Aliases for NPY4R Gene

Aliases for NPY4R Gene

  • Neuropeptide Y Receptor Y4 2 3 5
  • Pancreatic Polypeptide Receptor 1 2 3 4
  • PP1 2 3 4
  • Neuropeptide Y Receptor Type 4 3 4
  • NPY4-R 3 4
  • PPYR1 3 4
  • Y4 2 3
  • NPY4R 5

External Ids for NPY4R Gene

Previous HGNC Symbols for NPY4R Gene

  • PPYR1

Previous GeneCards Identifiers for NPY4R Gene

  • GC10P047084

Summaries for NPY4R Gene

GeneCards Summary for NPY4R Gene

NPY4R (Neuropeptide Y Receptor Y4) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and Peptide ligand-binding receptors. Gene Ontology (GO) annotations related to this gene include G protein-coupled receptor activity and peptide YY receptor activity. An important paralog of this gene is NPY4R2.

UniProtKB/Swiss-Prot Summary for NPY4R Gene

  • Receptor for neuropeptide Y and peptide YY. The rank order of affinity of this receptor for pancreatic polypeptides is PP, PP (2-36) and [Ile-31, Gln-34] PP > [Pro-34] PYY > PYY and [Leu-31, Pro-34] NPY > NPY > PYY (3-36) and NPY (2-36) > PP (13-36) > PP (31-36) > NPY free acid.

Gene Wiki entry for NPY4R Gene

Additional gene information for NPY4R Gene

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for NPY4R Gene

Genomics for NPY4R Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for NPY4R Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH10J046555 Promoter/Enhancer 2 EPDnew Ensembl ENCODE CraniofacialAtlas dbSUPER 600.2 -85.6 -85607 2.2 ZIC2 POLR2A KLF9 KLF7 USF1 YY1 ZNF274 ZFHX2 AEBP2 GLI4 GPRIN2 NPY4R PARGP1 BMS1P1 BMS1P2 AGAP9 AGAP4 WASHC2C AGAP10P ENSG00000229227
GH10J046471 Promoter/Enhancer 1.1 EPDnew Ensembl ENCODE 600.7 +0.5 456 0.9 SP1 ZBTB17 ZFHX2 SIN3A SPI1 POLR2A MYC MAX EGR2 ZBTB33 NPY4R piR-32307-001 ANXA8L1 ENSG00000285402
GH10J046465 Promoter/Enhancer 0.8 EPDnew Ensembl 600.7 +4.7 4693 0.4 HNRNPL ZNF512 KDM1A HDAC2 CTCF EZH2 NPY4R piR-32307-001 LINC00842 piR-50444-044 ANXA8L1 ENSG00000285402
GH10J046245 Enhancer 0.2 Ensembl 4.2 +224.2 224193 1 NPY4R piR-59287 AHCYP1 ANTXRLP1 lnc-MSMB-6 ANTXRL MSMB
GH10J046240 Enhancer 0.2 Ensembl 4 +229.9 229893 0.4 NPY4R piR-59287 AHCYP1 lnc-MSMB-6 ANTXRLP1 ANTXRL MSMB
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around NPY4R on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for NPY4R

Genomic Locations for NPY4R Gene

Genomic Locations for NPY4R Gene
12,147 bases
Minus strand
4,787 bases
Plus strand

Genomic View for NPY4R Gene

Genes around NPY4R on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
NPY4R Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for NPY4R Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NPY4R Gene

Proteins for NPY4R Gene

  • Protein details for NPY4R Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Neuropeptide Y receptor type 4
    Protein Accession:
    Secondary Accessions:
    • Q13456
    • Q5ISU3
    • Q5T2X9
    • Q6FH06

    Protein attributes for NPY4R Gene

    375 amino acids
    Molecular mass:
    42195 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for NPY4R Gene

neXtProt entry for NPY4R Gene

Post-translational modifications for NPY4R Gene

  • Glycosylation at Asn2, Asn19, Asn29, and Asn187
  • Modification sites at PhosphoSitePlus

Other Protein References for NPY4R Gene

No data available for DME Specific Peptides for NPY4R Gene

Domains & Families for NPY4R Gene

Gene Families for NPY4R Gene

Human Protein Atlas (HPA):
  • G-protein coupled receptors
  • Predicted membrane proteins

Protein Domains for NPY4R Gene

  • Neuropeptide Y receptor signature
  • Neuropeptide Y4 receptor signature

Suggested Antigen Peptide Sequences for NPY4R Gene

GenScript: Design optimal peptide antigens:
  • Pancreatic polypeptide receptor 1 (NPY4R_HUMAN)
  • Pancreatic polypeptide receptor 1 (Q4KKW2_HUMAN)

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the G-protein coupled receptor 1 family.
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with NPY4R: view

Function for NPY4R Gene

Molecular function for NPY4R Gene

UniProtKB/Swiss-Prot Function:
Receptor for neuropeptide Y and peptide YY. The rank order of affinity of this receptor for pancreatic polypeptides is PP, PP (2-36) and [Ile-31, Gln-34] PP > [Pro-34] PYY > PYY and [Leu-31, Pro-34] NPY > NPY > PYY (3-36) and NPY (2-36) > PP (13-36) > PP (31-36) > NPY free acid.

Gene Ontology (GO) - Molecular Function for NPY4R Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001602 pancreatic polypeptide receptor activity IDA --
GO:0004930 G protein-coupled receptor activity TAS --
GO:0004983 neuropeptide Y receptor activity IEA --
GO:0017046 peptide hormone binding IPI --
genes like me logo Genes that share ontologies with NPY4R: view
genes like me logo Genes that share phenotypes with NPY4R: view

Animal Model Products

  • Taconic Biosciences Mouse Models for NPY4R

CRISPR Products

miRNA for NPY4R Gene

miRTarBase miRNAs that target NPY4R

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for NPY4R

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for NPY4R Gene

Localization for NPY4R Gene

Subcellular locations from UniProtKB/Swiss-Prot for NPY4R Gene

Cell membrane. Multi-pass membrane protein.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for NPY4R gene
Compartment Confidence
plasma membrane 5
extracellular 2
nucleus 2
cytoskeleton 1
mitochondrion 1
endoplasmic reticulum 1
endosome 1
cytosol 1
lysosome 1
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for NPY4R Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0005887 integral component of plasma membrane TAS --
GO:0016020 membrane IDA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with NPY4R: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for NPY4R Gene

Pathways & Interactions for NPY4R Gene

genes like me logo Genes that share pathways with NPY4R: view

SIGNOR curated interactions for NPY4R Gene

Is activated by:

Gene Ontology (GO) - Biological Process for NPY4R Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction IEA --
GO:0007186 G protein-coupled receptor signaling pathway TAS --
GO:0007218 neuropeptide signaling pathway IEA --
genes like me logo Genes that share ontologies with NPY4R: view

Drugs & Compounds for NPY4R Gene

(36) Drugs for NPY4R Gene - From: DrugBank, DGIdb, Tocris, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
neuropeptide Y Approved, Investigational Pharma Agonist, Full agonist, Antagonist 0
Obinepitide Investigational Pharma Target 0
TM30339 Investigational Pharma Target, agonist 0
Peptide YY (3-36) Investigational Pharma Target 0
Pancreatic Polypeptide Investigational Pharma Agonist, Full agonist 23

(9) Additional Compounds for NPY4R Gene - From: Novoseek and Tocris

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
Neuropeptide Y (human, rat)

(5) Tocris Compounds for NPY4R Gene

Compound Action Cas Number
[Leu31,Pro34]-Neuropeptide Y (porcine) NPY Y1 receptor agonist 125580-28-1
BIBP 3226 trifluoroacetate Mixed NPY Y1 and NPFF receptor antagonist
GR 231118 Potent NPY Y1 antagonist/NPY Y4 agonist. Binds to NPFF receptors 158859-98-4
Neuropeptide Y (human, rat) Influences feeding and sexual behavior 90880-35-6
Pancreatic Polypeptide (human) NPY Y4 agonist; involved in gastrointestinal tract function 75976-10-2
genes like me logo Genes that share compounds with NPY4R: view

Transcripts for NPY4R Gene

mRNA/cDNA for NPY4R Gene

6 NCBI additional mRNA sequence :
2 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for NPY4R

Alternative Splicing Database (ASD) splice patterns (SP) for NPY4R Gene

No ASD Table

Relevant External Links for NPY4R Gene

GeneLoc Exon Structure for

Expression for NPY4R Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for NPY4R Gene

mRNA differential expression in normal tissues according to GTEx for NPY4R Gene

This gene is overexpressed in Colon - Transverse (x14.8) and Colon - Sigmoid (x7.2).

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for NPY4R

mRNA Expression by UniProt/SwissProt for NPY4R Gene:

Tissue specificity: Highest levels found in brain, coronary artery and ileum. Low levels in pancreas and kidney. Detected in colon and small intestine.

Evidence on tissue expression from TISSUES for NPY4R Gene

  • Nervous system(3)
  • Skin(2)
  • Intestine(2)
genes like me logo Genes that share expression patterns with NPY4R: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for NPY4R Gene

Orthologs for NPY4R Gene

This gene was present in the common ancestor of animals.

Orthologs for NPY4R Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia NPY4R 31
  • 97 (a)
(Canis familiaris)
Mammalia NPY4R 31
  • 86 (a)
(Bos Taurus)
Mammalia PPYR1 31
  • 86 (a)
(Mus musculus)
Mammalia Npy4r 31
  • 75 (a)
(Ornithorhynchus anatinus)
Mammalia NPY4R 31
  • 64 (a)
(Monodelphis domestica)
Mammalia NPY4R 31
  • 64 (a)
(Gallus gallus)
Aves PPYR1 30 31
  • 64.44 (n)
(Anolis carolinensis)
Reptilia NPY4R 31
  • 51 (a)
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia npy4r 30
  • 59.69 (n)
(Danio rerio)
Actinopterygii npy8ar 30
  • 58.81 (n)
npy4r 31
  • 46 (a)
npyryc 30
Fruit Fly
(Drosophila melanogaster)
Insecta NPFR1 31
  • 22 (a)
(Caenorhabditis elegans)
Secernentea npr-12 30 31
  • 41.78 (n)
npr-11 31
  • 26 (a)
Species where no ortholog for NPY4R was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rat (Rattus norvegicus)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)

Evolution for NPY4R Gene

Gene Tree for NPY4R (if available)
Gene Tree for NPY4R (if available)
Evolutionary constrained regions (ECRs) for NPY4R: view image

Paralogs for NPY4R Gene

(9) SIMAP similar genes for NPY4R Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with NPY4R: view

Variants for NPY4R Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for NPY4R Gene

SNP ID Clinical significance and condition Chr 10 pos Variation AA Info Type
714452 Benign: not provided 46,462,402(-) C/G SYNONYMOUS_VARIANT
768356 Benign: not provided 46,462,341(-) C/A MISSENSE_VARIANT
768357 Benign: not provided 46,461,945(-) A/. NO_SEQUENCE_ALTERATION
768358 Benign: not provided 46,461,918(-) A/G MISSENSE_VARIANT,NO_SEQUENCE_ALTERATION
768359 Benign: not provided 46,461,918(-) A/. MISSENSE_VARIANT,NO_SEQUENCE_ALTERATION

Additional dbSNP identifiers (rs#s) for NPY4R Gene

Structural Variations from Database of Genomic Variants (DGV) for NPY4R Gene

Variant ID Type Subtype PubMed ID
dgv1106n54 CNV gain 21841781
dgv147n67 CNV gain 20364138
dgv148n67 CNV gain 20364138
dgv218e212 CNV loss 25503493
dgv219e212 CNV gain 25503493
dgv223e212 CNV loss 25503493
dgv224e212 CNV gain 25503493
dgv227e212 CNV loss 25503493
dgv22e55 CNV gain 17911159
dgv409e59 CNV duplication 20981092
dgv440n106 CNV duplication 24896259
dgv734n100 CNV gain 25217958
dgv738n100 CNV loss 25217958
dgv740n100 CNV gain+loss 25217958
dgv743n100 CNV gain 25217958
dgv752n100 CNV loss 25217958
dgv753n100 CNV gain 25217958
dgv763n100 CNV gain 25217958
dgv764n100 CNV loss 25217958
dgv765n100 CNV loss 25217958
dgv767n100 CNV gain 25217958
dgv781n100 CNV loss 25217958
dgv783n100 CNV gain 25217958
dgv800n100 CNV gain 25217958
dgv801n100 CNV gain 25217958
dgv803n100 CNV gain 25217958
dgv806n100 CNV loss 25217958
dgv807n100 CNV gain 25217958
dgv810n100 CNV gain+loss 25217958
dgv811n100 CNV gain 25217958
dgv812n100 CNV loss 25217958
dgv813n100 CNV loss 25217958
dgv814n100 CNV loss 25217958
dgv815n100 CNV gain+loss 25217958
dgv817n100 CNV loss 25217958
dgv818n100 CNV loss 25217958
dgv819n100 CNV gain+loss 25217958
dgv820n100 CNV loss 25217958
dgv821n100 CNV gain 25217958
esv2545436 CNV deletion 19546169
esv2632472 CNV gain 19546169
esv2736152 CNV deletion 23290073
esv2857124 CNV duplication 24192839
esv3333912 CNV duplication 20981092
esv3334625 CNV duplication 20981092
esv3382741 CNV duplication 20981092
esv3577105 CNV gain 25503493
esv3578852 CNV loss 25503493
esv3584617 CNV loss 24956385
esv3891799 CNV gain 25118596
nsv1036434 CNV loss 25217958
nsv1041060 CNV gain+loss 25217958
nsv1043173 CNV gain 25217958
nsv1043881 CNV loss 25217958
nsv1044044 CNV gain+loss 25217958
nsv1046878 CNV gain+loss 25217958
nsv1049965 CNV gain 25217958
nsv1050225 CNV gain+loss 25217958
nsv1052733 CNV loss 25217958
nsv1152446 CNV duplication 26484159
nsv511437 CNV loss 21212237
nsv512161 CNV loss 21212237
nsv550723 CNV gain 21841781
nsv550726 CNV loss 21841781
nsv820817 CNV duplication 20802225
nsv825368 CNV gain 20364138
nsv831853 CNV gain 17160897
nsv947929 CNV duplication 23825009
nsv951576 CNV duplication 24416366

Variation tolerance for NPY4R Gene

Residual Variation Intolerance Score: 98% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.75; 57.81% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for NPY4R Gene

Human Gene Mutation Database (HGMD)
SNPedia medical, phenotypic, and genealogical associations of SNPs for

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NPY4R Gene

Disorders for NPY4R Gene

No disorders were found for NPY4R Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for NPY4R Gene

Publications for NPY4R Gene

  1. Neuropeptide Y receptor genes mapped in human and mouse: receptors with high affinity for pancreatic polypeptide are not clustered with receptors specific for neuropeptide Y and peptide YY. (PMID: 9417917) Lutz CM … Thompson DA (Genomics 1997) 2 3 23
  2. Cloning and functional expression of a human Y4 subtype receptor for pancreatic polypeptide, neuropeptide Y, and peptide YY. (PMID: 7592911) Bard JA … Weinshank RL (The Journal of biological chemistry 1995) 3 4 23
  3. Cloning and characterization of rabbit neuropeptide Y receptor subtypes. (PMID: 19481128) Umeda T … Iwaasa H (Peptides 2009) 3 23
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4
  5. Structure and receptor binding of PYY analogs. (PMID: 11825645) Keire DA … Reeve JR (Peptides 2002) 3 23

Products for NPY4R Gene

  • Signalway ELISA kits for NPY4R

Sources for NPY4R Gene