NPIPB2 Gene (Protein Coding)

Nuclear Pore Complex Interacting Protein Family Member B2

GC16M011935
GIFtS:
14
See more...

Aliases for NPIPB2 Gene

Aliases for NPIPB2 Gene

  • Nuclear Pore Complex Interacting Protein Family Member B2 2 3 5
  • Putative Nuclear Pore Complex-Interacting Protein Family Member B2 3 4
  • Putative NPIP-Like Protein LOC729978 3
  • NPIPB2 5

External Ids for NPIPB2 Gene

Summaries for NPIPB2 Gene

GeneCards Summary for NPIPB2 Gene

NPIPB2 (Nuclear Pore Complex Interacting Protein Family Member B2) is a Protein Coding gene. Diseases associated with NPIPB2 include Desmoplastic Small Round Cell Tumor. An important paralog of this gene is NPIPB4.

Additional gene information for NPIPB2 Gene

No data available for Entrez Gene Summary , CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for NPIPB2 Gene

Genomics for NPIPB2 Gene

GeneHancer (GH) Regulatory Elements Pubs

Download GeneHancer 2017 data
Promoters and enhancers for NPIPB2 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around NPIPB2 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for NPIPB2

Genomic Locations for NPIPB2 Gene

Genomic Locations for NPIPB2 Gene
chr16:11,927,259-11,976,650
(GRCh38/hg38)
Size:
49,392 bases
Orientation:
Minus strand
chr16:12,021,102-12,070,500
(GRCh37/hg19)
Size:
49,399 bases
Orientation:
Minus strand

Genomic View for NPIPB2 Gene

Genes around NPIPB2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
NPIPB2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for NPIPB2 Gene
GeneLoc Logo Genomic Neighborhood • Exon Structure • Gene Density

RefSeq DNA sequence for NPIPB2 Gene

Proteins for NPIPB2 Gene

Products:

  1. Antibody
  2. Protein
  3. Assay

  • Protein details for NPIPB2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    A6NJ64-NPIB2_HUMAN
    Recommended name:
    Putative nuclear pore complex-interacting protein family member B2
    Protein Accession:
    A6NJ64
    Secondary Accessions:
    • A0A0A6YYH2
    • J3KPX4

    Protein attributes for NPIPB2 Gene

    Size:
    397 amino acids
    Molecular mass:
    45575 Da
    Quaternary structure:
    No Data Available

neXtProt entry for NPIPB2 Gene

Post-translational modifications for NPIPB2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for NPIPB2 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for NPIPB2 Gene

Domains & Families for NPIPB2 Gene

Gene Families for NPIPB2 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Predicted membrane proteins

Protein Domains for NPIPB2 Gene

InterPro:
ProtoNet:

Graphical View of Domain Structure for InterPro Entry

A6NJ64

UniProtKB/Swiss-Prot:

NPIB2_HUMAN :
  • Belongs to the NPIP family.
Family:
  • Belongs to the NPIP family.
genes like me logo Genes that share domains with NPIPB2: view

No data available for Suggested Antigen Peptide Sequences for NPIPB2 Gene

Function for NPIPB2 Gene

Products:

  1. Animal Model
  2. CRISPR
  3. miRNA
  4. Inhibitory RNA
  5. Clone
  6. Cell Line

Phenotypes From GWAS Catalog for NPIPB2 Gene

Phenotypes for NPIPB2 Gene

GenomeRNAi human phenotypes for NPIPB2:
genes like me logo Genes that share phenotypes with NPIPB2: view

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for NPIPB2 Gene

Localization for NPIPB2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for NPIPB2 Gene

Nucleus.

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nucleoplasm (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for NPIPB2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005654 nucleoplasm IDA --
genes like me logo Genes that share ontologies with NPIPB2: view

No data available for Subcellular locations from COMPARTMENTS for NPIPB2 Gene

Pathways & Interactions for NPIPB2 Gene

PathCards logo

SuperPathways for NPIPB2 Gene

No Data Available

Interacting Proteins for NPIPB2 Gene

Gene Ontology (GO) - Biological Process for NPIPB2 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for NPIPB2 Gene

Drugs & Compounds for NPIPB2 Gene

Products:

  1. Drug
No Compound Related Data Available

Transcripts for NPIPB2 Gene

Products:

  1. CRISPR
  2. miRNA
  3. Inhibitory RNA
  4. Clone

mRNA/cDNA for NPIPB2 Gene

1 REFSEQ mRNAs :
1 NCBI additional mRNA sequence :
8 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for NPIPB2 Gene

No ASD Table

Relevant External Links for NPIPB2 Gene

GeneLoc Exon Structure for
NPIPB2

Expression for NPIPB2 Gene

Products:

  1. Primer
No Expression Related Data Available

No data available for mRNA expression in normal human tissues , mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for NPIPB2 Gene

Orthologs for NPIPB2 Gene

This gene was present in the common ancestor of human and chimp.

Orthologs for NPIPB2 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
 Mammalia -- 31
  • 71 (a)
 ManyToMany
-- 31
  • 71 (a)
 ManyToMany
Species where no ortholog for NPIPB2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • Cow (Bos Taurus)
  • Dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Lizard (Anolis carolinensis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Mouse (Mus musculus)
  • Oppossum (Monodelphis domestica)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Platypus (Ornithorhynchus anatinus)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rat (Rattus norvegicus)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)
  • Zebrafish (Danio rerio)

Evolution for NPIPB2 Gene

ENSEMBL:
Gene Tree for NPIPB2 (if available)
TreeFam:
Gene Tree for NPIPB2 (if available)

Paralogs for NPIPB2 Gene

Paralogs for NPIPB2 Gene

Pseudogenes.org Pseudogenes for NPIPB2 Gene

genes like me logo Genes that share paralogs with NPIPB2: view

Variants for NPIPB2 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for NPIPB2 Gene

SNP ID Clinical significance and condition Chr 16 pos Variation AA Info Type
779009 Benign: not provided 11,967,820(-) G/C MISSENSE_VARIANT
rs11570148 Uncertain Significance: not provided 11,966,287(-) T/G MISSENSE_VARIANT
rs371163866 Other: Desmoplastic small round cell tumor 11,967,816(-) C/T MISSENSE_VARIANT

Additional dbSNP identifiers (rs#s) for NPIPB2 Gene

Additional Variant Information for NPIPB2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
NPIPB2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Structural Variations from Database of Genomic Variants (DGV) and Variation tolerance for NPIPB2 Gene

Disorders for NPIPB2 Gene

MalaCards: The human disease database

(1) MalaCards diseases for NPIPB2 Gene - From: GeneCards

Disorder Aliases PubMed IDs
desmoplastic small round cell tumor
  • desmoplastic small round-cell tumor
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for NPIPB2

ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
genes like me logo Genes that share disorders with NPIPB2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for NPIPB2 Gene

Publications for NPIPB2 Gene

  1. The sequence and analysis of duplication-rich human chromosome 16. (PMID: 15616553) Martin J … Pennacchio LA (Nature 2004) 3 4
  2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. (PMID: 21873635) Gaudet P … Thomas PD (Briefings in bioinformatics 2011) 3
  3. Group X secretory phospholipase A2 can induce arachidonic acid release and eicosanoid production without activation of cytosolic phospholipase A2 alpha. (PMID: 15789617) Saiga A … Hanasaki K (Prostaglandins & other lipid mediators 2005) 3

ExternalLinks

View latest publications for NPIPB2 gene in Mastermind

Products for NPIPB2 Gene

Sources for NPIPB2 Gene