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Aliases for NPIPA7 Gene

Aliases for NPIPA7 Gene

  • Nuclear Pore Complex Interacting Protein Family Member A7 2 3 5
  • Nuclear Pore Complex-Interacting Protein Family Member A7 3 4
  • Nuclear Pore Complex Interacting Protein Family, Member A7 2
  • Nuclear Pore Complex-Interacting Protein Family Member A8 3
  • NPIPA8 3

External Ids for NPIPA7 Gene

Previous GeneCards Identifiers for NPIPA7 Gene

  • GC16P016472

Summaries for NPIPA7 Gene

GeneCards Summary for NPIPA7 Gene

NPIPA7 (Nuclear Pore Complex Interacting Protein Family Member A7) is a Protein Coding gene. An important paralog of this gene is NPIPA8.

Additional gene information for NPIPA7 Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NPIPA7 Gene

Genomics for NPIPA7 Gene

GeneHancer (GH) Regulatory Elements for NPIPA7 Gene

Promoters and enhancers for NPIPA7 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH16J017301 Enhancer 1 ENCODE dbSUPER 6.3 +925.2 925232 4.8 SP1 NKRF ZNF687 NCOA3 RELA CREM MLLT1 ZBED1 IKZF1 CREB1 NPIPA7 GC16P017341 ENSG00000279620 XYLT1
GH16J016384 Enhancer 0.2 Ensembl 0.4 +5.8 5807 1.2 NPIPA7 LOC105371098
GH16J016393 Enhancer 0.2 Ensembl 0.4 +14.8 14807 0.4 LOC105371098 NPIPA7
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around NPIPA7 on UCSC Golden Path with GeneCards custom track

Genomic Locations for NPIPA7 Gene

Genomic Locations for NPIPA7 Gene
15,179 bases
Plus strand
14,900 bases
Plus strand

Genomic View for NPIPA7 Gene

Genes around NPIPA7 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
NPIPA7 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for NPIPA7 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NPIPA7 Gene

Proteins for NPIPA7 Gene

  • Protein details for NPIPA7 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Nuclear pore complex-interacting protein family member A7
    Protein Accession:

    Protein attributes for NPIPA7 Gene

    369 amino acids
    Molecular mass:
    42230 Da
    Quaternary structure:
    No Data Available

neXtProt entry for NPIPA7 Gene

Post-translational modifications for NPIPA7 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for NPIPA7 Gene

Domains & Families for NPIPA7 Gene

Gene Families for NPIPA7 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Predicted membrane proteins

Protein Domains for NPIPA7 Gene


Graphical View of Domain Structure for InterPro Entry



  • Belongs to the NPIP family.
  • Belongs to the NPIP family.
genes like me logo Genes that share domains with NPIPA7: view

No data available for Suggested Antigen Peptide Sequences for NPIPA7 Gene

Function for NPIPA7 Gene

Gene Ontology (GO) - Molecular Function for NPIPA7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 25416956
genes like me logo Genes that share ontologies with NPIPA7: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for NPIPA7

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for NPIPA7 Gene

Localization for NPIPA7 Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for NPIPA7 gene
Compartment Confidence
nucleus 4
extracellular 2
plasma membrane 1
cytosol 0

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for NPIPA7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005654 nucleoplasm IDA --
genes like me logo Genes that share ontologies with NPIPA7: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for NPIPA7 Gene

Pathways & Interactions for NPIPA7 Gene

PathCards logo

SuperPathways for NPIPA7 Gene

No Data Available

Interacting Proteins for NPIPA7 Gene

Selected Interacting proteins: E9PJI5-NPIA7_HUMAN for NPIPA7 Gene via UniProtKB IID

Gene Ontology (GO) - Biological Process for NPIPA7 Gene


No data available for Pathways by source and SIGNOR curated interactions for NPIPA7 Gene

Drugs & Compounds for NPIPA7 Gene

No Compound Related Data Available

Transcripts for NPIPA7 Gene

mRNA/cDNA for NPIPA7 Gene

(1) REFSEQ mRNAs :
(2) Additional mRNA sequences :
(2) Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for NPIPA7

Alternative Splicing Database (ASD) splice patterns (SP) for NPIPA7 Gene

No ASD Table

Relevant External Links for NPIPA7 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for NPIPA7 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for NPIPA7 Gene

mRNA differential expression in normal tissues according to GTEx for NPIPA7 Gene

This gene is overexpressed in Brain - Cerebellum (x4.9).

NURSA nuclear receptor signaling pathways regulating expression of NPIPA7 Gene:

genes like me logo Genes that share expression patterns with NPIPA7: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for NPIPA7 Gene

Orthologs for NPIPA7 Gene

This gene was present in the common ancestor of human and chimp.

Orthologs for NPIPA7 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia -- 35
  • 84 (a)
Species where no ortholog for NPIPA7 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for NPIPA7 Gene

Gene Tree for NPIPA7 (if available)
Gene Tree for NPIPA7 (if available)

Paralogs for NPIPA7 Gene

(21) SIMAP similar genes for NPIPA7 Gene using alignment to 4 proteins:

  • H0Y2X3_HUMAN
  • I3L0H9_HUMAN
genes like me logo Genes that share paralogs with NPIPA7: view

Variants for NPIPA7 Gene

Sequence variations from dbSNP and Humsavar for NPIPA7 Gene

SNP ID Clin Chr 16 pos Variation AA Info Type
rs1002552820 -- 16,376,013(+) G/A upstream_transcript_variant
rs1003052961 -- 16,387,584(+) C/T intron_variant
rs1004836112 -- 16,387,539(+) T/G intron_variant
rs1004891623 -- 16,390,658(+) G/T intron_variant
rs1008729081 -- 16,386,901(+) C/T intron_variant

Structural Variations from Database of Genomic Variants (DGV) for NPIPA7 Gene

Variant ID Type Subtype PubMed ID
dgv2775n100 CNV gain 25217958
dgv2776n100 CNV gain+loss 25217958
dgv2777n100 CNV loss 25217958
dgv2781n100 CNV gain+loss 25217958
dgv2782n100 CNV loss 25217958
dgv2783n100 CNV gain 25217958
dgv2784n100 CNV gain 25217958
dgv4924n54 CNV gain 21841781
esv2714015 CNV deletion 23290073
esv2751550 CNV gain 17911159
esv2758633 CNV gain+loss 17122850
esv2758634 CNV gain+loss 17122850
esv2762276 CNV gain+loss 21179565
esv28069 CNV gain+loss 19812545
esv28183 CNV gain+loss 19812545
esv33614 CNV gain+loss 17666407
esv3382186 CNV duplication 20981092
esv3392452 CNV duplication 20981092
esv3409391 CNV duplication 20981092
esv34419 CNV gain 17911159
esv3449324 CNV duplication 20981092
esv3570398 CNV gain 25503493
esv3582069 CNV loss 25503493
esv3892799 CNV gain 25118596
nsv1043239 CNV gain 25217958
nsv1047898 CNV loss 25217958
nsv1048002 CNV gain 25217958
nsv1049647 CNV gain+loss 25217958
nsv1115496 CNV duplication 24896259
nsv1124728 CNV duplication 24896259
nsv1125134 CNV deletion 24896259
nsv1139642 CNV duplication 24896259
nsv1139643 CNV duplication 24896259
nsv1147818 CNV duplication 26484159
nsv1151531 CNV duplication 26484159
nsv1160365 CNV duplication 26073780
nsv1746 CNV insertion 18451855
nsv1751 CNV deletion 18451855
nsv428319 CNV loss 18775914
nsv428320 CNV loss 18775914
nsv433436 CNV gain 18776910
nsv435664 CNV deletion 17901297
nsv457428 CNV gain 19166990
nsv509599 CNV insertion 20534489
nsv509601 CNV insertion 20534489
nsv7278 OTHER inversion 18451855
nsv820784 CNV deletion 20802225
nsv820818 CNV deletion 20802225
nsv952939 CNV deletion 24416366
nsv952942 CNV deletion 24416366
nsv974868 CNV duplication 23825009
nsv977920 CNV duplication 23825009
nsv977929 CNV duplication 23825009
nsv978034 CNV duplication 23825009
nsv984384 CNV duplication 23825009

Variation tolerance for NPIPA7 Gene

Gene Damage Index Score: 0.32; 7.17% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for NPIPA7 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NPIPA7 Gene

Disorders for NPIPA7 Gene

Additional Disease Information for NPIPA7

No disorders were found for NPIPA7 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for NPIPA7 Gene

Publications for NPIPA7 Gene

  1. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T … Vidal M (Cell 2014) 3 58
  2. The sequence and analysis of duplication-rich human chromosome 16. (PMID: 15616553) Martin J … Pennacchio LA (Nature 2004) 4 58
  3. Shotgun sequencing of the human transcriptome with ORF expressed sequence tags. (PMID: 10737800) Dias Neto E … Simpson AJ (Proceedings of the National Academy of Sciences of the United States of America 2000) 3 58

Products for NPIPA7 Gene

Sources for NPIPA7 Gene

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