Aliases for NPPC Gene
External Ids for NPPC Gene
Previous GeneCards Identifiers for NPPC Gene
This gene encodes a preproprotein that is proteolytically processed to generate multiple protein products. These products include the cardiac natriuretic peptides CNP-53, CNP-29 and CNP-22, which belong to the natriuretic family of peptides. The encoded peptides exhibit vasorelaxation activity in laboratory animals and elevated levels of CNP-22 have been observed in the plasma of chronic heart failure patients. [provided by RefSeq, Oct 2015]
GeneCards Summary for NPPC Gene
NPPC (Natriuretic Peptide C) is a Protein Coding gene. Diseases associated with NPPC include Achondroplasia and Hypochondroplasia. Among its related pathways are Cardiac conduction and cGMP-PKG signaling pathway. Gene Ontology (GO) annotations related to this gene include protein homodimerization activity and hormone activity.
UniProtKB/Swiss-Prot Summary for NPPC Gene
Hormone which plays a role in endochondral ossification through regulation of cartilaginous growth plate chondrocytes proliferation and differentiation. May also be vasoactive and natriuretic. Specifically binds and stimulates the cGMP production of the NPR2 receptor. Binds the clearance receptor NPR3 (By similarity).