Aliases for NPPA-AS1 Gene

Subcategory (RNA class) for NPPA-AS1 Gene

lncRNA

Number of RNA Genes sources:

2 / 17

Aliases for NPPA-AS1 Gene

  • NPPA Antisense RNA 1 2 3
  • NPPA Antisense RNA 1 (Non-Protein Coding) 2 3
  • NPPA Antisense RNA (Non-Protein Coding) 2
  • HSALNG0000905 164
  • NPPA-AS1 2
  • NPPA-AS 3
  • NPPAAS 3

External Ids for NPPA-AS1 Gene

Previous HGNC Symbols for NPPA-AS1 Gene

  • NPPAAS
  • NPPA-AS

Previous GeneCards Identifiers for NPPA-AS1 Gene

  • GC01U903122
  • GC01P011905
  • GC01P011907
  • GC01P011844
  • GC01P011846
  • GC01P011856
  • GC01P011858
  • GC01P011859
  • GC01P011862
  • GC01P011848
  • GC01P011849
  • GC01P011850
  • GC01P011851
  • GC01P011852
  • GC01P011853
  • GC01P011854
  • GC01P011855

Summaries for NPPA-AS1 Gene

GeneCards Summary for NPPA-AS1 Gene

NPPA-AS1 (NPPA Antisense RNA 1) is an RNA Gene, and is affiliated with the lncRNA class. Diseases associated with NPPA-AS1 include Cardiovascular System Disease and Atrial Fibrillation, Familial, 6.

Rfam classification for NPPA-AS1 Gene

  • NPPA antisense RNA 1 conserved region 2
  • NPPA antisense RNA 1 conserved region 3
  • NPPA antisense RNA 1 conserved region 1

Additional gene information for NPPA-AS1 Gene

No data available for Entrez Gene Summary , CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary and piRNA Summary for NPPA-AS1 Gene

Genomics for NPPA-AS1 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for NPPA-AS1 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH01J011838 Enhancer 0.9 ENCODE 642.1 -1.5 -1480 0.2 GATAD2A CTCF ZNF692 POLR2A JUND STAT3 ZNF143 RXRB ZNF24 REST NPPA-AS1 piR-35944 NPPA lnc-C1orf167-1 MTHFR CLCN6
GH01J011840 Enhancer 1.2 Ensembl ENCODE 44.3 +2.1 2107 4.3 GATAD2A ATF7 REST TFE3 ZNF512 LEF1 SOX13 IKZF1 NFKBIZ JUND ENSG00000276470 piR-35944 NPPA-AS1 TARDBP ENSG00000226849 EXOSC10 MTHFR CLCN6 MIIP NPPA
GH01J011784 Promoter/Enhancer 2.2 VISTA EPDnew Ensembl ENCODE CraniofacialAtlas dbSUPER 17.4 -51.5 -51496 8.9 ARHGAP35 HNRNPL CREB1 GATAD2A CTCF TEAD4 ZNF629 REST TFE3 LEF1 piR-60961 C1orf167 MTHFR NPPA-AS1 CLCN6 AGTRAP NPPB C1orf167-AS1
GH01J011800 Promoter/Enhancer 2.4 EPDnew Ensembl ENCODE CraniofacialAtlas dbSUPER 13.7 -36.1 -36091 8.3 SP1 HNRNPL CREB1 GATAD2A PRDM10 REST ZNF629 TFE3 ZNF512 SIX5 CLCN6 MTHFR lnc-NPPA-1 ENSG00000226849 TARDBP EXOSC10 NPPA-AS1 ENSG00000271895 UBIAD1 TNFRSF8
GH01J011846 Promoter/Enhancer 1.1 VISTA EPDnew Ensembl 23.5 +7.4 7395 1.8 POLR2A RCOR1 CHD2 ENSG00000275915 NPPA NPPA-AS1 CLCN6 MIIP MTHFR
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around NPPA-AS1 on the GeneHancer Hub at the UCSC Golden Path

Genomic Locations for NPPA-AS1 Gene

Genomic Locations for NPPA-AS1 Gene
chr1:11,840,319-11,847,723
(GRCh38/hg38)
Size:
7,405 bases
Orientation:
Plus strand
chr1:11,900,376-11,908,136
(GRCh37/hg19)
Size:
7,761 bases
Orientation:
Plus strand

Genomic View for NPPA-AS1 Gene

Genes around NPPA-AS1 on UCSC Golden Path with GeneCards custom track
NPPA-AS1 in the GeneCards ncRNA compendium hub on the UCSC Golden Path

Cytogenetic band:
NPPA-AS1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for NPPA-AS1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NPPA-AS1 Gene

Proteins for NPPA-AS1 Gene

Post-translational modifications for NPPA-AS1 Gene

No Post-translational modifications

No data available for DME Specific Peptides for NPPA-AS1 Gene

Domains & Families for NPPA-AS1 Gene

Gene Families for NPPA-AS1 Gene

genes like me logo Genes that share domains with NPPA-AS1: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences , Graphical View of Domain Structure and UniProtKB/Swiss-Prot for NPPA-AS1 Gene

Function for NPPA-AS1 Gene

Phenotypes From GWAS Catalog for NPPA-AS1 Gene

Gene Ontology (GO) - Molecular Function for NPPA-AS1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003729 mRNA binding IEA --
genes like me logo Genes that share ontologies with NPPA-AS1: view

Animal Model Products

CRISPR Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for NPPA-AS1 Gene

Localization for NPPA-AS1 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for NPPA-AS1 gene
Compartment Confidence
nucleus 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for NPPA-AS1 Gene

Pathways & Interactions for NPPA-AS1 Gene

PathCards logo

SuperPathways for NPPA-AS1 Gene

No Data Available

Gene Ontology (GO) - Biological Process for NPPA-AS1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0010468 regulation of gene expression IEA --
genes like me logo Genes that share ontologies with NPPA-AS1: view

No data available for Pathways by source , Interacting Proteins and SIGNOR curated interactions for NPPA-AS1 Gene

Drugs & Compounds for NPPA-AS1 Gene

(3) Drugs for NPPA-AS1 Gene - From: PharmGKB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Bumetanide Approved Pharma Agonist, Inhibitor, Inhibition NKCC cotransporter inhibitor, Na+/2Cl-/K+ (NKCC) symporter inhibitor 26
Furosemide Approved, Vet_approved Pharma Agonist, Inhibitor, Inhibition GABAA receptors antagonist, Na+/2Cl-/K+ (NKCC) symporter inhibitor. Also antagonizes GABAA 263
Torasemide Approved Pharma 0
genes like me logo Genes that share compounds with NPPA-AS1: view

Transcripts for NPPA-AS1 Gene

Non-coding RNA (ncRNA) Transcripts from RNAcentral for NPPA-AS1 Gene

RNAcentral Transcript ID Subcategory Length (nts) # of Sources Source Identifiers and Annotations
URS000075D3D8_9606 lncRNA 1662 3

HGNC: 37635,

RefSeq: NR_037806,

LncBook: HSALNT0001792,

URS00002D6AB6_9606 antisense_RNA 1663 1

ENA: FJ706070.1:1..1663:ncRNA,

URS00001814EE_9606 antisense_RNA 1540 1

ENA: FJ706071.1:1..1540:ncRNA,

URS00002142E0_9606 antisense_RNA 957 1

ENA: FJ706072.1:1..957:ncRNA,

URS00003C110F_9606 antisense_RNA 934 1

ENA: FJ706073.1:1..934:ncRNA,

NPPA-AS1 in the GeneCards ncRNA compendium hub on the UCSC Golden Path

Additional transcripts not in RNAcentral for NPPA-AS1 Gene

12 NCBI additional mRNA sequence :

CRISPR Products

Alternative Splicing Database (ASD) splice patterns (SP) for NPPA-AS1 Gene

No ASD Table

Relevant External Links for NPPA-AS1 Gene

GeneLoc Exon Structure for
NPPA-AS1

Expression for NPPA-AS1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for NPPA-AS1 Gene

mRNA differential expression in normal tissues according to GTEx for NPPA-AS1 Gene

This gene is overexpressed in Heart - Atrial Appendage (x51.2).
genes like me logo Genes that share expression patterns with NPPA-AS1: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for NPPA-AS1 Gene

Orthologs for NPPA-AS1 Gene

No data available for Orthologs and Evolution for NPPA-AS1 Gene

Paralogs for NPPA-AS1 Gene

No data available for Paralogs for NPPA-AS1 Gene

Variants for NPPA-AS1 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for NPPA-AS1 Gene

SNP ID Clinical significance and condition Chr 01 pos Variation AA Info Type
642370 Uncertain Significance: Atrial fibrillation, familial, 6 11,847,355(+) C/A MISSENSE_VARIANT
643252 Uncertain Significance: Atrial fibrillation, familial, 6 11,847,213(+) G/A MISSENSE_VARIANT
644514 Uncertain Significance: Atrial fibrillation, familial, 6 11,847,573(+) T/C MISSENSE_VARIANT,NON_CODING_TRANSCRIPT_VARIANT
652171 Uncertain Significance: Atrial fibrillation, familial, 6 11,847,196(+) G/T SYNONYMOUS_VARIANT
727649 Likely Benign: not provided 11,847,404(+) T/C SYNONYMOUS_VARIANT

Additional dbSNP identifiers (rs#s) for NPPA-AS1 Gene

Structural Variations from Database of Genomic Variants (DGV) for NPPA-AS1 Gene

Variant ID Type Subtype PubMed ID
nsv527521 CNV loss 19592680

Additional Variant Information for NPPA-AS1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
NPPA-AS1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for NPPA-AS1 Gene

Disorders for NPPA-AS1 Gene

MalaCards: The human disease database

(4) MalaCards diseases for NPPA-AS1 Gene - From: LncRNADisease, DISEASES, and GeneCards

Disorder Aliases PubMed IDs
cardiovascular system disease
  • disease of subdivision of hemolymphoid system
atrial fibrillation, familial, 6
  • atfb6
atrial standstill 2
  • atrst2
atrial standstill
  • atrial cardiomyopathy with heart block
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for NPPA-AS1

genes like me logo Genes that share disorders with NPPA-AS1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for NPPA-AS1 Gene

Publications for NPPA-AS1 Gene

  1. Natural antisense transcript of natriuretic peptide precursor A (NPPA): structural organization and modulation of NPPA expression. (PMID: 19671135) Annilo T … Laan M (BMC molecular biology 2009) 2 3
  2. Genome-wide association analysis and fine mapping of NT-proBNP level provide novel insight into the role of the MTHFR-CLCN6-NPPA-NPPB gene cluster. (PMID: 21273288) Del Greco M F … Pramstaller PP (Human molecular genetics 2011) 3

Products for NPPA-AS1 Gene

Sources for NPPA-AS1 Gene