The protein encoded by this gene is a receptor for neuropeptide Y and peptide YY. The encoded protein appears to be involved in regulating food intake, with defects in this gene being associated with eating disorders. Also, the encoded protein is involved in a pathway that protects neuroblastoma cells from chemotherapy-induced cell death, providing a possible therapeutic target... See more...

Aliases for NPY5R Gene

Aliases for NPY5R Gene

  • Neuropeptide Y Receptor Y5 2 3 5
  • Neuropeptide Y Receptor Type 5 3 4
  • NPY-Y5 Receptor 3 4
  • Y5 Receptor 3 4
  • NPYY5-R 3 4
  • NPY5-R 3 4
  • NPYR5 3 4

External Ids for NPY5R Gene

Previous GeneCards Identifiers for NPY5R Gene

  • GC04P165118
  • GC04P164696
  • GC04P164842
  • GC04P164622
  • GC04P164484
  • GC04P164265
  • GC04P160019

Summaries for NPY5R Gene

Entrez Gene Summary for NPY5R Gene

  • The protein encoded by this gene is a receptor for neuropeptide Y and peptide YY. The encoded protein appears to be involved in regulating food intake, with defects in this gene being associated with eating disorders. Also, the encoded protein is involved in a pathway that protects neuroblastoma cells from chemotherapy-induced cell death, providing a possible therapeutic target against neuroblastoma. Three transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Nov 2015]

GeneCards Summary for NPY5R Gene

NPY5R (Neuropeptide Y Receptor Y5) is a Protein Coding gene. Diseases associated with NPY5R include Neuroblastoma and Body Mass Index Quantitative Trait Locus 11. Among its related pathways are Signaling by GPCR and Peptide ligand-binding receptors. Gene Ontology (GO) annotations related to this gene include G protein-coupled receptor activity and peptide YY receptor activity. An important paralog of this gene is NPY1R.

UniProtKB/Swiss-Prot Summary for NPY5R Gene

  • Receptor for neuropeptide Y and peptide YY. The activity of this receptor is mediated by G proteins that inhibit adenylate cyclase activity. Seems to be associated with food intake. Could be involved in feeding disorders.

Tocris Summary for NPY5R Gene

  • Neuropeptide Y (NPY) receptors are a family of Gi/o-protein-coupled receptors that are currently divided into four subtypes: Y1, Y2, Y4 and Y5. NPY receptors mediate a diverse range of biological actions including stimulation of food intake and modulation of circadian rhythm.

Gene Wiki entry for NPY5R Gene

Additional gene information for NPY5R Gene

No data available for CIViC Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for NPY5R Gene

Genomics for NPY5R Gene

GeneHancer (GH) Regulatory Elements for NPY5R Gene

Promoters and enhancers for NPY5R Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH04J163343 Promoter 1.1 EPDnew Ensembl 500.7 +0.3 333 2 USF1 EZH2 NFIC PHF8 NFIB SIN3A RNF2 L3MBTL2 SUZ12 E2F1 NPY1R NPY5R
GH04J163385 Enhancer 0.6 Ensembl 11.6 +41.7 41733 0.8 ZNF217 RFX1 CTBP1 ESRRA MBD2 ESR1 NEUROD1 ELF1 GATA3 DPF2 NPY1R NPY5R RPL35AP12 lnc-NPY5R-5 piR-31846-020
GH04J163448 Enhancer 0.6 Ensembl 10.4 +105.0 105032 0.2 GATAD2B ESRRA MBD2 FOS ESR1 JUND ZNF217 GATA3 JUN SMARCE1 piR-57461-175 TKTL2 NPY1R NPY5R piR-31846-020
GH04J163267 Enhancer 0.4 Ensembl 10.3 -75.6 -75567 1 NFIC NANOG ATF1 ENSG00000250547 LOC133332 lnc-NPY1R-2 NPY1R NPY5R lnc-NPY1R-1
GH04J163380 Enhancer 0.3 Ensembl 11.2 +37.0 37033 0.2 SPI1 RPL35AP12 lnc-NPY5R-5 NPY1R NPY5R piR-39701-046
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around NPY5R on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for NPY5R

Top Transcription factor binding sites by QIAGEN in the NPY5R gene promoter:
  • Evi-1
  • GR
  • GR-alpha
  • HNF-1
  • HNF-1A
  • ISGF-3
  • SREBP-1a
  • SREBP-1b
  • SREBP-1c
  • XBP-1

Genomic Locations for NPY5R Gene

Genomic Locations for NPY5R Gene
chr4:163,343,868-163,352,403
(GRCh38/hg38)
Size:
8,536 bases
Orientation:
Plus strand
chr4:164,265,091-164,273,086
(GRCh37/hg19)
Size:
7,996 bases
Orientation:
Plus strand

Genomic View for NPY5R Gene

Genes around NPY5R on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
NPY5R Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for NPY5R Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NPY5R Gene

Proteins for NPY5R Gene

  • Protein details for NPY5R Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q15761-NPY5R_HUMAN
    Recommended name:
    Neuropeptide Y receptor type 5
    Protein Accession:
    Q15761
    Secondary Accessions:
    • Q6GTR7
    • Q92916

    Protein attributes for NPY5R Gene

    Size:
    445 amino acids
    Molecular mass:
    50727 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAC50623.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for NPY5R Gene

neXtProt entry for NPY5R Gene

Post-translational modifications for NPY5R Gene

  • Glycosylation at Asn10 and Asn17
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for NPY5R Gene

Domains & Families for NPY5R Gene

Gene Families for NPY5R Gene

HGNC:
IUPHAR :
Human Protein Atlas (HPA):
  • G-protein coupled receptors
  • Predicted membrane proteins

Protein Domains for NPY5R Gene

Blocks:
  • Neuropeptide Y receptor signature
  • Neuropeptide Y5 receptor signature
InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for NPY5R Gene

GenScript: Design optimal peptide antigens:
  • NPY-Y5 receptor (NPY5R_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q15761

UniProtKB/Swiss-Prot:

NPY5R_HUMAN :
  • Belongs to the G-protein coupled receptor 1 family.
Family:
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with NPY5R: view

Function for NPY5R Gene

Molecular function for NPY5R Gene

UniProtKB/Swiss-Prot Function:
Receptor for neuropeptide Y and peptide YY. The activity of this receptor is mediated by G proteins that inhibit adenylate cyclase activity. Seems to be associated with food intake. Could be involved in feeding disorders.
GENATLAS Biochemistry:
neuropeptide Y receptor Y5,overlapping NPY1R,in opposite orientation,G protein coupled receptor superfamily

Gene Ontology (GO) - Molecular Function for NPY5R Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001601 peptide YY receptor activity IBA 21873635
GO:0001602 pancreatic polypeptide receptor activity IBA 21873635
GO:0004930 G protein-coupled receptor activity IEA --
GO:0004983 neuropeptide Y receptor activity TAS 8824284
genes like me logo Genes that share ontologies with NPY5R: view
genes like me logo Genes that share phenotypes with NPY5R: view

Animal Models for NPY5R Gene

MGI Knock Outs for NPY5R:

Animal Model Products

CRISPR Products

Clone Products

  • Addgene plasmids for NPY5R

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for NPY5R Gene

Localization for NPY5R Gene

Subcellular locations from UniProtKB/Swiss-Prot for NPY5R Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for NPY5R gene
Compartment Confidence
plasma membrane 5
extracellular 2
nucleus 2
cytoskeleton 1
mitochondrion 1
endoplasmic reticulum 1
cytosol 1
lysosome 1
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for NPY5R Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
GO:0005886 plasma membrane TAS --
GO:0005887 integral component of plasma membrane TAS 8824284
GO:0016020 membrane IBA 21873635
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with NPY5R: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for NPY5R Gene

Pathways & Interactions for NPY5R Gene

genes like me logo Genes that share pathways with NPY5R: view

SIGNOR curated interactions for NPY5R Gene

Is activated by:

Gene Ontology (GO) - Biological Process for NPY5R Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002675 positive regulation of acute inflammatory response IEA --
GO:0002865 negative regulation of acute inflammatory response to antigenic stimulus IEA --
GO:0003151 outflow tract morphogenesis IMP 19593212
GO:0003214 cardiac left ventricle morphogenesis IMP 19593212
GO:0007165 signal transduction IEA --
genes like me logo Genes that share ontologies with NPY5R: view

Drugs & Compounds for NPY5R Gene

(49) Drugs for NPY5R Gene - From: DrugBank, ApexBio, DGIdb, IUPHAR, Tocris, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
neuropeptide Y Approved, Investigational Pharma Full agonist, Agonist, Antagonist 0
Pancreatic Polypeptide Investigational Pharma Full agonist, Agonist 23
Peptide YY (3-36) Investigational Pharma Target 0
Velneperit Investigational Pharma antagonist 0
L-152,804 Pharma Antagonist 0

(4) Additional Compounds for NPY5R Gene - From: Novoseek and Tocris

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
Neuropeptide Y (human, rat)
90880-35-6

(5) Tocris Compounds for NPY5R Gene

Compound Action Cas Number
[Leu31,Pro34]-Neuropeptide Y (porcine) NPY Y1 receptor agonist 125580-28-1
BIBP 3226 trifluoroacetate Mixed NPY Y1 and NPFF receptor antagonist
GR 231118 Potent NPY Y1 antagonist/NPY Y4 agonist. Binds to NPFF receptors 158859-98-4
Neuropeptide Y (human, rat) Influences feeding and sexual behavior 90880-35-6
Pancreatic Polypeptide (human) NPY Y4 agonist; involved in gastrointestinal tract function 75976-10-2

(17) ApexBio Compounds for NPY5R Gene

Compound Action Cas Number
[cPP1-7,NPY19-23,Ala31,Aib32,Gln34] - hPancreatic Polypeptide 313988-89-5
[D-Trp34]-Neuropeptide Y 153549-84-9
[Leu31,Pro34]-Neuropeptide Y (human, rat) 132699-73-1
BWX 46 NPY Y5 receptor agonist,potent and highly selective 172997-92-1
CGP 71683 hydrochloride 192322-50-2
CYM 9484 1383478-94-1
GR 231118 158859-98-4
JNJ 5207787 683746-68-1
L-152,804 6508-43-6
LU AA33810 304008-29-5
Neuropeptide Y (scrambled) control in the research in NPY
NPY 5RA972 439861-56-0
NTNCB hydrochloride 191931-56-3
Pancreatic Polypeptide (human) 75976-10-2
PD 160170 181468-88-2
S 25585 263849-50-9
SF 11 443292-81-7
genes like me logo Genes that share compounds with NPY5R: view

Drug Products

Transcripts for NPY5R Gene

mRNA/cDNA for NPY5R Gene

3 REFSEQ mRNAs :
7 NCBI additional mRNA sequence :
3 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Clone Products

  • Addgene plasmids for NPY5R

Alternative Splicing Database (ASD) splice patterns (SP) for NPY5R Gene

No ASD Table

Relevant External Links for NPY5R Gene

GeneLoc Exon Structure for
NPY5R

Expression for NPY5R Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for NPY5R Gene

mRNA differential expression in normal tissues according to GTEx for NPY5R Gene

This gene is overexpressed in Brain - Nucleus accumbens (basal ganglia) (x4.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for NPY5R Gene



Transcriptomic regulation report from SPP (The Signaling Pathways Project) for NPY5R

SOURCE GeneReport for Unigene cluster for NPY5R Gene:

Hs.519058

mRNA Expression by UniProt/SwissProt for NPY5R Gene:

Q15761-NPY5R_HUMAN
Tissue specificity: Brain; hypothalamus.

Evidence on tissue expression from TISSUES for NPY5R Gene

  • Nervous system(4.4)
genes like me logo Genes that share expression patterns with NPY5R: view

No data available for Protein differential expression in normal tissues , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for NPY5R Gene

Orthologs for NPY5R Gene

This gene was present in the common ancestor of animals.

Orthologs for NPY5R Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia NPY5R 31 30
  • 99.93 (n)
OneToOne
dog
(Canis familiaris)
Mammalia NPY5R 31 30
  • 91.76 (n)
OneToOne
cow
(Bos Taurus)
Mammalia NPY5R 31 30
  • 86.67 (n)
OneToOne
mouse
(Mus musculus)
Mammalia Npy5r 17 31 30
  • 84.98 (n)
rat
(Rattus norvegicus)
Mammalia Npy5r 30
  • 84.23 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia NPY5R 31
  • 83 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia NPY5R 31
  • 63 (a)
OneToOne
chicken
(Gallus gallus)
Aves NPY5R 31 30
  • 71.5 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia NPY5R 31
  • 73 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia npy5r 30
  • 69.21 (n)
zebrafish
(Danio rerio)
Actinopterygii npy8br 31
  • 27 (a)
ManyToMany
fruit fly
(Drosophila melanogaster)
Insecta NPFR1 31 30
  • 43.25 (n)
OneToMany
African malaria mosquito
(Anopheles gambiae)
Insecta GPRNPY2 30
  • 43.05 (n)
worm
(Caenorhabditis elegans)
Secernentea npr-12 31
  • 23 (a)
ManyToMany
npr-11 31
  • 22 (a)
ManyToMany
Species where no ortholog for NPY5R was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for NPY5R Gene

ENSEMBL:
Gene Tree for NPY5R (if available)
TreeFam:
Gene Tree for NPY5R (if available)
Aminode:
Evolutionary constrained regions (ECRs) for NPY5R: view image

Paralogs for NPY5R Gene

Variants for NPY5R Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for NPY5R Gene

SNP ID Clinical significance and condition Chr 04 pos Variation AA Info Type
731216 Likely Benign: not provided 163,351,189(+) G/A MISSENSE_VARIANT
745812 Likely Benign: not provided 163,350,438(+) C/T SYNONYMOUS_VARIANT
746358 Likely Benign: not provided 163,350,687(+) C/T SYNONYMOUS_VARIANT

Additional dbSNP identifiers (rs#s) for NPY5R Gene

Structural Variations from Database of Genomic Variants (DGV) for NPY5R Gene

Variant ID Type Subtype PubMed ID
esv1000463 CNV loss 20482838
nsv1015505 CNV gain 25217958
nsv1030184 CNV loss 25217958
nsv596023 CNV loss 21841781

Variation tolerance for NPY5R Gene

Residual Variation Intolerance Score: 13% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.39; 8.65% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for NPY5R Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
NPY5R

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NPY5R Gene

Disorders for NPY5R Gene

MalaCards: The human disease database

(2) MalaCards diseases for NPY5R Gene - From: DISEASES, Novoseek, and GeneCards

- elite association - COSMIC cancer census association via MalaCards
Search NPY5R in MalaCards View complete list of genes associated with diseases

Additional Disease Information for NPY5R

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with NPY5R: view

No data available for UniProtKB/Swiss-Prot and Genatlas for NPY5R Gene

Publications for NPY5R Gene

  1. Association of neuropeptide Y receptor Y5 polymorphisms with dyslipidemia in Mexican Americans. (PMID: 17426313) Coletta DK … Jenkinson CP (Obesity (Silver Spring, Md.) 2007) 3 23 41 54
  2. Overlapping gene structure of the human neuropeptide Y receptor subtypes Y1 and Y5 suggests coordinate transcriptional regulation. (PMID: 9169127) Herzog H … Shine J (Genomics 1997) 3 4 23 54
  3. Identification of a novel hypothalamic neuropeptide Y receptor associated with feeding behavior. (PMID: 8824284) Hu Y … McCaleb ML (The Journal of biological chemistry 1996) 3 4 23 54
  4. A receptor subtype involved in neuropeptide-Y-induced food intake. (PMID: 8700207) Gerald C … Weinshank RL (Nature 1996) 2 3 4 54
  5. Physiogenomic analysis of statin-treated patients: domain-specific counter effects within the ACACB gene on low-density lipoprotein cholesterol? (PMID: 20602615) Ruaño G … Wu AH (Pharmacogenomics 2010) 3 41 54

Products for NPY5R Gene

  • Addgene plasmids for NPY5R

Sources for NPY5R Gene