Aliases for NPLOC4 Gene
External Ids for NPLOC4 Gene
Previous GeneCards Identifiers for NPLOC4 Gene
GeneCards Summary for NPLOC4 Gene
NPLOC4 (NPL4 Homolog, Ubiquitin Recognition Factor) is a Protein Coding gene. Diseases associated with NPLOC4 include Multisystem Proteinopathy and Inclusion Body Myopathy With Paget Disease Of Bone And Frontotemporal Dementia. Among its related pathways are DNA Double-Strand Break Repair and Protein processing in endoplasmic reticulum. Gene Ontology (GO) annotations related to this gene include ubiquitin protein ligase binding and ubiquitin binding.
UniProtKB/Swiss-Prot Summary for NPLOC4 Gene
The ternary complex containing UFD1, VCP and NPLOC4 binds ubiquitinated proteins and is necessary for the export of misfolded proteins from the ER to the cytoplasm, where they are degraded by the proteasome. The NPLOC4-UFD1-VCP complex regulates spindle disassembly at the end of mitosis and is necessary for the formation of a closed nuclear envelope (By similarity). Acts as a negative regulator of type I interferon production via the complex formed with VCP and UFD1, which binds to DDX58/RIG-I and recruits RNF125 to promote ubiquitination and degradation of DDX58/RIG-I (PubMed:26471729).