Aliases for NPIPB8 Gene

Aliases for NPIPB8 Gene

  • Nuclear Pore Complex Interacting Protein Family Member B8 2 3 5
  • Nuclear Pore Complex-Interacting Protein Family Member B8 3 3 4
  • Nuclear Pore Complex Interacting Protein Family, Member B8 2
  • NPIPB8 5

External Ids for NPIPB8 Gene

Previous GeneCards Identifiers for NPIPB8 Gene

  • GC16P028649
  • GC16P028624

Summaries for NPIPB8 Gene

GeneCards Summary for NPIPB8 Gene

NPIPB8 (Nuclear Pore Complex Interacting Protein Family Member B8) is a Protein Coding gene. An important paralog of this gene is NPIPB6.

Additional gene information for NPIPB8 Gene

No data available for Entrez Gene Summary , CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for NPIPB8 Gene

Genomics for NPIPB8 Gene

GeneHancer (GH) Regulatory Elements Pubs


GeneHancers around NPIPB8 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for NPIPB8

Genomic Locations for NPIPB8 Gene

Genomic Locations for NPIPB8 Gene
chr16:28,637,654-28,658,693
(GRCh38/hg38)
Size:
21,040 bases
Orientation:
Plus strand
chr16:28,648,597-28,670,003
(GRCh37/hg19)
Size:
21,407 bases
Orientation:
Plus strand

Genomic View for NPIPB8 Gene

Genes around NPIPB8 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
NPIPB8 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for NPIPB8 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NPIPB8 Gene

Proteins for NPIPB8 Gene

  • Protein details for NPIPB8 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    E9PQR5-NPIB8_HUMAN
    Recommended name:
    Nuclear pore complex-interacting protein family member B8
    Protein Accession:
    E9PQR5

    Protein attributes for NPIPB8 Gene

    Size:
    432 amino acids
    Molecular mass:
    49617 Da
    Quaternary structure:
    No Data Available

neXtProt entry for NPIPB8 Gene

Post-translational modifications for NPIPB8 Gene

No Post-translational modifications

No data available for DME Specific Peptides for NPIPB8 Gene

Domains & Families for NPIPB8 Gene

Gene Families for NPIPB8 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Predicted membrane proteins

Protein Domains for NPIPB8 Gene

InterPro:
ProtoNet:

Graphical View of Domain Structure for InterPro Entry

E9PQR5

UniProtKB/Swiss-Prot:

NPIB8_HUMAN :
  • Belongs to the NPIP family.
Family:
  • Belongs to the NPIP family.
genes like me logo Genes that share domains with NPIPB8: view

No data available for Suggested Antigen Peptide Sequences for NPIPB8 Gene

Function for NPIPB8 Gene

Phenotypes From GWAS Catalog for NPIPB8 Gene

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for NPIPB8 Gene

Localization for NPIPB8 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for NPIPB8 gene
Compartment Confidence
nucleus 4

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for NPIPB8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005654 nucleoplasm IBA,IDA --
genes like me logo Genes that share ontologies with NPIPB8: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for NPIPB8 Gene

Pathways & Interactions for NPIPB8 Gene

PathCards logo

SuperPathways for NPIPB8 Gene

No Data Available

Interacting Proteins for NPIPB8 Gene

Gene Ontology (GO) - Biological Process for NPIPB8 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for NPIPB8 Gene

Drugs & Compounds for NPIPB8 Gene

(3) Drugs for NPIPB8 Gene - From: PharmGKB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Acetaminophen Approved Pharma 1316
Tapentadol Approved Pharma 73
desmethylnaproxen Pharma 0
genes like me logo Genes that share compounds with NPIPB8: view

Transcripts for NPIPB8 Gene

mRNA/cDNA for NPIPB8 Gene

1 REFSEQ mRNAs :
2 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for NPIPB8 Gene

No ASD Table

Relevant External Links for NPIPB8 Gene

GeneLoc Exon Structure for
NPIPB8

Expression for NPIPB8 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for NPIPB8 Gene

mRNA differential expression in normal tissues according to GTEx for NPIPB8 Gene

This gene is overexpressed in Testis (x10.5).

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for NPIPB8

genes like me logo Genes that share expression patterns with NPIPB8: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for NPIPB8 Gene

Orthologs for NPIPB8 Gene

This gene was present in the common ancestor of human and chimp.

Orthologs for NPIPB8 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia -- 31
  • 91 (a)
ManyToMany
-- 31
  • 89 (a)
ManyToMany
-- 31
  • 87 (a)
ManyToMany
-- 31
  • 85 (a)
ManyToMany
-- 31
  • 82 (a)
ManyToMany
Species where no ortholog for NPIPB8 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • Cow (Bos Taurus)
  • Dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Lizard (Anolis carolinensis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Mouse (Mus musculus)
  • Oppossum (Monodelphis domestica)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Platypus (Ornithorhynchus anatinus)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rat (Rattus norvegicus)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)
  • Zebrafish (Danio rerio)

Evolution for NPIPB8 Gene

ENSEMBL:
Gene Tree for NPIPB8 (if available)
TreeFam:
Gene Tree for NPIPB8 (if available)

Paralogs for NPIPB8 Gene

(20) SIMAP similar genes for NPIPB8 Gene using alignment to 2 proteins:

  • NPIB8_HUMAN
  • H0YDQ7_HUMAN

Pseudogenes.org Pseudogenes for NPIPB8 Gene

genes like me logo Genes that share paralogs with NPIPB8: view

Variants for NPIPB8 Gene

Additional dbSNP identifiers (rs#s) for NPIPB8 Gene

Variation tolerance for NPIPB8 Gene

Gene Damage Index Score: 9.01; 87.43% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for NPIPB8 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
NPIPB8

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP and Structural Variations from Database of Genomic Variants (DGV) for NPIPB8 Gene

Disorders for NPIPB8 Gene

No disorders were found for NPIPB8 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for NPIPB8 Gene

Publications for NPIPB8 Gene

  1. The sequence and analysis of duplication-rich human chromosome 16. (PMID: 15616553) Martin J … Pennacchio LA (Nature 2004) 3 4
  2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. (PMID: 21873635) Gaudet P … Thomas PD (Briefings in bioinformatics 2011) 3

Products for NPIPB8 Gene

Sources for NPIPB8 Gene