Aliases for NPY5R Gene
External Ids for NPY5R Gene
Previous GeneCards Identifiers for NPY5R Gene
The protein encoded by this gene is a receptor for neuropeptide Y and peptide YY. The encoded protein appears to be involved in regulating food intake, with defects in this gene being associated with eating disorders. Also, the encoded protein is involved in a pathway that protects neuroblastoma cells from chemotherapy-induced cell death, providing a possible therapeutic target against neuroblastoma. Three transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Nov 2015]
GeneCards Summary for NPY5R Gene
NPY5R (Neuropeptide Y Receptor Y5) is a Protein Coding gene. Diseases associated with NPY5R include Neuroblastoma and Body Mass Index Quantitative Trait Locus 11. Among its related pathways are Signaling by GPCR and Peptide ligand-binding receptors. Gene Ontology (GO) annotations related to this gene include G protein-coupled receptor activity and peptide YY receptor activity. An important paralog of this gene is NPY1R.
UniProtKB/Swiss-Prot Summary for NPY5R Gene
Receptor for neuropeptide Y and peptide YY. The activity of this receptor is mediated by G proteins that inhibit adenylate cyclase activity. Seems to be associated with food intake. Could be involved in feeding disorders.
Neuropeptide Y (NPY) receptors are a family of Gi/o-protein-coupled receptors that are currently divided into four subtypes: Y1, Y2, Y4 and Y5. NPY receptors mediate a diverse range of biological actions including stimulation of food intake and modulation of circadian rhythm.