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Aliases for NPIPB8 Gene

Aliases for NPIPB8 Gene

  • Nuclear Pore Complex Interacting Protein Family Member B8 2 3 5
  • Nuclear Pore Complex-Interacting Protein Family Member B8 3 3 4
  • Nuclear Pore Complex Interacting Protein Family, Member B8 2

External Ids for NPIPB8 Gene

Previous GeneCards Identifiers for NPIPB8 Gene

  • GC16P028649

Summaries for NPIPB8 Gene

GeneCards Summary for NPIPB8 Gene

NPIPB8 (Nuclear Pore Complex Interacting Protein Family Member B8) is a Protein Coding gene. An important paralog of this gene is NPIPB9.

Additional gene information for NPIPB8 Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NPIPB8 Gene

Genomics for NPIPB8 Gene

GeneHancer (GH) Regulatory Elements for NPIPB8 Gene

Promoters and enhancers for NPIPB8 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH16J028622 Promoter/Enhancer 1.8 EPDnew Ensembl ENCODE dbSUPER 600.7 -1.3 -1312 2 POLR2A TARDBP ZFX RFX1 SMARCB1 MAX SIN3A ZNF687 SMAD4 MTA1 SULT1A2 NPIPB8 SULT1A1 TUFM CDC37P1 PIR38771
GH16J028844 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 14 +221.7 221744 3.1 ZNF473 SP1 CTCF ZFX ELF3 MNT SIX5 ZNF148 NKRF POLR2A TUFM SH2B1 ATXN2L NFATC2IP SPNS1 ENSG00000260853 SMG1P2 NPIPB10P ENSG00000260367 NPIPB12
GH16J029258 Promoter/Enhancer 2 FANTOM5 Ensembl ENCODE dbSUPER 14 +640.1 640110 11.3 ZNF473 ZFX ELF3 MLLT1 NFIB AHR IKZF1 ZNF24 MAFK TFE3 ENSG00000260953 SPNS1 ATXN2L NPIPB9 ENSG00000260853 ENSG00000260367 NPIPB10P SMG1P2 NFATC2IP NPIPB8
GH16J028950 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 13.2 +326.9 326884 2.8 SP1 ELF3 MNT SIX5 NKRF POLR2A MLLT1 GTF2F1 FOS MAFK NFATC2IP SGF29 EIF3C SULT1A2 ATXN2L NPIPB8 NPIPB10P SMG1P2 EIF3CL ENSG00000260853
GH16J028821 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 10.3 +199.5 199548 4.5 SP1 ELF3 ZFX MNT ZNF148 NKRF POLR2A ZNF121 CEBPG GTF2F1 ATXN2L ENSG00000275807 TUFM SH2B1 ENSG00000261766 NPIPB12 ENSG00000198106 ENSG00000251417 CDC37P1 NPIPB11
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around NPIPB8 on UCSC Golden Path with GeneCards custom track

Genomic Locations for NPIPB8 Gene

Genomic Locations for NPIPB8 Gene
chr16:28,624,517-28,658,725
(GRCh38/hg38)
Size:
34,209 bases
Orientation:
Plus strand
chr16:28,648,597-28,670,003
(GRCh37/hg19)
Size:
21,407 bases
Orientation:
Plus strand

Genomic View for NPIPB8 Gene

Genes around NPIPB8 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
NPIPB8 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for NPIPB8 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NPIPB8 Gene

Proteins for NPIPB8 Gene

  • Protein details for NPIPB8 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    E9PQR5-NPIB8_HUMAN
    Recommended name:
    Nuclear pore complex-interacting protein family member B8
    Protein Accession:
    E9PQR5

    Protein attributes for NPIPB8 Gene

    Size:
    432 amino acids
    Molecular mass:
    49617 Da
    Quaternary structure:
    No Data Available

neXtProt entry for NPIPB8 Gene

Post-translational modifications for NPIPB8 Gene

No Post-translational modifications

No data available for DME Specific Peptides for NPIPB8 Gene

Domains & Families for NPIPB8 Gene

Gene Families for NPIPB8 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Predicted membrane proteins

Protein Domains for NPIPB8 Gene

InterPro:
ProtoNet:

Graphical View of Domain Structure for InterPro Entry

E9PQR5

UniProtKB/Swiss-Prot:

NPIB8_HUMAN :
  • Belongs to the NPIP family.
Family:
  • Belongs to the NPIP family.
genes like me logo Genes that share domains with NPIPB8: view

No data available for Suggested Antigen Peptide Sequences for NPIPB8 Gene

Function for NPIPB8 Gene

Phenotypes From GWAS Catalog for NPIPB8 Gene

Animal Model Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for NPIPB8 Gene

Localization for NPIPB8 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for NPIPB8 gene
Compartment Confidence
nucleus 4

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for NPIPB8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005654 nucleoplasm IDA --
genes like me logo Genes that share ontologies with NPIPB8: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for NPIPB8 Gene

Pathways & Interactions for NPIPB8 Gene

PathCards logo

SuperPathways for NPIPB8 Gene

No Data Available

Interacting Proteins for NPIPB8 Gene

Gene Ontology (GO) - Biological Process for NPIPB8 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for NPIPB8 Gene

Drugs & Compounds for NPIPB8 Gene

No Compound Related Data Available

Transcripts for NPIPB8 Gene

mRNA/cDNA for NPIPB8 Gene

(1) REFSEQ mRNAs :
(2) Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for NPIPB8 Gene

No ASD Table

Relevant External Links for NPIPB8 Gene

GeneLoc Exon Structure for
NPIPB8
ECgene alternative splicing isoforms for
NPIPB8

Expression for NPIPB8 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for NPIPB8 Gene

mRNA differential expression in normal tissues according to GTEx for NPIPB8 Gene

This gene is overexpressed in Testis (x10.5).

NURSA nuclear receptor signaling pathways regulating expression of NPIPB8 Gene:

NPIPB8
genes like me logo Genes that share expression patterns with NPIPB8: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for NPIPB8 Gene

Orthologs for NPIPB8 Gene

This gene was present in the common ancestor of human and chimp.

Orthologs for NPIPB8 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia -- 35
  • 91 (a)
ManyToMany
-- 35
  • 89 (a)
ManyToMany
-- 35
  • 87 (a)
ManyToMany
-- 35
  • 85 (a)
ManyToMany
-- 35
  • 82 (a)
ManyToMany
Species where no ortholog for NPIPB8 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for NPIPB8 Gene

ENSEMBL:
Gene Tree for NPIPB8 (if available)
TreeFam:
Gene Tree for NPIPB8 (if available)

Paralogs for NPIPB8 Gene

(20) SIMAP similar genes for NPIPB8 Gene using alignment to 2 proteins:

  • NPIB8_HUMAN
  • H0YDQ7_HUMAN

Pseudogenes.org Pseudogenes for NPIPB8 Gene

genes like me logo Genes that share paralogs with NPIPB8: view

Variants for NPIPB8 Gene

Sequence variations from dbSNP and Humsavar for NPIPB8 Gene

SNP ID Clin Chr 16 pos Variation AA Info Type
rs1000022197 -- 28,652,979(+) G/C intron_variant
rs1000115233 -- 28,652,567(+) G/A intron_variant
rs1000290041 -- 28,636,703(+) A/G upstream_transcript_variant
rs1000297066 -- 28,640,995(+) C/T intron_variant
rs1000567276 -- 28,641,107(+) C/T intron_variant

Variation tolerance for NPIPB8 Gene

Gene Damage Index Score: 9.01; 87.43% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for NPIPB8 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
NPIPB8

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for NPIPB8 Gene

Disorders for NPIPB8 Gene

Additional Disease Information for NPIPB8

No disorders were found for NPIPB8 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for NPIPB8 Gene

Publications for NPIPB8 Gene

  1. The sequence and analysis of duplication-rich human chromosome 16. (PMID: 15616553) Martin J … Pennacchio LA (Nature 2004) 3 4 58

Products for NPIPB8 Gene

Sources for NPIPB8 Gene

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