQO1 Gene

genes like me logo Genes that share pathways with NQO1: view

Gene Ontology (GO) - Biological Process for NQO1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006521 regulation of cellular amino acid metabolic process TAS --
GO:0006801 superoxide metabolic process IEA --
GO:0006805 xenobiotic metabolic process TAS 10393963
GO:0006809 nitric oxide biosynthetic process TAS 9579781
GO:0006979 response to oxidative stress IEA --
genes like me logo Genes that share ontologies with NQO1: view

No data available for SIGNOR curated interactions for NQO1 Gene

Drugs & Compounds for NQO1 Gene

(89) Drugs for NQO1 Gene - From: DrugBank, PharmGKB, ApexBio, DGIdb, FDA Approved Drugs, HMDB, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Dicumarol Approved Pharma Target, inhibitor 0
Menadione Approved Nutra Target, inhibitor 257
FAD Approved Pharma Target 0
Vitamin E Approved, Vet_approved Nutra Enzyme, inducer 434,438
Cisplatin Approved Pharma Enzyme, substrate Inhibits DNA synthesis,chemotherapy drug, Potent pro-apoptotic anticancer agent; activates caspase-3, Platinum 2906

(67) Additional Compounds for NQO1 Gene - From: HMDB and Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
  • 2'-(Dihydrogen phosphate) 5'-(trihydrogen pyrophosphate) Adenosine 5'-ester with 1,4-dihydro-1-b-D-ribofuranosylnicotinamide
  • 2'-(Dihydrogen phosphate) 5'-(trihydrogen pyrophosphate) Adenosine 5'-ester with 1,4-dihydro-1-beta-delta-ribofuranosylnicotinamide
  • Adenosine 5'-(trihydrogen diphosphate) 2'-(dihydrogen phosphate) P'-5'-ester with 1,4-dihydro-1-beta-D-ribofuranosyl-3-pyridinecarboxamide
  • Adenosine 5'-(trihydrogen diphosphate) 2'-(dihydrogen phosphate) P'-5'-ester with 1,4-dihydro-1-beta-delta-ribofuranosyl-3-pyridinecarboxamide
  • b-NADPH
  • 1,4-Benzoquine
  • 1,4-Benzoquinone
  • 1,4-Cyclohexadiene dioxide
  • 1,4-Cyclohexadienedione
  • 1,4-Diossibenzene
vitamin k1
  • 2',3'-trans-Vitamin K1
  • 2-Methyl-3-phythyl-1,4-naphthochinon
  • 2-Methyl-3-phytyl-1,4-naphthochinon
  • 2-Methyl-3-phytyl-1,4-naphthoquinone
  • 2-Methyl-3-phytyl-1,4-napthoquinone
Hydrogen Ion
  • Hydrogen cation
  • Hydron
  • Proton

(4) ApexBio Compounds for NQO1 Gene

Compound Action Cas Number
Dicoumarol 66-76-2
DMXAA (Vadimezan) Tumnor vascular disrupting agent, apoptosis inducer 117570-53-3
ES 936 192820-78-3
Oltipraz An antischistosomal agent 64224-21-1
genes like me logo Genes that share compounds with NQO1: view

Drug Products

Transcripts for NQO1 Gene

Unigene Clusters for NQO1 Gene

NAD(P)H dehydrogenase, quinone 1:
Representative Sequences:

Clone Products

  • Addgene plasmids for NQO1

Alternative Splicing Database (ASD) splice patterns (SP) for NQO1 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2a · 2b ^ 3a · 3b ^ 4a · 4b · 4c ^ 5a · 5b ^ 6a · 6b · 6c · 6d · 6e ^ 7
SP2: - - - -
SP3: - -
SP4: - - -
SP5: -
SP6: - -
SP8: - - - - -
SP9: - - - - -

Relevant External Links for NQO1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for NQO1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for NQO1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for NQO1 Gene

This gene is overexpressed in Stomach (x5.2).

Protein differential expression in normal tissues from HIPED for NQO1 Gene

This gene is overexpressed in Nasopharynx (13.6), Skin (8.6), and Nasal epithelium (7.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for NQO1 Gene

Protein tissue co-expression partners for NQO1 Gene

NURSA nuclear receptor signaling pathways regulating expression of NQO1 Gene:


SOURCE GeneReport for Unigene cluster for NQO1 Gene:


Evidence on tissue expression from TISSUES for NQO1 Gene

  • Liver(4.9)
  • Intestine(4.8)
  • Nervous system(4.8)
  • Lung(4.5)
  • Skin(4.4)
  • Kidney(3.9)
  • Eye(3.5)
  • Stomach(3.4)
  • Pancreas(2.3)
  • Heart(2.2)
  • Adrenal gland(2.1)
  • Gall bladder(2.1)
  • Blood(2)
  • Muscle(2)
genes like me logo Genes that share expression patterns with NQO1: view

No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for NQO1 Gene

Orthologs for NQO1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for NQO1 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia NQO1 33 34
  • 99.58 (n)
(Bos Taurus)
Mammalia NQO1 33 34
  • 91.24 (n)
(Mus musculus)
Mammalia Nqo1 33 16 34
  • 85.89 (n)
(Canis familiaris)
Mammalia NQO1 33 34
  • 85.59 (n)
(Rattus norvegicus)
Mammalia Nqo1 33
  • 85.04 (n)
(Ornithorhynchus anatinus)
Mammalia NQO1 34
  • 85 (a)
(Monodelphis domestica)
Mammalia NQO1 34
  • 80 (a)
(Gallus gallus)
Aves NQO1 33 34
  • 61.68 (n)
(Anolis carolinensis)
Reptilia NQO1 34
  • 65 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia nqo1 33
  • 66.79 (n)
(Danio rerio)
Actinopterygii nqo1 33 34
  • 58.27 (n)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.8645 33
Species where no ortholog for NQO1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for NQO1 Gene

Gene Tree for NQO1 (if available)
Gene Tree for NQO1 (if available)

Paralogs for NQO1 Gene

Paralogs for NQO1 Gene

(1) SIMAP similar genes for NQO1 Gene using alignment to 7 proteins:

genes like me logo Genes that share paralogs with NQO1: view

Variants for NQO1 Gene

Polymorphic Variants from UniProtKB/Swiss-Prot for NQO1 Gene

The Ser-187 polymorphism may be linked to susceptibility to forms of cancers.

Sequence variations from dbSNP and Humsavar for NQO1 Gene

SNP ID Clin Chr 16 pos Variation AA Info Type
rs1800566 risk-factor, pathogenic, drug-response, not-provided, Benzene toxicity, susceptibility to, Leukemia, post-chemotherapy, susceptibility to, Breast cancer, post-chemotherapy poor survival in, Alkylating Agents, anthracyclines and related substances, fluorouracil, and Platinum compounds response - Efficacy, Lung cancer 69,711,242(-) G/A coding_sequence_variant, missense_variant
rs1000175037 -- 69,719,302(-) T/C intron_variant
rs1000340955 -- 69,717,719(-) TCTC/TC intron_variant
rs1000387241 -- 69,714,121(-) C/T intron_variant
rs1000779197 -- 69,711,450(-) C/T intron_variant

Structural Variations from Database of Genomic Variants (DGV) for NQO1 Gene

Variant ID Type Subtype PubMed ID
esv3638928 CNV gain 21293372
esv3638929 CNV gain 21293372
esv3892878 CNV gain 25118596
nsv517207 CNV loss 19592680
nsv524364 CNV loss 19592680

Variation tolerance for NQO1 Gene

Residual Variation Intolerance Score: 78.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 11.04; 92.13% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for NQO1 Gene

Human Gene Mutation Database (HGMD)
SNPedia medical, phenotypic, and genealogical associations of SNPs for

SNP Genotyping and Copy Number Assay Products

Disorders for NQO1 Gene

MalaCards: The human disease database

(19) MalaCards diseases for NQO1 Gene - From: HGMD, ClinVar, DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
tardive dyskinesia
  • td
north american indian childhood cirrhosis
  • naic
lung cancer
  • lung cancer, susceptibility to
papillary thyroid microcarcinoma
anal canal carcinoma
  • anal canal and perianal gland carcinoma
- elite association - COSMIC cancer census association via MalaCards
Search NQO1 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for NQO1

Genetic Association Database
Human Genome Epidemiology Navigator
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with NQO1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for NQO1 Gene

Publications for NQO1 Gene

  1. Investigation of NQO1 genetic polymorphism, NQO1 gene expression and PAH-DNA adducts in ESCC. A case-control study from Iran. (PMID: 20198579) Marjani HA … Malekzadeh R (Genetics and molecular research : GMR 2010) 3 22 44 58
  2. Genotype polymorphisms of GGCX, NQO1, and VKORC1 genes associated with risk susceptibility in patients with large-artery atherosclerotic stroke. (PMID: 20193673) Shyu HY … Cheng CW (Clinica chimica acta; international journal of clinical chemistry 2010) 3 22 44 58
  3. Oxidative stress in tardive dyskinesia: genetic association study and meta-analysis of NADPH quinine oxidoreductase 1 (NQO1) and Superoxide dismutase 2 (SOD2, MnSOD) genes. (PMID: 19778569) Zai CC … Kennedy JL (Progress in neuro-psychopharmacology & biological psychiatry 2010) 3 22 44 58
  4. Role of the CYP2D6, EPHX1, MPO, and NQO1 genes in the susceptibility to acute lymphoblastic leukemia in Brazilian children. (PMID: 19593802) Silveira Vda S … Tone LG (Environmental and molecular mutagenesis 2010) 3 22 44 58
  5. Associations of common variants in genes involved in metabolism and response to exogenous chemicals with risk of multiple myeloma. (PMID: 19736056) Gold LS … Baris D (Cancer epidemiology 2009) 3 22 44 58

Products for NQO1 Gene

  • Addgene plasmids for NQO1

Sources for NQO1 Gene

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