Aliases for NPY6R Gene

Aliases for NPY6R Gene

  • Neuropeptide Y Receptor Y6 (Pseudogene) 2 3 5
  • NPY1RL 3 4
  • PP2 3 4
  • Y2B 3 4
  • Putative Pancreatic Polypeptide Receptor 2 4
  • Putative Neuropeptide Y Receptor Type 6 4
  • NPY Y1-Like Receptor 4
  • NPY6RP 3
  • NPY6-R 4

External Ids for NPY6R Gene

Previous GeneCards Identifiers for NPY6R Gene

  • GC05P137018
  • GC05P137174
  • GC05P137213
  • GC05P137220
  • GC05P137171
  • GC05P132328

Summaries for NPY6R Gene

GeneCards Summary for NPY6R Gene

NPY6R (Neuropeptide Y Receptor Y6 (Pseudogene)) is a Pseudogene. Among its related pathways are Peptide ligand-binding receptors. Gene Ontology (GO) annotations related to this gene include neuropeptide Y receptor activity.

UniProtKB/Swiss-Prot Summary for NPY6R Gene

  • When expressed, is unable to bind pancreatic polypeptide (PP), neuropeptide Y (NPY), or peptide YY (PYY), suggesting that either it is functionally inactive or that it may have acquired a pancreatic polypeptide-independent function.

Gene Wiki entry for NPY6R Gene

Additional gene information for NPY6R Gene

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for NPY6R Gene

Genomics for NPY6R Gene

GeneHancer (GH) Regulatory Elements for NPY6R Gene

Promoters and enhancers for NPY6R Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH05J137953 Enhancer 0.8 Ensembl ENCODE 4.4 +153.3 153302 1.8 JUND FOS REST MXI1 FOSL2 PBX2 JUN ELF1 POLR2A SIN3A lnc-NME5-3 RNU6-1148P NPY6R RF00017-4915 RF00017-4914 FAM13B RF00017-4912
GH05J138519 Enhancer 0.6 Ensembl 4.6 +720.4 720408 5.2 TOE1 ZBTB17 CEBPG EZH2 ZNF18 MITF ATF4 CEBPB ZBTB33 USF2 RF00017-4926 SNORD63 SNORD63B HSPA9 BRD8 KIF20A REEP2 NPY6R ETF1 lnc-HSPA9-1
GH05J137796 Enhancer 0.5 Ensembl 0.7 -5.0 -4992 0.4 TCF7L2 SRF ZNF843 BCL11B PRDM6 FEZF1 ZBTB12 RNU6-1148P NPY6R piR-60885-119
GH05J137802 Enhancer 0.4 dbSUPER 0.7 +2.1 2066 2.3 HNF4A YY1 SP1 MYOT RNU6-1148P NPY6R piR-42799-016
GH05J137792 Enhancer 0.3 Ensembl 0.4 -9.1 -9092 0.2 FOXA1 MYOT RNU6-1148P RNU6-888P NME5 NPY6R piR-60885-119
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around NPY6R on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the NPY6R gene promoter:
  • AP-1
  • ATF-2
  • c-Jun
  • p53
  • Sp1
  • STAT3
  • STAT5A

Genomic Locations for NPY6R Gene

Genomic Locations for NPY6R Gene
chr5:137,801,193-137,810,751
(GRCh38/hg38)
Size:
9,559 bases
Orientation:
Plus strand
chr5:137,136,882-137,146,440
(GRCh37/hg19)
Size:
9,559 bases
Orientation:
Plus strand

Genomic View for NPY6R Gene

Genes around NPY6R on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
NPY6R Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for NPY6R Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NPY6R Gene

Proteins for NPY6R Gene

  • Protein details for NPY6R Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q99463-NPY6R_HUMAN
    Recommended name:
    Putative neuropeptide Y receptor type 6
    Protein Accession:
    Q99463
    Secondary Accessions:
    • D3DQB4

    Protein attributes for NPY6R Gene

    Size:
    290 amino acids
    Molecular mass:
    33180 Da
    Quaternary structure:
    No Data Available

neXtProt entry for NPY6R Gene

Post-translational modifications for NPY6R Gene

  • Glycosylation at Asn11
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for NPY6R Gene

Domains & Families for NPY6R Gene

Gene Families for NPY6R Gene

Protein Domains for NPY6R Gene

Suggested Antigen Peptide Sequences for NPY6R Gene

GenScript: Design optimal peptide antigens:
  • Putative pancreatic polypeptide receptor 2 (NPY6R_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q99463

UniProtKB/Swiss-Prot:

NPY6R_HUMAN :
  • Belongs to the G-protein coupled receptor 1 family.
Family:
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with NPY6R: view

Function for NPY6R Gene

Molecular function for NPY6R Gene

UniProtKB/Swiss-Prot Function:
When expressed, is unable to bind pancreatic polypeptide (PP), neuropeptide Y (NPY), or peptide YY (PYY), suggesting that either it is functionally inactive or that it may have acquired a pancreatic polypeptide-independent function.
GENATLAS Biochemistry:
neuropeptide Y receptor Y6,expressed in pancreas,G protein coupled receptor superfamily

Phenotypes From GWAS Catalog for NPY6R Gene

Gene Ontology (GO) - Molecular Function for NPY6R Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001602 pancreatic polypeptide receptor activity IBA 21873635
GO:0004983 NOT neuropeptide Y receptor activity IKR 8910290
genes like me logo Genes that share ontologies with NPY6R: view

Animal Model Products

  • Taconic Biosciences Mouse Models for NPY6R

CRISPR Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for NPY6R Gene

Localization for NPY6R Gene

Subcellular locations from UniProtKB/Swiss-Prot for NPY6R Gene

Membrane; Multi-pass membrane protein.

Gene Ontology (GO) - Cellular Components for NPY6R Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with NPY6R: view

No data available for Subcellular locations from COMPARTMENTS and Subcellular locations from the Human Protein Atlas (HPA) for NPY6R Gene

Pathways & Interactions for NPY6R Gene

PathCards logo

SuperPathways for NPY6R Gene

genes like me logo Genes that share pathways with NPY6R: view

Pathways by source for NPY6R Gene

2 BioSystems pathways for NPY6R Gene
;

Gene Ontology (GO) - Biological Process for NPY6R Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007186 NOT G protein-coupled receptor signaling pathway IKR 8910290
GO:0007218 neuropeptide signaling pathway IEA --
genes like me logo Genes that share ontologies with NPY6R: view

No data available for Interacting Proteins and SIGNOR curated interactions for NPY6R Gene

Drugs & Compounds for NPY6R Gene

No Compound Related Data Available

Transcripts for NPY6R Gene

mRNA/cDNA for NPY6R Gene

6 NCBI additional mRNA sequence :
2 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Alternative Splicing Database (ASD) splice patterns (SP) for NPY6R Gene

No ASD Table

Relevant External Links for NPY6R Gene

GeneLoc Exon Structure for
NPY6R

Expression for NPY6R Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for NPY6R Gene

mRNA differential expression in normal tissues according to GTEx for NPY6R Gene

This gene is overexpressed in Heart - Left Ventricle (x29.4) and Heart - Atrial Appendage (x13.6).

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for NPY6R

SOURCE GeneReport for Unigene cluster for NPY6R Gene:

Hs.643466

mRNA Expression by UniProt/SwissProt for NPY6R Gene:

Q99463-NPY6R_HUMAN
Tissue specificity: Expressed in heart, skeletal muscle, gastrointestinal tissues, spleen, brain and adrenal glands.
genes like me logo Genes that share expression patterns with NPY6R: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for NPY6R Gene

Orthologs for NPY6R Gene

Evolution for NPY6R Gene

ENSEMBL:
Gene Tree for NPY6R (if available)
TreeFam:
Gene Tree for NPY6R (if available)

No data available for Orthologs for NPY6R Gene

Paralogs for NPY6R Gene

(11) SIMAP similar genes for NPY6R Gene using alignment to 1 proteins:

  • NPY6R_HUMAN
genes like me logo Genes that share paralogs with NPY6R: view

No data available for Paralogs for NPY6R Gene

Variants for NPY6R Gene

Structural Variations from Database of Genomic Variants (DGV) for NPY6R Gene

Variant ID Type Subtype PubMed ID
esv2671421 CNV deletion 23128226
esv3570428 CNV loss 25503493
esv3606910 CNV loss 21293372
nsv830500 CNV loss 17160897
nsv830501 CNV gain 17160897

Additional Variant Information for NPY6R Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
NPY6R

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP , Additional dbSNP identifiers (rs#s) and Variation tolerance for NPY6R Gene

Disorders for NPY6R Gene

Additional Disease Information for NPY6R

No disorders were found for NPY6R Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for NPY6R Gene

Publications for NPY6R Gene

  1. Inactivation of a novel neuropeptide Y/peptide YY receptor gene in primate species. (PMID: 8910290) Matsumoto M … Yamaguchi T (The Journal of biological chemistry 1996) 2 3 4 54
  2. Molecular characterization of a second mouse pancreatic polypeptide receptor and its inactivated human homologue. (PMID: 8910373) Gregor P … McCaleb ML (The Journal of biological chemistry 1996) 2 3 4 54
  3. Neuropeptide Y receptor gene y6: multiple deaths or resurrections? (PMID: 11027673) Starbäck P … Larhammar D (Biochemical and biophysical research communications 2000) 3 23 54
  4. Molecular genetic analysis of a human neuropeptide Y receptor. The human homolog of the murine "Y5" receptor may be a pseudogene. (PMID: 9013614) Rose PM … Fernandes P (The Journal of biological chemistry 1997) 3 4 54
  5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. (PMID: 21873635) Gaudet P … Thomas PD (Briefings in bioinformatics 2011) 3 54

Products for NPY6R Gene

Sources for NPY6R Gene