Free for academic non-profit institutions. Other users need a Commercial license

Aliases for NPIPB5 Gene

Aliases for NPIPB5 Gene

  • Nuclear Pore Complex Interacting Protein Family Member B5 2 3 5
  • Nuclear Pore Complex Interacting Protein Family, Member B5 2

External Ids for NPIPB5 Gene

Previous GeneCards Identifiers for NPIPB5 Gene

  • GC16P022504
  • GC16P022507

Summaries for NPIPB5 Gene

GeneCards Summary for NPIPB5 Gene

NPIPB5 (Nuclear Pore Complex Interacting Protein Family Member B5) is a Protein Coding gene. An important paralog of this gene is NPIPB4.

Additional gene information for NPIPB5 Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NPIPB5 Gene

Genomics for NPIPB5 Gene

GeneHancer (GH) Regulatory Elements for NPIPB5 Gene

Promoters and enhancers for NPIPB5 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH16I022513 Promoter 0.5 EPDnew 550.3 +34.4 34367 0.1 PIR59026 NPIPB5 PIR38259 GC16P022691 GC16P022690 GC16P022685 GC16P022569 GC16P022568
GH16I021819 Promoter/Enhancer 1.5 Ensembl ENCODE 146.7 -658.8 -658820 1.8 HDGF SMAD1 ZFP64 SIN3A FEZF1 ZNF2 YY1 ZNF213 ZNF302 ZNF207 RRN3P1 NPIPB4 NPIPB5 NPIPB3 SMG1P3 ENSG00000260635 SMG1P4 SMG1P1 POLR3E ENSG00000260905
GH16I022296 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE 43.1 -181.3 -181339 3.2 CLOCK MLX FEZF1 DMAP1 IRF4 YY1 SLC30A9 ZNF213 E2F8 ZNF143 POLR3E TRL-AAG2-4 C16orf52 NPIPB4 SMG1P3 NPIPB3 RRN3P1 NPIPB5 SMG1P1 SMG1P4
GH16I022006 Promoter/Enhancer 2.2 EPDnew FANTOM5 Ensembl ENCODE 39.3 -470.9 -470864 2.8 PKNOX1 ATF1 FOXA2 ARID4B SIN3A ZNF48 YY1 ZNF213 ZNF548 ATF7 C16orf52 ENSG00000275445 GC16P022007 SMG1P4 SMG1P1 SMG1P3 NPIPB4 NPIPB5 NPIPB3 ENSG00000260635
GH16I021950 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 24.5 -526.4 -526416 3.9 CLOCK DMAP1 YBX1 YY1 SLC30A9 E2F8 ZNF143 SP3 NFYC MEF2D ENSG00000274460 GC16M021951 UQCRC2 ENSG00000260635 SMG1P1 SMG1P4 SMG1P3 NPIPB4 NPIPB5 NPIPB3
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around NPIPB5 on UCSC Golden Path with GeneCards custom track

Genomic Locations for NPIPB5 Gene

Genomic Locations for NPIPB5 Gene
chr16:22,479,121-22,536,535
(GRCh38/hg38)
Size:
57,415 bases
Orientation:
Plus strand
chr16:22,490,442-22,547,842
(GRCh37/hg19)

Genomic View for NPIPB5 Gene

Genes around NPIPB5 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
NPIPB5 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for NPIPB5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NPIPB5 Gene

Proteins for NPIPB5 Gene

  • Protein details for NPIPB5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    A8MRT5-NPIB5_HUMAN
    Recommended name:
    Nuclear pore complex-interacting protein family member B5
    Protein Accession:
    A8MRT5
    Secondary Accessions:
    • B4DK13

    Protein attributes for NPIPB5 Gene

    Size:
    1133 amino acids
    Molecular mass:
    126459 Da
    Quaternary structure:
    No Data Available

neXtProt entry for NPIPB5 Gene

Post-translational modifications for NPIPB5 Gene

No Post-translational modifications

No data available for DME Specific Peptides for NPIPB5 Gene

Domains & Families for NPIPB5 Gene

Gene Families for NPIPB5 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Predicted membrane proteins

Protein Domains for NPIPB5 Gene

InterPro:
ProtoNet:

Graphical View of Domain Structure for InterPro Entry

A8MRT5

UniProtKB/Swiss-Prot:

NPIB5_HUMAN :
  • Belongs to the NPIP family.
Family:
  • Belongs to the NPIP family.
genes like me logo Genes that share domains with NPIPB5: view

No data available for Suggested Antigen Peptide Sequences for NPIPB5 Gene

Function for NPIPB5 Gene

Phenotypes From GWAS Catalog for NPIPB5 Gene

Phenotypes for NPIPB5 Gene

GenomeRNAi human phenotypes for NPIPB5:
genes like me logo Genes that share phenotypes with NPIPB5: view

Animal Model Products

Inhibitory RNA Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for NPIPB5 Gene

Localization for NPIPB5 Gene

Subcellular locations from UniProtKB/Swiss-Prot for NPIPB5 Gene

Membrane; Single-pass membrane protein.

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for NPIPB5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with NPIPB5: view

No data available for Subcellular locations from COMPARTMENTS for NPIPB5 Gene

Pathways & Interactions for NPIPB5 Gene

SuperPathways for NPIPB5 Gene

No Data Available

Interacting Proteins for NPIPB5 Gene

Gene Ontology (GO) - Biological Process for NPIPB5 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for NPIPB5 Gene

Drugs & Compounds for NPIPB5 Gene

No Compound Related Data Available

Transcripts for NPIPB5 Gene

mRNA/cDNA for NPIPB5 Gene

(1) REFSEQ mRNAs :
(27) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for NPIPB5 Gene

No ASD Table

Relevant External Links for NPIPB5 Gene

GeneLoc Exon Structure for
NPIPB5
ECgene alternative splicing isoforms for
NPIPB5

Expression for NPIPB5 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for NPIPB5 Gene

NURSA nuclear receptor signaling pathways regulating expression of NPIPB5 Gene:

NPIPB5
genes like me logo Genes that share expression patterns with NPIPB5: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for NPIPB5 Gene

Orthologs for NPIPB5 Gene

This gene was present in the common ancestor of human and chimp.

Orthologs for NPIPB5 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia LOC750787 33
  • 88.33 (n)
-- 34
  • 76 (a)
ManyToMany
-- 34
  • 75 (a)
ManyToMany
Species where no ortholog for NPIPB5 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for NPIPB5 Gene

ENSEMBL:
Gene Tree for NPIPB5 (if available)
TreeFam:
Gene Tree for NPIPB5 (if available)

Paralogs for NPIPB5 Gene

genes like me logo Genes that share paralogs with NPIPB5: view

Variants for NPIPB5 Gene

Sequence variations from dbSNP and Humsavar for NPIPB5 Gene

SNP ID Clin Chr 16 pos Variation AA Info Type
rs755632125 likely-benign, not specified 22,534,471(+) C/T coding_sequence_variant, synonymous_variant
rs1004803656 -- 22,536,885(+) A/G/T downstream_transcript_variant
rs1005093068 -- 22,529,614(+) G/A intron_variant
rs1008986428 -- 22,529,365(+) C/T intron_variant
rs1020960 -- 22,535,893(+) C/T coding_sequence_variant, synonymous_variant

Structural Variations from Database of Genomic Variants (DGV) for NPIPB5 Gene

Variant ID Type Subtype PubMed ID
nsv984396 CNV duplication 23825009
nsv978206 CNV duplication 23825009
nsv978205 CNV duplication 23825009
nsv978043 CNV duplication 23825009
nsv977940 CNV duplication 23825009
nsv974882 CNV duplication 23825009
nsv9406 CNV gain+loss 18304495
nsv9405 CNV gain+loss 18304495
nsv833171 CNV gain+loss 17160897
nsv833168 CNV gain+loss 17160897
nsv827593 CNV gain 20364138
nsv820453 CNV duplication 20802225
nsv7280 OTHER inversion 18451855
nsv499139 OTHER inversion 21111241
nsv471691 CNV gain+loss 15918152
nsv471386 CNV gain 19718026
nsv469882 CNV loss 16826518
nsv433440 CNV gain 18776910
nsv433439 CNV gain 18776910
nsv428324 CNV gain 18775914
nsv1160373 CNV duplication 26073780
nsv1148848 CNV duplication 26484159
nsv1140248 OTHER inversion 24896259
nsv1077819 CNV duplication 25765185
nsv1077770 OTHER inversion 25765185
nsv1052004 CNV gain 25217958
nsv1051649 CNV gain+loss 25217958
esv998989 OTHER inversion 20482838
esv3407717 CNV duplication 20981092
esv3368991 OTHER inversion 20981092
esv32980 CNV loss 17666407
esv2758637 CNV gain+loss 17122850
esv25819 CNV gain 19812545
dgv47n16 OTHER inversion 17901297
dgv3n1 OTHER inversion 15895083
dgv33n68 CNV loss 17160897
dgv2813n100 CNV loss 25217958
dgv1318n106 CNV duplication 24896259
dgv115n111 CNV duplication 26073780

Variation tolerance for NPIPB5 Gene

Gene Damage Index Score: 1.55; 30.03% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for NPIPB5 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
NPIPB5

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NPIPB5 Gene

Disorders for NPIPB5 Gene

Additional Disease Information for NPIPB5

No disorders were found for NPIPB5 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for NPIPB5 Gene

Publications for NPIPB5 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 4 58
  2. The sequence and analysis of duplication-rich human chromosome 16. (PMID: 15616553) Martin J … Pennacchio LA (Nature 2004) 4 58
  3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg RL … Mammalian Gene Collection Program Team (Proceedings of the National Academy of Sciences of the United States of America 2002) 3 58
  4. Divergent origins and concerted expansion of two segmental duplications on chromosome 16. (PMID: 11948212) Eichler EE … Rocchi M (The Journal of heredity 2001) 3 58
  5. Normalization and subtraction: two approaches to facilitate gene discovery. (PMID: 8889548) Bonaldo MF … Soares MB (Genome research 1996) 3 58

Products for NPIPB5 Gene

Sources for NPIPB5 Gene

Content
Loading form....