Aliases for NPPA-AS1 Gene

Subcategory (RNA class) for NPPA-AS1 Gene

lncRNA

Quality Score for this RNA gene is

13

Aliases for NPPA-AS1 Gene

  • NPPA Antisense RNA 1 2 3
  • NPPA Antisense RNA 1 (Non-Protein Coding) 2 3
  • NPPA Antisense RNA (Non-Protein Coding) 2
  • HSALNG0000905 169
  • NPPA-AS1 2
  • NPPA-AS 3
  • NPPAAS 3

External Ids for NPPA-AS1 Gene

Previous HGNC Symbols for NPPA-AS1 Gene

  • NPPAAS
  • NPPA-AS

Previous GeneCards Identifiers for NPPA-AS1 Gene

  • GC01U903122
  • GC01P011905
  • GC01P011907
  • GC01P011844
  • GC01P011846
  • GC01P011856
  • GC01P011858
  • GC01P011848
  • GC01P011849
  • GC01P011850
  • GC01P011851
  • GC01P011852
  • GC01P011853
  • GC01P011854
  • GC01P011855

Summaries for NPPA-AS1 Gene

GeneCards Summary for NPPA-AS1 Gene

NPPA-AS1 (NPPA Antisense RNA 1) is an RNA Gene, and is affiliated with the lncRNA class. Diseases associated with NPPA-AS1 include Atrial Fibrillation, Familial, 6 and Atrial Standstill 2.

Rfam classification for NPPA-AS1 Gene

  • NPPA antisense RNA 1 conserved region 2
  • NPPA antisense RNA 1 conserved region 3
  • NPPA antisense RNA 1 conserved region 1

Additional gene information for NPPA-AS1 Gene

No data available for Entrez Gene Summary , CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary and piRNA Summary for NPPA-AS1 Gene

Genomics for NPPA-AS1 Gene

GeneHancer (GH) Regulatory Elements for NPPA-AS1 Gene

Promoters and enhancers for NPPA-AS1 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH01J011838 Enhancer 0.8 ENCODE 792 -1.5 -1480 0.2 CTCF RBPJ CC2D1A RAD21 HDGF ELF3 CSDE1 AHR CEBPG SP7 NPPA-AS1 piR-35944 UBIAD1 TARDBP lnc-C1orf167-1 CLCN6
GH01J011840 Enhancer 1.2 Ensembl ENCODE 44.2 +2.1 2107 4.3 LCORL FOXA1 MLX RBPJ SMARCE1 NR2F1 NR2F6 ATF1 CREB1 MIXL1 ENSG00000276470 piR-35944 NPPA-AS1 TARDBP ENSG00000226849 AGTRAP EXOSC10 MTHFR CLCN6 MIIP
GH01J011784 Promoter/Enhancer 2.2 VISTA EPDnew Ensembl ENCODE CraniofacialAtlas dbSUPER 17.4 -51.5 -51496 8.9 CTCF FOXA1 MLX SMARCE1 RUNX1 CC2D1A L3MBTL2 RAD21 ZNF121 MNT piR-60961 C1orf167 CLCN6 AGTRAP MTHFR NPPA-AS1 NPPB C1orf167-AS1
GH01J011800 Promoter/Enhancer 2.4 EPDnew Ensembl ENCODE CraniofacialAtlas dbSUPER 13.7 -36.1 -36091 8.3 SIN3A SP1 ZBTB40 SREBF1 SIX5 ZBTB6 MLX RBPJ SMARCE1 POLR2A CLCN6 MTHFR lnc-NPPA-1 TARDBP ENSG00000226849 EXOSC10 UBIAD1 NPPA-AS1 AGTRAP KIAA2013
GH01J011846 Promoter/Enhancer 1 VISTA EPDnew Ensembl 23.4 +7.4 7395 1.8 POLR2A RCOR1 ENSG00000275915 NPPA NPPA-AS1 CLCN6 MIIP
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around NPPA-AS1 on UCSC Golden Path with GeneCards custom track

Genomic Locations for NPPA-AS1 Gene

Genomic Locations for NPPA-AS1 Gene
chr1:11,840,319-11,847,723
(GRCh38/hg38)
Size:
7,405 bases
Orientation:
Plus strand
chr1:11,900,376-11,908,136
(GRCh37/hg19)
Size:
7,761 bases
Orientation:
Plus strand

Genomic View for NPPA-AS1 Gene

Genes around NPPA-AS1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
NPPA-AS1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for NPPA-AS1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NPPA-AS1 Gene

Proteins for NPPA-AS1 Gene

Post-translational modifications for NPPA-AS1 Gene

No Post-translational modifications

No data available for DME Specific Peptides for NPPA-AS1 Gene

Domains & Families for NPPA-AS1 Gene

No data available for Gene Families , Protein Domains , Suggested Antigen Peptide Sequences , Graphical View of Domain Structure and UniProtKB/Swiss-Prot for NPPA-AS1 Gene

Function for NPPA-AS1 Gene

Phenotypes From GWAS Catalog for NPPA-AS1 Gene

Gene Ontology (GO) - Molecular Function for NPPA-AS1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003729 mRNA binding IEA --
genes like me logo Genes that share ontologies with NPPA-AS1: view

Animal Model Products

CRISPR Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for NPPA-AS1 Gene

Localization for NPPA-AS1 Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for NPPA-AS1 Gene

Pathways & Interactions for NPPA-AS1 Gene

PathCards logo

SuperPathways for NPPA-AS1 Gene

No Data Available

Gene Ontology (GO) - Biological Process for NPPA-AS1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0010468 regulation of gene expression IEA --
genes like me logo Genes that share ontologies with NPPA-AS1: view

No data available for Pathways by source and SIGNOR curated interactions for NPPA-AS1 Gene

Drugs & Compounds for NPPA-AS1 Gene

(3) Drugs for NPPA-AS1 Gene - From: PharmGKB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Bumetanide Approved Pharma Agonist, Inhibition, Inhibitor NKCC cotransporter inhibitor, Na+/2Cl-/K+ (NKCC) symporter inhibitor 25
Furosemide Approved, Vet_approved Pharma Agonist, Inhibition, Inhibitor GABAA receptors antagonist, Na+/2Cl-/K+ (NKCC) symporter inhibitor. Also antagonizes GABAA 241
Torasemide Approved Pharma 0
genes like me logo Genes that share compounds with NPPA-AS1: view

Transcripts for NPPA-AS1 Gene

CRISPR Products

Alternative Splicing Database (ASD) splice patterns (SP) for NPPA-AS1 Gene

No ASD Table

Relevant External Links for NPPA-AS1 Gene

GeneLoc Exon Structure for
NPPA-AS1
ECgene alternative splicing isoforms for
NPPA-AS1

Expression for NPPA-AS1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for NPPA-AS1 Gene

mRNA differential expression in normal tissues according to GTEx for NPPA-AS1 Gene

This gene is overexpressed in Heart - Atrial Appendage (x51.2).
genes like me logo Genes that share expression patterns with NPPA-AS1: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for NPPA-AS1 Gene

Orthologs for NPPA-AS1 Gene

No data available for Orthologs and Evolution for NPPA-AS1 Gene

Paralogs for NPPA-AS1 Gene

No data available for Paralogs for NPPA-AS1 Gene

Variants for NPPA-AS1 Gene

Sequence variations from dbSNP and Humsavar for NPPA-AS1 Gene

SNP ID Clin Chr 01 pos Variation AA Info Type
rs1215729892 uncertain-significance, Atrial fibrillation, familial, 6 11,847,193(+) T/C intron_variant
rs142022010 likely-benign, Atrial fibrillation, familial, 6 11,847,271(+) C/T intron_variant
rs142116829 likely-benign, benign, Atrial fibrillation, familial, 6, not specified 11,847,602(+) A/G/T non_coding_transcript_variant
rs142653342 uncertain-significance, Atrial fibrillation, familial, 6 11,847,662(+) G/A downstream_transcript_variant
rs147081122 uncertain-significance, likely-benign, Atrial fibrillation, familial, 6, not specified 11,847,211(+) G/A/T intron_variant

Structural Variations from Database of Genomic Variants (DGV) for NPPA-AS1 Gene

Variant ID Type Subtype PubMed ID
nsv527521 CNV loss 19592680

Additional Variant Information for NPPA-AS1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
NPPA-AS1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for NPPA-AS1 Gene

Disorders for NPPA-AS1 Gene

MalaCards: The human disease database

(3) MalaCards diseases for NPPA-AS1 Gene - From: GeneCards

Disorder Aliases PubMed IDs
atrial fibrillation, familial, 6
  • atfb6
atrial standstill 2
  • atrst2
atrial standstill
  • atrial cardiomyopathy with heart block
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for NPPA-AS1

genes like me logo Genes that share disorders with NPPA-AS1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for NPPA-AS1 Gene

Publications for NPPA-AS1 Gene

  1. Natural antisense transcript of natriuretic peptide precursor A (NPPA): structural organization and modulation of NPPA expression. (PMID: 19671135) Annilo T … Laan M (BMC molecular biology 2009) 2 3 56
  2. Genome-wide association analysis and fine mapping of NT-proBNP level provide novel insight into the role of the MTHFR-CLCN6-NPPA-NPPB gene cluster. (PMID: 21273288) Del Greco M F … Pramstaller PP (Human molecular genetics 2011) 3 56

Products for NPPA-AS1 Gene

Sources for NPPA-AS1 Gene