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Aliases for NPR1 Gene

Aliases for NPR1 Gene

  • Natriuretic Peptide Receptor 1 2 3 5
  • Guanylate Cyclase A 2 3 4
  • Atrial Natriuretic Peptide Receptor Type A 3 4
  • Atrionatriuretic Peptide Receptor A 2 3
  • Natriuretic Peptide Receptor A 2 3
  • ANPR-A 3 4
  • ANPRA 3 4
  • ANP-A 3 4
  • NPR-A 3 4
  • GC-A 3 4
  • Natriuretic Peptide Receptor A/Guanylate Cyclase A (Atrionatriuretic Peptide Receptor A) 3
  • Atrial Natriuretic Peptide Receptor 1 3
  • Natriuretic Peptide A Type Receptor 3
  • Testicular Tissue Protein Li 20 3
  • EC 4
  • GUCY2A 3
  • GUC2A 3
  • ANPa 3
  • NPRA 3

External Ids for NPR1 Gene

Previous HGNC Symbols for NPR1 Gene

  • NPRA

Previous GeneCards Identifiers for NPR1 Gene

  • GC01P151499
  • GC01P149382
  • GC01P150426
  • GC01P150867
  • GC01P150465
  • GC01P151917
  • GC01P153651
  • GC01P125014

Summaries for NPR1 Gene

Entrez Gene Summary for NPR1 Gene

  • Guanylyl cyclases, catalyzing the production of cGMP from GTP, are classified as soluble and membrane forms (Garbers and Lowe, 1994 [PubMed 7982997]). The membrane guanylyl cyclases, often termed guanylyl cyclases A through F, form a family of cell-surface receptors with a similar topographic structure: an extracellular ligand-binding domain, a single membrane-spanning domain, and an intracellular region that contains a protein kinase-like domain and a cyclase catalytic domain. GC-A and GC-B function as receptors for natriuretic peptides; they are also referred to as atrial natriuretic peptide receptor A (NPR1) and type B (NPR2; MIM 108961). Also see NPR3 (MIM 108962), which encodes a protein with only the ligand-binding transmembrane and 37-amino acid cytoplasmic domains. NPR1 is a membrane-bound guanylate cyclase that serves as the receptor for both atrial and brain natriuretic peptides (ANP (MIM 108780) and BNP (MIM 600295), respectively).[supplied by OMIM, May 2009]

GeneCards Summary for NPR1 Gene

NPR1 (Natriuretic Peptide Receptor 1) is a Protein Coding gene. Diseases associated with NPR1 include Acromesomelic Dysplasia and Congestive Heart Failure. Among its related pathways are G-Beta Gamma Signaling and Pyrimidine metabolism (KEGG). Gene Ontology (GO) annotations related to this gene include transferase activity, transferring phosphorus-containing groups and protein tyrosine kinase activity. An important paralog of this gene is NPR2.

UniProtKB/Swiss-Prot for NPR1 Gene

  • Receptor for the atrial natriuretic peptide NPPA/ANP and the brain natriuretic peptide NPPB/BNP which are potent vasoactive hormones playing a key role in cardiovascular homeostasis. Has guanylate cyclase activity upon binding of the ligand.

Tocris Summary for NPR1 Gene

  • Natriuretic peptide (NP) receptors are single transmembrane catalytic receptors with intracellular guanylyl cyclase activity. There are three isoforms of NP receptors; NPR1-3, which have conserved catalytic and regulatory domains and divergent ligand binding domains.

Gene Wiki entry for NPR1 Gene

Additional gene information for NPR1 Gene

No data available for CIViC summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NPR1 Gene

Genomics for NPR1 Gene

GeneHancer (GH) Regulatory Elements for NPR1 Gene

Promoters and enhancers for NPR1 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH01J153677 Promoter/Enhancer 1.9 EPDnew Ensembl ENCODE dbSUPER 650.7 +0.6 631 3.3 HDGF ARID4B SIN3A GLI4 ZNF2 ZBTB7B GLIS2 ZNF143 ZNF548 DEK NPR1 S100A15A UBAP2L NUP210L SLC27A3 CRTC2 CHTOP S100A13 MIR8083
GH01J153727 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE dbSUPER 11.5 +50.9 50863 4.2 HDGF PKNOX1 SMAD1 FOXA2 ARID4B SIN3A FEZF1 DMAP1 ZNF2 YY1 INTS3 UBAP2L ILF2 CRTC2 SLC27A3 CHTOP S100A1 ADAR ATP8B2 SLC39A1
GH01J153561 Promoter/Enhancer 2.3 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 9.7 -113.1 -113056 8.8 DMAP1 YY1 ZNF213 ZNF143 SP3 MEF2D GLIS1 NBN KDM1A WT1 S100A3 S100A2 S100A6 S100A5 ENSG00000238279 S100A16 S100A13 S100A14 SNAPIN S100A1
GH01J153803 Enhancer 1.2 Ensembl ENCODE dbSUPER 9.8 +126.8 126804 4 HDGF PKNOX1 SMAD1 KLF17 STAT5A BMI1 BATF IRF4 ZNF121 ZNF143 CREB3L4 GATAD2B CRTC2 ENSG00000233222 ENSG00000243613 INTS3 NPR1 HAX1 S100A1 LOC105371448
GH01J153733 Enhancer 1 Ensembl ENCODE dbSUPER 11.5 +56.3 56256 2.2 HDGF SMARCA5 PKNOX1 ZBTB7A ZNF217 IKZF1 NBN MLLT1 PRDM1 IKZF2 S100A1 ILF2 NPR1 SNAPIN CHTOP S100A13 C1orf189 INTS3 ENSG00000243613
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around NPR1 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the NPR1 gene promoter:
  • Sp1
  • GATA-1
  • E2F-1
  • E2F
  • Nkx2-5

Genomic Locations for NPR1 Gene

Genomic Locations for NPR1 Gene
15,376 bases
Plus strand
15,356 bases
Plus strand

Genomic View for NPR1 Gene

Genes around NPR1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
NPR1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for NPR1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NPR1 Gene

Proteins for NPR1 Gene

  • Protein details for NPR1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Atrial natriuretic peptide receptor 1
    Protein Accession:
    Secondary Accessions:
    • B0ZBF0
    • Q5SR08
    • Q6P4Q3

    Protein attributes for NPR1 Gene

    1061 amino acids
    Molecular mass:
    118919 Da
    Quaternary structure:
    • Homodimer.

neXtProt entry for NPR1 Gene

Post-translational modifications for NPR1 Gene

  • Phosphorylation of the protein kinase-like domain is required for full activation by ANP.
  • Glycosylation at Asn427, Asn386, Asn379, isoforms=338, Asn212, isoforms=45, and Asn34
  • Modification sites at PhosphoSitePlus

Other Protein References for NPR1 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for NPR1 Gene

Domains & Families for NPR1 Gene

Gene Families for NPR1 Gene

Human Protein Atlas (HPA):
  • Enzymes
  • FDA approved drug targets
  • Predicted membrane proteins

Suggested Antigen Peptide Sequences for NPR1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.
  • Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.
genes like me logo Genes that share domains with NPR1: view

Function for NPR1 Gene

Molecular function for NPR1 Gene

UniProtKB/Swiss-Prot Function:
Receptor for the atrial natriuretic peptide NPPA/ANP and the brain natriuretic peptide NPPB/BNP which are potent vasoactive hormones playing a key role in cardiovascular homeostasis. Has guanylate cyclase activity upon binding of the ligand.
UniProtKB/Swiss-Prot CatalyticActivity:
GTP = 3,5-cyclic GMP + diphosphate.
GENATLAS Biochemistry:
natriuretic peptide,receptor A,expressed in kidney,vascular endothelium and adrenal glands,responding to ANP (NPPA) and to a lesser degree to BNP by mediating vasorelaxant and natriuretic functions and decreasing aldosterone synthesis

Enzyme Numbers (IUBMB) for NPR1 Gene

Phenotypes From GWAS Catalog for NPR1 Gene

Gene Ontology (GO) - Molecular Function for NPR1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004016 adenylate cyclase activity IBA --
GO:0004383 guanylate cyclase activity IEA,IDA 1672777
GO:0004672 protein kinase activity IEA --
GO:0005524 ATP binding IEA --
GO:0005525 GTP binding IEA --
genes like me logo Genes that share ontologies with NPR1: view
genes like me logo Genes that share phenotypes with NPR1: view

Animal Models for NPR1 Gene

MGI Knock Outs for NPR1:

Animal Model Products

miRNA for NPR1 Gene

miRTarBase miRNAs that target NPR1

Clone Products

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for NPR1 Gene

Localization for NPR1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for NPR1 Gene

Membrane; Single-pass type I membrane protein.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for NPR1 gene
Compartment Confidence
plasma membrane 5
nucleus 3
cytosol 3
extracellular 2
endoplasmic reticulum 1
lysosome 1
golgi apparatus 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nucleoli (2)
  • Nucleus (2)
  • Plasma membrane (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for NPR1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IEA --
GO:0005886 plasma membrane IEA,TAS --
GO:0008074 guanylate cyclase complex, soluble IBA --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with NPR1: view

Pathways & Interactions for NPR1 Gene

genes like me logo Genes that share pathways with NPR1: view

SIGNOR curated interactions for NPR1 Gene

Is activated by:

Gene Ontology (GO) - Biological Process for NPR1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006182 cGMP biosynthetic process IDA,IEA 1672777
GO:0006468 protein phosphorylation IEA --
GO:0007165 signal transduction IBA --
GO:0007166 cell surface receptor signaling pathway NAS 12547834
GO:0007168 receptor guanylyl cyclase signaling pathway IDA 1672777
genes like me logo Genes that share ontologies with NPR1: view

Drugs & Compounds for NPR1 Gene

(40) Drugs for NPR1 Gene - From: DrugBank, DGIdb, IUPHAR, HMDB, Tocris, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Erythrityl Tetranitrate Approved, Investigational Pharma stimulator, Target, agonist 0
Isosorbide Dinitrate Approved, Investigational Pharma stimulator, Target, agonist 62
Nitroglycerin Approved, Investigational Pharma inhibitor, stimulator, Target, agonist 179
Nitroprusside Approved, Investigational Pharma antagonist, Target, agonist 67
Amyl Nitrite Approved Pharma Target, agonist 1

(12) Additional Compounds for NPR1 Gene - From: Novoseek, IUPHAR, Tocris, and HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
  • [(ho)2P(O)OP(O)(OH)2]
  • Acide diphosphorique
  • Diphosphorsaeure
  • H4P2O7
  • PYROphosphATE
AP 811

(5) Tocris Compounds for NPR1 Gene

Compound Action Cas Number
AP 811 High affinity, selective NPR3 antagonist 124833-45-0
Atrial natriuretic factor (1-28) (human, porcine) Endogenous peptide regulating blood pressure 91917-63-4
Atrial natriuretic factor (1-28) (rat) Endogenous peptide regulating blood pressure 88898-17-3
Brain natriuretic peptide (1-32) (human) Endogenous peptide agonist at ANP receptor A (NPR1) 124584-08-3
C-type natriuretic peptide (1-22) (human, rat, swine) Endogenous peptide agonist at NPR2 127869-51-6
genes like me logo Genes that share compounds with NPR1: view

Transcripts for NPR1 Gene

mRNA/cDNA for NPR1 Gene

Unigene Clusters for NPR1 Gene

Natriuretic peptide receptor A/guanylate cyclase A (atrionatriuretic peptide receptor A):
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for NPR1 Gene

ExUns: 1 ^ 2a · 2b ^ 3 ^ 4 ^ 5a · 5b · 5c · 5d ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12
SP3: - - -
SP4: - -
SP5: -

Relevant External Links for NPR1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for NPR1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for NPR1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for NPR1 Gene

This gene is overexpressed in Artery - Aorta (x9.6) and Adipose - Visceral (Omentum) (x5.1).

Protein differential expression in normal tissues from HIPED for NPR1 Gene

This gene is overexpressed in Cervix (26.2), Serum (24.4), and Adipocyte (12.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for NPR1 Gene

NURSA nuclear receptor signaling pathways regulating expression of NPR1 Gene:


SOURCE GeneReport for Unigene cluster for NPR1 Gene:


Evidence on tissue expression from TISSUES for NPR1 Gene

  • Kidney(4.5)
  • Blood(4.4)
  • Eye(4.3)
  • Nervous system(2.7)
  • Heart(2.5)
  • Muscle(2.3)
  • Adrenal gland(2)
genes like me logo Genes that share expression patterns with NPR1: view

No data available for Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for NPR1 Gene

Orthologs for NPR1 Gene

This gene was present in the common ancestor of animals.

Orthologs for NPR1 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia NPR1 34 33
  • 98.71 (n)
(Bos Taurus)
Mammalia NPR1 34 33
  • 91.05 (n)
(Canis familiaris)
Mammalia NPR1 34 33
  • 90.03 (n)
(Rattus norvegicus)
Mammalia Npr1 33
  • 87.54 (n)
(Mus musculus)
Mammalia Npr1 16 34 33
  • 87.04 (n)
(Ornithorhynchus anatinus)
Mammalia NPR1 34
  • 71 (a)
(Monodelphis domestica)
Mammalia -- 34
  • 34 (a)
(Gallus gallus)
Aves -- 34
  • 34 (a)
(Anolis carolinensis)
Reptilia NPR1 34
  • 87 (a)
African clawed frog
(Xenopus laevis)
Amphibia MGC68769 33
(Danio rerio)
Actinopterygii npr1a 34 33
  • 66.01 (n)
NPR1 (1 of 2) 34
  • 62 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG5719 35
  • 56 (a)
CG3216 35 33
  • 54.41 (n)
CG14886 35
  • 38 (a)
CG10738 35
  • 37 (a)
Gyc76C 35
  • 35 (a)
Gyc32E 35
  • 35 (a)
CG31183 34
  • 32 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP008691 33
  • 54.47 (n)
(Caenorhabditis elegans)
Secernentea T01A4.1b 35
  • 58 (a)
T01A4.1a 35
  • 54 (a)
gcy-21 35
  • 46 (a)
gcy-15 35
  • 45 (a)
gcy-14 35
  • 42 (a)
gcy-31 35
  • 40 (a)
gcy-28 34
  • 36 (a)
gcy-11 35
  • 36 (a)
gcy-7 35
  • 34 (a)
gcy-12 35
  • 32 (a)
gcy-20 35
  • 32 (a)
gcy-27 35
  • 32 (a)
odr-1 35
  • 32 (a)
gcy-6 35
  • 31 (a)
gcy-5 35
  • 31 (a)
gcy-22 35
  • 31 (a)
gcy-3 35
  • 30 (a)
gcy-19 35
  • 30 (a)
gcy-9 35
  • 30 (a)
daf-11 35
  • 30 (a)
gcy-13 35
  • 30 (a)
gcy-2 35
  • 30 (a)
gcy-23 35
  • 29 (a)
gcy-4 35
  • 29 (a)
gcy-8 35
  • 28 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 66 (a)
-- 34
  • 46 (a)
Species where no ortholog for NPR1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for NPR1 Gene

Gene Tree for NPR1 (if available)
Gene Tree for NPR1 (if available)
Evolutionary constrained regions (ECRs) for NPR1: view image

Paralogs for NPR1 Gene

Paralogs for NPR1 Gene

(15) SIMAP similar genes for NPR1 Gene using alignment to 3 proteins:

  • L8E7A1_HUMAN
genes like me logo Genes that share paralogs with NPR1: view

Variants for NPR1 Gene

Sequence variations from dbSNP and Humsavar for NPR1 Gene

SNP ID Clin Chr 01 pos Variation AA Info Type
VAR_042215 A breast pleomorphic lobular carcinoma sample p.Phe270Cys
rs1000265339 -- 153,693,860(+) T/TT 3_prime_UTR_variant, genic_downstream_transcript_variant
rs1000281998 -- 153,684,435(+) A/G intron_variant
rs1000559466 -- 153,692,123(+) G/A genic_downstream_transcript_variant, intron_variant
rs1000607029 -- 153,692,264(+) A/G genic_downstream_transcript_variant, intron_variant

Structural Variations from Database of Genomic Variants (DGV) for NPR1 Gene

Variant ID Type Subtype PubMed ID
dgv582n54 CNV gain 21841781
nsv464028 CNV gain 19166990

Variation tolerance for NPR1 Gene

Residual Variation Intolerance Score: 38% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 7.22; 81.02% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for NPR1 Gene

Human Gene Mutation Database (HGMD)
SNPedia medical, phenotypic, and genealogical associations of SNPs for

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NPR1 Gene

Disorders for NPR1 Gene

MalaCards: The human disease database

(4) MalaCards diseases for NPR1 Gene - From: HGMD, DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
acromesomelic dysplasia
  • acromesomelic dwarfism
congestive heart failure
  • cardiac failure congestive
hypertensive heart disease
hypertension, essential
  • eht
- elite association - COSMIC cancer census association via MalaCards
Search NPR1 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for NPR1

Genetic Association Database
Human Genome Epidemiology Navigator
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with NPR1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for NPR1 Gene

Publications for NPR1 Gene

  1. Multi-ethnic genetic association study of carotid intima-media thickness using a targeted cardiovascular SNP microarray. (PMID: 19679847) Lanktree MB … Anand SS (Stroke 2009) 3 22 44 58
  2. Association of renin-angiotensin system and natriuretic peptide receptor A gene polymorphisms with hypertension in a Hellenic population. (PMID: 19126660) Tsezou A … Triposkiadis F (Journal of the renin-angiotensin-aldosterone system : JRAAS 2008) 3 22 44 58
  3. Genetic polymorphism of the type A human natriuretic peptide receptor (NPR-A) gene contributes to the interindividual variability in the BNP system. (PMID: 18436476) Weber M … Geisslinger G (European journal of heart failure 2008) 3 22 44 58
  4. Investigation of the association between normal-tension glaucoma and single nucleotide polymorphisms in natriuretic peptide gene. (PMID: 17460430) Jeoung JW … Yoo TW (Korean journal of ophthalmology : KJO 2007) 3 22 44 58
  5. Association of atrial natriuretic peptide and type a natriuretic peptide receptor gene polymorphisms with left ventricular mass in human essential hypertension. (PMID: 16875975) Rubattu S … Stella P (Journal of the American College of Cardiology 2006) 3 22 44 58

Products for NPR1 Gene

Sources for NPR1 Gene

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