Aliases for NPY4R2 Gene

Aliases for NPY4R2 Gene

  • Neuropeptide Y Receptor Y4-2 2 3 5
  • Neuropeptide Y Receptor Type 4-2 3 3 4
  • CH17-360D5.1 2 3
  • Pancreatic Polypeptide Receptor 1 3
  • Neuropeptide Y Receptor Type 4 3
  • Neuropeptide Y Receptor Y42 3
  • NPY4-R 3
  • NPY4R2 5
  • NPY4R 3
  • PPYR1 3
  • PP1 3

External Ids for NPY4R2 Gene

Summaries for NPY4R2 Gene

GeneCards Summary for NPY4R2 Gene

NPY4R2 (Neuropeptide Y Receptor Y4-2) is a Protein Coding gene. Among its related pathways are Peptide ligand-binding receptors. An important paralog of this gene is NPY4R.

UniProtKB/Swiss-Prot Summary for NPY4R2 Gene

  • Receptor for neuropeptide Y and peptide YY. The rank order of affinity of this receptor for pancreatic polypeptides is PP, PP (2-36) and [Ile-31, Gln-34] PP > [Pro-34] PYY > PYY and [Leu-31, Pro-34] NPY > NPY > PYY (3-36) and NPY (2-36) > PP (13-36) > PP (31-36) > NPY free acid.

Additional gene information for NPY4R2 Gene

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for NPY4R2 Gene

Genomics for NPY4R2 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for NPY4R2 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH10J047913 Enhancer 0.2 Ensembl 600.7 +0.5 471 1.1 NPY4R2 piR-32307-002 ANXA8 ENSG00000276850
GH10J047915 Enhancer 0.2 Ensembl 600.7 +1.9 1902 0.2 NPY4R2 piR-32307-002 ANXA8 ENSG00000276850
GH10J047918 Enhancer 0.5 Ensembl 0.7 +4.6 4602 0.4 ZNF512 KDM1A PTBP1 ZNF143 HDAC2 CTCF EZH2 piR-32307-002 NPY4R2 ENSG00000273760 ANXA8 ENSG00000276850
GH10J047990 Promoter/Enhancer 1.1 EPDnew Ensembl ENCODE 0.2 +77.7 77683 2.2 CEBPB SIN3A FOXA1 KLF1 SREBF1 SP1 ANXA8 piR-52986-002 ENSG00000276850 NPY4R2
GH10J047988 Promoter/Enhancer 0.7 Ensembl ENCODE 0.2 +75.3 75289 1.9 PRDM10 SIN3A EGR2 piR-52986-002 ANXA8 ENSG00000276850 NPY4R2
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around NPY4R2 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for NPY4R2

Genomic Locations for NPY4R2 Gene

Genomic Locations for NPY4R2 Gene
12,071 bases
Plus strand

Genomic View for NPY4R2 Gene

Genes around NPY4R2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
NPY4R2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for NPY4R2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NPY4R2 Gene

Proteins for NPY4R2 Gene

  • Protein details for NPY4R2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Neuropeptide Y receptor type 4-2
    Protein Accession:

    Protein attributes for NPY4R2 Gene

    375 amino acids
    Molecular mass:
    42195 Da
    Quaternary structure:
    No Data Available

neXtProt entry for NPY4R2 Gene

Post-translational modifications for NPY4R2 Gene

  • Glycosylation at Asn2, Asn19, Asn29, and Asn187

Other Protein References for NPY4R2 Gene

No data available for DME Specific Peptides for NPY4R2 Gene

Domains & Families for NPY4R2 Gene

Gene Families for NPY4R2 Gene

Human Protein Atlas (HPA):
  • Predicted membrane proteins

Protein Domains for NPY4R2 Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the G-protein coupled receptor 1 family.
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with NPY4R2: view

No data available for Suggested Antigen Peptide Sequences for NPY4R2 Gene

Function for NPY4R2 Gene

Molecular function for NPY4R2 Gene

UniProtKB/Swiss-Prot Function:
Receptor for neuropeptide Y and peptide YY. The rank order of affinity of this receptor for pancreatic polypeptides is PP, PP (2-36) and [Ile-31, Gln-34] PP > [Pro-34] PYY > PYY and [Leu-31, Pro-34] NPY > NPY > PYY (3-36) and NPY (2-36) > PP (13-36) > PP (31-36) > NPY free acid.

Gene Ontology (GO) - Molecular Function for NPY4R2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001602 pancreatic polypeptide receptor activity IDA, IBA 7493937
GO:0004930 G protein-coupled receptor activity IEA,TAS 8643460
GO:0004983 neuropeptide Y receptor activity IEA --
GO:0017046 peptide hormone binding IPI 7493937
genes like me logo Genes that share ontologies with NPY4R2: view

miRNA for NPY4R2 Gene

miRTarBase miRNAs that target NPY4R2

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Phenotypes , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for NPY4R2 Gene

Localization for NPY4R2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for NPY4R2 Gene

Cell membrane. Multi-pass membrane protein.

Gene Ontology (GO) - Cellular Components for NPY4R2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane IEA,TAS --
GO:0005887 integral component of plasma membrane TAS 8643460
GO:0016020 membrane IEA,IDA 7493937
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with NPY4R2: view

No data available for Subcellular locations from COMPARTMENTS and Subcellular locations from the Human Protein Atlas (HPA) for NPY4R2 Gene

Pathways & Interactions for NPY4R2 Gene

PathCards logo

SuperPathways for NPY4R2 Gene

genes like me logo Genes that share pathways with NPY4R2: view

Pathways by source for NPY4R2 Gene

1 KEGG pathway for NPY4R2 Gene

Interacting Proteins for NPY4R2 Gene

Gene Ontology (GO) - Biological Process for NPY4R2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction IEA --
GO:0007186 G protein-coupled receptor signaling pathway IEA,TAS --
GO:0007218 neuropeptide signaling pathway IEA --
genes like me logo Genes that share ontologies with NPY4R2: view

No data available for SIGNOR curated interactions for NPY4R2 Gene

Drugs & Compounds for NPY4R2 Gene

No Compound Related Data Available

Transcripts for NPY4R2 Gene

mRNA/cDNA for NPY4R2 Gene

1 NCBI additional mRNA sequence :
2 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for NPY4R2 Gene

No ASD Table

Relevant External Links for NPY4R2 Gene

GeneLoc Exon Structure for

Expression for NPY4R2 Gene

No Expression Related Data Available

No data available for mRNA expression in normal human tissues , mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for NPY4R2 Gene

Orthologs for NPY4R2 Gene

This gene was present in the common ancestor of animals.

Orthologs for NPY4R2 Gene

Organism Taxonomy Gene Similarity Type Details
(Gallus gallus)
Aves PPYR1 30
  • 64.54 (n)
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia npy4r 30
  • 59.69 (n)
(Danio rerio)
Actinopterygii npy8ar 30
  • 58.91 (n)
(Caenorhabditis elegans)
Secernentea npr-12 30
  • 41.9 (n)
Species where no ortholog for NPY4R2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chimpanzee (Pan troglodytes)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • Cow (Bos Taurus)
  • Dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Lizard (Anolis carolinensis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Mouse (Mus musculus)
  • Oppossum (Monodelphis domestica)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Platypus (Ornithorhynchus anatinus)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rat (Rattus norvegicus)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)

Evolution for NPY4R2 Gene

Gene Tree for NPY4R2 (if available)
Gene Tree for NPY4R2 (if available)

Paralogs for NPY4R2 Gene

Variants for NPY4R2 Gene

Additional dbSNP identifiers (rs#s) for NPY4R2 Gene

Additional Variant Information for NPY4R2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP , Structural Variations from Database of Genomic Variants (DGV) and Variation tolerance for NPY4R2 Gene

Disorders for NPY4R2 Gene

No disorders were found for NPY4R2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for NPY4R2 Gene

Publications for NPY4R2 Gene

  1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. (PMID: 21873635) Gaudet P … Thomas PD (Briefings in bioinformatics 2011) 3
  2. The DNA sequence and comparative analysis of human chromosome 10. (PMID: 15164054) Deloukas P … Rogers J (Nature 2004) 4
  3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg RL … Mammalian Gene Collection Program Team (Proceedings of the National Academy of Sciences of the United States of America 2002) 3
  4. Cloning and functional expression of cDNAs encoding human and rat pancreatic polypeptide receptors. (PMID: 8643460) Yan H … Karbon W (Proceedings of the National Academy of Sciences of the United States of America 1996) 3
  5. Cloning of a human receptor of the NPY receptor family with high affinity for pancreatic polypeptide and peptide YY. (PMID: 7493937) Lundell I … Larhammar D (The Journal of biological chemistry 1995) 3

Products for NPY4R2 Gene

Sources for NPY4R2 Gene