Aliases for NPRL2 Gene
External Ids for NPRL2 Gene
Previous HGNC Symbols for NPRL2 Gene
GeneCards Summary for NPRL2 Gene
NPRL2 (NPR2 Like, GATOR1 Complex Subunit) is a Protein Coding gene. Diseases associated with NPRL2 include Epilepsy, Familial Focal, With Variable Foci 2 and Epilepsy, Familial Focal, With Variable Foci 1. Among its related pathways are mTOR signaling pathway (KEGG) and PI3K / Akt Signaling. Gene Ontology (GO) annotations related to this gene include protein kinase activity and GTPase activator activity.
UniProtKB/Swiss-Prot for NPRL2 Gene
As a component of the GATOR1 complex functions as an inhibitor of the amino acid-sensing branch of the TORC1 pathway. The GATOR1 complex strongly increases GTP hydrolysis by RRAGA and RRAGB within RRAGC-containing heterodimers, thereby deactivating RRAGs, releasing mTORC1 from lysosomal surface and inhibiting mTORC1 signaling. The GATOR1 complex is negatively regulated by GATOR2 the other GATOR subcomplex in this amino acid-sensing branch of the TORC1 pathway.
Suppresses Src-dependent tyrosine phosphorylation and activation of PDPK1 and its downstream signaling. Down-regulates PDPK1 kinase activity by interfering with tyrosine phosphorylation at Tyr-9, Tyr-373 and Tyr-376 residues. May act as a tumor suppressor. Suppresses cell growth and enhances sensitivity to various anticancer drugs.