Aliases for NPTX2 Gene
External Ids for NPTX2 Gene
Previous GeneCards Identifiers for NPTX2 Gene
This gene encodes a member of the family of neuronal petraxins, synaptic proteins that are related to C-reactive protein. This protein is involved in excitatory synapse formation. It also plays a role in clustering of alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA)-type glutamate receptors at established synapses, resulting in non-apoptotic cell death of dopaminergic nerve cells. Up-regulation of this gene in Parkinson disease (PD) tissues suggests that the protein may be involved in the pathology of PD. [provided by RefSeq, Feb 2009]
GeneCards Summary for NPTX2 Gene
NPTX2 (Neuronal Pentraxin 2) is a Protein Coding gene. Diseases associated with NPTX2 include Narcolepsy and Diabetes Insipidus. Gene Ontology (GO) annotations related to this gene include carbohydrate binding. An important paralog of this gene is NPTX1.
UniProtKB/Swiss-Prot Summary for NPTX2 Gene
Likely to play role in the modification of cellular properties that underlie long-term plasticity. Binds to agar matrix in a calcium-dependent manner (By similarity).