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Aliases for NPR3 Gene

Aliases for NPR3 Gene

  • Natriuretic Peptide Receptor 3 2 3 5
  • Natriuretic Peptide Receptor C/Guanylate Cyclase C (Atrionatriuretic Peptide Receptor C) 2 3
  • Atrial Natriuretic Peptide Clearance Receptor 3 4
  • Atrial Natriuretic Peptide Receptor Type C 3 4
  • Atrionatriuretic Peptide Receptor C 2 3
  • Guanylate Cyclase C 2 3
  • C5orf23 3 4
  • ANPR-C 3 4
  • ANPRC 3 4
  • ANP-C 3 4
  • NPR-C 3 4
  • NPRC 3 4
  • Atrial Natriuretic Peptide Receptor 3 3
  • Chromosome 5 Open Reading Frame 23 2
  • Natriuretic Peptide Receptor C 2
  • GUCY2B 3

External Ids for NPR3 Gene

Previous HGNC Symbols for NPR3 Gene

  • NPRC
  • ANPRC
  • C5orf23

Previous GeneCards Identifiers for NPR3 Gene

  • GC05P032498
  • GC05P033158
  • GC05P032688
  • GC05P032757
  • GC05P032747

Summaries for NPR3 Gene

Entrez Gene Summary for NPR3 Gene

  • This gene encodes one of three natriuretic peptide receptors. Natriutetic peptides are small peptides which regulate blood volume and pressure, pulmonary hypertension, and cardiac function as well as some metabolic and growth processes. The product of this gene encodes a natriuretic peptide receptor responsible for clearing circulating and extracellular natriuretic peptides through endocytosis of the receptor. Multiple transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Feb 2011]

GeneCards Summary for NPR3 Gene

NPR3 (Natriuretic Peptide Receptor 3) is a Protein Coding gene. Diseases associated with NPR3 include Short-Rib Thoracic Dysplasia 5 With Or Without Polydactyly and Acromesomelic Dysplasia. Gene Ontology (GO) annotations related to this gene include protein homodimerization activity and hormone binding.

UniProtKB/Swiss-Prot for NPR3 Gene

  • Receptor for the natriuretic peptide hormones, binding with similar affinities atrial natriuretic peptide NPPA/ANP, brain natriuretic peptide NPPB/BNP, and C-type natriuretic peptide NPPC/CNP. May function as a clearance receptor for NPPA, NPPB and NPPC, regulating their local concentrations and effects. May regulate diuresis, blood pressure and skeletal development. Does not have guanylate cyclase activity.

Tocris Summary for NPR3 Gene

  • Natriuretic peptide (NP) receptors are single transmembrane catalytic receptors with intracellular guanylyl cyclase activity. There are three isoforms of NP receptors; NPR1-3, which have conserved catalytic and regulatory domains and divergent ligand binding domains.

Gene Wiki entry for NPR3 Gene

Additional gene information for NPR3 Gene

No data available for CIViC summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NPR3 Gene

Genomics for NPR3 Gene

GeneHancer (GH) Regulatory Elements for NPR3 Gene

Promoters and enhancers for NPR3 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH05I032708 Promoter/Enhancer 2.6 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 552.3 +23.8 23792 7.8 CLOCK NEUROD1 SIN3A ZNF2 BRCA1 GLIS2 ZNF143 RXRA REST SMARCB1 NPR3 ENSG00000249572 MTMR12 GC05M032746
GH05I032831 Enhancer 0.6 ENCODE 17.1 +142.8 142760 0.2 MAX CEBPB EP300 RAD21 RFX5 JUND STAT3 SMC3 RCOR1 CHD2 NPR3 GC05M032746 GC05P032857
GH05I033308 Enhancer 1.4 FANTOM5 Ensembl ENCODE dbSUPER 6.8 +622.3 622343 5.4 JUN MAX RAD21 RFX5 GATA3 ELK1 POLR2A NFYB ZNF350 FOSL2 ENSG00000250697 NPR3 ENSG00000251281 PIR55286
GH05I033369 Enhancer 1.1 FANTOM5 Ensembl ENCODE 5.9 +682.2 682198 3.6 ELK4 STAT1 SMARCC1 JUN MNT EP300 ZKSCAN1 MAFF JUND POLR2A ENSG00000250697 NPR3 ENSG00000249572 PIR55286
GH05I032851 Enhancer 0.8 Ensembl ENCODE 6.3 +163.6 163581 1.4 SMARCA5 SP1 CTCF STAT1 GLIS1 SMC3 HNF4A RAD21 NPR3 GC05P032857 GC05M032746
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around NPR3 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the NPR3 gene promoter:

Genomic Locations for NPR3 Gene

Genomic Locations for NPR3 Gene
chr5:32,689,070-32,791,724
(GRCh38/hg38)
Size:
102,655 bases
Orientation:
Plus strand
chr5:32,689,176-32,791,830
(GRCh37/hg19)

Genomic View for NPR3 Gene

Genes around NPR3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
NPR3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for NPR3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NPR3 Gene

Proteins for NPR3 Gene

  • Protein details for NPR3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P17342-ANPRC_HUMAN
    Recommended name:
    Atrial natriuretic peptide receptor 3
    Protein Accession:
    P17342
    Secondary Accessions:
    • A2RRD1
    • B4DT84
    • E7EPG9

    Protein attributes for NPR3 Gene

    Size:
    541 amino acids
    Molecular mass:
    59808 Da
    Quaternary structure:
    • Homodimer; disulfide-linked (PubMed:11533490). Dimers can also be formed through the C-terminal cysteine of isoform 2 (PubMed:11533490). Interacts with OSTN (By similarity).
    Miscellaneous:
    • Has low affinity for peptide hormones in the absence of bound chloride.

    Three dimensional structures from OCA and Proteopedia for NPR3 Gene

    Alternative splice isoforms for NPR3 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for NPR3 Gene

Post-translational modifications for NPR3 Gene

  • Glycosylation at isoforms=286, Asn293, and Asn394

Antibody Products

No data available for DME Specific Peptides for NPR3 Gene

Domains & Families for NPR3 Gene

Gene Families for NPR3 Gene

HGNC:
IUPHAR :
Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Predicted membrane proteins

Graphical View of Domain Structure for InterPro Entry

P17342

UniProtKB/Swiss-Prot:

ANPRC_HUMAN :
  • Belongs to the ANF receptor family.
Family:
  • Belongs to the ANF receptor family.
genes like me logo Genes that share domains with NPR3: view

Function for NPR3 Gene

Molecular function for NPR3 Gene

GENATLAS Biochemistry:
natriuretic peptide,receptor C,widely and abundantly expressed,involved in the systemic clearance of circulating natriuretic peptides and in the control of local effects of the natriuretic peptide system.Its complete absence,unexpectidly produces skeletal abnormalities in mice
UniProtKB/Swiss-Prot Function:
Receptor for the natriuretic peptide hormones, binding with similar affinities atrial natriuretic peptide NPPA/ANP, brain natriuretic peptide NPPB/BNP, and C-type natriuretic peptide NPPC/CNP. May function as a clearance receptor for NPPA, NPPB and NPPC, regulating their local concentrations and effects. May regulate diuresis, blood pressure and skeletal development. Does not have guanylate cyclase activity.

Phenotypes From GWAS Catalog for NPR3 Gene

Gene Ontology (GO) - Molecular Function for NPR3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 16870210
GO:0008528 G-protein coupled peptide receptor activity ISS --
GO:0016941 natriuretic peptide receptor activity IDA 1660465
GO:0017046 peptide hormone binding ISS --
GO:0031404 chloride ion binding IDA 16870210
genes like me logo Genes that share ontologies with NPR3: view
genes like me logo Genes that share phenotypes with NPR3: view

Animal Models for NPR3 Gene

MGI Knock Outs for NPR3:

Animal Model Products

miRNA for NPR3 Gene

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for NPR3 Gene

Localization for NPR3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for NPR3 Gene

Membrane; Single-pass type I membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for NPR3 gene
Compartment Confidence
plasma membrane 5
extracellular 5
peroxisome 1
endoplasmic reticulum 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for NPR3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IEA --
GO:0005887 integral component of plasma membrane IC 1660465
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
GO:0043234 protein complex IDA 16870210
genes like me logo Genes that share ontologies with NPR3: view

Pathways & Interactions for NPR3 Gene

No Data Available

Gene Ontology (GO) - Biological Process for NPR3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001501 skeletal system development ISS --
GO:0002158 osteoclast proliferation ISS --
GO:0007193 adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway IEA --
GO:0007194 negative regulation of adenylate cyclase activity IEA --
GO:0007200 phospholipase C-activating G-protein coupled receptor signaling pathway IEA --
genes like me logo Genes that share ontologies with NPR3: view

No data available for Pathways by source and SIGNOR curated interactions for NPR3 Gene

Drugs & Compounds for NPR3 Gene

(26) Drugs for NPR3 Gene - From: DrugBank, ApexBio, DGIdb, IUPHAR, HMDB, Tocris, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Nesiritide Approved, Investigational Pharma Target, binder 0
mannose Investigational Pharma 0
AP811 Pharma Antagonist 0
cANF<sup>4-23</sup> Pharma Agonist 0
M372049 Pharma Antagonist 0

(10) Additional Compounds for NPR3 Gene - From: Novoseek, IUPHAR, HMDB, and Tocris

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
[<sup>125</sup>I]ANP
Chloride ion
  • Bertholite
  • Chloor
  • Chlor
  • Chlore
  • Chloride
16887-00-6
AP 811
124833-45-0

(5) Tocris Compounds for NPR3 Gene

Compound Action Cas Number
AP 811 High affinity, selective NPR3 antagonist 124833-45-0
Atrial natriuretic factor (1-28) (human, porcine) Endogenous peptide regulating blood pressure 91917-63-4
Atrial natriuretic factor (1-28) (rat) Endogenous peptide regulating blood pressure 88898-17-3
Brain natriuretic peptide (1-32) (human) Endogenous peptide agonist at ANP receptor A (NPR1) 124584-08-3
C-type natriuretic peptide (1-22) (human, rat, swine) Endogenous peptide agonist at NPR2 127869-51-6

(1) ApexBio Compounds for NPR3 Gene

Compound Action Cas Number
BNP (1-32), human Brain natriuretic peptide 114471-18-0
genes like me logo Genes that share compounds with NPR3: view

Drug Products

Transcripts for NPR3 Gene

Unigene Clusters for NPR3 Gene

Natriuretic peptide receptor C/guanylate cyclase C (atrionatriuretic peptide receptor C):
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for NPR3 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8a · 8b
SP1:
SP2:

Relevant External Links for NPR3 Gene

GeneLoc Exon Structure for
NPR3
ECgene alternative splicing isoforms for
NPR3

Expression for NPR3 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for NPR3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for NPR3 Gene

This gene is overexpressed in Kidney - Cortex (x4.7) and Heart - Atrial Appendage (x4.0).

Protein differential expression in normal tissues from HIPED for NPR3 Gene

This gene is overexpressed in Urine (49.9) and Plasma (13.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for NPR3 Gene



Protein tissue co-expression partners for NPR3 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of NPR3 Gene:

NPR3

SOURCE GeneReport for Unigene cluster for NPR3 Gene:

Hs.13528

Evidence on tissue expression from TISSUES for NPR3 Gene

  • Kidney(4.7)
  • Eye(4.1)
  • Heart(2.7)
  • Muscle(2.6)
  • Lung(2.1)
  • Nervous system(2.1)
genes like me logo Genes that share expression patterns with NPR3: view

No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for NPR3 Gene

Orthologs for NPR3 Gene

This gene was present in the common ancestor of animals.

Orthologs for NPR3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia NPR3 33 34
  • 99.88 (n)
oppossum
(Monodelphis domestica)
Mammalia NPR3 34
  • 90 (a)
OneToOne
cow
(Bos Taurus)
Mammalia NPR3 33 34
  • 89.8 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia NPR3 34
  • 88 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Npr3 33
  • 87.1 (n)
mouse
(Mus musculus)
Mammalia Npr3 33 16 34
  • 86.79 (n)
dog
(Canis familiaris)
Mammalia NPR3 33 34
  • 85.87 (n)
chicken
(Gallus gallus)
Aves NPR3 33 34
  • 78.03 (n)
lizard
(Anolis carolinensis)
Reptilia NPR3 34
  • 21 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia npr3 33
  • 74.91 (n)
Str.10435 33
African clawed frog
(Xenopus laevis)
Amphibia Xl.689 33
zebrafish
(Danio rerio)
Actinopterygii npr3 33 34
  • 61.67 (n)
fruit fly
(Drosophila melanogaster)
Insecta CG14877 34
  • 24 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 30 (a)
OneToMany
-- 34
  • 29 (a)
OneToMany
Species where no ortholog for NPR3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for NPR3 Gene

ENSEMBL:
Gene Tree for NPR3 (if available)
TreeFam:
Gene Tree for NPR3 (if available)

Paralogs for NPR3 Gene

(1) SIMAP similar genes for NPR3 Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with NPR3: view

No data available for Paralogs for NPR3 Gene

Variants for NPR3 Gene

Sequence variations from dbSNP and Humsavar for NPR3 Gene

SNP ID Clin Chr 05 pos Variation AA Info Type
rs1000003665 -- 32,764,332(+) G/C genic_downstream_transcript_variant, intron_variant
rs1000003704 -- 32,750,082(+) T/A/C genic_downstream_transcript_variant, intron_variant
rs1000005457 -- 32,722,640(+) C/A genic_downstream_transcript_variant, intron_variant
rs1000021590 -- 32,709,251(+) T/C genic_upstream_transcript_variant, intron_variant, upstream_transcript_variant
rs1000096057 -- 32,753,562(+) T/C genic_downstream_transcript_variant, intron_variant

Structural Variations from Database of Genomic Variants (DGV) for NPR3 Gene

Variant ID Type Subtype PubMed ID
nsv950666 CNV deletion 24416366
nsv520364 CNV loss 19592680
nsv507242 OTHER sequence alteration 20534489
nsv329971 CNV deletion 16902084
nsv329020 CNV deletion 16902084
nsv1017141 CNV gain 25217958
esv3604619 CNV gain 21293372
esv3604616 CNV gain 21293372
esv2759338 CNV loss 17122850
esv2451636 CNV deletion 19546169

Variation tolerance for NPR3 Gene

Residual Variation Intolerance Score: 30.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 7.78; 83.32% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for NPR3 Gene

Human Gene Mutation Database (HGMD)
NPR3
SNPedia medical, phenotypic, and genealogical associations of SNPs for
NPR3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NPR3 Gene

Disorders for NPR3 Gene

MalaCards: The human disease database

(3) MalaCards diseases for NPR3 Gene - From: HGMD, DISEASES, and Novoseek

- elite association - COSMIC cancer census association via MalaCards
Search NPR3 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for NPR3

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with NPR3: view

No data available for UniProtKB/Swiss-Prot and Genatlas for NPR3 Gene

Publications for NPR3 Gene

  1. Influence of ScaI and natriuretic peptide (NP) clearance receptor polymorphisms of the NP System on NP concentration in chronic heart failure. (PMID: 17890443) Vassalle C … Emdin M (Clinical chemistry 2007) 3 22 44 58
  2. Structural determinants of natriuretic peptide receptor specificity and degeneracy. (PMID: 16870210) He XL … Garcia KC (Journal of molecular biology 2006) 3 4 22 58
  3. Variable number of tandem repeat of the 5'-flanking region of type-C human natriuretic peptide receptor gene influences blood pressure levels in obesity-associated hypertension. (PMID: 15785005) Aoi N … Matsumoto K (Hypertension research : official journal of the Japanese Society of Hypertension 2004) 3 22 44 58
  4. Allelic variants of natriuretic peptide receptor genes are associated with family history of hypertension and cardiovascular phenotype. (PMID: 12872042) Pitzalis MV … Rizzon P (Journal of hypertension 2003) 3 22 44 58
  5. The disulfide linkages and glycosylation sites of the human natriuretic peptide receptor-C homodimer. (PMID: 7727388) Stults JT … Lowe DG (Biochemistry 1994) 3 4 22 58

Products for NPR3 Gene

Sources for NPR3 Gene

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