This gene is a member of the natriuretic peptide family and encodes a secreted protein which functions as a cardiac hormone. The protein undergoes two cleavage events, one within the cell and a second after secretion into the blood. The protein's biological actions include natriuresis, diuresis, vasorelaxation, inhibition of renin and aldosterone secretion, and a key role in ca... See more...

Aliases for NPPB Gene

Aliases for NPPB Gene

  • Natriuretic Peptide B 2 3 5
  • Brain Natriuretic Factor Prohormone 3 4
  • Natriuretic Peptide Precursor B 2 3
  • Gamma-Brain Natriuretic Peptide 3 4
  • Natriuretic Peptides B 3 4
  • PreproBNP 3 4
  • Iso-ANP 3 4
  • ProBNP 3 4
  • Brain Type Natriuretic Peptide 3
  • Natriuretic Protein 3
  • NPPB 5
  • BNP 3

External Ids for NPPB Gene

Previous GeneCards Identifiers for NPPB Gene

  • GC01M011981
  • GC01M011762
  • GC01M011526
  • GC01M011627
  • GC01M011851
  • GC01M011918
  • GC01M011073

Summaries for NPPB Gene

Entrez Gene Summary for NPPB Gene

  • This gene is a member of the natriuretic peptide family and encodes a secreted protein which functions as a cardiac hormone. The protein undergoes two cleavage events, one within the cell and a second after secretion into the blood. The protein's biological actions include natriuresis, diuresis, vasorelaxation, inhibition of renin and aldosterone secretion, and a key role in cardiovascular homeostasis. A high concentration of this protein in the bloodstream is indicative of heart failure. The presence of myocardial injury is a significant predictor of mortality in hospitalized coronavirus disease 2019 (COVID-19) patients, and there is evidence of increased levels of natriuretic peptide B in hospitalized non-survivor COVID-19 patients. The protein also acts as an antimicrobial peptide with antibacterial and antifungal activity. Mutations in this gene have been associated with postmenopausal osteoporosis. [provided by RefSeq, Aug 2020]

GeneCards Summary for NPPB Gene

NPPB (Natriuretic Peptide B) is a Protein Coding gene. Diseases associated with NPPB include Constrictive Pericarditis and Systolic Heart Failure. Among its related pathways are cGMP-PKG signaling pathway and Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.. Gene Ontology (GO) annotations related to this gene include signaling receptor binding and diuretic hormone activity. An important paralog of this gene is NPPA.

UniProtKB/Swiss-Prot Summary for NPPB Gene

  • [Brain natriuretic peptide 32]: Cardiac hormone that plays a key role in mediating cardio-renal homeostasis (PubMed:9458824, PubMed:1672777, PubMed:1914098, PubMed:17372040). May also function as a paracrine antifibrotic factor in the heart (By similarity). Acts by specifically binding and stimulating NPR1 to produce cGMP, which in turn activates effector proteins that drive various biological responses (PubMed:9458824, PubMed:1672777, PubMed:17372040, PubMed:21098034, PubMed:17349887, PubMed:25339504). Involved in regulating the extracellular fluid volume and maintaining the fluid-electrolyte balance through natriuresis, diuresis, vasorelaxation, and inhibition of renin and aldosterone secretion (PubMed:9458824, PubMed:1914098). Binds the clearance receptor NPR3 (PubMed:16870210).
  • [NT-proBNP]: May affect cardio-renal homeostasis (PubMed:17372040). Able to promote the production of cGMP although its potency is very low compared to brain natriuretic peptide 32 (PubMed:17372040).
  • [BNP(3-32)]: May have a role in cardio-renal homeostasis (PubMed:17372040). Able to promote the production of cGMP (PubMed:17372040).

Gene Wiki entry for NPPB Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for NPPB Gene

Genomics for NPPB Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for NPPB Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around NPPB on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for NPPB

Top Transcription factor binding sites by QIAGEN in the NPPB gene promoter:
  • AP-1
  • ATF-2
  • c-Jun
  • CREB
  • Nkx2-5
  • NRSF form 1
  • NRSF form 2

Genomic Locations for NPPB Gene

Latest Assembly
chr1:11,857,464-11,858,945
(GRCh38/hg38)
Size:
1,482 bases
Orientation:
Minus strand

Previous Assembly
chr1:11,917,521-11,919,002
(GRCh37/hg19 by Entrez Gene)
Size:
1,482 bases
Orientation:
Minus strand

chr1:11,917,521-11,918,988
(GRCh37/hg19 by Ensembl)
Size:
1,468 bases
Orientation:
Minus strand

Genomic View for NPPB Gene

Genes around NPPB on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
NPPB Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for NPPB Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NPPB Gene

Proteins for NPPB Gene

  • Protein details for NPPB Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P16860-ANFB_HUMAN
    Recommended name:
    Natriuretic peptides B
    Protein Accession:
    P16860
    Secondary Accessions:
    • B0ZBE9
    • Q6FGY0
    • Q9P2Q7

    Protein attributes for NPPB Gene

    Size:
    134 amino acids
    Molecular mass:
    14726 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAA90441.1; Type=Frameshift; Evidence={ECO:0000305};
    Miscellaneous:
    • Plasma levels of natriuretic peptides B, brain natriuretic peptide 32 and NT-proBNP are widely used for screening and diagnosis of heart failure (HF), as these markers are typically higher in patients with severe HF.

    Three dimensional structures from OCA and Proteopedia for NPPB Gene

neXtProt entry for NPPB Gene

Post-translational modifications for NPPB Gene

  • The precursor molecule is proteolytically cleaved by the endoproteases FURIN or CORIN at Arg-102 to produce brain natriuretic peptide 32 and NT-proBNP (PubMed:21314817, PubMed:10880574, PubMed:21763278, PubMed:20489134, PubMed:21482747). This likely occurs after it has been secreted into the blood, either during circulation or in the target cells (PubMed:21482747). CORIN also cleaves the precursor molecule at additional residues including Arg-99 and possibly Lys-105 (PubMed:20489134, PubMed:21763278). In patients with heart failure, processing and degradation of natriuretic peptides B occurs but is delayed, possibly due to a decrease in enzyme level or activity of CORIN and DPP4 (PubMed:25339504).
  • [Brain natriuretic peptide 32]: Undergoes further proteolytic cleavage by various proteases such as DPP4, MME and possibly FAP, to give rise to a variety of shorter peptides (PubMed:16254193, PubMed:19808300, PubMed:21314817, PubMed:21098034). Cleaved at Pro-104 by the prolyl endopeptidase FAP (seprase) activity (in vitro) (PubMed:21314817). Degraded by IDE (PubMed:21098034). During IDE degradation, the resulting products initially increase the activation of NPR1 and can also stimulate NPR2 to produce cGMP before the fragments are completely degraded and inactivated by IDE (in vitro) (PubMed:21098034).
  • O-glycosylated on at least seven residues (PubMed:20489134, PubMed:21763278, PubMed:16750161, PubMed:17349887, PubMed:21482747). In cardiomyocytes, glycosylation at Thr-97 is essential for the stability and processing of the extracellular natriuretic peptides B (PubMed:21482747). Glycosylation, especially at Thr-97, may also be important for brain natriuretic peptide 32 stability and/or extracellular distribution (PubMed:21763278). Glycosylation at Thr-97 appears to inhibit FURIN- or CORIN-mediated proteolytic processing, at least in HEK293 cells (PubMed:20489134, PubMed:21763278).
  • Glycosylation at Thr62, Ser63, Ser70, Thr74, Ser79, Thr84, and Thr97
  • Modification sites at PhosphoSitePlus

Other Protein References for NPPB Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibodies for research

No data available for DME Specific Peptides for NPPB Gene

Domains & Families for NPPB Gene

Gene Families for NPPB Gene

HGNC:
Human Protein Atlas (HPA):
  • Candidate cardiovascular disease genes
  • Plasma proteins
  • Predicted secreted proteins

Protein Domains for NPPB Gene

InterPro:
Blocks:
  • Brain natriuretic peptide signature

Suggested Antigen Peptide Sequences for NPPB Gene

GenScript: Design optimal peptide antigens:
  • Gamma-brain natriuretic peptide (ANFB_HUMAN)

Graphical View of Domain Structure for InterPro Entry

P16860

UniProtKB/Swiss-Prot:

ANFB_HUMAN :
  • Belongs to the natriuretic peptide family.
Family:
  • Belongs to the natriuretic peptide family.
genes like me logo Genes that share domains with NPPB: view

Function for NPPB Gene

Molecular function for NPPB Gene

UniProtKB/Swiss-Prot Function:
[Brain natriuretic peptide 32]: Cardiac hormone that plays a key role in mediating cardio-renal homeostasis (PubMed:9458824, PubMed:1672777, PubMed:1914098, PubMed:17372040). May also function as a paracrine antifibrotic factor in the heart (By similarity). Acts by specifically binding and stimulating NPR1 to produce cGMP, which in turn activates effector proteins that drive various biological responses (PubMed:9458824, PubMed:1672777, PubMed:17372040, PubMed:21098034, PubMed:17349887, PubMed:25339504). Involved in regulating the extracellular fluid volume and maintaining the fluid-electrolyte balance through natriuresis, diuresis, vasorelaxation, and inhibition of renin and aldosterone secretion (PubMed:9458824, PubMed:1914098). Binds the clearance receptor NPR3 (PubMed:16870210).
UniProtKB/Swiss-Prot Function:
[NT-proBNP]: May affect cardio-renal homeostasis (PubMed:17372040). Able to promote the production of cGMP although its potency is very low compared to brain natriuretic peptide 32 (PubMed:17372040).
UniProtKB/Swiss-Prot Function:
[BNP(3-32)]: May have a role in cardio-renal homeostasis (PubMed:17372040). Able to promote the production of cGMP (PubMed:17372040).
GENATLAS Biochemistry:
natriuretic peptide precursor B,predominantly expressed in ventricles,also expressed in atria,present in the circulation and directly influencing blood pressure and body fluid homeostasis

Phenotypes From GWAS Catalog for NPPB Gene

Gene Ontology (GO) - Molecular Function for NPPB Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005102 signaling receptor binding IPI 12727915
GO:0005179 hormone activity IBA,NAS 7601467
GO:0005515 protein binding IPI 25416956
GO:0008613 diuretic hormone activity TAS 14960748
GO:0051427 hormone receptor binding IBA,IPI 1660465
genes like me logo Genes that share ontologies with NPPB: view
genes like me logo Genes that share phenotypes with NPPB: view

miRNA for NPPB Gene

miRTarBase miRNAs that target NPPB

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for NPPB

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for NPPB Gene

Localization for NPPB Gene

Subcellular locations from UniProtKB/Swiss-Prot for NPPB Gene

[NT-proBNP]: Secreted. Note=Detected in blood. {ECO:0000269 PubMed:18466803, ECO:0000269 PubMed:25339504}.
[proBNP(3-108)]: Secreted. Note=Detected in blood. {ECO:0000269 PubMed:17367664}.
[Brain natriuretic peptide 32]: Secreted. Note=Detected in blood. {ECO:0000269 PubMed:17367664, ECO:0000269 PubMed:18466803, ECO:0000269 PubMed:1914098, ECO:0000269 PubMed:25339504}.
[BNP(3-32)]: Secreted. Note=Detected in blood. {ECO:0000269 PubMed:17367664}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for NPPB gene
Compartment Confidence
extracellular 5
nucleus 4
cytoskeleton 3
cytosol 3
plasma membrane 2
mitochondrion 2
endoplasmic reticulum 2
peroxisome 1
endosome 1
lysosome 1
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for NPPB Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS 14960748
GO:0005615 extracellular space IBA,NAS 7601467
GO:0005634 nucleus IBA 21873635
GO:0005737 cytoplasm IBA 21873635
GO:0032991 protein-containing complex IDA 16870210
genes like me logo Genes that share ontologies with NPPB: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for NPPB Gene

Pathways & Interactions for NPPB Gene

genes like me logo Genes that share pathways with NPPB: view

Pathways by source for NPPB Gene

1 GeneGo (Thomson Reuters) pathway for NPPB Gene
  • Development Endothelin-1/EDNRA signaling
2 Qiagen pathways for NPPB Gene
  • Cardiomyocyte Differentiation through BMP Receptors
  • Factors Promoting Cardiogenesis in Vertebrates

SIGNOR curated interactions for NPPB Gene

Is activated by:
Other effect:

Gene Ontology (GO) - Biological Process for NPPB Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003085 negative regulation of systemic arterial blood pressure IBA 21873635
GO:0006182 cGMP biosynthetic process IDA 1672777
GO:0006457 protein folding IDA 16870210
GO:0007166 cell surface receptor signaling pathway NAS 12727915
GO:0007168 receptor guanylyl cyclase signaling pathway IBA,IDA 1672777
genes like me logo Genes that share ontologies with NPPB: view

Drugs & Compounds for NPPB Gene

(111) Drugs for NPPB Gene - From: DrugBank, ApexBio, HMDB, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Carvedilol Approved, Investigational Pharma Target, other 207
Testosterone Approved, Investigational Pharma Endogenous androgen receptor agonist 711
oxymetholone Approved, Illicit Pharma Target 0
Water Approved Pharma 0
Aldosterone Experimental, Investigational Pharma 0

(41) Additional Compounds for NPPB Gene - From: Novoseek and HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
8-Hydroxycarvedilol

(3) ApexBio Compounds for NPPB Gene

Compound Action Cas Number
Atrial natriuretic factor (1-28) (rat) 88898-17-3
BNP (1-32), human Brain natriuretic peptide 114471-18-0
Brain natriuretic peptide (1-32) (human) 124584-08-3
genes like me logo Genes that share compounds with NPPB: view

Transcripts for NPPB Gene

mRNA/cDNA for NPPB Gene

1 REFSEQ mRNAs :
5 NCBI additional mRNA sequence :
1 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for NPPB

Alternative Splicing Database (ASD) splice patterns (SP) for NPPB Gene

No ASD Table

Relevant External Links for NPPB Gene

GeneLoc Exon Structure for
NPPB

Expression for NPPB Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for NPPB Gene

mRNA differential expression in normal tissues according to GTEx for NPPB Gene

This gene is overexpressed in Heart - Atrial Appendage (x37.9) and Heart - Left Ventricle (x14.7).

Protein differential expression in normal tissues from HIPED for NPPB Gene

This gene is overexpressed in Plasma (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for NPPB Gene



Protein tissue co-expression partners for NPPB Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for NPPB

SOURCE GeneReport for Unigene cluster for NPPB Gene:

Hs.219140

mRNA Expression by UniProt/SwissProt for NPPB Gene:

P16860-ANFB_HUMAN
Tissue specificity: [Brain natriuretic peptide 32]: Detected in the cardiac atria (at protein level) (PubMed:2138890, PubMed:2136732). Detected in the kidney distal tubular cells (at protein level) (PubMed:9794555).

Evidence on tissue expression from TISSUES for NPPB Gene

  • Heart(4.3)
  • Muscle(4.2)
  • Pancreas(4.2)
  • Spleen(4.2)
  • Blood(2.8)
  • Nervous system(2.8)
  • Kidney(2.2)
  • Urine(2.2)
  • Skin(2.1)
genes like me logo Genes that share expression patterns with NPPB: view

Primer products for research

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for NPPB Gene

Orthologs for NPPB Gene

This gene was present in the common ancestor of chordates.

Orthologs for NPPB Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia NPPB 29 30
  • 99 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia NPPB 29 30
  • 73.13 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia NPPB 29 30
  • 67.86 (n)
OneToOne
Platypus
(Ornithorhynchus anatinus)
Mammalia NPPB 30
  • 34 (a)
OneToOne
Chicken
(Gallus gallus)
Aves NPPA 30
  • 28 (a)
OneToOne
Species where no ortholog for NPPB was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Lizard (Anolis carolinensis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Mouse (Mus musculus)
  • Oppossum (Monodelphis domestica)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rat (Rattus norvegicus)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)
  • Zebrafish (Danio rerio)

Evolution for NPPB Gene

ENSEMBL:
Gene Tree for NPPB (if available)
TreeFam:
Gene Tree for NPPB (if available)
Aminode:
Evolutionary constrained regions (ECRs) for NPPB: view image
Alliance of Genome Resources:
Additional Orthologs for NPPB

Paralogs for NPPB Gene

Paralogs for NPPB Gene

genes like me logo Genes that share paralogs with NPPB: view

Variants for NPPB Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for NPPB Gene

SNP ID Clinical significance and condition Chr 01 pos Variation AA Info Type
rs141128240 Benign: not provided 11,858,204(-) G/T
NM_002521.3(NPPB):c.388+10C>A
INTRON
rs35628673 Benign: not provided 11,858,780(-) A/G
NM_002521.3(NPPB):c.54T>C (p.His18=)
SYNONYMOUS
rs35640285 Benign: not provided 11,858,322(-) C/A
NM_002521.3(NPPB):c.280G>T (p.Val94Phe)
MISSENSE
rs35690395 Benign: not provided 11,858,365(-) G/A
NM_002521.3(NPPB):c.237C>T (p.Ser79=)
SYNONYMOUS
rs5227 Benign: not provided 11,858,760(-) C/Ap.Arg25Leu
NM_002521.3(NPPB):c.74G>T (p.Arg25Leu)
MISSENSE

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for NPPB Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Variation tolerance for NPPB Gene

Residual Variation Intolerance Score: 83.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.20; 24.21% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for NPPB Gene

Human Gene Mutation Database (HGMD)
NPPB
SNPedia medical, phenotypic, and genealogical associations of SNPs for
NPPB
Leiden Open Variation Database (LOVD)
NPPB

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for NPPB Gene

Disorders for NPPB Gene

MalaCards: The human disease database

(113) MalaCards diseases for NPPB Gene - From: COP and GCD

Disorder Aliases PubMed IDs
constrictive pericarditis
  • pericarditis constrictive
systolic heart failure
  • heart failure, systolic
hypertensive heart disease
left bundle branch hemiblock
  • left bundle branch block
cardiogenic shock
  • shock cardiogenic
- elite association - COSMIC cancer census association via MalaCards
Search NPPB in MalaCards View complete list of genes associated with diseases

Additional Disease Information for NPPB

Human Genome Epidemiology Navigator
(HuGE)
Atlas
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
Open Targets Platform
genes like me logo Genes that share disorders with NPPB: view

No data available for UniProtKB/Swiss-Prot and Genatlas for NPPB Gene

Publications for NPPB Gene

  1. Dysfunctional corin i555(p568) allele is associated with impaired brain natriuretic peptide processing and adverse outcomes in blacks with systolic heart failure: results from the Genetic Risk Assessment in Heart Failure substudy. (PMID: 19919978) Rame JE … Dries DL (Circulation. Heart failure 2009) 3 22 40
  2. Association between the T-381C polymorphism of the brain natriuretic peptide gene and risk of type 2 diabetes in human populations. (PMID: 17412758) Meirhaeghe A … Amouyel P (Human molecular genetics 2007) 3 22 40
  3. A novel variable number of tandem repeat of the natriuretic peptide precursor B gene's 5'-flanking region is associated with essential hypertension among Japanese females. (PMID: 17554401) Kosuge K … Matsumoto K (International journal of medical sciences 2007) 3 22 40
  4. Mutation analysis of the natriuretic peptide precursor B (NPPB) gene in patients with hypertrophic cardiomyopathy. (PMID: 17343213) Chiu C … Semsarian C (DNA sequence : the journal of DNA sequencing and mapping 2006) 3 22 40
  5. Structural determinants of natriuretic peptide receptor specificity and degeneracy. (PMID: 16870210) He XL … Garcia KC (Journal of molecular biology 2006) 3 4 22

Products for NPPB Gene

  • Addgene plasmids for NPPB

Sources for NPPB Gene