Aliases for NPY2R Gene

Aliases for NPY2R Gene

  • Neuropeptide Y Receptor Y2 2 3 5
  • Neuropeptide Y Receptor Type 2 3 4
  • NPY-Y2 Receptor 3 4
  • NPY2-R 3 4
  • Y2 Receptor 4
  • NPY2R 5

External Ids for NPY2R Gene

Previous GeneCards Identifiers for NPY2R Gene

  • GC04P157017
  • GC04P156557
  • GC04P156707
  • GC04P156671
  • GC04P156487
  • GC04P156349
  • GC04P156129
  • GC04P151868

Summaries for NPY2R Gene

GeneCards Summary for NPY2R Gene

NPY2R (Neuropeptide Y Receptor Y2) is a Protein Coding gene. Diseases associated with NPY2R include Cocaine Dependence and Nephronophthisis 4. Among its related pathways are Signaling by GPCR and Sympathetic Nerve Pathway (Neuroeffector Junction). Gene Ontology (GO) annotations related to this gene include G protein-coupled receptor activity and calcium channel regulator activity. An important paralog of this gene is PRLHR.

UniProtKB/Swiss-Prot Summary for NPY2R Gene

  • Receptor for neuropeptide Y and peptide YY. The rank order of affinity of this receptor for pancreatic polypeptides is PYY > NPY > PYY (3-36) > NPY (2-36) > [Ile-31, Gln-34] PP > [Leu-31, Pro-34] NPY > PP, [Pro-34] PYY and NPY free acid.

Tocris Summary for NPY2R Gene

  • Neuropeptide Y (NPY) receptors are a family of Gi/o-protein-coupled receptors that are currently divided into four subtypes: Y1, Y2, Y4 and Y5. NPY receptors mediate a diverse range of biological actions including stimulation of food intake and modulation of circadian rhythm.

Gene Wiki entry for NPY2R Gene

No data available for Entrez Gene Summary , CIViC Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for NPY2R Gene

Genomics for NPY2R Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for NPY2R Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH04J155209 Promoter 1 EPDnew Ensembl 604.5 +35.2 35177 1.8 CTCF KDM1A EZH2 ZBTB20 ZBTB48 GLIS2 ENSG00000250538 NPY2R LOC107986321 ENSG00000250910 MAP9
GH04J155173 Promoter 0.3 EPDnew 600.7 0.0 0 0.1 ENSG00000250910 NPY2R ENSG00000250538 RBM46
GH04J155818 Enhancer 0.6 Ensembl ENCODE 5.8 +645.4 645369 0.8 ZNF316 MAFF MAFK TDO2 NPY2R LOC105377507 GUCY1B1
GH04J155157 Enhancer 0.2 Ensembl 5.4 -16.4 -16422 0.2 NPY2R ENSG00000250910 piR-37656-199 RBM46
GH04J155375 Promoter/Enhancer 1.9 EPDnew Ensembl ENCODE CraniofacialAtlas 0.1 +202.8 202816 2.3 SP1 CREB1 RFX1 RFX5 LARP7 GABPA ZNF143 ZIC2 POLR2A PATZ1 MAP9 ENSG00000250910 ENSG00000249924 LOC102724776 NPY2R
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around NPY2R on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for NPY2R

Top Transcription factor binding sites by QIAGEN in the NPY2R gene promoter:
  • AML1a
  • Brachyury
  • Msx-1
  • Nkx3-1
  • Nkx3-1 v1
  • Nkx3-1 v2
  • Nkx3-1 v3
  • NRF-2
  • RelA

Genomic Locations for NPY2R Gene

Genomic Locations for NPY2R Gene
43,356 bases
Plus strand
8,450 bases
Plus strand

Genomic View for NPY2R Gene

Genes around NPY2R on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
NPY2R Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for NPY2R Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NPY2R Gene

Proteins for NPY2R Gene

  • Protein details for NPY2R Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Neuropeptide Y receptor type 2
    Protein Accession:
    Secondary Accessions:
    • Q13281
    • Q13457
    • Q4W5G7
    • Q6AZZ6
    • Q9UE67

    Protein attributes for NPY2R Gene

    381 amino acids
    Molecular mass:
    42731 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for NPY2R Gene

neXtProt entry for NPY2R Gene

Post-translational modifications for NPY2R Gene

  • Glycosylation at Asn11
  • Modification sites at PhosphoSitePlus

Other Protein References for NPY2R Gene

No data available for DME Specific Peptides for NPY2R Gene

Domains & Families for NPY2R Gene

Gene Families for NPY2R Gene

Human Protein Atlas (HPA):
  • G-protein coupled receptors
  • Predicted membrane proteins

Protein Domains for NPY2R Gene

  • Neuropeptide Y receptor signature
  • Neuropeptide Y2 receptor signature

Suggested Antigen Peptide Sequences for NPY2R Gene

GenScript: Design optimal peptide antigens:
  • NPY-Y2 receptor (NPY2R_HUMAN)

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the G-protein coupled receptor 1 family.
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with NPY2R: view

Function for NPY2R Gene

Molecular function for NPY2R Gene

UniProtKB/Swiss-Prot Function:
Receptor for neuropeptide Y and peptide YY. The rank order of affinity of this receptor for pancreatic polypeptides is PYY > NPY > PYY (3-36) > NPY (2-36) > [Ile-31, Gln-34] PP > [Leu-31, Pro-34] NPY > PP, [Pro-34] PYY and NPY free acid.
GENATLAS Biochemistry:
neuropeptide Y receptor Y2 rhodopsin-like,G protein coupled receptor superfamily,expressed in the hippocampus,involved in the presynaptic inhibition of neurotransmitter release

Phenotypes From GWAS Catalog for NPY2R Gene

Gene Ontology (GO) - Molecular Function for NPY2R Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001601 peptide YY receptor activity IEA --
GO:0004930 G protein-coupled receptor activity IEA --
GO:0004983 neuropeptide Y receptor activity TAS 7559383
GO:0005246 calcium channel regulator activity TAS 8132547
GO:0005515 protein binding IPI 23597562
genes like me logo Genes that share ontologies with NPY2R: view
genes like me logo Genes that share phenotypes with NPY2R: view

Animal Models for NPY2R Gene

MGI Knock Outs for NPY2R:

Animal Model Products

  • Taconic Biosciences Mouse Models for NPY2R

CRISPR Products

miRNA for NPY2R Gene

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for NPY2R

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for NPY2R Gene

Localization for NPY2R Gene

Subcellular locations from UniProtKB/Swiss-Prot for NPY2R Gene

Cell membrane. Multi-pass membrane protein.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for NPY2R gene
Compartment Confidence
plasma membrane 5
extracellular 2
nucleus 2
cytoskeleton 1
mitochondrion 1
endoplasmic reticulum 1
endosome 1
cytosol 1
lysosome 1
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for NPY2R Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005623 cell IEA --
GO:0005886 plasma membrane TAS --
GO:0005887 integral component of plasma membrane TAS,IEA --
GO:0005929 cilium IDA 28154160
GO:0016020 membrane IEA --
genes like me logo Genes that share ontologies with NPY2R: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for NPY2R Gene

Pathways & Interactions for NPY2R Gene

genes like me logo Genes that share pathways with NPY2R: view

SIGNOR curated interactions for NPY2R Gene

Is activated by:

Gene Ontology (GO) - Biological Process for NPY2R Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001662 behavioral fear response IEA --
GO:0002793 positive regulation of peptide secretion IEA --
GO:0003151 outflow tract morphogenesis IMP 19593212
GO:0003214 cardiac left ventricle morphogenesis IMP 19593212
GO:0007165 signal transduction IEA --
genes like me logo Genes that share ontologies with NPY2R: view

Drugs & Compounds for NPY2R Gene

(51) Drugs for NPY2R Gene - From: DrugBank, ApexBio, DGIdb, IUPHAR, Tocris, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
neuropeptide Y Approved, Investigational Pharma Agonist, Full agonist, Antagonist 0
Cysteamine Approved, Investigational Pharma Target, other/unknown 29
Obinepitide Investigational Pharma Target 0
Peptide YY (3-36) Investigational Pharma Target 0
BIIE0246 Pharma Antagonist 0

(2) Additional Compounds for NPY2R Gene - From: IUPHAR and Tocris

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
Agonist, Full agonist
Neuropeptide Y (human, rat)

(5) Tocris Compounds for NPY2R Gene

Compound Action Cas Number
[Leu31,Pro34]-Neuropeptide Y (porcine) NPY Y1 receptor agonist 125580-28-1
BIBP 3226 trifluoroacetate Mixed NPY Y1 and NPFF receptor antagonist
GR 231118 Potent NPY Y1 antagonist/NPY Y4 agonist. Binds to NPFF receptors 158859-98-4
Neuropeptide Y (human, rat) Influences feeding and sexual behavior 90880-35-6
Pancreatic Polypeptide (human) NPY Y4 agonist; involved in gastrointestinal tract function 75976-10-2

(16) ApexBio Compounds for NPY2R Gene

Compound Action Cas Number
[D-Trp34]-Neuropeptide Y 153549-84-9
BIIE 0246 NPY Y2 receptor antagonist 246146-55-4
CGP 71683 hydrochloride 192322-50-2
CYM 9484 1383478-94-1
GR 231118 158859-98-4
JNJ 5207787 683746-68-1
L-152,804 6508-43-6
LU AA33810 304008-29-5
Neuropeptide Y (scrambled) control in the research in NPY
NPY 5RA972 439861-56-0
NTNCB hydrochloride 191931-56-3
Pancreatic Polypeptide (human) 75976-10-2
PD 160170 181468-88-2
Peptide YY(3-36), PYY, human Y2R agonist 123583-37-9
S 25585 263849-50-9
SF 11 443292-81-7
genes like me logo Genes that share compounds with NPY2R: view

Drug Products

Transcripts for NPY2R Gene

mRNA/cDNA for NPY2R Gene

6 NCBI additional mRNA sequence :
2 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for NPY2R

Alternative Splicing Database (ASD) splice patterns (SP) for NPY2R Gene

ExUns: 1a · 1b ^ 2a · 2b

Relevant External Links for NPY2R Gene

GeneLoc Exon Structure for

Expression for NPY2R Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for NPY2R Gene

mRNA differential expression in normal tissues according to GTEx for NPY2R Gene

This gene is overexpressed in Brain - Hypothalamus (x6.9), Brain - Nucleus accumbens (basal ganglia) (x6.1), Brain - Hippocampus (x4.5), Brain - Spinal cord (cervical c-1) (x4.5), and Brain - Amygdala (x4.1).

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for NPY2R

SOURCE GeneReport for Unigene cluster for NPY2R Gene:


mRNA Expression by UniProt/SwissProt for NPY2R Gene:

Tissue specificity: High levels in amygdala, corpus callosum, hippocampus and subthalamic nucleus. Also detectable in caudate nucleus, hypothalamus and substantia nigra.

Evidence on tissue expression from TISSUES for NPY2R Gene

  • Nervous system(4.6)
  • Skin(2.1)
  • Muscle(2)
  • Adrenal gland(2)
  • Intestine(2)
genes like me logo Genes that share expression patterns with NPY2R: view

No data available for Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for NPY2R Gene

Orthologs for NPY2R Gene

This gene was present in the common ancestor of animals.

Orthologs for NPY2R Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia NPY2R 30 31
  • 99.56 (n)
(Canis familiaris)
Mammalia NPY2R 30
  • 91.16 (n)
(Bos Taurus)
Mammalia NPY2R 30 31
  • 90.03 (n)
(Monodelphis domestica)
Mammalia NPY2R 31
  • 89 (a)
(Mus musculus)
Mammalia Npy2r 30 17 31
  • 87.89 (n)
(Rattus norvegicus)
Mammalia Npy2r 30
  • 86.84 (n)
(Ornithorhynchus anatinus)
Mammalia NPY2R 31
  • 86 (a)
(Gallus gallus)
Aves NPY2R 30 31
  • 74.56 (n)
(Anolis carolinensis)
Reptilia NPY2R 31
  • 72 (a)
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia npy2r 30
  • 66.58 (n)
(Danio rerio)
Actinopterygii npy2rl 30 31 31
  • 68.5 (n)
npy2r 31
  • 54 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta GPRNPY3 30
  • 49.67 (n)
Fruit Fly
(Drosophila melanogaster)
Insecta NepYr 32
  • 33 (a)
CG10626 32
  • 32 (a)
NPFR1 31 32
  • 22 (a)
(Caenorhabditis elegans)
Secernentea npr-6 30
  • 46.88 (n)
F41E7.3 32
  • 30 (a)
Y59H11AL.1 32
  • 30 (a)
npr-11 31
  • 26 (a)
npr-12 31
  • 20 (a)
Species where no ortholog for NPY2R was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)

Evolution for NPY2R Gene

Gene Tree for NPY2R (if available)
Gene Tree for NPY2R (if available)
Evolutionary constrained regions (ECRs) for NPY2R: view image

Paralogs for NPY2R Gene

(16) SIMAP similar genes for NPY2R Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with NPY2R: view

Variants for NPY2R Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for NPY2R Gene

SNP ID Clinical significance and condition Chr 04 pos Variation AA Info Type
717287 Likely Benign: not provided 155,214,973(+) G/A MISSENSE_VARIANT
719094 Benign: not provided 155,214,593(+) C/G SYNONYMOUS_VARIANT
725104 Benign: not provided 155,214,917(+) C/T SYNONYMOUS_VARIANT
729523 Likely Benign: not provided 155,214,003(+) T/C MISSENSE_VARIANT
735705 Likely Benign: not provided 155,214,305(+) G/A SYNONYMOUS_VARIANT

Additional dbSNP identifiers (rs#s) for NPY2R Gene

Structural Variations from Database of Genomic Variants (DGV) for NPY2R Gene

Variant ID Type Subtype PubMed ID
nsv1136916 CNV deletion 24896259

Variation tolerance for NPY2R Gene

Residual Variation Intolerance Score: 29.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.37; 26.98% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for NPY2R Gene

Human Gene Mutation Database (HGMD)
SNPedia medical, phenotypic, and genealogical associations of SNPs for

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NPY2R Gene

Disorders for NPY2R Gene

MalaCards: The human disease database

(4) MalaCards diseases for NPY2R Gene - From: DISEASES, Novoseek, and GeneCards

- elite association - COSMIC cancer census association via MalaCards
Search NPY2R in MalaCards View complete list of genes associated with diseases

Additional Disease Information for NPY2R

Genetic Association Database
Human Genome Epidemiology Navigator
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
genes like me logo Genes that share disorders with NPY2R: view

No data available for UniProtKB/Swiss-Prot and Genatlas for NPY2R Gene

Publications for NPY2R Gene

  1. Association studies of BMI and type 2 diabetes in the neuropeptide Y pathway: a possible role for NPY2R as a candidate gene for type 2 diabetes in men. (PMID: 17325259) Campbell CD … Hirschhorn JN (Diabetes 2007) 3 23 41
  2. Single nucleotide polymorphisms in the neuropeptide Y2 receptor (NPY2R) gene and association with severe obesity in French white subjects. (PMID: 17235527) Siddiq A … Froguel P (Diabetologia 2007) 3 23 41
  3. Variants in the 5' region of the neuropeptide Y receptor Y2 gene (NPY2R) are associated with obesity in 5,971 white subjects. (PMID: 17019604) Torekov SS … Pedersen O (Diabetologia 2006) 3 23 41
  4. Expression cloning of a human brain neuropeptide Y Y2 receptor. (PMID: 8632753) Gehlert DR … Gadski RA (Molecular pharmacology 1996) 3 4 23
  5. Cloning and functional expression of a cDNA encoding a human type 2 neuropeptide Y receptor. (PMID: 7559383) Rose PM … Seethala R (The Journal of biological chemistry 1995) 2 3 4

Products for NPY2R Gene

  • Addgene plasmids for NPY2R
  • Signalway ELISA kits for NPY2R

Sources for NPY2R Gene