The product of this gene is processed into 23- and 30-amino acid neuropeptides that bind and activate two G-protein coupled receptors in the central nervous system. The neuropeptides have been shown to enhance cortisol secretion from adrenal cells through the adenylate cyclase/protein kinase A signaling cascade. The preproprotein is translated using a non-AUG initiation codon t... See more...

Aliases for NPW Gene

Aliases for NPW Gene

  • Neuropeptide W 2 3 4 5
  • PPL8 2 3 4
  • Prepro-Neuropeptide W 2 3
  • Preproprotein L8 3 4
  • PPNPW 3 4
  • HPPL8 3 4
  • L8C 3
  • NPW 5
  • L8 3

External Ids for NPW Gene

Previous GeneCards Identifiers for NPW Gene

  • GC16P002012
  • GC16P002013
  • GC16P002069
  • GC16P001993
  • GC16P002059
  • GC16P002064
  • GC16P002283
  • GC16P002319
  • GC16P002342
  • GC16P002382
  • GC16P002065
  • GC16P002171
  • GC16P002173
  • GC16P002201
  • GC16P002239

Summaries for NPW Gene

Entrez Gene Summary for NPW Gene

  • The product of this gene is processed into 23- and 30-amino acid neuropeptides that bind and activate two G-protein coupled receptors in the central nervous system. The neuropeptides have been shown to enhance cortisol secretion from adrenal cells through the adenylate cyclase/protein kinase A signaling cascade. The preproprotein is translated using a non-AUG initiation codon that is inferred from analyses of the mouse ortholog. [provided by RefSeq, Jul 2008]

GeneCards Summary for NPW Gene

NPW (Neuropeptide W) is a Protein Coding gene. Diseases associated with NPW include Neurodegeneration With Brain Iron Accumulation 6 and Schimmelpenning-Feuerstein-Mims Syndrome. Among its related pathways are Signaling by GPCR and Peptide ligand-binding receptors. Gene Ontology (GO) annotations related to this gene include G protein-coupled receptor binding. An important paralog of this gene is NPB.

UniProtKB/Swiss-Prot Summary for NPW Gene

  • Plays a regulatory role in the organization of neuroendocrine signals accessing the anterior pituitary gland. Stimulates water drinking and food intake. May play a role in the hypothalamic response to stress (By similarity). NPW23 activates GPR7 and GPR8 more efficiently than NPW30.

Gene Wiki entry for NPW Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for NPW Gene

Genomics for NPW Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for NPW Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around NPW on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for NPW

Top Transcription factor binding sites by QIAGEN in the NPW gene promoter:
  • AP-1
  • AREB6
  • Egr-3
  • Elk-1
  • Nkx2-5
  • Pax-5
  • USF-1
  • USF-1:USF-2

Genomic Locations for NPW Gene

Genomic Locations for NPW Gene
chr16:2,009,926-2,020,755
(GRCh38/hg38)
Size:
10,830 bases
Orientation:
Plus strand
chr16:2,059,927-2,070,756
(GRCh37/hg19)
Size:
10,830 bases
Orientation:
Plus strand

Genomic View for NPW Gene

Genes around NPW on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
NPW Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for NPW Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NPW Gene

Proteins for NPW Gene

  • Protein details for NPW Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8N729-NPW_HUMAN
    Recommended name:
    Neuropeptide W
    Protein Accession:
    Q8N729

    Protein attributes for NPW Gene

    Size:
    165 amino acids
    Molecular mass:
    18048 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAC07172.1; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for NPW Gene

Post-translational modifications for NPW Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for NPW Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for NPW Gene

Domains & Families for NPW Gene

Gene Families for NPW Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Predicted secreted proteins

Protein Domains for NPW Gene

Suggested Antigen Peptide Sequences for NPW Gene

GenScript: Design optimal peptide antigens:
  • Preproprotein L8 (NPW_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q8N729

UniProtKB/Swiss-Prot:

NPW_HUMAN :
  • Belongs to the neuropeptide B/W family.
Family:
  • Belongs to the neuropeptide B/W family.
genes like me logo Genes that share domains with NPW: view

Function for NPW Gene

Molecular function for NPW Gene

UniProtKB/Swiss-Prot Function:
Plays a regulatory role in the organization of neuroendocrine signals accessing the anterior pituitary gland. Stimulates water drinking and food intake. May play a role in the hypothalamic response to stress (By similarity). NPW23 activates GPR7 and GPR8 more efficiently than NPW30.

Phenotypes From GWAS Catalog for NPW Gene

Gene Ontology (GO) - Molecular Function for NPW Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001664 G protein-coupled receptor binding IEA,IBA 21873635
GO:0005515 protein binding IPI 12401809
genes like me logo Genes that share ontologies with NPW: view

Phenotypes for NPW Gene

genes like me logo Genes that share phenotypes with NPW: view

Animal Model Products

  • Taconic Biosciences Mouse Models for NPW

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for NPW

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for NPW Gene

Localization for NPW Gene

Subcellular locations from UniProtKB/Swiss-Prot for NPW Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for NPW gene
Compartment Confidence
extracellular 5
nucleus 2
plasma membrane 1
cytoskeleton 1
mitochondrion 1
peroxisome 1
cytosol 1
golgi apparatus 0

Gene Ontology (GO) - Cellular Components for NPW Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS --
genes like me logo Genes that share ontologies with NPW: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for NPW Gene

Pathways & Interactions for NPW Gene

genes like me logo Genes that share pathways with NPW: view

Interacting Proteins for NPW Gene

Gene Ontology (GO) - Biological Process for NPW Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007186 G protein-coupled receptor signaling pathway IEA,TAS --
GO:0007218 neuropeptide signaling pathway IEA --
GO:0007631 feeding behavior IDA, IBA 12959997
genes like me logo Genes that share ontologies with NPW: view

No data available for SIGNOR curated interactions for NPW Gene

Drugs & Compounds for NPW Gene

(1) Drugs for NPW Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
genes like me logo Genes that share compounds with NPW: view

Transcripts for NPW Gene

mRNA/cDNA for NPW Gene

1 REFSEQ mRNAs :
7 NCBI additional mRNA sequence :
2 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for NPW

Alternative Splicing Database (ASD) splice patterns (SP) for NPW Gene

No ASD Table

Relevant External Links for NPW Gene

GeneLoc Exon Structure for
NPW

Expression for NPW Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for NPW Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for NPW Gene

This gene is overexpressed in Liver (x16.8) and Pituitary (x5.0).

Protein differential expression in normal tissues from HIPED for NPW Gene

This gene is overexpressed in Pancreatic juice (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for NPW Gene



Protein tissue co-expression partners for NPW Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for NPW

SOURCE GeneReport for Unigene cluster for NPW Gene:

Hs.233533

mRNA Expression by UniProt/SwissProt for NPW Gene:

Q8N729-NPW_HUMAN
Tissue specificity: Detected at high levels in the substantia nigra, fetal kidney and trachea; at lower levels in testis, uterus, ovary and placenta. Not detectable in many regions of the central nervous system. Also detected at high levels in lymphoblastic leukemia and colorectal adenocarcinoma.
genes like me logo Genes that share expression patterns with NPW: view

No data available for Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for NPW Gene

Orthologs for NPW Gene

This gene was present in the common ancestor of mammals.

Orthologs for NPW Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia NPW 30 31
  • 99.04 (n)
OneToOne
Mouse
(Mus musculus)
Mammalia Npw 30 17 31
  • 77.49 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Npw 30
  • 73.89 (n)
Dog
(Canis familiaris)
Mammalia -- 31
  • 71 (a)
OneToMany
-- 31
  • 46 (a)
OneToMany
Cow
(Bos Taurus)
Mammalia NPW 31
  • 59 (a)
OneToOne
Species where no ortholog for NPW was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Lizard (Anolis carolinensis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Oppossum (Monodelphis domestica)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Platypus (Ornithorhynchus anatinus)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)
  • Zebrafish (Danio rerio)

Evolution for NPW Gene

ENSEMBL:
Gene Tree for NPW (if available)
TreeFam:
Gene Tree for NPW (if available)
Aminode:
Evolutionary constrained regions (ECRs) for NPW: view image

Paralogs for NPW Gene

Paralogs for NPW Gene

genes like me logo Genes that share paralogs with NPW: view

Variants for NPW Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for NPW Gene

SNP ID Clinical significance and condition Chr 16 pos Variation AA Info Type
rs2286472 - p.Asp149Ala

Additional dbSNP identifiers (rs#s) for NPW Gene

Structural Variations from Database of Genomic Variants (DGV) for NPW Gene

Variant ID Type Subtype PubMed ID
dgv336n27 CNV loss 19166990
dgv4858n54 CNV loss 21841781
dgv4859n54 CNV loss 21841781
esv2422427 CNV duplication 17116639
nsv1160329 CNV deletion 26073780
nsv457348 CNV loss 19166990
nsv471070 CNV gain 18288195
nsv471072 CNV loss 18288195
nsv521569 CNV loss 19592680
nsv523037 CNV loss 19592680
nsv571189 CNV loss 21841781
nsv952901 CNV deletion 24416366

Variation tolerance for NPW Gene

Gene Damage Index Score: 7.38; 81.70% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for NPW Gene

Human Gene Mutation Database (HGMD)
NPW
SNPedia medical, phenotypic, and genealogical associations of SNPs for
NPW

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NPW Gene

Disorders for NPW Gene

MalaCards: The human disease database

(2) MalaCards diseases for NPW Gene - From: DISEASES

- elite association - COSMIC cancer census association via MalaCards
Search NPW in MalaCards View complete list of genes associated with diseases
genes like me logo Genes that share disorders with NPW: view

No data available for UniProtKB/Swiss-Prot and Genatlas for NPW Gene

Publications for NPW Gene

  1. Identification of natural ligands for the orphan G protein-coupled receptors GPR7 and GPR8. (PMID: 12401809) Brezillon S … Parmentier M (The Journal of biological chemistry 2003) 2 3 4 23
  2. Identification of neuropeptide W as the endogenous ligand for orphan G-protein-coupled receptors GPR7 and GPR8. (PMID: 12130646) Shimomura Y … Fujino M (The Journal of biological chemistry 2002) 3 4 23
  3. Neuropeptide B and W: neurotransmitters in an emerging G-protein-coupled receptor system. (PMID: 16847439) Singh G … Davenport AP (British journal of pharmacology 2006) 3 23
  4. Neuropeptide W is present in antral G cells of rat, mouse, and human stomach. (PMID: 16394174) Mondal MS … Nakazato M (The Journal of endocrinology 2006) 3 23
  5. Characterization of a family of endogenous neuropeptide ligands for the G protein-coupled receptors GPR7 and GPR8. (PMID: 12719537) Tanaka H … Yanagisawa M (Proceedings of the National Academy of Sciences of the United States of America 2003) 3 23

Products for NPW Gene

Sources for NPW Gene