This gene encodes a neuropeptide that is widely expressed in the central nervous system and influences many physiological processes, including cortical excitability, stress response, food intake, circadian rhythms, and cardiovascular function. The neuropeptide functions through G protein-coupled receptors to inhibit adenylyl cyclase, activate mitogen-activated protein kinase (M... See more...

Aliases for NPY Gene

Aliases for NPY Gene

  • Neuropeptide Y 2 3 5
  • Prepro-Neuropeptide Y 2 3
  • Pro-Neuropeptide Y 3 4
  • PYY4 2 3
  • NPY 5

External Ids for NPY Gene

Previous GeneCards Identifiers for NPY Gene

  • GC07P023966
  • GC07P024032
  • GC07P024066
  • GC07P024097

Summaries for NPY Gene

Entrez Gene Summary for NPY Gene

  • This gene encodes a neuropeptide that is widely expressed in the central nervous system and influences many physiological processes, including cortical excitability, stress response, food intake, circadian rhythms, and cardiovascular function. The neuropeptide functions through G protein-coupled receptors to inhibit adenylyl cyclase, activate mitogen-activated protein kinase (MAPK), regulate intracellular calcium levels, and activate potassium channels. A polymorphism in this gene resulting in a change of leucine 7 to proline in the signal peptide is associated with elevated cholesterol levels, higher alcohol consumption, and may be a risk factor for various metabolic and cardiovascular diseases. The protein also exhibits antimicrobial activity against bacteria and fungi. [provided by RefSeq, Oct 2014]

GeneCards Summary for NPY Gene

NPY (Neuropeptide Y) is a Protein Coding gene. Diseases associated with NPY include Eating Disorder and Adjustment Disorder. Among its related pathways are Neuroscience and Signaling by GPCR. Gene Ontology (GO) annotations related to this gene include G protein-coupled receptor activity and hormone activity. An important paralog of this gene is PYY.

UniProtKB/Swiss-Prot Summary for NPY Gene

  • NPY is implicated in the control of feeding and in secretion of gonadotrophin-release hormone.

Tocris Summary for NPY Gene

  • Neuropeptide Y (NPY) receptors are a family of Gi/o-protein-coupled receptors that are currently divided into four subtypes: Y1, Y2, Y4 and Y5. NPY receptors mediate a diverse range of biological actions including stimulation of food intake and modulation of circadian rhythm.

Gene Wiki entry for NPY Gene

No data available for CIViC Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for NPY Gene

Genomics for NPY Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for NPY Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH07J024284 Promoter 1.1 EPDnew Ensembl 600.7 +0.4 413 1.6 CTCF EZH2 ZBTB20 ZBTB26 ZBTB17 ZBTB11 ZNF777 ZNF335 ZFP37 RAD21 NPY lnc-NPY-1 ENSG00000228944 LOC107986777 MPP6
GH07J023528 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE CraniofacialAtlas 4.9 -753.7 -753700 5 BRCA1 SP1 HNRNPL CREB1 GATAD2A ZBTB33 ATF7 ZNF629 PRDM10 REST TRA2A lnc-IGF2BP3-3 piR-56376 NPY KLHL7-DT lnc-CCDC126-1 piR-30791-087 IGF2BP3
GH07J024226 Enhancer 0.5 Ensembl 11.3 -55.7 -55687 3.4 POLR2A HDAC1 RUNX3 EBF1 KDM1A CHD2 ESRRA GATA2 NPY lnc-GSDME-9 SNODB798 ENSG00000228944 LOC107986777 STK31
GH07J024290 Enhancer 0.9 Ensembl ENCODE 4.9 +6.2 6167 0.7 CTCF FOXA1 ZNF143 ZIC2 PKNOX1 REST RAD21 RCOR1 TRIM22 SIN3A NPY lnc-NPY-1 ENSG00000228944 LOC107986777 MPP6
GH07J024379 Enhancer 0.7 Ensembl ENCODE 5.7 +96.0 96012 2.8 JUND CEBPB JUN RCOR1 MAX EP300 RFX5 GATA3 SMC3 TCF7L2 NPY piR-56229-087 lnc-NPY-1 ENSG00000228944 ENSG00000287523 LOC107986777 MPP6
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around NPY on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for NPY

Top Transcription factor binding sites by QIAGEN in the NPY gene promoter:
  • AML1a
  • AP-1
  • ATF-2
  • Bach2
  • c-Jun
  • CREB
  • deltaCREB
  • Gfi-1
  • RREB-1
  • YY1

Genomic Locations for NPY Gene

Genomic Locations for NPY Gene
chr7:24,284,188-24,291,862
(GRCh38/hg38)
Size:
7,675 bases
Orientation:
Plus strand
chr7:24,323,782-24,331,484
(GRCh37/hg19)
Size:
7,703 bases
Orientation:
Plus strand

Genomic View for NPY Gene

Genes around NPY on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
NPY Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for NPY Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NPY Gene

Proteins for NPY Gene

  • Protein details for NPY Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P01303-NPY_HUMAN
    Recommended name:
    Pro-neuropeptide Y
    Protein Accession:
    P01303

    Protein attributes for NPY Gene

    Size:
    97 amino acids
    Molecular mass:
    10851 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for NPY Gene

neXtProt entry for NPY Gene

Post-translational modifications for NPY Gene

  • The neuropeptide Y form is cleaved at Pro-30 by the prolyl endopeptidase FAP (seprase) activity (in vitro).
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for NPY Gene

ENSEMBL proteins:
REFSEQ proteins:

Protein Products

No data available for DME Specific Peptides for NPY Gene

Domains & Families for NPY Gene

Gene Families for NPY Gene

HGNC:
Human Protein Atlas (HPA):
  • Plasma proteins
  • Predicted secreted proteins

Protein Domains for NPY Gene

InterPro:
Blocks:
  • Pancreatic hormone
ProtoNet:

Suggested Antigen Peptide Sequences for NPY Gene

GenScript: Design optimal peptide antigens:
  • cDNA, FLJ92442, Homo sapiens neuropeptide Y (NPY), mRNA (A4D158_HUMAN)
  • Pro-neuropeptide Y (NPY_HUMAN)

Graphical View of Domain Structure for InterPro Entry

P01303

UniProtKB/Swiss-Prot:

NPY_HUMAN :
  • Belongs to the NPY family.
Family:
  • Belongs to the NPY family.
genes like me logo Genes that share domains with NPY: view

Function for NPY Gene

Molecular function for NPY Gene

UniProtKB/Swiss-Prot Function:
NPY is implicated in the control of feeding and in secretion of gonadotrophin-release hormone.
GENATLAS Biochemistry:
neuropeptide Y,melanostatin,expressed in brain (hypothalamus),adrenals,heart,involved in the hypothalamic regulation of energy balance by stimulating food intake and favoring energy storage through increased lipoprotein lipase activity in white adipose tissue,inhibited by leptin,with a polymorphism putatively associated with high serum cholesterol and LDL-cholesterol levels

Phenotypes From GWAS Catalog for NPY Gene

Gene Ontology (GO) - Molecular Function for NPY Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001664 G protein-coupled receptor binding IBA 21873635
GO:0004930 G protein-coupled receptor activity TAS 1321422
GO:0005102 signaling receptor binding TAS 8132547
GO:0005179 hormone activity IBA 21873635
GO:0005184 neuropeptide hormone activity TAS,IBA 21873635
genes like me logo Genes that share ontologies with NPY: view
genes like me logo Genes that share phenotypes with NPY: view

Animal Models for NPY Gene

MGI Knock Outs for NPY:
  • Npy Npy<tm1Rpa>
  • Npy Npy<tm1(cre)Tkar>
  • Npy Npy<tm1(rtTA,tetO-cre/EGFP)Snby>

Animal Model Products

CRISPR Products

miRNA for NPY Gene

miRTarBase miRNAs that target NPY

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for NPY

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for NPY Gene

Localization for NPY Gene

Subcellular locations from UniProtKB/Swiss-Prot for NPY Gene

Secreted. Cytoplasmic vesicle, secretory vesicle, neuronal dense core vesicle.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for NPY gene
Compartment Confidence
extracellular 5
golgi apparatus 5
plasma membrane 3
nucleus 3
cytoskeleton 2
mitochondrion 2
peroxisome 2
endoplasmic reticulum 2
endosome 2
cytosol 2
lysosome 2

Subcellular locations from the

Human Protein Atlas (HPA)
  • Golgi apparatus (4)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for NPY Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS --
GO:0005615 extracellular space ISS --
GO:0005623 cell TAS --
GO:0005737 cytoplasm IEA --
GO:0005794 Golgi apparatus IDA --
genes like me logo Genes that share ontologies with NPY: view

Pathways & Interactions for NPY Gene

genes like me logo Genes that share pathways with NPY: view

SIGNOR curated interactions for NPY Gene

Activates:
Is inactivated by:

Gene Ontology (GO) - Biological Process for NPY Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007186 G protein-coupled receptor signaling pathway TAS --
GO:0007187 G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger TAS 8132547
GO:0007218 neuropeptide signaling pathway IBA 21873635
GO:0007268 chemical synaptic transmission TAS 10557353
GO:0007631 feeding behavior IBA 21873635
genes like me logo Genes that share ontologies with NPY: view

Drugs & Compounds for NPY Gene

(98) Drugs for NPY Gene - From: DrugBank, ApexBio, Tocris, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Phentermine Approved, Illicit Pharma Target, inhibitor 52
2-aminoisobutyric acid Experimental Pharma Target 0
L-tyrosinamide Experimental Pharma Target 0
[Leu31,Pro34]-Neuropeptide Y (porcine) Pharma NPY Y1 receptor agonist 0
BIBP 3226 trifluoroacetate Pharma Mixed NPY1-R and NPFF receptor inhibitor, Mixed NPY Y1 and NPFF receptor antagonist 0

(45) Additional Compounds for NPY Gene - From: Novoseek and Tocris

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
Neuropeptide Y (human, rat)
90880-35-6

(5) Tocris Compounds for NPY Gene

Compound Action Cas Number
[Leu31,Pro34]-Neuropeptide Y (porcine) NPY Y1 receptor agonist 125580-28-1
BIBP 3226 trifluoroacetate Mixed NPY Y1 and NPFF receptor antagonist
GR 231118 Potent NPY Y1 antagonist/NPY Y4 agonist. Binds to NPFF receptors 158859-98-4
Neuropeptide Y (human, rat) Influences feeding and sexual behavior 90880-35-6
Pancreatic Polypeptide (human) NPY Y4 agonist; involved in gastrointestinal tract function 75976-10-2

(1) ApexBio Compounds for NPY Gene

Compound Action Cas Number
[Leu31,Pro34]-Neuropeptide Y (porcine) 125580-28-1
genes like me logo Genes that share compounds with NPY: view

Drug Products

Transcripts for NPY Gene

mRNA/cDNA for NPY Gene

1 REFSEQ mRNAs :
5 NCBI additional mRNA sequence :
3 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for NPY

Alternative Splicing Database (ASD) splice patterns (SP) for NPY Gene

ExUns: 1a · 1b ^ 2 ^ 3a · 3b ^ 4 ^ 5a · 5b · 5c
SP1: -
SP2: - -
SP3:

Relevant External Links for NPY Gene

GeneLoc Exon Structure for
NPY

Expression for NPY Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for NPY Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for NPY Gene

This gene is overexpressed in Brain - Putamen (basal ganglia) (x9.2), Prostate (x8.4), Brain - Caudate (basal ganglia) (x7.6), Brain - Nucleus accumbens (basal ganglia) (x5.3), and Brain - Amygdala (x4.4).

Protein differential expression in normal tissues from HIPED for NPY Gene

This gene is overexpressed in Cerebrospinal fluid (37.4), Seminal vesicle (17.9), and Ovary (6.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for NPY Gene



Transcriptomic regulation report from SPP (The Signaling Pathways Project) for NPY

SOURCE GeneReport for Unigene cluster for NPY Gene:

Hs.1832

mRNA Expression by UniProt/SwissProt for NPY Gene:

P01303-NPY_HUMAN
Tissue specificity: One of the most abundant peptides in the nervous system. Also found in some chromaffin cells of the adrenal medulla.

Evidence on tissue expression from TISSUES for NPY Gene

  • Nervous system(4.9)
  • Liver(4.5)
  • Adrenal gland(3.7)
  • Pancreas(3.1)
  • Heart(3.1)
  • Blood(3.1)
  • Intestine(3)
  • Muscle(2.9)
  • Stomach(2.8)
  • Kidney(2.7)
  • Skin(2.6)
  • Thyroid gland(2.4)
  • Eye(2.3)
  • Bone(2.3)
genes like me logo Genes that share expression patterns with NPY: view

No data available for Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for NPY Gene

Orthologs for NPY Gene

This gene was present in the common ancestor of chordates.

Orthologs for NPY Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia NPY 30 31
  • 99.31 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia NPY 30 31
  • 92.1 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia NPY 30 31
  • 91.07 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Npy 30
  • 88.66 (n)
Mouse
(Mus musculus)
Mammalia Npy 30 17 31
  • 87.97 (n)
OneToOne
Platypus
(Ornithorhynchus anatinus)
Mammalia NPY 31
  • 86 (a)
OneToOne
Oppossum
(Monodelphis domestica)
Mammalia NPY 31
  • 76 (a)
OneToOne
Chicken
(Gallus gallus)
Aves NPY 30 31
  • 84.19 (n)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia NPY 31
  • 86 (a)
OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia npy 30
  • 74.23 (n)
African clawed frog
(Xenopus laevis)
Amphibia NPY 30
Zebrafish
(Danio rerio)
Actinopterygii npy 30 31
  • 65.59 (n)
OneToOne
Rainbow Trout
(Oncorhynchus mykiss)
Actinopterygii Omy.12071 30
Species where no ortholog for NPY was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)

Evolution for NPY Gene

ENSEMBL:
Gene Tree for NPY (if available)
TreeFam:
Gene Tree for NPY (if available)
Aminode:
Evolutionary constrained regions (ECRs) for NPY: view image

Paralogs for NPY Gene

Paralogs for NPY Gene

(3) SIMAP similar genes for NPY Gene using alignment to 2 proteins:

  • NPY_HUMAN
  • A4D158_HUMAN
genes like me logo Genes that share paralogs with NPY: view

Variants for NPY Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for NPY Gene

SNP ID Clinical significance and condition Chr 07 pos Variation AA Info Type
776210 Benign: not provided 24,285,324(+) G/A SYNONYMOUS_VARIANT
rs16139 Benign: NEUROPEPTIDE Y POLYMORPHISM. - 24,285,260(+) T/Cp.Leu7Pro MISSENSE_VARIANT
rs5571 - p.Leu22Met

Additional dbSNP identifiers (rs#s) for NPY Gene

Structural Variations from Database of Genomic Variants (DGV) for NPY Gene

Variant ID Type Subtype PubMed ID
esv2673027 CNV deletion 23128226
nsv517053 CNV gain+loss 19592680
nsv7393 OTHER inversion 18451855
nsv830927 CNV gain 17160897

Variation tolerance for NPY Gene

Residual Variation Intolerance Score: 54.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.47; 43.37% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for NPY Gene

Human Gene Mutation Database (HGMD)
NPY
SNPedia medical, phenotypic, and genealogical associations of SNPs for
NPY

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NPY Gene

Disorders for NPY Gene

MalaCards: The human disease database

(86) MalaCards diseases for NPY Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
eating disorder
  • eating disorders
adjustment disorder
  • adjustment disease
anorexia nervosa
  • an
breath-holding spells
  • bhs
reflex sympathetic dystrophy
  • complex regional pain syndrome
- elite association - COSMIC cancer census association via MalaCards
Search NPY in MalaCards View complete list of genes associated with diseases

Additional Disease Information for NPY

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
genes like me logo Genes that share disorders with NPY: view

No data available for UniProtKB/Swiss-Prot and Genatlas for NPY Gene

Publications for NPY Gene

  1. PreproNPY Pro7 protects against depression despite exposure to environmental risk factors. (PMID: 19264362) Sjöholm LK … Lavebratt C (Journal of affective disorders 2009) 3 23 41
  2. Association between neuropeptide Y gene and its receptor Y1 gene and methamphetamine dependence. (PMID: 19566775) Okahisa Y … Kuroda S (Psychiatry and clinical neurosciences 2009) 3 23 41
  3. Effects of functional polymorphisms related to catecholaminergic systems on changes in blood catecholamine and cardiovascular measures after alcohol ingestion in the Japanese population. (PMID: 18715275) Nishimura FT … Saijoh K (Alcoholism, clinical and experimental research 2008) 3 23 41
  4. Genetic variation may influence obesity only under conditions of diet: analysis of three candidate genes. (PMID: 18815063) Aberle J … Beil FU (Molecular genetics and metabolism 2008) 3 23 41
  5. Neuropeptide Y receptor genes are associated with alcohol dependence, alcohol withdrawal phenotypes, and cocaine dependence. (PMID: 18828811) Wetherill L … Foroud T (Alcoholism, clinical and experimental research 2008) 3 23 41

Products for NPY Gene

  • Addgene plasmids for NPY

Sources for NPY Gene