This gene belongs to the G-protein-coupled receptor superfamily. The encoded transmembrane protein mediates the function of neuropeptide Y (NPY), a neurotransmitter, and peptide YY (PYY), a gastrointestinal hormone. The encoded receptor undergoes fast agonist-induced internalization through clathrin-coated pits and is subsequently recycled back to the cell membrane. Activation ... See more...

Aliases for NPY1R Gene

Aliases for NPY1R Gene

  • Neuropeptide Y Receptor Y1 2 3 5
  • Neuropeptide Y Receptor Type 1 3 4
  • NPY1-R 3 4
  • NPYR 3 4
  • NPYY1 4

External Ids for NPY1R Gene

Previous HGNC Symbols for NPY1R Gene

  • NPYR

Previous GeneCards Identifiers for NPY1R Gene

  • GC04M165094
  • GC04M164673
  • GC04M164822
  • GC04M164602
  • GC04M164464
  • GC04M164245
  • GC04M159999

Summaries for NPY1R Gene

Entrez Gene Summary for NPY1R Gene

  • This gene belongs to the G-protein-coupled receptor superfamily. The encoded transmembrane protein mediates the function of neuropeptide Y (NPY), a neurotransmitter, and peptide YY (PYY), a gastrointestinal hormone. The encoded receptor undergoes fast agonist-induced internalization through clathrin-coated pits and is subsequently recycled back to the cell membrane. Activation of Y1 receptors may result in mobilization of intracellular calcium and inhibition of adenylate cyclase activity. [provided by RefSeq, Aug 2013]

GeneCards Summary for NPY1R Gene

NPY1R (Neuropeptide Y Receptor Y1) is a Protein Coding gene. Diseases associated with NPY1R include Body Mass Index Quantitative Trait Locus 11. Among its related pathways are Signaling by GPCR and Sympathetic Nerve Pathway (Neuroeffector Junction). Gene Ontology (GO) annotations related to this gene include G protein-coupled receptor activity and peptide YY receptor activity. An important paralog of this gene is NPY4R.

UniProtKB/Swiss-Prot Summary for NPY1R Gene

  • Receptor for neuropeptide Y and peptide YY. The rank order of affinity of this receptor for pancreatic polypeptides is NPY > [Pro-34] PYY, PYY and [Leu-31, Pro-34] NPY > NPY (2-36) > [Ile-31, Gln-34] PP and PYY (3-36) > PP > NPY free acid.

Tocris Summary for NPY1R Gene

  • Neuropeptide Y (NPY) receptors are a family of Gi/o-protein-coupled receptors that are currently divided into four subtypes: Y1, Y2, Y4 and Y5. NPY receptors mediate a diverse range of biological actions including stimulation of food intake and modulation of circadian rhythm.

Gene Wiki entry for NPY1R Gene

Additional gene information for NPY1R Gene

No data available for CIViC Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for NPY1R Gene

Genomics for NPY1R Gene

GeneHancer (GH) Regulatory Elements for NPY1R Gene

Promoters and enhancers for NPY1R Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH04J163331 Promoter/Enhancer 1.8 EPDnew Ensembl ENCODE CraniofacialAtlas 500.4 +12.6 12631 2.8 CTCF USF1 REST TOE1 RAD21 SMC3 HDAC2 POLR2A EZH2 RAD51 NPY1R ENSG00000250027 NPY5R lnc-NPY1R-1
GH04J163343 Promoter 1.1 EPDnew Ensembl 500.7 +0.6 631 2 USF1 EZH2 NFIC PHF8 NFIB SIN3A RNF2 L3MBTL2 SUZ12 E2F1 NPY1R NPY5R
GH04J163385 Enhancer 0.6 Ensembl 11.6 -40.8 -40769 0.8 ZNF217 RFX1 CTBP1 ESRRA MBD2 ESR1 NEUROD1 ELF1 GATA3 DPF2 NPY1R NPY5R RPL35AP12 lnc-NPY5R-5 piR-31846-020
GH04J163448 Enhancer 0.6 Ensembl 10.4 -104.1 -104068 0.2 GATAD2B ESRRA MBD2 FOS ESR1 JUND ZNF217 GATA3 JUN SMARCE1 piR-57461-175 TKTL2 NPY1R NPY5R piR-31846-020
GH04J163267 Enhancer 0.4 Ensembl 10.3 +76.5 76531 1 NFIC NANOG ATF1 ENSG00000250547 LOC133332 lnc-NPY1R-2 NPY1R NPY5R lnc-NPY1R-1
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around NPY1R on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for NPY1R

Top Transcription factor binding sites by QIAGEN in the NPY1R gene promoter:
  • Evi-1
  • GR
  • GR-alpha
  • HNF-1
  • HNF-1A
  • p53
  • SREBP-1a
  • SREBP-1b
  • SREBP-1c
  • XBP-1

Genomic Locations for NPY1R Gene

Genomic Locations for NPY1R Gene
chr4:163,323,962-163,344,832
(GRCh38/hg38)
Size:
20,871 bases
Orientation:
Minus strand
chr4:164,245,113-164,265,984
(GRCh37/hg19)
Size:
20,872 bases
Orientation:
Minus strand

Genomic View for NPY1R Gene

Genes around NPY1R on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
NPY1R Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for NPY1R Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NPY1R Gene

Proteins for NPY1R Gene

  • Protein details for NPY1R Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P25929-NPY1R_HUMAN
    Recommended name:
    Neuropeptide Y receptor type 1
    Protein Accession:
    P25929
    Secondary Accessions:
    • B2R6H5

    Protein attributes for NPY1R Gene

    Size:
    384 amino acids
    Molecular mass:
    44392 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for NPY1R Gene

neXtProt entry for NPY1R Gene

Post-translational modifications for NPY1R Gene

  • Glycosylation at Asn2, Asn11, and Asn17
  • Modification sites at PhosphoSitePlus

Antibody Products

  • Abcam antibodies for NPY1R
  • Boster Bio Antibodies for NPY1R
  • Santa Cruz Biotechnology (SCBT) Antibodies for NPY1R

No data available for DME Specific Peptides for NPY1R Gene

Domains & Families for NPY1R Gene

Gene Families for NPY1R Gene

HGNC:
IUPHAR :
Human Protein Atlas (HPA):
  • G-protein coupled receptors
  • Predicted intracellular proteins
  • Predicted membrane proteins

Protein Domains for NPY1R Gene

Blocks:
  • Neuropeptide Y receptor signature
  • Neuropeptide Y1 receptor signature
InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for NPY1R Gene

GenScript: Design optimal peptide antigens:
  • cDNA FLJ51985, highly similar to Neuropeptide Y receptor type 1 (B4DKL9_HUMAN)
  • Neuropeptide Y receptor type 1 (NPY1R_HUMAN)

Graphical View of Domain Structure for InterPro Entry

P25929

UniProtKB/Swiss-Prot:

NPY1R_HUMAN :
  • Belongs to the G-protein coupled receptor 1 family.
Family:
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with NPY1R: view

Function for NPY1R Gene

Molecular function for NPY1R Gene

UniProtKB/Swiss-Prot Function:
Receptor for neuropeptide Y and peptide YY. The rank order of affinity of this receptor for pancreatic polypeptides is NPY > [Pro-34] PYY, PYY and [Leu-31, Pro-34] NPY > NPY (2-36) > [Ile-31, Gln-34] PP and PYY (3-36) > PP > NPY free acid.
GENATLAS Biochemistry:
neuropeptide Y receptor Y1,overlapping NPY5R,in opposite orientation,G protein coupled receptor superfamily

Phenotypes From GWAS Catalog for NPY1R Gene

Gene Ontology (GO) - Molecular Function for NPY1R Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001601 peptide YY receptor activity IEA --
GO:0001602 pancreatic polypeptide receptor activity IBA 21873635
GO:0004930 G protein-coupled receptor activity IEA --
GO:0004983 neuropeptide Y receptor activity TAS,IEA 1317848
GO:0005515 protein binding IPI 23597562
genes like me logo Genes that share ontologies with NPY1R: view
genes like me logo Genes that share phenotypes with NPY1R: view

Animal Models for NPY1R Gene

MGI Knock Outs for NPY1R:

Animal Model Products

CRISPR Products

miRNA for NPY1R Gene

miRTarBase miRNAs that target NPY1R

Clone Products

  • Addgene plasmids for NPY1R

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for NPY1R Gene

Localization for NPY1R Gene

Subcellular locations from UniProtKB/Swiss-Prot for NPY1R Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for NPY1R gene
Compartment Confidence
plasma membrane 5
extracellular 2
nucleus 2
cytoskeleton 1
mitochondrion 1
endoplasmic reticulum 1
endosome 1
cytosol 1
lysosome 1
golgi apparatus 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (2)
  • Mitochondria (2)
  • Nucleoplasm (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for NPY1R Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0005887 integral component of plasma membrane TAS 1317848
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with NPY1R: view

Pathways & Interactions for NPY1R Gene

genes like me logo Genes that share pathways with NPY1R: view

SIGNOR curated interactions for NPY1R Gene

Is activated by:

Gene Ontology (GO) - Biological Process for NPY1R Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003151 outflow tract morphogenesis IMP 19593212
GO:0006006 glucose metabolic process IEA --
GO:0007165 signal transduction IEA --
GO:0007186 G protein-coupled receptor signaling pathway IEA,TAS --
GO:0007187 G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger TAS 1317848
genes like me logo Genes that share ontologies with NPY1R: view

Drugs & Compounds for NPY1R Gene

(40) Drugs for NPY1R Gene - From: DrugBank, ApexBio, DGIdb, IUPHAR, Tocris, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Peptide YY (3-36) Investigational Pharma Target 0
BIBP3226 Pharma Antagonist 0
BIBP 3226 trifluoroacetate Pharma Mixed NPY1-R and NPFF receptor inhibitor, Mixed NPY Y1 and NPFF receptor antagonist 0
GR 231118 Pharma Potent NPY Y1 antagonist/NPY Y4 agonist. Binds to NPFF receptors 0
Pancreatic Polypeptide (human) Pharma NPY Y4 agonist; involved in gastrointestinal tract function 0

(1) Additional Compounds for NPY1R Gene - From: Tocris

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
Neuropeptide Y (human, rat)
90880-35-6

(5) Tocris Compounds for NPY1R Gene

Compound Action Cas Number
[Leu31,Pro34]-Neuropeptide Y (porcine) NPY Y1 receptor agonist 125580-28-1
BIBP 3226 trifluoroacetate Mixed NPY Y1 and NPFF receptor antagonist
GR 231118 Potent NPY Y1 antagonist/NPY Y4 agonist. Binds to NPFF receptors 158859-98-4
Neuropeptide Y (human, rat) Influences feeding and sexual behavior 90880-35-6
Pancreatic Polypeptide (human) NPY Y4 agonist; involved in gastrointestinal tract function 75976-10-2

(20) ApexBio Compounds for NPY1R Gene

Compound Action Cas Number
[cPP1-7,NPY19-23,Ala31,Aib32,Gln34] - hPancreatic Polypeptide 313988-89-5
[D-Trp34]-Neuropeptide Y 153549-84-9
[Leu31,Pro34]-Neuropeptide Y (human, rat) 132699-73-1
BIBO 3304 trifluoroacetate NPY Y1 receptor antagonist,highly selective 191868-14-1
BIBP 3226 trifluoroacetate Mixed NPY1-R and NPFF receptor inhibitor 1068148-47-9
BMS 193885 Competitive NPY Y1 receptor antagonist 679839-66-8
BVD 10 NPY Y1 receptor antagonist,highly selective 262418-00-8
CGP 71683 hydrochloride 192322-50-2
CYM 9484 1383478-94-1
GR 231118 158859-98-4
JNJ 5207787 683746-68-1
L-152,804 6508-43-6
LU AA33810 304008-29-5
Neuropeptide Y (scrambled) control in the research in NPY
NPY 5RA972 439861-56-0
NTNCB hydrochloride 191931-56-3
Pancreatic Polypeptide (human) 75976-10-2
PD 160170 181468-88-2
S 25585 263849-50-9
SF 11 443292-81-7
genes like me logo Genes that share compounds with NPY1R: view

Drug Products

Transcripts for NPY1R Gene

mRNA/cDNA for NPY1R Gene

1 REFSEQ mRNAs :
11 NCBI additional mRNA sequence :
7 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Clone Products

  • Addgene plasmids for NPY1R

Alternative Splicing Database (ASD) splice patterns (SP) for NPY1R Gene

ExUns: 1 ^ 2 ^ 3a · 3b ^ 4 ^ 5
SP1: -
SP2: -
SP3:

Relevant External Links for NPY1R Gene

GeneLoc Exon Structure for
NPY1R

Expression for NPY1R Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for NPY1R Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for NPY1R Gene

This gene is overexpressed in Spleen (x8.6) and Artery - Tibial (x4.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for NPY1R Gene



Transcriptomic regulation report from SPP (The Signaling Pathways Project) for NPY1R

SOURCE GeneReport for Unigene cluster for NPY1R Gene:

Hs.519057

Evidence on tissue expression from TISSUES for NPY1R Gene

  • Nervous system(4.6)
  • Blood(4.3)
  • Pancreas(4.2)
  • Adrenal gland(2.1)
genes like me logo Genes that share expression patterns with NPY1R: view

No data available for Protein differential expression in normal tissues , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for NPY1R Gene

Orthologs for NPY1R Gene

This gene was present in the common ancestor of animals.

Orthologs for NPY1R Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia NPY1R 31 30
  • 99.56 (n)
OneToOne
dog
(Canis familiaris)
Mammalia NPY1R 31 30
  • 91.97 (n)
OneToOne
cow
(Bos Taurus)
Mammalia NPY1R 31 30
  • 89.82 (n)
OneToOne
mouse
(Mus musculus)
Mammalia Npy1r 17 31 30
  • 85.43 (n)
rat
(Rattus norvegicus)
Mammalia Npy1r 30
  • 85.43 (n)
oppossum
(Monodelphis domestica)
Mammalia mdo-mir-7323 31
  • 71 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia NPY1R 31
  • 48 (a)
OneToOne
chicken
(Gallus gallus)
Aves NPY1R 31 30
  • 78.18 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia NPY1R 31
  • 81 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia npy1r 30
  • 73.99 (n)
African clawed frog
(Xenopus laevis)
Amphibia npy1r-A 30
zebrafish
(Danio rerio)
Actinopterygii npy1r 31 30
  • 60.78 (n)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CG10626 32
  • 31 (a)
NPFR1 31 32
  • 22 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea npr-7 30
  • 43.04 (n)
npr-11 31
  • 25 (a)
ManyToMany
npr-12 31
  • 24 (a)
ManyToMany
Species where no ortholog for NPY1R was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for NPY1R Gene

ENSEMBL:
Gene Tree for NPY1R (if available)
TreeFam:
Gene Tree for NPY1R (if available)
Aminode:
Evolutionary constrained regions (ECRs) for NPY1R: view image

Paralogs for NPY1R Gene

(9) SIMAP similar genes for NPY1R Gene using alignment to 7 proteins:

  • NPY1R_HUMAN
  • B4DKL9_HUMAN
  • D6R9D0_HUMAN
  • D6RC44_HUMAN
  • D6REY0_HUMAN
  • D6RHH6_HUMAN
  • D6RI97_HUMAN

Pseudogenes.org Pseudogenes for NPY1R Gene

genes like me logo Genes that share paralogs with NPY1R: view

Variants for NPY1R Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for NPY1R Gene

SNP ID Clinical significance and condition Chr 04 pos Variation AA Info Type
774176 Benign: not provided 163,325,337(-) T/G MISSENSE_VARIANT
rs5578 - p.Lys374Thr

Additional dbSNP identifiers (rs#s) for NPY1R Gene

Structural Variations from Database of Genomic Variants (DGV) for NPY1R Gene

Variant ID Type Subtype PubMed ID
nsv1015505 CNV gain 25217958
nsv1030184 CNV loss 25217958
nsv822812 CNV gain 20364138

Variation tolerance for NPY1R Gene

Residual Variation Intolerance Score: 35.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.94; 19.37% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for NPY1R Gene

Human Gene Mutation Database (HGMD)
NPY1R
SNPedia medical, phenotypic, and genealogical associations of SNPs for
NPY1R

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NPY1R Gene

Disorders for NPY1R Gene

MalaCards: The human disease database

(1) MalaCards diseases for NPY1R Gene - From: DISEASES and Novoseek

Disorder Aliases PubMed IDs
body mass index quantitative trait locus 11
  • bmiq11
- elite association - COSMIC cancer census association via MalaCards
Search NPY1R in MalaCards View complete list of genes associated with diseases

Additional Disease Information for NPY1R

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with NPY1R: view

No data available for UniProtKB/Swiss-Prot and Genatlas for NPY1R Gene

Publications for NPY1R Gene

  1. Genomic organization, localization, and allelic differences in the gene for the human neuropeptide Y Y1 receptor. (PMID: 8095935) Herzog H … Shine J (The Journal of biological chemistry 1993) 2 3 4 23 54
  2. Three common variants of LEP, NPY1R and GPR54 show no association with age at menarche. (PMID: 19506390) Rothenbuhler A … Fradin D (Hormone research 2009) 3 23 41 54
  3. Variants in neuropeptide Y receptor 1 and 5 are associated with nutrient-specific food intake and are under recent selection in Europeans. (PMID: 19759915) Elbers CC … Onland-Moret NC (PloS one 2009) 3 23 41 54
  4. Association studies of BMI and type 2 diabetes in the neuropeptide Y pathway: a possible role for NPY2R as a candidate gene for type 2 diabetes in men. (PMID: 17325259) Campbell CD … Hirschhorn JN (Diabetes 2007) 3 23 41 54
  5. Melanocortin-4 receptor gene and physical activity in the Québec Family Study. (PMID: 15597110) Loos RJ … Bouchard C (International journal of obesity (2005) 2005) 3 23 41 54

Products for NPY1R Gene

  • Addgene plasmids for NPY1R

Sources for NPY1R Gene