Free for academic non-profit institutions. Other users need a Commercial license

Aliases for NPPA-AS1 Gene

Subcategory (RNA class) for NPPA-AS1 Gene

non-coding RNA

Quality Score for this RNA gene is

3

Aliases for NPPA-AS1 Gene

  • NPPA Antisense RNA 1 2 3 5
  • NPPA Antisense RNA 1 (Non-Protein Coding) 2 3
  • NPPA Antisense RNA (Non-Protein Coding) 2
  • NPPA-AS 3
  • NPPAAS 3

External Ids for NPPA-AS1 Gene

Previous HGNC Symbols for NPPA-AS1 Gene

  • NPPAAS
  • NPPA-AS

Previous GeneCards Identifiers for NPPA-AS1 Gene

  • GC01U903122
  • GC01P011905
  • GC01P011907
  • GC01P011844
  • GC01P011846
  • GC01P011848
  • GC01P011849
  • GC01P011850
  • GC01P011851
  • GC01P011852

Summaries for NPPA-AS1 Gene

GeneCards Summary for NPPA-AS1 Gene

NPPA-AS1 (NPPA Antisense RNA 1) is an RNA Gene, and is affiliated with the non-coding RNA class.

Additional gene information for NPPA-AS1 Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NPPA-AS1 Gene

Genomics for NPPA-AS1 Gene

GeneHancer (GH) Regulatory Elements for NPPA-AS1 Gene

Promoters and enhancers for NPPA-AS1 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH01I011840 Enhancer 1.3 Ensembl ENCODE 594.4 +1.9 1911 4 HDGF PKNOX1 SMAD1 FOXA2 MLX ARNT ZFP64 ARID4B DMAP1 YY1 NPPA-AS1 ENSG00000276470 GC01P011841 PIR58989 TARDBP ENSG00000226849 EXOSC10 MTHFR CLCN6 MIIP
GH01I011838 Enhancer 0.9 ENCODE 592.2 -1.5 -1480 0.2 ELF3 HDGF RB1 ARID4B KLF17 SIN3A ZNF2 ZNF48 RAD21 E2F8 NPPA-AS1 GC01P011841 PIR58989 CLCN6 MTHFR
GH01I011800 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 13.7 -36.1 -36091 8.3 CLOCK MLX DMAP1 YY1 E2F8 ZNF143 SP3 NFYC MEF2D ZNF610 CLCN6 MTHFR ENSG00000226849 TARDBP NPPA-AS1 EXOSC10 UBIAD1 TNFRSF8 MIIP GC01M011785
GH01I011784 Enhancer 1.6 VISTA Ensembl ENCODE dbSUPER 17.4 -51.7 -51667 9.2 HDGF FOXA2 PKNOX1 SMAD1 ZFP64 ARID4B SIN3A ZNF2 YY1 POLR2B GC01M011790 PIR55960 MTHFR NPPA-AS1 CLCN6 AGTRAP NPPB GC01M011785 LOC102724659 C1orf167
GH01I011846 Promoter/Enhancer 1.1 VISTA EPDnew 23.4 +7.4 7395 1.8 POLR2A RCOR1 CHD2 ENSG00000275915 NPPA NPPA-AS1 CLCN6 MIIP
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around NPPA-AS1 on UCSC Golden Path with GeneCards custom track

Genomic Locations for NPPA-AS1 Gene

Genomic Locations for NPPA-AS1 Gene
chr1:11,840,319-11,848,079
(GRCh38/hg38)
Size:
7,761 bases
Orientation:
Plus strand
chr1:11,900,376-11,908,136
(GRCh37/hg19)

Genomic View for NPPA-AS1 Gene

Genes around NPPA-AS1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
NPPA-AS1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for NPPA-AS1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NPPA-AS1 Gene

Proteins for NPPA-AS1 Gene

Post-translational modifications for NPPA-AS1 Gene

No Post-translational modifications

No data available for DME Specific Peptides for NPPA-AS1 Gene

Domains & Families for NPPA-AS1 Gene

Graphical View of Domain Structure for InterPro Entry

No data available for Gene Families , Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for NPPA-AS1 Gene

Function for NPPA-AS1 Gene

Phenotypes From GWAS Catalog for NPPA-AS1 Gene

Animal Model Products

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for NPPA-AS1 Gene

Localization for NPPA-AS1 Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for NPPA-AS1 Gene

Pathways & Interactions for NPPA-AS1 Gene

SuperPathways for NPPA-AS1 Gene

No Data Available

Interacting Proteins for NPPA-AS1 Gene

Gene Ontology (GO) - Biological Process for NPPA-AS1 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for NPPA-AS1 Gene

Drugs & Compounds for NPPA-AS1 Gene

(3) Drugs for NPPA-AS1 Gene - From: PharmGKB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Bumetanide Approved Pharma Agonist NKCC cotransporter inhibitor, Na+/2Cl-/K+ (NKCC) symporter inhibitor 19
Furosemide Approved, Vet_approved Pharma Agonist GABAA receptors antagonist, Na+/2Cl-/K+ (NKCC) symporter inhibitor. Also antagonizes GABAA 209
Torasemide Approved Pharma 0
genes like me logo Genes that share compounds with NPPA-AS1: view

Transcripts for NPPA-AS1 Gene

mRNA/cDNA for NPPA-AS1 Gene

(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for NPPA-AS1 Gene

No ASD Table

Relevant External Links for NPPA-AS1 Gene

GeneLoc Exon Structure for
NPPA-AS1
ECgene alternative splicing isoforms for
NPPA-AS1

Expression for NPPA-AS1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for NPPA-AS1 Gene

mRNA differential expression in normal tissues according to GTEx for NPPA-AS1 Gene

This gene is overexpressed in Heart - Atrial Appendage (x51.2).
genes like me logo Genes that share expression patterns with NPPA-AS1: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for NPPA-AS1 Gene

Orthologs for NPPA-AS1 Gene

Evolution for NPPA-AS1 Gene

ENSEMBL:
Gene Tree for NPPA-AS1 (if available)
TreeFam:
Gene Tree for NPPA-AS1 (if available)

No data available for Orthologs for NPPA-AS1 Gene

Paralogs for NPPA-AS1 Gene

No data available for Paralogs for NPPA-AS1 Gene

Variants for NPPA-AS1 Gene

Sequence variations from dbSNP and Humsavar for NPPA-AS1 Gene

SNP ID Clin Chr 01 pos Variation AA Info Type
rs142022010 likely-benign, Atrial fibrillation, familial, 6 11,847,271(+) C/T intron_variant
rs142116829 likely-benign, Atrial fibrillation, familial, 6 11,847,602(+) A/G non_coding_transcript_variant
rs148712945 likely-benign, Atrial fibrillation, familial, 6 11,847,428(+) G/A intron_variant
rs150794709 uncertain-significance, Atrial fibrillation, familial, 6 11,847,366(+) G/A intron_variant
rs201879717 uncertain-significance, Atrial fibrillation, familial, 6 11,847,291(+) T/C intron_variant

Structural Variations from Database of Genomic Variants (DGV) for NPPA-AS1 Gene

Variant ID Type Subtype PubMed ID
nsv527521 CNV loss 19592680

Additional Variant Information for NPPA-AS1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
NPPA-AS1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for NPPA-AS1 Gene

Disorders for NPPA-AS1 Gene

Additional Disease Information for NPPA-AS1

No disorders were found for NPPA-AS1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for NPPA-AS1 Gene

Publications for NPPA-AS1 Gene

  1. Natural antisense transcript of natriuretic peptide precursor A (NPPA): structural organization and modulation of NPPA expression. (PMID: 19671135) Annilo T … Laan M (BMC molecular biology 2009) 2 3 58
  2. Genome-wide association analysis and fine mapping of NT-proBNP level provide novel insight into the role of the MTHFR-CLCN6-NPPA-NPPB gene cluster. (PMID: 21273288) Del Greco M F … Pramstaller PP (Human molecular genetics 2011) 3 58

Products for NPPA-AS1 Gene

Sources for NPPA-AS1 Gene

Content
Loading form....