Aliases for NPS Gene

Aliases for NPS Gene

  • Neuropeptide S 2 3 4 5
  • Prepro-Neuropeptide S 2 3
  • NPS 5

External Ids for NPS Gene

Previous GeneCards Identifiers for NPS Gene

  • GC10U900621
  • GC10P129237
  • GC10P129347
  • GC10P122920

Summaries for NPS Gene

GeneCards Summary for NPS Gene

NPS (Neuropeptide S) is a Protein Coding gene. Diseases associated with NPS include Anxiety and Phobia, Specific. Among its related pathways are Signaling by GPCR and Peptide ligand-binding receptors.

UniProtKB/Swiss-Prot Summary for NPS Gene

  • Modulates arousal and anxiety. May play an important anorexigenic role (By similarity). Binds to its receptor NPSR1 with nanomolar affinity to increase intracellular calcium concentrations (PubMed:15312648, PubMed:16790440).

Gene Wiki entry for NPS Gene

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for NPS Gene

Genomics for NPS Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for NPS Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH10J127550 Enhancer 0.2 Ensembl 250.7 +1.6 1592 0.2 NPS HSALNG0081480 FOXI2 HSALNG0081476
GH10J127486 Enhancer 0.7 Ensembl ENCODE 12.1 -64.0 -63955 0.7 ZIC2 SIN3A REST MIER2 MNT CREB1 FOS HIC1 NPS HSALNG0081475 HSALNG0081473 INSYN2A
GH10J127524 Enhancer 0.5 Ensembl 12 -23.7 -23709 1.2 ZIC2 ZKSCAN1 JUND FOS POLR2A EP300 EZH2 NPS HSALNG0081479 piR-56341-022 HSALNG0081476 INSYN2A
GH10J127576 Enhancer 0.5 Ensembl 12.2 +27.3 27292 1.2 RAD51 SPI1 TOE1 CREB1 USF2 NPS HSALNG0081480 FOXI2 HSALNG0081476
GH10J126652 Enhancer 0.3 dbSUPER 9.1 -897.1 -897079 1.7 CEBPB CEBPG NPS C10orf90 HSALNG0081452 HSALNG0081454 ADAM12
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around NPS on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for NPS

Top Transcription factor binding sites by QIAGEN in the NPS gene promoter:
  • C/EBPbeta
  • Cart-1
  • CUTL1
  • FOXL1
  • FOXO1
  • FOXO1a
  • HOXA3
  • Pax-3
  • S8
  • TBP

Genomic Locations for NPS Gene

Latest Assembly
4,232 bases
Plus strand

Previous Assembly
(GRCh37/hg19 by Entrez Gene)
4,232 bases
Plus strand

(GRCh37/hg19 by Ensembl)
3,323 bases
Plus strand

Genomic View for NPS Gene

Genes around NPS on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
NPS Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for NPS Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NPS Gene

Proteins for NPS Gene

  • Protein details for NPS Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Neuropeptide S
    Protein Accession:

    Protein attributes for NPS Gene

    89 amino acids
    Molecular mass:
    10103 Da
    Quaternary structure:
    No Data Available

neXtProt entry for NPS Gene

Post-translational modifications for NPS Gene

No Post-translational modifications

Other Protein References for NPS Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for NPS Gene

Domains & Families for NPS Gene

Gene Families for NPS Gene

Human Protein Atlas (HPA):
  • Predicted secreted proteins

Protein Domains for NPS Gene


Suggested Antigen Peptide Sequences for NPS Gene

GenScript: Design optimal peptide antigens:
  • Neuropeptide S (NPS_HUMAN)
genes like me logo Genes that share domains with NPS: view

No data available for Graphical View of Domain Structure and UniProtKB/Swiss-Prot for NPS Gene

Function for NPS Gene

Molecular function for NPS Gene

UniProtKB/Swiss-Prot Function:
Modulates arousal and anxiety. May play an important anorexigenic role (By similarity). Binds to its receptor NPSR1 with nanomolar affinity to increase intracellular calcium concentrations (PubMed:15312648, PubMed:16790440).

Phenotypes From GWAS Catalog for NPS Gene

Animal Models for research

  • Taconic Biosciences Mouse Models for NPS

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for NPS

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for NPS Gene

Localization for NPS Gene

Subcellular locations from UniProtKB/Swiss-Prot for NPS Gene


Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for NPS gene
Compartment Confidence
extracellular 5
nucleus 2
plasma membrane 1
cytoskeleton 1
endoplasmic reticulum 1
cytosol 1

Gene Ontology (GO) - Cellular Components for NPS Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS --
genes like me logo Genes that share ontologies with NPS: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for NPS Gene

Pathways & Interactions for NPS Gene

genes like me logo Genes that share pathways with NPS: view

Interacting Proteins for NPS Gene

Gene Ontology (GO) - Biological Process for NPS Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007186 G protein-coupled receptor signaling pathway TAS --
GO:0007218 neuropeptide signaling pathway IEA --
GO:0008542 visual learning IEA --
GO:0010841 positive regulation of circadian sleep/wake cycle, wakefulness IEA --
GO:0032230 positive regulation of synaptic transmission, GABAergic IBA 21873635
genes like me logo Genes that share ontologies with NPS: view

No data available for SIGNOR curated interactions for NPS Gene

Drugs & Compounds for NPS Gene

No Compound Related Data Available

Transcripts for NPS Gene

mRNA/cDNA for NPS Gene

1 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for NPS

Alternative Splicing Database (ASD) splice patterns (SP) for NPS Gene

No ASD Table

Relevant External Links for NPS Gene

GeneLoc Exon Structure for

Expression for NPS Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for NPS Gene

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for NPS Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for NPS

SOURCE GeneReport for Unigene cluster for NPS Gene:


Evidence on tissue expression from TISSUES for NPS Gene

  • Nervous system(2.8)
genes like me logo Genes that share expression patterns with NPS: view

Primer products for research

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for NPS Gene

Orthologs for NPS Gene

This gene was present in the common ancestor of chordates.

Orthologs for NPS Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia NPS 29 30
  • 98.13 (n)
(Rattus norvegicus)
Mammalia Nps 29
  • 82.58 (n)
(Mus musculus)
Mammalia Nps 29 16 30
  • 81.44 (n)
(Canis familiaris)
Mammalia NPS 30
  • 78 (a)
(Monodelphis domestica)
Mammalia NPS 30
  • 56 (a)
(Anolis carolinensis)
Reptilia NPS 30
  • 67 (a)
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia nps 29
  • 60.85 (n)
Species where no ortholog for NPS was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • Cow (Bos Taurus)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Platypus (Ornithorhynchus anatinus)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)
  • Zebrafish (Danio rerio)

Evolution for NPS Gene

Gene Tree for NPS (if available)
Gene Tree for NPS (if available)
Evolutionary constrained regions (ECRs) for NPS: view image
Alliance of Genome Resources:
Additional Orthologs for NPS

Paralogs for NPS Gene

No data available for Paralogs for NPS Gene

Variants for NPS Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for NPS Gene

SNP ID Clinical significance and condition Chr 10 pos Variation AA Info Type
rs79477530 Benign: not provided 127,552,625(+) A/G
NM_001030013.2(NPS):c.256A>G (p.Arg86Gly)
rs4751440 -- p.Val75Leu
rs990310 -- p.Ser14Leu

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for NPS Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for NPS Gene

Variant ID Type Subtype PubMed ID
nsv1048716 CNV loss 25217958
nsv7607 CNV deletion 18451855

Variation tolerance for NPS Gene

Residual Variation Intolerance Score: 77.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.26; 62.46% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for NPS Gene

Human Gene Mutation Database (HGMD)
SNPedia medical, phenotypic, and genealogical associations of SNPs for
Leiden Open Variation Database (LOVD)

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NPS Gene

Disorders for NPS Gene

MalaCards: The human disease database

(4) MalaCards diseases for NPS Gene - From: COP and GCD

Disorder Aliases PubMed IDs
  • anxiety disorder
phobia, specific
  • phobia, simple
hematuria, benign familial
  • bfh
disease of mental health
  • mental health
- elite association - COSMIC cancer census association via MalaCards
Search NPS in MalaCards View complete list of genes associated with diseases

Additional Disease Information for NPS

Human Genome Epidemiology Navigator
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
Open Targets Platform
genes like me logo Genes that share disorders with NPS: view

No data available for UniProtKB/Swiss-Prot and Genatlas for NPS Gene

Publications for NPS Gene

  1. Neuropeptide S: a neuropeptide promoting arousal and anxiolytic-like effects. (PMID: 15312648) Xu YL … Civelli O (Neuron 2004) 2 3 4
  2. Assessment of the neuropeptide S system in anxiety disorders. (PMID: 20705147) Donner J … Hovatta I (Biological psychiatry 2010) 3 40
  3. Coeliac disease-associated risk variants in TNFAIP3 and REL implicate altered NF-kappaB signalling. (PMID: 19240061) Trynka G … Wijmenga C (Gut 2009) 3 40
  4. Synthesis and biological activity of human neuropeptide S analogues modified in position 2. (PMID: 18181564) Camarda V … Salvadori S (Journal of medicinal chemistry 2008) 2 3
  5. Structure-function relationships in the neuropeptide S receptor: molecular consequences of the asthma-associated mutation N107I. (PMID: 16790440) Bernier V … Therien AG (The Journal of biological chemistry 2006) 3 4

Products for NPS Gene

Sources for NPS Gene