Aliases for NPY4R2 Gene

Aliases for NPY4R2 Gene

  • Neuropeptide Y Receptor Y4-2 2 3 5
  • Neuropeptide Y Receptor Type 4-2 3 3 4
  • Pancreatic Polypeptide Receptor 1 3
  • Neuropeptide Y Receptor Type 4 3
  • Neuropeptide Y Receptor Y42 3
  • CH17-360D5.1 3
  • NPY4-R 3
  • NPY4R 3
  • PPYR1 3
  • PP1 3

External Ids for NPY4R2 Gene

Summaries for NPY4R2 Gene

GeneCards Summary for NPY4R2 Gene

NPY4R2 (Neuropeptide Y Receptor Y4-2) is a Protein Coding gene. Among its related pathways are Peptide ligand-binding receptors. An important paralog of this gene is NPY4R.

UniProtKB/Swiss-Prot Summary for NPY4R2 Gene

  • Receptor for neuropeptide Y and peptide YY. The rank order of affinity of this receptor for pancreatic polypeptides is PP, PP (2-36) and [Ile-31, Gln-34] PP > [Pro-34] PYY > PYY and [Leu-31, Pro-34] NPY > NPY > PYY (3-36) and NPY (2-36) > PP (13-36) > PP (31-36) > NPY free acid.

Additional gene information for NPY4R2 Gene

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for NPY4R2 Gene

Genomics for NPY4R2 Gene

GeneHancer (GH) Regulatory Elements for NPY4R2 Gene

Promoters and enhancers for NPY4R2 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH10J047913 Enhancer 0.2 Ensembl 750.6 +0.5 458 1.1 NPY4R2 piR-32307-002 ENSG00000276850 ANXA8
GH10J047915 Enhancer 0.2 Ensembl 750.6 +1.9 1889 0.2 NPY4R2 piR-32307-002 ENSG00000276850 ANXA8
GH10J047918 Enhancer 0.5 Ensembl 0.6 +4.6 4589 0.4 CTCF ZNF512 PTBP1 ZNF143 KDM1A HDAC2 piR-32307-002 SHLD2P3 NPY4R2 ENSG00000273760 ENSG00000276850 ANXA8
GH10J047916 Enhancer 0.2 Ensembl 0.6 +2.5 2488 0.2 piR-32307-002 NPY4R2 ENSG00000276850 ANXA8
GH10J047909 Enhancer 0.2 Ensembl 0.6 -4.1 -4111 1.8 piR-61475-002 NPY4R2 ANXA8 ENSG00000276850
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around NPY4R2 on UCSC Golden Path with GeneCards custom track

Genomic Locations for NPY4R2 Gene

Genomic Locations for NPY4R2 Gene
chr10:47,914,012-47,926,069
(GRCh38/hg38)
Size:
12,058 bases
Orientation:
Plus strand

Genomic View for NPY4R2 Gene

Genes around NPY4R2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
NPY4R2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for NPY4R2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NPY4R2 Gene

Proteins for NPY4R2 Gene

  • Protein details for NPY4R2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P0DQD5-NPY42_HUMAN
    Recommended name:
    Neuropeptide Y receptor type 4-2
    Protein Accession:
    P0DQD5

    Protein attributes for NPY4R2 Gene

    Size:
    375 amino acids
    Molecular mass:
    42195 Da
    Quaternary structure:
    No Data Available

neXtProt entry for NPY4R2 Gene

Post-translational modifications for NPY4R2 Gene

No Post-translational modifications

Other Protein References for NPY4R2 Gene

No data available for DME Specific Peptides for NPY4R2 Gene

Domains & Families for NPY4R2 Gene

Gene Families for NPY4R2 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted membrane proteins

Protein Domains for NPY4R2 Gene

Graphical View of Domain Structure for InterPro Entry

P0DQD5

UniProtKB/Swiss-Prot:

NPY42_HUMAN :
  • Belongs to the G-protein coupled receptor 1 family.
Family:
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with NPY4R2: view

No data available for Suggested Antigen Peptide Sequences for NPY4R2 Gene

Function for NPY4R2 Gene

Molecular function for NPY4R2 Gene

UniProtKB/Swiss-Prot Function:
Receptor for neuropeptide Y and peptide YY. The rank order of affinity of this receptor for pancreatic polypeptides is PP, PP (2-36) and [Ile-31, Gln-34] PP > [Pro-34] PYY > PYY and [Leu-31, Pro-34] NPY > NPY > PYY (3-36) and NPY (2-36) > PP (13-36) > PP (31-36) > NPY free acid.

Gene Ontology (GO) - Molecular Function for NPY4R2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001602 pancreatic polypeptide receptor activity IDA 7493937
GO:0004930 G protein-coupled receptor activity TAS 8643460
GO:0004983 neuropeptide Y receptor activity IEA --
GO:0017046 peptide hormone binding IPI 7493937
genes like me logo Genes that share ontologies with NPY4R2: view

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for NPY4R2 Gene

Localization for NPY4R2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for NPY4R2 Gene

Cell membrane; Multi-pass membrane protein.

Gene Ontology (GO) - Cellular Components for NPY4R2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0005887 integral component of plasma membrane TAS 8643460
GO:0016020 membrane IDA 7493937
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with NPY4R2: view

No data available for Subcellular locations from COMPARTMENTS and Subcellular locations from the Human Protein Atlas (HPA) for NPY4R2 Gene

Pathways & Interactions for NPY4R2 Gene

PathCards logo

SuperPathways for NPY4R2 Gene

genes like me logo Genes that share pathways with NPY4R2: view

Pathways by source for NPY4R2 Gene

1 KEGG pathway for NPY4R2 Gene

Interacting Proteins for NPY4R2 Gene

Gene Ontology (GO) - Biological Process for NPY4R2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007186 G protein-coupled receptor signaling pathway TAS,IEA --
GO:0007218 neuropeptide signaling pathway IEA --
genes like me logo Genes that share ontologies with NPY4R2: view

No data available for SIGNOR curated interactions for NPY4R2 Gene

Drugs & Compounds for NPY4R2 Gene

No Compound Related Data Available

Transcripts for NPY4R2 Gene

mRNA/cDNA for NPY4R2 Gene

(1) REFSEQ mRNAs :
(1) Additional mRNA sequences :
(2) Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for NPY4R2 Gene

No ASD Table

Relevant External Links for NPY4R2 Gene

GeneLoc Exon Structure for
NPY4R2
ECgene alternative splicing isoforms for
NPY4R2

Expression for NPY4R2 Gene

No Expression Related Data Available

No data available for mRNA expression in normal human tissues , mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for NPY4R2 Gene

Orthologs for NPY4R2 Gene

This gene was present in the common ancestor of animals.

Orthologs for NPY4R2 Gene

Organism Taxonomy Gene Similarity Type Details
chicken
(Gallus gallus)
Aves PPYR1 32
  • 64.54 (n)
tropical clawed frog
(Silurana tropicalis)
Amphibia npy4r 32
  • 59.69 (n)
zebrafish
(Danio rerio)
Actinopterygii npy8ar 32
  • 58.91 (n)
worm
(Caenorhabditis elegans)
Secernentea npr-12 32
  • 41.9 (n)
Species where no ortholog for NPY4R2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chimpanzee (Pan troglodytes)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for NPY4R2 Gene

ENSEMBL:
Gene Tree for NPY4R2 (if available)
TreeFam:
Gene Tree for NPY4R2 (if available)

Paralogs for NPY4R2 Gene

Variants for NPY4R2 Gene

Sequence variations from dbSNP and Humsavar for NPY4R2 Gene

SNP ID Clin Chr 10 pos Variation AA Info Type
rs1048157 -- 47,922,884(+) T/C coding_sequence_variant, synonymous_variant
rs1048158 -- 47,922,935(+) T/C coding_sequence_variant, synonymous_variant
rs111253474 -- 47,913,814(+) T/C upstream_transcript_variant
rs111415797 -- 47,918,909(+) C/G 5_prime_UTR_variant, genic_upstream_transcript_variant, intron_variant, upstream_transcript_variant
rs111590571 -- 47,915,604(+) G/C genic_upstream_transcript_variant, intron_variant, upstream_transcript_variant

Additional Variant Information for NPY4R2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
NPY4R2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Structural Variations from Database of Genomic Variants (DGV) and Variation tolerance for NPY4R2 Gene

Disorders for NPY4R2 Gene

Additional Disease Information for NPY4R2

No disorders were found for NPY4R2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for NPY4R2 Gene

Publications for NPY4R2 Gene

  1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. (PMID: 21873635) Gaudet P … Thomas PD (Briefings in bioinformatics 2011) 3 56
  2. The DNA sequence and comparative analysis of human chromosome 10. (PMID: 15164054) Deloukas P … Rogers J (Nature 2004) 4 56
  3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg RL … Mammalian Gene Collection Program Team (Proceedings of the National Academy of Sciences of the United States of America 2002) 3 56
  4. Cloning and functional expression of cDNAs encoding human and rat pancreatic polypeptide receptors. (PMID: 8643460) Yan H … Karbon W (Proceedings of the National Academy of Sciences of the United States of America 1996) 3 56
  5. Cloning and functional expression of a human Y4 subtype receptor for pancreatic polypeptide, neuropeptide Y, and peptide YY. (PMID: 7592911) Bard JA … Weinshank RL (The Journal of biological chemistry 1995) 3 56

Products for NPY4R2 Gene

Sources for NPY4R2 Gene