Aliases for NPIPB5 Gene

Aliases for NPIPB5 Gene

  • Nuclear Pore Complex Interacting Protein Family Member B5 2 3 5
  • Nuclear Pore Complex Interacting Protein Family, Member B5 2
  • Nuclear Pore Complex-Interacting Protein Family Member B5 4
  • Nuclear Pore Complex Interacting Protein Family Member 3
  • Nuclear Pore Complex Interacting Protein Related 3
  • NPIPB5 5

External Ids for NPIPB5 Gene

Previous GeneCards Identifiers for NPIPB5 Gene

  • GC16P022504
  • GC16P022507

Summaries for NPIPB5 Gene

GeneCards Summary for NPIPB5 Gene

NPIPB5 (Nuclear Pore Complex Interacting Protein Family Member B5) is a Protein Coding gene. Diseases associated with NPIPB5 include Renal Cell Carcinoma, Papillary, 1. An important paralog of this gene is NPIPB4.

Additional gene information for NPIPB5 Gene

No data available for Entrez Gene Summary , CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for NPIPB5 Gene

Genomics for NPIPB5 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for NPIPB5 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around NPIPB5 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for NPIPB5

Genomic Locations for NPIPB5 Gene

Genomic Locations for NPIPB5 Gene
chr16:22,479,121-22,536,521
(GRCh38/hg38)
Size:
57,401 bases
Orientation:
Plus strand
chr16:22,490,442-22,547,842
(GRCh37/hg19)
Size:
57,401 bases
Orientation:
Plus strand

Genomic View for NPIPB5 Gene

Genes around NPIPB5 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
NPIPB5 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for NPIPB5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NPIPB5 Gene

Proteins for NPIPB5 Gene

  • Protein details for NPIPB5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    A8MRT5-NPIB5_HUMAN
    Recommended name:
    Nuclear pore complex-interacting protein family member B5
    Protein Accession:
    A8MRT5
    Secondary Accessions:
    • B4DK13

    Protein attributes for NPIPB5 Gene

    Size:
    1133 amino acids
    Molecular mass:
    126459 Da
    Quaternary structure:
    No Data Available

neXtProt entry for NPIPB5 Gene

Post-translational modifications for NPIPB5 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for NPIPB5 Gene

Domains & Families for NPIPB5 Gene

Gene Families for NPIPB5 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Predicted membrane proteins

Protein Domains for NPIPB5 Gene

InterPro:
ProtoNet:

Graphical View of Domain Structure for InterPro Entry

A8MRT5

UniProtKB/Swiss-Prot:

NPIB5_HUMAN :
  • Belongs to the NPIP family.
Family:
  • Belongs to the NPIP family.
genes like me logo Genes that share domains with NPIPB5: view

No data available for Suggested Antigen Peptide Sequences for NPIPB5 Gene

Function for NPIPB5 Gene

Phenotypes From GWAS Catalog for NPIPB5 Gene

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for NPIPB5 Gene

Localization for NPIPB5 Gene

Subcellular locations from UniProtKB/Swiss-Prot for NPIPB5 Gene

Membrane. Single-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for NPIPB5 gene
Compartment Confidence
nucleus 4
plasma membrane 2
extracellular 1
endoplasmic reticulum 0
golgi apparatus 0

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for NPIPB5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005654 nucleoplasm IDA --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with NPIPB5: view

Pathways & Interactions for NPIPB5 Gene

PathCards logo

SuperPathways for NPIPB5 Gene

No Data Available

Interacting Proteins for NPIPB5 Gene

Gene Ontology (GO) - Biological Process for NPIPB5 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for NPIPB5 Gene

Drugs & Compounds for NPIPB5 Gene

No Compound Related Data Available

Transcripts for NPIPB5 Gene

mRNA/cDNA for NPIPB5 Gene

1 REFSEQ mRNAs :
8 NCBI additional mRNA sequence :
27 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for NPIPB5

Alternative Splicing Database (ASD) splice patterns (SP) for NPIPB5 Gene

No ASD Table

Relevant External Links for NPIPB5 Gene

GeneLoc Exon Structure for
NPIPB5

Expression for NPIPB5 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for NPIPB5 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for NPIPB5

Evidence on tissue expression from TISSUES for NPIPB5 Gene

  • Nervous system(4.2)
genes like me logo Genes that share expression patterns with NPIPB5: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for NPIPB5 Gene

Orthologs for NPIPB5 Gene

This gene was present in the common ancestor of human and chimp.

Orthologs for NPIPB5 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia LOC750787 30
  • 88.33 (n)
-- 31
  • 76 (a)
ManyToMany
-- 31
  • 75 (a)
ManyToMany
Species where no ortholog for NPIPB5 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • Cow (Bos Taurus)
  • Dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Lizard (Anolis carolinensis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Mouse (Mus musculus)
  • Oppossum (Monodelphis domestica)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Platypus (Ornithorhynchus anatinus)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rat (Rattus norvegicus)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)
  • Zebrafish (Danio rerio)

Evolution for NPIPB5 Gene

ENSEMBL:
Gene Tree for NPIPB5 (if available)
TreeFam:
Gene Tree for NPIPB5 (if available)

Paralogs for NPIPB5 Gene

(25) SIMAP similar genes for NPIPB5 Gene using alignment to 11 proteins:

  • NPIB5_HUMAN
  • E5RHP9_HUMAN
  • E9PKP1_HUMAN
  • F5GWQ4_HUMAN
  • F5GXZ6_HUMAN
  • F5GYP3_HUMAN
  • F5GZP9_HUMAN
  • F5H6Y6_HUMAN
  • F6SDX0_HUMAN
  • H0YIL3_HUMAN
  • U3KRG3_HUMAN
genes like me logo Genes that share paralogs with NPIPB5: view

Variants for NPIPB5 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for NPIPB5 Gene

SNP ID Clinical significance and condition Chr 16 pos Variation AA Info Type
rs755632125 Likely Benign: not specified 22,534,471(+) C/T SYNONYMOUS_VARIANT

Additional dbSNP identifiers (rs#s) for NPIPB5 Gene

Structural Variations from Database of Genomic Variants (DGV) for NPIPB5 Gene

Variant ID Type Subtype PubMed ID
dgv115n111 CNV duplication 26073780
dgv1318n106 CNV duplication 24896259
dgv2813n100 CNV loss 25217958
dgv33n68 CNV loss 17160897
dgv3n1 OTHER inversion 15895083
dgv47n16 OTHER inversion 17901297
esv25819 CNV gain 19812545
esv2758637 CNV gain+loss 17122850
esv32980 CNV loss 17666407
esv3368991 OTHER inversion 20981092
esv3407717 CNV duplication 20981092
esv998989 OTHER inversion 20482838
nsv1051649 CNV gain+loss 25217958
nsv1052004 CNV gain 25217958
nsv1077770 OTHER inversion 25765185
nsv1077819 CNV duplication 25765185
nsv1140248 OTHER inversion 24896259
nsv1148848 CNV duplication 26484159
nsv1160373 CNV duplication 26073780
nsv428324 CNV gain 18775914
nsv433439 CNV gain 18776910
nsv433440 CNV gain 18776910
nsv469882 CNV loss 16826518
nsv471386 CNV gain 19718026
nsv471691 CNV gain+loss 15918152
nsv499139 OTHER inversion 21111241
nsv7280 OTHER inversion 18451855
nsv820453 CNV duplication 20802225
nsv827593 CNV gain 20364138
nsv833168 CNV gain+loss 17160897
nsv833171 CNV gain+loss 17160897
nsv9405 CNV gain+loss 18304495
nsv9406 CNV gain+loss 18304495
nsv974882 CNV duplication 23825009
nsv977940 CNV duplication 23825009
nsv978043 CNV duplication 23825009
nsv978205 CNV duplication 23825009
nsv978206 CNV duplication 23825009
nsv984396 CNV duplication 23825009

Variation tolerance for NPIPB5 Gene

Gene Damage Index Score: 1.55; 30.03% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for NPIPB5 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
NPIPB5

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NPIPB5 Gene

Disorders for NPIPB5 Gene

MalaCards: The human disease database

(1) MalaCards diseases for NPIPB5 Gene - From: DISEASES

Disorder Aliases PubMed IDs
renal cell carcinoma, papillary, 1
  • rccp1
- elite association - COSMIC cancer census association via MalaCards
genes like me logo Genes that share disorders with NPIPB5: view

No data available for UniProtKB/Swiss-Prot and Genatlas for NPIPB5 Gene

Publications for NPIPB5 Gene

  1. A reference map of the human binary protein interactome. (PMID: 32296183) Luck K … Calderwood MA (Nature 2020) 3
  2. Mammalian APE1 controls miRNA processing and its interactome is linked to cancer RNA metabolism. (PMID: 28986522) Antoniali G … Tell G (Nature communications 2017) 3
  3. The sequence and analysis of duplication-rich human chromosome 16. (PMID: 15616553) Martin J … Pennacchio LA (Nature 2004) 4
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 4
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg RL … Mammalian Gene Collection Program Team (Proceedings of the National Academy of Sciences of the United States of America 2002) 3

Products for NPIPB5 Gene

Sources for NPIPB5 Gene