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This gene is a member of the natriuretic peptide family and encodes a secreted protein which functions as a cardiac hormone. The protein undergoes two cleavage events, one within the cell and a second after secretion into the blood. The protein's biological actions include natriuresis, diuresis, vasorelaxation, inhibition of renin and aldosterone secretion, and a key role in cardiovascular homeostasis. A high concentration of this protein in the bloodstream is indicative of heart failure. The protein also acts as an antimicrobial peptide with antibacterial and antifungal activity. Mutations in this gene have been associated with postmenopausal osteoporosis. [provided by RefSeq, Nov 2014]
NPPB (Natriuretic Peptide B) is a Protein Coding gene. Diseases associated with NPPB include Constrictive Pericarditis and Systolic Heart Failure. Among its related pathways are Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins. and MicroRNAs in cardiomyocyte hypertrophy. Gene Ontology (GO) annotations related to this gene include signaling receptor binding and diuretic hormone activity. An important paralog of this gene is NPPA.
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005102 | signaling receptor binding | IPI | 12727915 |
GO:0005179 | hormone activity | IBA,NAS | 7601467 |
GO:0005515 | protein binding | IPI | 25416956 |
GO:0008613 | diuretic hormone activity | TAS | 14960748 |
GO:0051427 | hormone receptor binding | IBA,IPI | 1660465 |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005576 | extracellular region | TAS | 14960748 |
GO:0005615 | extracellular space | IBA,NAS | 7601467 |
GO:0005634 | nucleus | IBA | 21873635 |
GO:0005737 | cytoplasm | IBA | 21873635 |
GO:0032991 | protein-containing complex | IDA | 16870210 |
SuperPathway | Contained pathways | ||
---|---|---|---|
1 | cGMP-PKG signaling pathway | ||
2 | Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins. |
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3 | Oxytocin signaling pathway | ||
4 | Cardiomyocyte Differentiation through BMP Receptors |
Cardiomyocyte Differentiation through BMP Receptors
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5 | Human Embryonic Stem Cell Pluripotency |
Factors Promoting Cardiogenesis in Vertebrates
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GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0003085 | negative regulation of systemic arterial blood pressure | IBA | 21873635 |
GO:0006182 | cGMP biosynthetic process | IDA | 1672777 |
GO:0006457 | protein folding | IDA | 16870210 |
GO:0007166 | cell surface receptor signaling pathway | NAS | 12727915 |
GO:0007168 | receptor guanylyl cyclase signaling pathway | IBA,IDA | 1672777 |
Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
---|---|---|---|---|---|---|
Carvedilol | Approved, Investigational | Pharma | Antagonist, Target, other | 199 | ||
Testosterone | Approved, Experimental, Investigational | Pharma | Endogenous androgen receptor agonist | 660 | ||
oxymetholone | Approved, Illicit | Pharma | Target | 0 | ||
Water | Approved | Pharma | 0 | |||
Aldosterone | Experimental, Investigational | Pharma | Agonist | 0 |
Compound | Action | Cas Number |
---|---|---|
Atrial natriuretic factor (1-28) (rat) | 88898-17-3 | |
BNP (1-32), human | Brain natriuretic peptide | 114471-18-0 |
Brain natriuretic peptide (1-32) (human) | 124584-08-3 |
This gene was present in the common ancestor of chordates.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
Chimpanzee (Pan troglodytes) |
Mammalia | NPPB 30 31 |
|
OneToOne | |
Cow (Bos Taurus) |
Mammalia | NPPB 30 31 |
|
OneToOne | |
Dog (Canis familiaris) |
Mammalia | NPPB 30 31 |
|
OneToOne | |
Platypus (Ornithorhynchus anatinus) |
Mammalia | NPPB 31 |
|
OneToOne | |
Chicken (Gallus gallus) |
Aves | NPPA 31 |
|
OneToOne |
SNP ID | Clinical significance and condition | Chr 01 pos | Variation | AA Info | Type |
---|---|---|---|---|---|
710871 | Benign: not provided | 11,858,760(-) | C/A | MISSENSE_VARIANT | |
722224 | Benign: not provided | 11,858,387(-) | C/T | MISSENSE_VARIANT | |
770839 | Benign: not provided | 11,858,365(-) | G/A | SYNONYMOUS_VARIANT | |
777883 | Benign: not provided | 11,858,780(-) | A/G | SYNONYMOUS_VARIANT | |
787694 | Benign: not provided | 11,858,322(-) | C/A | MISSENSE_VARIANT |
Disorder | Aliases | PubMed IDs |
---|---|---|
constrictive pericarditis |
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systolic heart failure |
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hypertensive heart disease |
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pulmonary valve insufficiency |
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left bundle branch hemiblock |
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