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Aliases for NPY1R Gene

Aliases for NPY1R Gene

  • Neuropeptide Y Receptor Y1 2 3 5
  • NPY1-R 3 4
  • NPYR 3 4
  • Neuropeptide Y Receptor Type 1 3
  • NPYY1 4

External Ids for NPY1R Gene

Previous HGNC Symbols for NPY1R Gene

  • NPYR

Previous GeneCards Identifiers for NPY1R Gene

  • GC04M165094
  • GC04M164673
  • GC04M164822
  • GC04M164602
  • GC04M164464
  • GC04M164245
  • GC04M159999

Summaries for NPY1R Gene

Entrez Gene Summary for NPY1R Gene

  • This gene belongs to the G-protein-coupled receptor superfamily. The encoded transmembrane protein mediates the function of neuropeptide Y (NPY), a neurotransmitter, and peptide YY (PYY), a gastrointestinal hormone. The encoded receptor undergoes fast agonist-induced internalization through clathrin-coated pits and is subsequently recycled back to the cell membrane. Activation of Y1 receptors may result in mobilization of intracellular calcium and inhibition of adenylate cyclase activity. [provided by RefSeq, Aug 2013]

GeneCards Summary for NPY1R Gene

NPY1R (Neuropeptide Y Receptor Y1) is a Protein Coding gene. Among its related pathways are Peptide ligand-binding receptors and cAMP signaling pathway. Gene Ontology (GO) annotations related to this gene include G-protein coupled receptor activity and peptide YY receptor activity. An important paralog of this gene is NPY4R2.

UniProtKB/Swiss-Prot for NPY1R Gene

  • Receptor for neuropeptide Y and peptide YY. The rank order of affinity of this receptor for pancreatic polypeptides is NPY > [Pro-34] PYY, PYY and [Leu-31, Pro-34] NPY > NPY (2-36) > [Ile-31, Gln-34] PP and PYY (3-36) > PP > NPY free acid.

Tocris Summary for NPY1R Gene

  • Neuropeptide Y (NPY) receptors are a family of Gi/o-protein-coupled receptors that are currently divided into four subtypes: Y1, Y2, Y4 and Y5. NPY receptors mediate a diverse range of biological actions including stimulation of food intake and modulation of circadian rhythm.

Gene Wiki entry for NPY1R Gene

Additional gene information for NPY1R Gene

No data available for CIViC summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NPY1R Gene

Genomics for NPY1R Gene

GeneHancer (GH) Regulatory Elements for NPY1R Gene

Promoters and enhancers for NPY1R Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH04I163331 Promoter/Enhancer 1.8 EPDnew Ensembl ENCODE 550.4 +12.2 12203 1.7 GTF2F1 CTCF MXI1 USF1 RB1 MAX SIN3A RAD21 YY1 ZNF507 NPY1R LOC101928081 NPY5R LOC133332
GH04I163343 Promoter/Enhancer 1.1 EPDnew Ensembl 550.8 +0.8 805 1.3 USF1 NFIB SUZ12 SIN3A USF2 E2F1 NFIC CBX8 POLR2A CTBP2 NPY1R NPY5R
GH04I163543 Enhancer 0.3 FANTOM5 1.9 -198.3 -198293 0.1 TMA16 TKTL2 MARCH1 NPY5R NPY1R ENSG00000273449 PIR37872
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around NPY1R on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the NPY1R gene promoter:

Genomic Locations for NPY1R Gene

Genomic Locations for NPY1R Gene
20,872 bases
Minus strand

Genomic View for NPY1R Gene

Genes around NPY1R on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
NPY1R Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for NPY1R Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NPY1R Gene

Proteins for NPY1R Gene

  • Protein details for NPY1R Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Neuropeptide Y receptor type 1
    Protein Accession:
    Secondary Accessions:
    • B2R6H5

    Protein attributes for NPY1R Gene

    384 amino acids
    Molecular mass:
    44392 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for NPY1R Gene

neXtProt entry for NPY1R Gene

Post-translational modifications for NPY1R Gene

  • Glycosylation at Asn2, isoforms=11, and isoforms=17
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for NPY1R Gene

Domains & Families for NPY1R Gene

Gene Families for NPY1R Gene

Human Protein Atlas (HPA):
  • G-protein coupled receptors
  • Predicted intracellular proteins
  • Predicted membrane proteins

Suggested Antigen Peptide Sequences for NPY1R Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the G-protein coupled receptor 1 family.
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with NPY1R: view

Function for NPY1R Gene

Molecular function for NPY1R Gene

GENATLAS Biochemistry:
neuropeptide Y receptor Y1,overlapping NPY5R,in opposite orientation,G protein coupled receptor superfamily
UniProtKB/Swiss-Prot Function:
Receptor for neuropeptide Y and peptide YY. The rank order of affinity of this receptor for pancreatic polypeptides is NPY > [Pro-34] PYY, PYY and [Leu-31, Pro-34] NPY > NPY (2-36) > [Ile-31, Gln-34] PP and PYY (3-36) > PP > NPY free acid.

Phenotypes From GWAS Catalog for NPY1R Gene

Gene Ontology (GO) - Molecular Function for NPY1R Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001601 peptide YY receptor activity IEA --
GO:0001602 pancreatic polypeptide receptor activity IEA,IBA --
GO:0004871 signal transducer activity IEA --
GO:0004930 G-protein coupled receptor activity IEA --
GO:0004983 neuropeptide Y receptor activity IEA,TAS 1317848
genes like me logo Genes that share ontologies with NPY1R: view
genes like me logo Genes that share phenotypes with NPY1R: view

Animal Models for NPY1R Gene

MGI Knock Outs for NPY1R:

miRNA for NPY1R Gene

miRTarBase miRNAs that target NPY1R

Clone Products

  • Addgene plasmids for NPY1R

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for NPY1R Gene

Localization for NPY1R Gene

Subcellular locations from UniProtKB/Swiss-Prot for NPY1R Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for NPY1R gene
Compartment Confidence
plasma membrane 5
nucleus 2
extracellular 1
cytosol 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (2)
  • Mitochondria (2)
  • Nucleus (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for NPY1R Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0005887 integral component of plasma membrane TAS 1317848
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with NPY1R: view

Pathways & Interactions for NPY1R Gene

genes like me logo Genes that share pathways with NPY1R: view

SIGNOR curated interactions for NPY1R Gene

Is activated by:

Gene Ontology (GO) - Biological Process for NPY1R Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003151 outflow tract morphogenesis IMP 19593212
GO:0006006 glucose metabolic process IEA --
GO:0007165 signal transduction IEA --
GO:0007186 G-protein coupled receptor signaling pathway TAS,IEA --
GO:0007187 G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger TAS 1317848
genes like me logo Genes that share ontologies with NPY1R: view

Drugs & Compounds for NPY1R Gene

(40) Drugs for NPY1R Gene - From: DrugBank, ApexBio, DGIdb, IUPHAR, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
AC162352 Investigational Pharma Target 0
BIBP3226 Pharma Antagonist 0
[<sup>125</sup>I][Leu<sup>31</sup>,Pro<sup>34</sup>]NPY Pharma Full agonist, Agonist 0
[<sup>125</sup>I]PYY (pig) Pharma Full agonist, Agonist 0
[<sup>3</sup>H]BIBP3226 Pharma Antagonist 0

(1) Additional Compounds for NPY1R Gene - From: Tocris

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
Neuropeptide Y (human, rat)

(5) Tocris Compounds for NPY1R Gene

Compound Action Cas Number
[Leu31,Pro34]-Neuropeptide Y (porcine) NPY Y1 receptor agonist 125580-28-1
BIBP 3226 trifluoroacetate Mixed NPY Y1 and NPFF receptor antagonist
GR 231118 Potent NPY Y1 antagonist/NPY Y4 agonist. Binds to NPFF receptors 158859-98-4
Neuropeptide Y (human, rat) Influences feeding and sexual behavior 90880-35-6
Pancreatic Polypeptide (human) NPY Y4 agonist; involved in gastrointestinal tract function 75976-10-2

(20) ApexBio Compounds for NPY1R Gene

Compound Action Cas Number
[cPP1-7,NPY19-23,Ala31,Aib32,Gln34] - hPancreatic Polypeptide 313988-89-5
[D-Trp34]-Neuropeptide Y 153549-84-9
[Leu31,Pro34]-Neuropeptide Y (human, rat) 132699-73-1
BIBO 3304 trifluoroacetate NPY Y1 receptor antagonist,highly selective 191868-14-1
BIBP 3226 trifluoroacetate Mixed NPY1-R and NPFF receptor inhibitor 1068148-47-9
BMS 193885 Competitive NPY Y1 receptor antagonist 679839-66-8
BVD 10 NPY Y1 receptor antagonist,highly selective 262418-00-8
CGP 71683 hydrochloride 192322-50-2
CYM 9484 1383478-94-1
GR 231118 158859-98-4
JNJ 5207787 683746-68-1
L-152,804 6508-43-6
LU AA33810 304008-29-5
Neuropeptide Y (scrambled) control in the research in NPY
NPY 5RA972 439861-56-0
NTNCB hydrochloride 191931-56-3
Pancreatic Polypeptide (human) 75976-10-2
PD 160170 181468-88-2
S 25585 263849-50-9
SF 11 443292-81-7
genes like me logo Genes that share compounds with NPY1R: view

Drug Products

Transcripts for NPY1R Gene

Unigene Clusters for NPY1R Gene

Neuropeptide Y receptor Y1:
Representative Sequences:

Clone Products

  • Addgene plasmids for NPY1R

Alternative Splicing Database (ASD) splice patterns (SP) for NPY1R Gene

ExUns: 1 ^ 2 ^ 3a · 3b ^ 4 ^ 5
SP1: -
SP2: -

Relevant External Links for NPY1R Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for NPY1R Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for NPY1R Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for NPY1R Gene

This gene is overexpressed in Spleen (x8.6) and Artery - Tibial (x4.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for NPY1R Gene

NURSA nuclear receptor signaling pathways regulating expression of NPY1R Gene:


SOURCE GeneReport for Unigene cluster for NPY1R Gene:


Evidence on tissue expression from TISSUES for NPY1R Gene

  • Nervous system(4.6)
  • Blood(4.3)
  • Pancreas(4.2)
  • Adrenal gland(2.1)
genes like me logo Genes that share expression patterns with NPY1R: view

No data available for Protein differential expression in normal tissues , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for NPY1R Gene

Orthologs for NPY1R Gene

This gene was present in the common ancestor of animals.

Orthologs for NPY1R Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia NPY1R 33 34
  • 99.56 (n)
(Canis familiaris)
Mammalia NPY1R 33 34
  • 91.97 (n)
(Bos Taurus)
Mammalia NPY1R 33 34
  • 89.82 (n)
(Mus musculus)
Mammalia Npy1r 33 16 34
  • 85.43 (n)
(Rattus norvegicus)
Mammalia Npy1r 33
  • 85.43 (n)
(Monodelphis domestica)
Mammalia mdo-mir-7323 34
  • 71 (a)
(Ornithorhynchus anatinus)
Mammalia NPY1R 34
  • 48 (a)
(Gallus gallus)
Aves NPY1R 33 34
  • 78.18 (n)
(Anolis carolinensis)
Reptilia NPY1R 34
  • 81 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia npy1r 33
  • 73.99 (n)
African clawed frog
(Xenopus laevis)
Amphibia npy1r-A 33
(Danio rerio)
Actinopterygii npy1r 33 34
  • 60.78 (n)
fruit fly
(Drosophila melanogaster)
Insecta CG10626 35
  • 31 (a)
NPFR1 35 34
  • 31 (a)
(Caenorhabditis elegans)
Secernentea npr-7 33
  • 43.04 (n)
npr-11 34
  • 25 (a)
npr-12 34
  • 24 (a)
Species where no ortholog for NPY1R was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for NPY1R Gene

Gene Tree for NPY1R (if available)
Gene Tree for NPY1R (if available)

Paralogs for NPY1R Gene

Paralogs for NPY1R Gene

(9) SIMAP similar genes for NPY1R Gene using alignment to 7 proteins: Pseudogenes for NPY1R Gene

genes like me logo Genes that share paralogs with NPY1R: view

Variants for NPY1R Gene

Sequence variations from dbSNP and Humsavar for NPY1R Gene

SNP ID Clin Chr 04 pos Variation AA Info Type
rs1000116856 -- 163,325,019(-) T/C 3_prime_UTR_variant
rs1000175280 -- 163,345,554(-) T/C upstream_transcript_variant
rs1000210239 -- 163,338,318(-) T/G genic_upstream_transcript_variant, intron_variant
rs1000387640 -- 163,332,190(-) G/T 5_prime_UTR_variant, intron_variant
rs1000438912 -- 163,345,196(-) A/C upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for NPY1R Gene

Variant ID Type Subtype PubMed ID
nsv1015505 CNV gain 25217958
nsv1030184 CNV loss 25217958
nsv822812 CNV gain 20364138

Variation tolerance for NPY1R Gene

Residual Variation Intolerance Score: 35.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.94; 19.37% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for NPY1R Gene

Human Gene Mutation Database (HGMD)
SNPedia medical, phenotypic, and genealogical associations of SNPs for

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NPY1R Gene

Disorders for NPY1R Gene

Additional Disease Information for NPY1R

Genetic Association Database
Human Genome Epidemiology Navigator
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for NPY1R Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for NPY1R Gene

Publications for NPY1R Gene

  1. Genomic organization, localization, and allelic differences in the gene for the human neuropeptide Y Y1 receptor. (PMID: 8095935) Herzog H … Shine J (The Journal of biological chemistry 1993) 2 3 4 22 58
  2. Three common variants of LEP, NPY1R and GPR54 show no association with age at menarche. (PMID: 19506390) Rothenbuhler A … Fradin D (Hormone research 2009) 3 22 44 58
  3. Variants in neuropeptide Y receptor 1 and 5 are associated with nutrient-specific food intake and are under recent selection in Europeans. (PMID: 19759915) Elbers CC … Onland-Moret NC (PloS one 2009) 3 22 44 58
  4. Association studies of BMI and type 2 diabetes in the neuropeptide Y pathway: a possible role for NPY2R as a candidate gene for type 2 diabetes in men. (PMID: 17325259) Campbell CD … Hirschhorn JN (Diabetes 2007) 3 22 44 58
  5. Melanocortin-4 receptor gene and physical activity in the Québec Family Study. (PMID: 15597110) Loos RJ … Bouchard C (International journal of obesity (2005) 2005) 3 22 44 58

Products for NPY1R Gene

  • Addgene plasmids for NPY1R

Sources for NPY1R Gene

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