Aliases for NPY1R Gene
External Ids for NPY1R Gene
Previous HGNC Symbols for NPY1R Gene
Previous GeneCards Identifiers for NPY1R Gene
This gene belongs to the G-protein-coupled receptor superfamily. The encoded transmembrane protein mediates the function of neuropeptide Y (NPY), a neurotransmitter, and peptide YY (PYY), a gastrointestinal hormone. The encoded receptor undergoes fast agonist-induced internalization through clathrin-coated pits and is subsequently recycled back to the cell membrane. Activation of Y1 receptors may result in mobilization of intracellular calcium and inhibition of adenylate cyclase activity. [provided by RefSeq, Aug 2013]
GeneCards Summary for NPY1R Gene
NPY1R (Neuropeptide Y Receptor Y1) is a Protein Coding gene. Diseases associated with NPY1R include Body Mass Index Quantitative Trait Locus 11 and Disease Of Mental Health. Among its related pathways are Peptide ligand-binding receptors and Signaling by GPCR. Gene Ontology (GO) annotations related to this gene include G protein-coupled receptor activity and peptide YY receptor activity. An important paralog of this gene is NPY4R2.
UniProtKB/Swiss-Prot Summary for NPY1R Gene
Receptor for neuropeptide Y and peptide YY. The rank order of affinity of this receptor for pancreatic polypeptides is NPY > [Pro-34] PYY, PYY and [Leu-31, Pro-34] NPY > NPY (2-36) > [Ile-31, Gln-34] PP and PYY (3-36) > PP > NPY free acid.
Neuropeptide Y (NPY) receptors are a family of Gi/o-protein-coupled receptors that are currently divided into four subtypes: Y1, Y2, Y4 and Y5. NPY receptors mediate a diverse range of biological actions including stimulation of food intake and modulation of circadian rhythm.