Aliases for NPTN Gene
External Ids for NPTN Gene
Previous HGNC Symbols for NPTN Gene
Previous GeneCards Identifiers for NPTN Gene
This gene encodes a type I transmembrane protein belonging to the Ig superfamily. The protein is believed to be involved in cell-cell interactions or cell-substrate interactions. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2009]
GeneCards Summary for NPTN Gene
NPTN (Neuroplastin) is a Protein Coding gene. Diseases associated with NPTN include Allergic Bronchopulmonary Aspergillosis and Chromosome 15Q24 Deletion Syndrome. Among its related pathways are Akt Signaling and Transmission across Chemical Synapses. Gene Ontology (GO) annotations related to this gene include cell adhesion molecule binding and type 1 fibroblast growth factor receptor binding. An important paralog of this gene is BSG.
UniProtKB/Swiss-Prot for NPTN Gene
Probable homophilic and heterophilic cell adhesion molecule involved in long term potentiation at hippocampal excitatory synapses through activation of p38MAPK. May also regulate neurite outgrowth by activating the FGFR1 signaling pathway. May play a role in synaptic plasticity (By similarity).