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Aliases for NPSR1 Gene

Aliases for NPSR1 Gene

  • Neuropeptide S Receptor 1 2 3 5
  • G-Protein Coupled Receptor For Asthma Susceptibility 3 4
  • G-Protein Coupled Receptor PGR14 3 4
  • G-Protein Coupled Receptor 154 3 4
  • GPR154 3 4
  • PGR14 3 4
  • GPRA 3 4
  • Vasopressin Receptor-Related Receptor 1 3
  • G Protein-Coupled Receptor 154 2
  • Neuropeptide S Receptor 3
  • ASRT2 3
  • NPSR 3
  • VRR1 3

External Ids for NPSR1 Gene

Previous HGNC Symbols for NPSR1 Gene

  • GPR154

Summaries for NPSR1 Gene

Entrez Gene Summary for NPSR1 Gene

  • This gene encodes a member of the vasopressin/oxytocin subfamily of G protein-coupled receptors. The encoded membrane protein acts as a receptor for neuropeptide S and affects a variety of cellular processes through its signaling. Increased expression of this gene in ciliated cells of the respiratory epithelium and in bronchial smooth muscle cells is associated with asthma. Polymorphisms in this gene have also been associated with asthma susceptibility, panic disorders, inflammatory bowel disease, and rheumatoid arthritis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2014]

GeneCards Summary for NPSR1 Gene

NPSR1 (Neuropeptide S Receptor 1) is a Protein Coding gene. Diseases associated with NPSR1 include Asthma-Related Traits 2 and Asthma. Among its related pathways are Signaling by GPCR and Peptide ligand-binding receptors. Gene Ontology (GO) annotations related to this gene include G-protein coupled receptor activity and vasopressin receptor activity. An important paralog of this gene is AVPR1B.

UniProtKB/Swiss-Prot for NPSR1 Gene

  • G-protein coupled receptor for neuropeptide S (NPS) (PubMed:16790440). Promotes mobilization of intracellular Ca(2+) stores (PubMed:16790440). Inhibits cell growth in response to NPS binding (PubMed:15947423). Involved in pathogenesis of asthma and other IgE-mediated diseases.

Gene Wiki entry for NPSR1 Gene

Additional gene information for NPSR1 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NPSR1 Gene

Genomics for NPSR1 Gene

GeneHancer (GH) Regulatory Elements for NPSR1 Gene

Promoters and enhancers for NPSR1 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH07J034658 Promoter 0.5 EPDnew 650.7 +0.1 57 0.1 NPSR1 GC07P034699 NPSR1-AS1
GH07J034747 Enhancer 1.4 Ensembl ENCODE dbSUPER 10.8 +90.4 90358 2.7 PKNOX1 FOXA2 MLX ARID4B ZNF2 ZNF48 ETS1 TCF12 SLC30A9 ZNF143 NPSR1 DPY19L1 NCAPD2P1 RPL7P31 NPSR1-AS1
GH07J034754 Enhancer 1.3 FANTOM5 ENCODE dbSUPER 10.4 +99.1 99140 4.8 PKNOX1 FOXA2 SMAD1 ARID4B YBX1 YY1 ZNF143 ATF7 KAT8 NFIL3 NPSR1 RN7SL132P GC07P034789 NPSR1-AS1
GH07J034839 Enhancer 0.6 ENCODE 10.5 +182.0 181979 1.2 AFF1 ESRRA USF1 HCFC1 SUZ12 SIX5 USF2 ZNF507 MITF ZNF217 NPSR1 GC07P034858 NPSR1-AS1 GC07P034789
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around NPSR1 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the NPSR1 gene promoter:
  • HNF-3beta
  • En-1
  • HTF
  • POU3F2
  • Pbx1a
  • HSF2
  • ATF6
  • CHOP-10
  • C/EBPalpha
  • Bach1

Genomic Locations for NPSR1 Gene

Genomic Locations for NPSR1 Gene
220,094 bases
Plus strand
220,094 bases
Plus strand

Genomic View for NPSR1 Gene

Genes around NPSR1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
NPSR1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for NPSR1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NPSR1 Gene

Proteins for NPSR1 Gene

  • Protein details for NPSR1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Neuropeptide S receptor
    Protein Accession:
    Secondary Accessions:
    • A2RTZ4
    • Q2XP58
    • Q56H76
    • Q56H77
    • Q56H78
    • Q6JSL4
    • Q6JSL5
    • Q6JSL6
    • Q6JSL7
    • Q6JSL8
    • Q6W5P3
    • Q6ZMB8

    Protein attributes for NPSR1 Gene

    371 amino acids
    Molecular mass:
    42687 Da
    Quaternary structure:
    No Data Available
    • Only isoforms with 7 transmembrane topology (isoform 1, isoform 3 and isoform 4) are transported into the plasma membrane in transfected cells, while the truncated ones retain intracellular compartments.

    Alternative splice isoforms for NPSR1 Gene

neXtProt entry for NPSR1 Gene

Post-translational modifications for NPSR1 Gene

  • Glycosylation at isoforms=2, 3, 4, 5, 6, 7, 8, 94
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for NPSR1 Gene

Domains & Families for NPSR1 Gene

Gene Families for NPSR1 Gene

Human Protein Atlas (HPA):
  • Disease related genes
  • G-protein coupled receptors
  • Potential drug targets
  • Predicted membrane proteins

Protein Domains for NPSR1 Gene

Suggested Antigen Peptide Sequences for NPSR1 Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the G-protein coupled receptor 1 family. Vasopressin/oxytocin receptor subfamily.
  • Belongs to the G-protein coupled receptor 1 family. Vasopressin/oxytocin receptor subfamily.
genes like me logo Genes that share domains with NPSR1: view

Function for NPSR1 Gene

Molecular function for NPSR1 Gene

UniProtKB/Swiss-Prot Function:
G-protein coupled receptor for neuropeptide S (NPS) (PubMed:16790440). Promotes mobilization of intracellular Ca(2+) stores (PubMed:16790440). Inhibits cell growth in response to NPS binding (PubMed:15947423). Involved in pathogenesis of asthma and other IgE-mediated diseases.

Phenotypes From GWAS Catalog for NPSR1 Gene

Gene Ontology (GO) - Molecular Function for NPSR1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004930 G-protein coupled receptor activity IEA --
GO:0005000 vasopressin receptor activity IEA --
GO:0008188 neuropeptide receptor activity IDA 16790440
genes like me logo Genes that share ontologies with NPSR1: view
genes like me logo Genes that share phenotypes with NPSR1: view

Animal Models for NPSR1 Gene

MGI Knock Outs for NPSR1:

Animal Model Products

  • Taconic Biosciences Mouse Models for NPSR1

Clone Products

  • Addgene plasmids for NPSR1

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for NPSR1 Gene

Localization for NPSR1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for NPSR1 Gene

Isoform 1: Cell membrane; Multi-pass membrane protein.
Isoform 3: Cell membrane; Multi-pass membrane protein.
Isoform 4: Cell membrane; Multi-pass membrane protein.
Isoform 2: Cytoplasm.
Isoform 5: Cytoplasm.
Isoform 6: Cytoplasm.
Isoform 7: Cytoplasm.
Isoform 9: Cytoplasm.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for NPSR1 gene
Compartment Confidence
plasma membrane 5
cytoskeleton 2
extracellular 1

Gene Ontology (GO) - Cellular Components for NPSR1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
GO:0005886 plasma membrane TAS --
GO:0005887 integral component of plasma membrane IDA 16790440
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with NPSR1: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for NPSR1 Gene

Pathways & Interactions for NPSR1 Gene

genes like me logo Genes that share pathways with NPSR1: view

Gene Ontology (GO) - Biological Process for NPSR1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction IEA --
GO:0007186 G-protein coupled receptor signaling pathway TAS --
GO:0007218 neuropeptide signaling pathway IEA --
GO:0051281 positive regulation of release of sequestered calcium ion into cytosol IDA 16790440
genes like me logo Genes that share ontologies with NPSR1: view

No data available for SIGNOR curated interactions for NPSR1 Gene

Drugs & Compounds for NPSR1 Gene

(7) Drugs for NPSR1 Gene - From: DrugBank, DGIdb, IUPHAR, HMDB, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Halothane Approved, Vet_approved Pharma Inhibitor, Activator, Target, other/unknown 2
Vasopressin Approved Pharma Full agonist, Agonist, Partial agonist 0
[<sup>125</sup>I]Tyr<sup>10</sup>NPS (human) Pharma Full agonist, Agonist 0
neuropeptide S Pharma Full agonist, Agonist 0
PI1 Pharma Antagonist 0

(1) Additional Compounds for NPSR1 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
trifluoroacetic acid
  • Acide trifluoroacetique
  • Perfluoroacetic acid
  • Trifluoressigsaeure
  • Trifluoroacetate
genes like me logo Genes that share compounds with NPSR1: view

Transcripts for NPSR1 Gene

mRNA/cDNA for NPSR1 Gene

(5) REFSEQ mRNAs :
(13) Additional mRNA sequences :
(14) Selected AceView cDNA sequences:
(9) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for NPSR1 Gene

Neuropeptide S receptor 1:
Representative Sequences:

Clone Products

  • Addgene plasmids for NPSR1

Alternative Splicing Database (ASD) splice patterns (SP) for NPSR1 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10
SP1: -
SP2: - -
SP3: - -
SP4: - - -

Relevant External Links for NPSR1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for NPSR1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for NPSR1 Gene

mRNA differential expression in normal tissues according to GTEx for NPSR1 Gene

This gene is overexpressed in Brain - Hypothalamus (x15.9), Brain - Hippocampus (x6.4), and Brain - Substantia nigra (x4.2).

NURSA nuclear receptor signaling pathways regulating expression of NPSR1 Gene:


SOURCE GeneReport for Unigene cluster for NPSR1 Gene:


mRNA Expression by UniProt/SwissProt for NPSR1 Gene:

Tissue specificity: Isoform 4 is ubiquitous; it is detected in glandular epithelia of bronchus, stomach, small intestine, colon, uterus, esophagus, spleen, kidney, pancreas, prostate and breast. Isoform 1 is detected in uterus, colon and prostate, and in the smooth muscle cell layer in bronchial and arterial walls (at protein level) (PubMed:15947423). Isoform 1 is predominantly expressed in smooth muscle. Isoform 4 is predominantly expressed in epithelial cells. In bronchial biopsies, it is expressed in smooth muscle cells of asthma patients, but not in control patients; whereas in epithelial cells, its expression is consistently stronger in asthma patients.

Evidence on tissue expression from TISSUES for NPSR1 Gene

  • Nervous system(4.5)
  • Thyroid gland(2.1)
genes like me logo Genes that share expression patterns with NPSR1: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for NPSR1 Gene

Orthologs for NPSR1 Gene

This gene was present in the common ancestor of animals.

Orthologs for NPSR1 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia NPSR1 34 33
  • 99.01 (n)
(Bos Taurus)
Mammalia NPSR1 34 33
  • 90.72 (n)
(Canis familiaris)
Mammalia NPSR1 34 33
  • 88.14 (n)
(Ornithorhynchus anatinus)
Mammalia NPSR1 34
  • 88 (a)
(Rattus norvegicus)
Mammalia Npsr1 33
  • 86.88 (n)
(Mus musculus)
Mammalia Npsr1 16 34 33
  • 86.61 (n)
(Monodelphis domestica)
Mammalia NPSR1 34
  • 80 (a)
(Gallus gallus)
Aves NPSR1 34 33
  • 74.39 (n)
(Anolis carolinensis)
Reptilia NPSR1 34
  • 67 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia npsr1 33
  • 68.19 (n)
(Danio rerio)
Actinopterygii gnrhr1 34
  • 24 (a)
fruit fly
(Drosophila melanogaster)
Insecta CcapR 34 33
  • 52.81 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta GPRVPR1 33
  • 50.36 (n)
(Caenorhabditis elegans)
Secernentea ntr-1 34
  • 17 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 28 (a)
Species where no ortholog for NPSR1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for NPSR1 Gene

Gene Tree for NPSR1 (if available)
Gene Tree for NPSR1 (if available)
Evolutionary constrained regions (ECRs) for NPSR1: view image

Paralogs for NPSR1 Gene

Paralogs for NPSR1 Gene

(4) SIMAP similar genes for NPSR1 Gene using alignment to 2 proteins:

  • B7ZMA2_HUMAN Pseudogenes for NPSR1 Gene

genes like me logo Genes that share paralogs with NPSR1: view

Variants for NPSR1 Gene

Sequence variations from dbSNP and Humsavar for NPSR1 Gene

SNP ID Clin Chr 07 pos Variation AA Info Type
rs324981 risk-factor, Asthma-related traits, susceptibility to, 2 34,778,501(+) A/T coding_sequence_variant, intron_variant, missense_variant
rs1000034503 -- 34,733,076(+) T/C intron_variant
rs1000041024 -- 34,686,010(+) A/G intron_variant
rs1000044990 -- 34,692,020(+) A/C intron_variant
rs1000049450 -- 34,726,014(+) G/A/C intron_variant

Structural Variations from Database of Genomic Variants (DGV) for NPSR1 Gene

Variant ID Type Subtype PubMed ID
dgv1080e201 CNV deletion 23290073
dgv1883e212 CNV loss 25503493
dgv1884e212 CNV loss 25503493
dgv418n21 CNV loss 19592680
dgv6320n100 CNV gain 25217958
esv2421641 CNV deletion 20811451
esv25996 CNV loss 19812545
esv2668941 CNV deletion 23128226
esv2761149 CNV loss 21179565
esv3571735 CNV loss 25503493
esv3571743 CNV loss 25503493
esv3612750 OTHER inversion 21293372
esv3612805 CNV loss 21293372
nsv1020423 CNV gain 25217958
nsv1075024 CNV deletion 25765185
nsv1132047 CNV deletion 24896259
nsv1132048 CNV deletion 24896259
nsv1135982 CNV deletion 24896259
nsv436907 CNV insertion 17901297
nsv442038 CNV loss 18776908
nsv517860 CNV loss 19592680
nsv523149 CNV loss 19592680
nsv523190 CNV gain 19592680
nsv606615 CNV loss 21841781
nsv606616 CNV loss 21841781
nsv818494 CNV loss 17921354
nsv818495 CNV loss 17921354
nsv819499 CNV loss 19587683
nsv970458 CNV duplication 23825009
nsv970812 CNV duplication 23825009
nsv971552 CNV duplication 23825009

Variation tolerance for NPSR1 Gene

Residual Variation Intolerance Score: 97.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 14.62; 96.55% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for NPSR1 Gene

Human Gene Mutation Database (HGMD)
SNPedia medical, phenotypic, and genealogical associations of SNPs for

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NPSR1 Gene

Disorders for NPSR1 Gene

MalaCards: The human disease database

(7) MalaCards diseases for NPSR1 Gene - From: HGMD, OMIM, ClinVar, GTR, DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
asthma-related traits 2
  • asthma-related traits, susceptibility to, 2
  • asthma, susceptibility to
allergic asthma
  • atopic asthma
panic disorder
  • panic disorder 1
  • eczema
- elite association - COSMIC cancer census association via MalaCards
Search NPSR1 in MalaCards View complete list of genes associated with diseases


  • Asthma-related traits 2 (ASRT2) [MIM:608584]: Asthma-related traits include clinical symptoms of asthma, such as coughing, wheezing, dyspnea, bronchial hyperresponsiveness as assessed by methacholine challenge test, serum IgE levels, atopy and atopic dermatitis. {ECO:0000269 PubMed:15073379, ECO:0000269 PubMed:15710598, ECO:0000269 PubMed:15764725}. Note=Disease susceptibility is associated with variations affecting the gene represented in this entry.

Additional Disease Information for NPSR1

Genetic Association Database
Human Genome Epidemiology Navigator
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with NPSR1: view

No data available for Genatlas for NPSR1 Gene

Publications for NPSR1 Gene

  1. Neuropeptide S receptor induces neuropeptide expression and associates with intermediate phenotypes of functional gastrointestinal disorders. (PMID: 19732772) Camilleri M … D'Amato M (Gastroenterology 2010) 3 22 44 58
  2. Lack of association between genetic variation in G-protein-coupled receptor for asthma susceptibility and childhood asthma and atopy. (PMID: 18340359) Wu H … London SJ (Genes and immunity 2008) 3 22 44 58
  3. Biological and genetic interaction between tenascin C and neuropeptide S receptor 1 in allergic diseases. (PMID: 18305139) Orsmark-Pietras C … PARSIFAL Genetics Study Group (Human molecular genetics 2008) 3 22 44 58
  4. Chromosome 7p linkage and GPR154 gene association in Italian families with allergic asthma. (PMID: 17210045) Malerba G … Pignatti PF (Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology 2007) 3 22 44 58
  5. Neuropeptide s receptor 1 gene polymorphism is associated with susceptibility to inflammatory bowel disease. (PMID: 17854592) D'Amato M … Kere J (Gastroenterology 2007) 3 22 44 58

Products for NPSR1 Gene

Sources for NPSR1 Gene

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