Aliases for NPIPB15 Gene

Aliases for NPIPB15 Gene

  • Nuclear Pore Complex Interacting Protein Family Member B15 2 3 5
  • Nuclear Pore Complex-Interacting Protein Family Member B15 3 4
  • Nuclear Pore Complex Interacting Protein-Like 2 2 3
  • NPIPL2 3 4
  • Nuclear Pore Complex Interacting Protein Family, Member B15 2
  • Nuclear Pore Complex-Interacting Protein-Like 2 4
  • A-761H5.4 3
  • LOC440348 2
  • NPIPB15 5

External Ids for NPIPB15 Gene

Previous HGNC Symbols for NPIPB15 Gene

  • NPIPL2

Previous GeneCards Identifiers for NPIPB15 Gene

  • GC16P074412

Summaries for NPIPB15 Gene

GeneCards Summary for NPIPB15 Gene

NPIPB15 (Nuclear Pore Complex Interacting Protein Family Member B15) is a Protein Coding gene. An important paralog of this gene is NPIPB6.

Additional gene information for NPIPB15 Gene

No data available for Entrez Gene Summary , CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for NPIPB15 Gene

Genomics for NPIPB15 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for NPIPB15 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH16J075241 Promoter/Enhancer 2.6 EPDnew FANTOM5 Ensembl ENCODE CraniofacialAtlas dbSUPER 13.1 +875.5 875470 17.5 CEBPG HNRNPL CREB1 GATAD2A ZBTB33 TEAD4 PRDM10 TFE3 NFKBIZ ZNF692 BCAR1 ENSG00000280152 lnc-CTRB2-1 ENSG00000214331 RFWD3 ENSG00000259972 WDR59 ENSG00000261783 ADAT1 ENSG00000260884
GH16J074740 Promoter/Enhancer 1.9 FANTOM5 Ensembl ENCODE CraniofacialAtlas dbSUPER 13.1 +368.2 368208 5.1 HNRNPL CREB1 PRDM10 ZNF629 IKZF1 ZNF692 TARDBP ZHX2 JUND FOXA1 FA2H ENSG00000214331 ENSG00000261079 ENSG00000259972 NPIPB15 ADAT1 MLKL WDR59 ENSG00000260884 RNU6-237P
GH16J074983 Promoter/Enhancer 2.4 EPDnew Ensembl ENCODE CraniofacialAtlas dbSUPER 10.2 +611.9 611914 6.2 ZNF221 BRCA1 SP1 CREB1 GATAD2A ZBTB33 PRDM10 ZNF512 SIX5 LEF1 WDR59 ENSG00000214331 RFWD3 ENSG00000261783 ENSG00000239763 ENSG00000259972 ENSG00000260884 ADAT1 ENSG00000261079 NPIPB15
GH16J074665 Promoter/Enhancer 2.3 EPDnew FANTOM5 Ensembl ENCODE CraniofacialAtlas 10.2 +291.8 291814 3.2 SP1 HNRNPL CREB1 GATAD2A ZNF629 ZNF512 POLR2A BACH1 FOS LARP7 RFWD3 TMPOP2 lnc-MLKL-3 lnc-NPIPB15-6 ENSG00000214331 ADAT1 KARS1 ENSG00000261079 GLG1 NPIPB15
GH16J075147 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE CraniofacialAtlas 9.7 +774.0 774036 2.4 ZNF221 HNRNPL PRDM10 ZNF629 SIX5 NFKBIZ POLR2A ZNF692 BACH1 TARDBP ZFP1 lnc-LDHD-3 lnc-ZNRF1-1 ENSG00000239763 ENSG00000260884 ENSG00000259972 WDR59 ENSG00000214331 NPIPB15 RF00017-2157
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around NPIPB15 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for NPIPB15

Genomic Locations for NPIPB15 Gene

Genomic Locations for NPIPB15 Gene
17,130 bases
Plus strand
14,238 bases
Plus strand

Genomic View for NPIPB15 Gene

Genes around NPIPB15 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
NPIPB15 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for NPIPB15 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NPIPB15 Gene

Proteins for NPIPB15 Gene

  • Protein details for NPIPB15 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Nuclear pore complex-interacting protein family member B15
    Protein Accession:
    Secondary Accessions:
    • C9J9U8

    Protein attributes for NPIPB15 Gene

    443 amino acids
    Molecular mass:
    51267 Da
    Quaternary structure:
    No Data Available

neXtProt entry for NPIPB15 Gene

Post-translational modifications for NPIPB15 Gene

  • Glycosylation at Asn111
  • Modification sites at PhosphoSitePlus

Other Protein References for NPIPB15 Gene

No data available for DME Specific Peptides for NPIPB15 Gene

Domains & Families for NPIPB15 Gene

Gene Families for NPIPB15 Gene

Human Protein Atlas (HPA):
  • Predicted membrane proteins

Protein Domains for NPIPB15 Gene


Suggested Antigen Peptide Sequences for NPIPB15 Gene

GenScript: Design optimal peptide antigens:
  • Nuclear pore complex-interacting protein-like 2 (NPPL2_HUMAN)

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the NPIP family.
  • Belongs to the NPIP family.
genes like me logo Genes that share domains with NPIPB15: view

Function for NPIPB15 Gene

Phenotypes From GWAS Catalog for NPIPB15 Gene

genes like me logo Genes that share phenotypes with NPIPB15: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for NPIPB15

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for NPIPB15 Gene

Localization for NPIPB15 Gene

Subcellular locations from UniProtKB/Swiss-Prot for NPIPB15 Gene


Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for NPIPB15 gene
Compartment Confidence
extracellular 4
nucleus 4
mitochondrion 1
peroxisome 0
endoplasmic reticulum 0
cytosol 0

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for NPIPB15 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
GO:0005654 nucleoplasm IBA,IDA --
genes like me logo Genes that share ontologies with NPIPB15: view

Pathways & Interactions for NPIPB15 Gene

PathCards logo

SuperPathways for NPIPB15 Gene

No Data Available

Interacting Proteins for NPIPB15 Gene

Gene Ontology (GO) - Biological Process for NPIPB15 Gene


No data available for Pathways by source and SIGNOR curated interactions for NPIPB15 Gene

Drugs & Compounds for NPIPB15 Gene

No Compound Related Data Available

Transcripts for NPIPB15 Gene

mRNA/cDNA for NPIPB15 Gene

2 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for NPIPB15

Alternative Splicing Database (ASD) splice patterns (SP) for NPIPB15 Gene

No ASD Table

Relevant External Links for NPIPB15 Gene

GeneLoc Exon Structure for

Expression for NPIPB15 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for NPIPB15 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

  • Testis (Reproductive System)

mRNA differential expression in normal tissues according to GTEx for NPIPB15 Gene

This gene is overexpressed in Testis (x4.8).

Protein differential expression in normal tissues from HIPED for NPIPB15 Gene

This gene is overexpressed in Testis (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for NPIPB15 Gene

Protein tissue co-expression partners for NPIPB15 Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for NPIPB15

genes like me logo Genes that share expression patterns with NPIPB15: view

Primer Products

No data available for mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for NPIPB15 Gene

Orthologs for NPIPB15 Gene

This gene was present in the common ancestor of human and chimp.

Orthologs for NPIPB15 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia -- 31
  • 89 (a)
-- 31
  • 88 (a)
-- 31
  • 87 (a)
-- 31
  • 83 (a)
-- 31
  • 74 (a)
Species where no ortholog for NPIPB15 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • Cow (Bos Taurus)
  • Dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Lizard (Anolis carolinensis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Mouse (Mus musculus)
  • Oppossum (Monodelphis domestica)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Platypus (Ornithorhynchus anatinus)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rat (Rattus norvegicus)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)
  • Zebrafish (Danio rerio)

Evolution for NPIPB15 Gene

Gene Tree for NPIPB15 (if available)
Gene Tree for NPIPB15 (if available)

Paralogs for NPIPB15 Gene

(21) SIMAP similar genes for NPIPB15 Gene using alignment to 1 proteins:

  • NPB15_HUMAN Pseudogenes for NPIPB15 Gene

genes like me logo Genes that share paralogs with NPIPB15: view

Variants for NPIPB15 Gene

Additional dbSNP identifiers (rs#s) for NPIPB15 Gene

Variation tolerance for NPIPB15 Gene

Gene Damage Index Score: 5.47; 71.60% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for NPIPB15 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP and Structural Variations from Database of Genomic Variants (DGV) for NPIPB15 Gene

Disorders for NPIPB15 Gene

No disorders were found for NPIPB15 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for NPIPB15 Gene

Publications for NPIPB15 Gene

  1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. (PMID: 21873635) Gaudet P … Thomas PD (Briefings in bioinformatics 2011) 3
  2. The sequence and analysis of duplication-rich human chromosome 16. (PMID: 15616553) Martin J … Pennacchio LA (Nature 2004) 4
  3. Genome duplications and other features in 12 Mb of DNA sequence from human chromosome 16p and 16q. (PMID: 10493829) Loftus BJ … Adams MD (Genomics 1999) 3

Products for NPIPB15 Gene

Sources for NPIPB15 Gene