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Aliases for NPIPB3 Gene

Aliases for NPIPB3 Gene

  • Nuclear Pore Complex Interacting Protein Family Member B3 2 3 5
  • Nuclear Pore Complex-Interacting Protein-Like 3 3 4
  • Protein Pps22-1 3 4
  • NPIPL3 3 4
  • Nuclear Pore Complex Interacting Protein Family, Member B3 2
  • Nuclear Pore Complex-Interacting Protein Family Member B3 3
  • PI-3-Kinase-Related Kinase SMG-1 Isoform 1 Homolog 3
  • Nuclear Pore Complex Interacting Protein-Like 3 2
  • Nuclear Pore Complex-Interacting Protein B Type 3
  • KIAA0220-Like Protein 3
  • KIAA0220L 3
  • KIAA0220 4
  • NPIPB5 3
  • NPIPB 3
  • NPIP 3

External Ids for NPIPB3 Gene

Previous HGNC Symbols for NPIPB3 Gene

  • NPIPL3

Summaries for NPIPB3 Gene

GeneCards Summary for NPIPB3 Gene

NPIPB3 (Nuclear Pore Complex Interacting Protein Family Member B3) is a Protein Coding gene. An important paralog of this gene is NPIPB13.

Additional gene information for NPIPB3 Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NPIPB3 Gene

Genomics for NPIPB3 Gene

GeneHancer (GH) Regulatory Elements for NPIPB3 Gene

Promoters and enhancers for NPIPB3 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH16I021819 Promoter/Enhancer 1.5 Ensembl ENCODE 136.5 -371.7 -371734 1.8 HDGF SMAD1 ZFP64 SIN3A FEZF1 ZNF2 YY1 ZNF213 ZNF302 ZNF207 RRN3P1 NPIPB4 NPIPB5 NPIPB3 SMG1P3 ENSG00000260635 SMG1P4 SMG1P1 POLR3E ENSG00000260905
GH16I022296 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE 51.6 -849.2 -849215 3.2 CLOCK MLX FEZF1 DMAP1 IRF4 YY1 SLC30A9 ZNF213 E2F8 ZNF143 POLR3E TRL-AAG2-4 C16orf52 NPIPB4 SMG1P3 NPIPB3 RRN3P1 NPIPB5 SMG1P1 SMG1P4
GH16I022006 Promoter/Enhancer 2.2 EPDnew FANTOM5 Ensembl ENCODE 35.6 -559.7 -559690 2.8 PKNOX1 ATF1 FOXA2 ARID4B SIN3A ZNF48 YY1 ZNF213 ZNF548 ATF7 C16orf52 ENSG00000275445 GC16P022007 SMG1P4 SMG1P1 SMG1P3 NPIPB4 NPIPB5 NPIPB3 ENSG00000260635
GH16I022194 Enhancer 1.7 FANTOM5 Ensembl ENCODE dbSUPER 31.5 -747.1 -747133 2.2 HDGF MLX ZFP64 ARID4B SIN3A DMAP1 YBX1 ZNF2 ZBTB7B IRF4 GC16M022196 TRL-TAG3-1 NPIPB3 C16orf52 NPIPB4 NPIPB5 SMG1P3 SMG1P4 SMG1P1 ENSG00000260635
GH16I021950 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 23.2 -504.1 -504138 3.9 CLOCK DMAP1 YBX1 YY1 SLC30A9 E2F8 ZNF143 SP3 NFYC MEF2D ENSG00000274460 GC16M021951 UQCRC2 ENSG00000260635 SMG1P1 SMG1P4 SMG1P3 NPIPB4 NPIPB5 NPIPB3
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around NPIPB3 on UCSC Golden Path with GeneCards custom track

Genomic Locations for NPIPB3 Gene

Genomic Locations for NPIPB3 Gene
chr16:21,402,134-21,448,567
(GRCh38/hg38)
Size:
46,434 bases
Orientation:
Minus strand
chr16:21,413,455-21,459,888
(GRCh37/hg19)

Genomic View for NPIPB3 Gene

Genes around NPIPB3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
NPIPB3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for NPIPB3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NPIPB3 Gene

Proteins for NPIPB3 Gene

  • Protein details for NPIPB3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q92617-NPIB3_HUMAN
    Recommended name:
    Nuclear pore complex-interacting protein family member B3
    Protein Accession:
    Q92617
    Secondary Accessions:
    • O43332
    • Q504Q6
    • Q59F29
    • Q6GMR1
    • Q6P7T2
    • Q6PIE2
    • Q6RH21

    Protein attributes for NPIPB3 Gene

    Size:
    1050 amino acids
    Molecular mass:
    116847 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAA13210.2; Type=Frameshift; Positions=203; Evidence={ECO:0000305}; Sequence=BAD92869.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for NPIPB3 Gene

neXtProt entry for NPIPB3 Gene

Post-translational modifications for NPIPB3 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for NPIPB3 Gene

No data available for DME Specific Peptides for NPIPB3 Gene

Domains & Families for NPIPB3 Gene

Gene Families for NPIPB3 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Predicted membrane proteins

Protein Domains for NPIPB3 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for NPIPB3 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q92617

UniProtKB/Swiss-Prot:

NPIB3_HUMAN :
  • Belongs to the NPIP family.
Family:
  • Belongs to the NPIP family.
genes like me logo Genes that share domains with NPIPB3: view

Function for NPIPB3 Gene

Phenotypes From GWAS Catalog for NPIPB3 Gene

Gene Ontology (GO) - Molecular Function for NPIPB3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
genes like me logo Genes that share ontologies with NPIPB3: view

Phenotypes for NPIPB3 Gene

GenomeRNAi human phenotypes for NPIPB3:
genes like me logo Genes that share phenotypes with NPIPB3: view

Animal Model Products

Inhibitory RNA Products

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for NPIPB3 Gene

Localization for NPIPB3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for NPIPB3 Gene

Membrane; Single-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for NPIPB3 gene
Compartment Confidence
nucleus 5

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for NPIPB3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005575 cellular_component ND --
GO:0005654 nucleoplasm IDA --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with NPIPB3: view

Pathways & Interactions for NPIPB3 Gene

SuperPathways for NPIPB3 Gene

No Data Available

Interacting Proteins for NPIPB3 Gene

Gene Ontology (GO) - Biological Process for NPIPB3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008150 biological_process ND --
genes like me logo Genes that share ontologies with NPIPB3: view

No data available for Pathways by source and SIGNOR curated interactions for NPIPB3 Gene

Drugs & Compounds for NPIPB3 Gene

No Compound Related Data Available

Transcripts for NPIPB3 Gene

mRNA/cDNA for NPIPB3 Gene

(1) REFSEQ mRNAs :
(1) Selected AceView cDNA sequences:
(14) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for NPIPB3 Gene

No ASD Table

Relevant External Links for NPIPB3 Gene

GeneLoc Exon Structure for
NPIPB3
ECgene alternative splicing isoforms for
NPIPB3

Expression for NPIPB3 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for NPIPB3 Gene

Protein differential expression in normal tissues from HIPED for NPIPB3 Gene

This gene is overexpressed in Heart (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for NPIPB3 Gene



Protein tissue co-expression partners for NPIPB3 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of NPIPB3 Gene:

NPIPB3

Evidence on tissue expression from TISSUES for NPIPB3 Gene

  • Nervous system(5)
  • Pancreas(4.4)
  • Spleen(4.2)
  • Bone marrow(4)
  • Lung(3.4)
  • Intestine(3.3)
  • Thyroid gland(2.3)
  • Eye(2.2)
genes like me logo Genes that share expression patterns with NPIPB3: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for NPIPB3 Gene

Orthologs for NPIPB3 Gene

This gene was present in the common ancestor of human and chimp.

Orthologs for NPIPB3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia LOC750787 33
  • 89.91 (n)
-- 34
  • 42 (a)
ManyToMany
-- 34
  • 36 (a)
ManyToMany
Species where no ortholog for NPIPB3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for NPIPB3 Gene

ENSEMBL:
Gene Tree for NPIPB3 (if available)
TreeFam:
Gene Tree for NPIPB3 (if available)

Paralogs for NPIPB3 Gene

genes like me logo Genes that share paralogs with NPIPB3: view

Variants for NPIPB3 Gene

Sequence variations from dbSNP and Humsavar for NPIPB3 Gene

SNP ID Clin Chr 16 pos Variation AA Info Type
rs1004194121 -- 21,410,669(-) A/G intron_variant
rs1008753376 -- 21,401,841(-) AGTTA/AGTTAGTTA downstream_transcript_variant
rs1009447408 -- 21,401,805(-) G/A downstream_transcript_variant
rs1015786374 -- 21,412,218(-) A/G intron_variant
rs1019690554 -- 21,401,843(-) T/G downstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for NPIPB3 Gene

Variant ID Type Subtype PubMed ID
dgv2800n100 CNV gain 25217958
dgv2801n100 CNV loss 25217958
esv25717 CNV gain+loss 19812545
esv2758636 CNV gain+loss 17122850
esv3325121 CNV duplication 20981092
esv3382085 CNV duplication 20981092
esv34235 CNV gain 17911159
esv3638167 CNV loss 21293372
nsv1110272 CNV duplication 24896259
nsv1139646 CNV duplication 24896259
nsv1150881 CNV duplication 26484159
nsv1160372 CNV duplication 26073780
nsv433437 CNV gain 18776910
nsv433438 CNV gain 18776910
nsv436835 CNV insertion 17901297
nsv827584 CNV gain 20364138
nsv9394 CNV gain 18304495
nsv9395 CNV gain 18304495
nsv978107 CNV duplication 23825009
nsv978204 CNV duplication 23825009
nsv984291 CNV duplication 23825009
nsv984393 CNV duplication 23825009
nsv984394 CNV duplication 23825009

Variation tolerance for NPIPB3 Gene

Gene Damage Index Score: 0.06; 1.28% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for NPIPB3 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
NPIPB3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NPIPB3 Gene

Disorders for NPIPB3 Gene

Additional Disease Information for NPIPB3

No disorders were found for NPIPB3 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for NPIPB3 Gene

Publications for NPIPB3 Gene

  1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  2. The sequence and analysis of duplication-rich human chromosome 16. (PMID: 15616553) Martin J … Pennacchio LA (Nature 2004) 3 4 58
  3. Divergent origins and concerted expansion of two segmental duplications on chromosome 16. (PMID: 11948212) Eichler EE … Rocchi M (The Journal of heredity 2001) 2 3 58
  4. Prediction of the coding sequences of unidentified human genes. VI. The coding sequences of 80 new genes (KIAA0201-KIAA0280) deduced by analysis of cDNA clones from cell line KG-1 and brain. (PMID: 9039502) Nagase T … Nomura N (DNA research : an international journal for rapid publication of reports on genes and genomes 1996) 3 4 58
  5. A human interactome in three quantitative dimensions organized by stoichiometries and abundances. (PMID: 26496610) Hein MY … Mann M (Cell 2015) 3 58

Products for NPIPB3 Gene

Sources for NPIPB3 Gene

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