The protein encoded by this gene is involved in several cellular processes, including centrosome duplication, protein chaperoning, and cell proliferation. The encoded phosphoprotein shuttles between the nucleolus, nucleus, and cytoplasm, chaperoning ribosomal proteins and core histones from the nucleus to the cytoplasm. This protein is also known to sequester the tumor suppress... See more...

Aliases for NPM1 Gene

Aliases for NPM1 Gene

  • Nucleophosmin 1 2 3 5
  • Nucleophosmin 2 3 4
  • Nucleophosmin (Nucleolar Phosphoprotein B23, Numatrin) 2 3
  • Nucleophosmin/Nucleoplasmin Family, Member 1 2 3
  • Nucleolar Phosphoprotein B23 2 4
  • Nucleolar Protein NO38 3 4
  • Numatrin 2 4
  • NPM 3 4
  • Testicular Tissue Protein Li 128 3
  • B23 3

External Ids for NPM1 Gene

Previous GeneCards Identifiers for NPM1 Gene

  • GC05P171050
  • GC05P171517
  • GC05P170750
  • GC05P170795
  • GC05P170746
  • GC05P170747
  • GC05P170814
  • GC05P165912

Summaries for NPM1 Gene

Entrez Gene Summary for NPM1 Gene

  • The protein encoded by this gene is involved in several cellular processes, including centrosome duplication, protein chaperoning, and cell proliferation. The encoded phosphoprotein shuttles between the nucleolus, nucleus, and cytoplasm, chaperoning ribosomal proteins and core histones from the nucleus to the cytoplasm. This protein is also known to sequester the tumor suppressor ARF in the nucleolus, protecting it from degradation until it is needed. Mutations in this gene are associated with acute myeloid leukemia. Dozens of pseudogenes of this gene have been identified. [provided by RefSeq, Aug 2017]

CIViC Summary for NPM1 Gene

  • AML with mutated NPM1 is a provisional entity in the WHO classification of AML and is recommended to be tested in patients with cytogenetically normal AML (CN-AML). FLT3 mutations should be evaluated concurrently as they have prognostic consequences. NPM1 mutations are concentrated in exon 12, most frequently W288fs which results in cytoplasmic sequestration of the protein. Exon 12 NPM1 mutations in the absence of FLT3-ITD are associated with good prognostic outcomes. Mice expressing the Npm1-W288fs mutation develop myeloproliferative neoplasms but not overt leukemia, indicating it may require additional mutations to promote leukemic development.

GeneCards Summary for NPM1 Gene

NPM1 (Nucleophosmin 1) is a Protein Coding gene. Diseases associated with NPM1 include Leukemia, Acute Myeloid and Lymphomatoid Papulosis. Among its related pathways are HIV Life Cycle and Gene Expression. Gene Ontology (GO) annotations related to this gene include nucleic acid binding and protein homodimerization activity. An important paralog of this gene is NPM2.

UniProtKB/Swiss-Prot Summary for NPM1 Gene

  • Involved in diverse cellular processes such as ribosome biogenesis, centrosome duplication, protein chaperoning, histone assembly, cell proliferation, and regulation of tumor suppressors p53/TP53 and ARF. Binds ribosome presumably to drive ribosome nuclear export. Associated with nucleolar ribonucleoprotein structures and bind single-stranded nucleic acids. Acts as a chaperonin for the core histones H3, H2B and H4. Stimulates APEX1 endonuclease activity on apurinic/apyrimidinic (AP) double-stranded DNA but inhibits APEX1 endonuclease activity on AP single-stranded RNA. May exert a control of APEX1 endonuclease activity within nucleoli devoted to repair AP on rDNA and the removal of oxidized rRNA molecules. In concert with BRCA2, regulates centrosome duplication. Regulates centriole duplication: phosphorylation by PLK2 is able to trigger centriole replication. Negatively regulates the activation of EIF2AK2/PKR and suppresses apoptosis through inhibition of EIF2AK2/PKR autophosphorylation. Antagonizes the inhibitory effect of ATF5 on cell proliferation and relieves ATF5-induced G2/M blockade (PubMed:22528486). In complex with MYC enhances the transcription of MYC target genes (PubMed:25956029).

Gene Wiki entry for NPM1 Gene

Additional gene information for NPM1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for NPM1 Gene

Genomics for NPM1 Gene

GeneHancer (GH) Regulatory Elements for NPM1 Gene

Promoters and enhancers for NPM1 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH05J171386 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE CraniofacialAtlas 520.5 +2.1 2085 5.6 HNRNPK ZNF217 EP300 SIN3A NRF1 TCF12 MYC POLR2G USF1 SP1 NPM1 NONHSAG042217.2 UBTD2 MIR3912 piR-47132-004 RF00017-5091
GH05J172002 Promoter/Enhancer 2.7 EPDnew FANTOM5 Ensembl ENCODE CraniofacialAtlas dbSUPER 16.4 +619.5 619465 7.2 ZBTB40 ZNF217 EP300 SIN3A NRF1 TCF12 POLR2G GTF2E2 PHF8 TEAD4 FBXW11 lnc-EFCAB9-5 lnc-STK10-2 NPM1 SH3PXD2B STK10 UBTD2
GH05J170755 Enhancer 1.2 Ensembl ENCODE dbSUPER 22.8 -630.1 -630082 3 TCF12 ZNF300 JUND RELA ZNF662 ZNF491 NR2F2 ZNF132 ZNF195 NFIC NPM1 KCNIP1 piR-32559-367 ENSG00000253348 HSALNG0046523
GH05J171308 Promoter/Enhancer 1.6 EPDnew Ensembl ENCODE 14.4 -77.6 -77615 3 JUND CTCF ZNF639 ZBTB10 ZNF423 ZBTB26 ATF2 ZEB1 MXI1 EZH2 ENSG00000275038 TLX3 NPM1 RF00017-5091
GH05J172098 Enhancer 0.8 Ensembl 26.3 +711.8 711785 0.2 ZNF300 FOXA1 GATAD2B CTBP1 ZNF282 HES1 SALL2 CREB1 ZNF207 ZNF707 NPM1 SH3PXD2B FBXW11 UBTD2 RPL10P8 CREBRF lnc-FBXW11-6 piR-48759-256 RF00017-5102 STK10
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around NPM1 on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for NPM1

Top Transcription factor binding sites by QIAGEN in the NPM1 gene promoter:
  • AP-1
  • STAT3

Genomic Locations for NPM1 Gene

Genomic Locations for NPM1 Gene
chr5:171,387,116-171,411,137
(GRCh38/hg38)
Size:
24,022 bases
Orientation:
Plus strand
chr5:170,814,120-170,838,141
(GRCh37/hg19)
Size:
24,022 bases
Orientation:
Plus strand

Genomic View for NPM1 Gene

Genes around NPM1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
NPM1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for NPM1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NPM1 Gene

Proteins for NPM1 Gene

  • Protein details for NPM1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P06748-NPM_HUMAN
    Recommended name:
    Nucleophosmin
    Protein Accession:
    P06748
    Secondary Accessions:
    • A8K3N7
    • B5BU00
    • D3DQL6
    • P08693
    • Q12826
    • Q13440
    • Q13441
    • Q14115
    • Q5EU94
    • Q5EU95
    • Q5EU96
    • Q5EU97
    • Q5EU98
    • Q5EU99
    • Q6V962
    • Q8WTW5
    • Q96AT6
    • Q96DC4
    • Q96EA5
    • Q9BYG9
    • Q9UDJ7

    Protein attributes for NPM1 Gene

    Size:
    294 amino acids
    Molecular mass:
    32575 Da
    Quaternary structure:
    • Decamer formed by two pentameric rings associated in a head-to-head fashion (By similarity). Disulfide-linked dimers under certain conditions (PubMed:25818168). The SWAP complex consists of NPM1, NCL, PARP1 and SWAP70 (By similarity). Interacts with NSUN2 and SENP3. Interacts with the methylated form of RPS10. Interacts (via N-terminal domain) with APEX1; the interaction is RNA-dependent and decreases in hydrogen peroxide-damaged cells. Interacts with isoform 1 of NEK2. Interacts with ROCK2 and BRCA2. Interacts with RPGR. Interacts with CENPW. Interacts with EIF2AK2/PKR. Interacts with CEBPA (isoform 4) (PubMed:20075868). Interacts with DDX31; this interaction prevents interaction between NPM1 and HDM2 (PubMed:23019224). Interacts with MYC; competitive with NOP53 (PubMed:25956029). Interacts with NOP53; the interaction is direct and competitive with MYC (PubMed:25956029). Interacts with LRRC34 (By similarity). Interacts with RRP1B (PubMed:19710015, PubMed:20926688). Interacts with NPM3 (PubMed:22362753).
    • (Microbial infection) Interacts with hepatitis delta virus S-HDAg.
    • (Microbial infection) Interacts with HTLV1 Rex protein (via N-terminal nuclear localization signal).

    Three dimensional structures from OCA and Proteopedia for NPM1 Gene

    Alternative splice isoforms for NPM1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for NPM1 Gene

Post-translational modifications for NPM1 Gene

  • Acetylated at C-terminal lysine residues, thereby increasing affinity to histones.
  • ADP-ribosylated.
  • Phosphorylated at Ser-4 by PLK1 and PLK2. Phosphorylation at Ser-4 by PLK2 in S phase is required for centriole duplication and is sufficient to trigger centriole replication. Phosphorylation at Ser-4 by PLK1 takes place during mitosis. Phosphorylated by CDK2 at Ser-125 and Thr-199. Phosphorylation at Thr-199 may trigger initiation of centrosome duplication. Phosphorylated by CDK1 at Thr-199, Thr-219, Thr-234 and Thr-237 during cell mitosis. When these four sites are phosphorated, RNA-binding activity seem to be abolished. May be phosphorylated at Ser-70 by NEK2. The Thr-199 phosphorylated form has higher affinity for ROCK2. CDK6 triggers Thr-199 phosphorylation when complexed to Kaposi's sarcoma herpesvirus (KSHV) V-cyclin, leading to viral reactivation by reducing viral LANA levels.
  • Sumoylated by ARF.
  • Ubiquitinated. Ubiquitination leads to proteasomal degradation. Deubiquitinated by USP36 (PubMed:19208757).
  • Ubiquitination at Lys27, Lys32, Lys54, Lys80, Lys202, Lys248, Lys250, Lys267, and Lys273
  • Modification sites at PhosphoSitePlus

Antibody Products

No data available for DME Specific Peptides for NPM1 Gene

Domains & Families for NPM1 Gene

Gene Families for NPM1 Gene

Human Protein Atlas (HPA):
  • Cancer-related genes
  • Disease related genes
  • Predicted intracellular proteins

Protein Domains for NPM1 Gene

Suggested Antigen Peptide Sequences for NPM1 Gene

GenScript: Design optimal peptide antigens:
  • Truncated nucleolar phosphoprotein B23 (A4ZU86_HUMAN)
  • Mutant NPM1 protein (B1PHD4_HUMAN)
  • Numatrin (NPM_HUMAN)
  • NPM1 protein (Q9BTI9_HUMAN)

Graphical View of Domain Structure for InterPro Entry

P06748

UniProtKB/Swiss-Prot:

NPM_HUMAN :
  • Belongs to the nucleoplasmin family.
Family:
  • Belongs to the nucleoplasmin family.
genes like me logo Genes that share domains with NPM1: view

Function for NPM1 Gene

Molecular function for NPM1 Gene

UniProtKB/Swiss-Prot Function:
Involved in diverse cellular processes such as ribosome biogenesis, centrosome duplication, protein chaperoning, histone assembly, cell proliferation, and regulation of tumor suppressors p53/TP53 and ARF. Binds ribosome presumably to drive ribosome nuclear export. Associated with nucleolar ribonucleoprotein structures and bind single-stranded nucleic acids. Acts as a chaperonin for the core histones H3, H2B and H4. Stimulates APEX1 endonuclease activity on apurinic/apyrimidinic (AP) double-stranded DNA but inhibits APEX1 endonuclease activity on AP single-stranded RNA. May exert a control of APEX1 endonuclease activity within nucleoli devoted to repair AP on rDNA and the removal of oxidized rRNA molecules. In concert with BRCA2, regulates centrosome duplication. Regulates centriole duplication: phosphorylation by PLK2 is able to trigger centriole replication. Negatively regulates the activation of EIF2AK2/PKR and suppresses apoptosis through inhibition of EIF2AK2/PKR autophosphorylation. Antagonizes the inhibitory effect of ATF5 on cell proliferation and relieves ATF5-induced G2/M blockade (PubMed:22528486). In complex with MYC enhances the tran