Aliases for NPPB Gene
External Ids for NPPB Gene
Previous GeneCards Identifiers for NPPB Gene
This gene is a member of the natriuretic peptide family and encodes a secreted protein which functions as a cardiac hormone. The protein undergoes two cleavage events, one within the cell and a second after secretion into the blood. The protein's biological actions include natriuresis, diuresis, vasorelaxation, inhibition of renin and aldosterone secretion, and a key role in cardiovascular homeostasis. A high concentration of this protein in the bloodstream is indicative of heart failure. The protein also acts as an antimicrobial peptide with antibacterial and antifungal activity. Mutations in this gene have been associated with postmenopausal osteoporosis. [provided by RefSeq, Nov 2014]
GeneCards Summary for NPPB Gene
NPPB (Natriuretic Peptide B) is a Protein Coding gene. Diseases associated with NPPB include Constrictive Pericarditis and Systolic Heart Failure. Among its related pathways are Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins. and MicroRNAs in cardiomyocyte hypertrophy. Gene Ontology (GO) annotations related to this gene include signaling receptor binding and diuretic hormone activity. An important paralog of this gene is NPPA.
UniProtKB/Swiss-Prot Summary for NPPB Gene
Cardiac hormone which may function as a paracrine antifibrotic factor in the heart. Also plays a key role in cardiovascular homeostasis through natriuresis, diuresis, vasorelaxation, and inhibition of renin and aldosterone secretion. Specifically binds and stimulates the cGMP production of the NPR1 receptor. Binds the clearance receptor NPR3.