Aliases for NPR3 Gene
- Natriuretic Peptide Receptor 3 2 3 5
- Natriuretic Peptide Receptor C/Guanylate Cyclase C (Atrionatriuretic Peptide Receptor C) 2 3
- Atrial Natriuretic Peptide Clearance Receptor 3 4
- Atrial Natriuretic Peptide Receptor Type C 3 4
- Atrial Natriuretic Peptide Receptor 3 3 4
- Atrionatriuretic Peptide Receptor C 2 3
- Guanylate Cyclase C 2 3
- C5orf23 3 4
External Ids for NPR3 Gene
Previous HGNC Symbols for NPR3 Gene
Previous GeneCards Identifiers for NPR3 Gene
This gene encodes one of three natriuretic peptide receptors. Natriutetic peptides are small peptides which regulate blood volume and pressure, pulmonary hypertension, and cardiac function as well as some metabolic and growth processes. The product of this gene encodes a natriuretic peptide receptor responsible for clearing circulating and extracellular natriuretic peptides through endocytosis of the receptor. Multiple transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Feb 2011]
GeneCards Summary for NPR3 Gene
NPR3 (Natriuretic Peptide Receptor 3) is a Protein Coding gene. Diseases associated with NPR3 include Functional Diarrhea and Acromesomelic Dysplasia. Gene Ontology (GO) annotations related to this gene include protein homodimerization activity and hormone binding. An important paralog of this gene is GUCY2F.
UniProtKB/Swiss-Prot Summary for NPR3 Gene
Receptor for the natriuretic peptide hormones, binding with similar affinities atrial natriuretic peptide NPPA/ANP, brain natriuretic peptide NPPB/BNP, and C-type natriuretic peptide NPPC/CNP. May function as a clearance receptor for NPPA, NPPB and NPPC, regulating their local concentrations and effects. May regulate diuresis, blood pressure and skeletal development. Does not have guanylate cyclase activity.
Natriuretic peptide (NP) receptors are single transmembrane catalytic receptors with intracellular guanylyl cyclase activity. There are three isoforms of NP receptors; NPR1-3, which have conserved catalytic and regulatory domains and divergent ligand binding domains.