Aliases for NPW Gene
External Ids for NPW Gene
Previous GeneCards Identifiers for NPW Gene
The product of this gene is processed into 23- and 30-amino acid neuropeptides that bind and activate two G-protein coupled receptors in the central nervous system. The neuropeptides have been shown to enhance cortisol secretion from adrenal cells through the adenylate cyclase/protein kinase A signaling cascade. The preproprotein is translated using a non-AUG initiation codon that is inferred from analyses of the mouse ortholog. [provided by RefSeq, Jul 2008]
GeneCards Summary for NPW Gene
NPW (Neuropeptide W) is a Protein Coding gene. Diseases associated with NPW include Neurodegeneration With Brain Iron Accumulation 6 and Retinitis Pigmentosa 4. Among its related pathways are Signaling by GPCR and Peptide ligand-binding receptors. Gene Ontology (GO) annotations related to this gene include G protein-coupled receptor binding. An important paralog of this gene is NPB.
UniProtKB/Swiss-Prot Summary for NPW Gene
Plays a regulatory role in the organization of neuroendocrine signals accessing the anterior pituitary gland. Stimulates water drinking and food intake. May play a role in the hypothalamic response to stress (By similarity). NPW23 activates GPR7 and GPR8 more efficiently than NPW30.