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Aliases for NPIPA3 Gene

Aliases for NPIPA3 Gene

  • Nuclear Pore Complex Interacting Protein Family Member A3 2 3 5
  • Nuclear Pore Complex Interacting Protein Family, Member A3 2

External Ids for NPIPA3 Gene

Previous GeneCards Identifiers for NPIPA3 Gene

  • GC16P014857
  • GC16P014869

Summaries for NPIPA3 Gene

GeneCards Summary for NPIPA3 Gene

NPIPA3 (Nuclear Pore Complex Interacting Protein Family Member A3) is a Protein Coding gene. An important paralog of this gene is NPIPA2.

Additional gene information for NPIPA3 Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NPIPA3 Gene

Genomics for NPIPA3 Gene

GeneHancer (GH) Regulatory Elements for NPIPA3 Gene

Promoters and enhancers for NPIPA3 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH16I014706 Enhancer 0.2 Ensembl 550.8 +0.6 628 0.6 NPIPA3 PIR52522 PIR62877 LOC105371095
GH16I014283 Enhancer 1.3 Ensembl ENCODE 55.6 -421.1 -421069 3.7 MLX ZFP64 IRF4 YY1 SLC30A9 ZNF213 ZNF143 SP3 SSRP1 ZNF610 TRT-CGT2-1 GC16P014288 ENSG00000183458 NPIPA3 NPIPP1 NPIPA1 LOC100505915 NPIPA2 PARN PKD1P6
GH16I014973 Promoter/Enhancer 2.5 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 27.5 +268.8 268848 2.8 PKNOX1 CLOCK ARNT ZFP64 ARID4B SIN3A DMAP1 ZNF2 YY1 SLC30A9 PDXDC1 NPIPA2 ENSG00000183458 NPIPA3 NPIPA1 PARN LOC100505915 NPIPA5 ENSG00000261819 BFAR
GH16I014337 Enhancer 1.3 Ensembl ENCODE dbSUPER 47 -368.6 -368609 1 FOXA2 MLX ZFP64 ARID4B YBX1 DMAP1 ZNF48 YY1 RXRA YY2 ENSG00000183458 PARN NPIPA2 LOC100505915 NPIPA3 NPIPA1 NPIPP1 ERCC4 ENSG00000261819 PKD1P6
GH16I014095 Enhancer 1.1 Ensembl ENCODE 32 -609.6 -609566 3.8 CLOCK FOXA2 ZNF493 ZFP64 ZNF133 NEUROD1 FEZF1 ZNF213 FOS ZNF202 LOC100505915 PARN ENSG00000183458 RRN3 NPIPA3 NPIPA1 NPIPA2 ERCC4 BFAR PDXDC1
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around NPIPA3 on UCSC Golden Path with GeneCards custom track

Genomic Locations for NPIPA3 Gene

Genomic Locations for NPIPA3 Gene
chr16:14,706,473-14,726,338
(GRCh38/hg38)
Size:
19,866 bases
Orientation:
Plus strand
chr16:14,802,801-14,820,195
(GRCh37/hg19)

Genomic View for NPIPA3 Gene

Genes around NPIPA3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
NPIPA3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for NPIPA3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NPIPA3 Gene

Proteins for NPIPA3 Gene

  • Protein details for NPIPA3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    F8WFD2-NPIA3_HUMAN
    Recommended name:
    Nuclear pore complex-interacting protein family member A3
    Protein Accession:
    F8WFD2

    Protein attributes for NPIPA3 Gene

    Size:
    350 amino acids
    Molecular mass:
    40061 Da
    Quaternary structure:
    No Data Available

neXtProt entry for NPIPA3 Gene

Post-translational modifications for NPIPA3 Gene

No Post-translational modifications

No data available for DME Specific Peptides for NPIPA3 Gene

Domains & Families for NPIPA3 Gene

Gene Families for NPIPA3 Gene

Human Protein Atlas (HPA):
  • Predicted membrane proteins

Protein Domains for NPIPA3 Gene

InterPro:
ProtoNet:

Graphical View of Domain Structure for InterPro Entry

F8WFD2

UniProtKB/Swiss-Prot:

NPIA3_HUMAN :
  • Belongs to the NPIP family.
Family:
  • Belongs to the NPIP family.
genes like me logo Genes that share domains with NPIPA3: view

No data available for Suggested Antigen Peptide Sequences for NPIPA3 Gene

Function for NPIPA3 Gene

Animal Model Products

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for NPIPA3 Gene

Localization for NPIPA3 Gene

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for NPIPA3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005654 nucleoplasm IDA --
genes like me logo Genes that share ontologies with NPIPA3: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Subcellular locations from COMPARTMENTS for NPIPA3 Gene

Pathways & Interactions for NPIPA3 Gene

SuperPathways for NPIPA3 Gene

No Data Available

Interacting Proteins for NPIPA3 Gene

Gene Ontology (GO) - Biological Process for NPIPA3 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for NPIPA3 Gene

Drugs & Compounds for NPIPA3 Gene

No Compound Related Data Available

Transcripts for NPIPA3 Gene

mRNA/cDNA for NPIPA3 Gene

(14) REFSEQ mRNAs :
(3) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for NPIPA3 Gene

No ASD Table

Relevant External Links for NPIPA3 Gene

GeneLoc Exon Structure for
NPIPA3
ECgene alternative splicing isoforms for
NPIPA3

Expression for NPIPA3 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for NPIPA3 Gene

mRNA differential expression in normal tissues according to GTEx for NPIPA3 Gene

This gene is overexpressed in Brain - Cerebellum (x6.1) and Brain - Cerebellar Hemisphere (x5.0).

NURSA nuclear receptor signaling pathways regulating expression of NPIPA3 Gene:

NPIPA3
genes like me logo Genes that share expression patterns with NPIPA3: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for NPIPA3 Gene

Orthologs for NPIPA3 Gene

This gene was present in the common ancestor of human and chimp.

Orthologs for NPIPA3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia -- 34
  • 84 (a)
OneToMany
Species where no ortholog for NPIPA3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for NPIPA3 Gene

ENSEMBL:
Gene Tree for NPIPA3 (if available)
TreeFam:
Gene Tree for NPIPA3 (if available)

Paralogs for NPIPA3 Gene

Variants for NPIPA3 Gene

Sequence variations from dbSNP and Humsavar for NPIPA3 Gene

SNP ID Clin Chr 16 pos Variation AA Info Type
rs1002326812 -- 14,724,200(+) T/C intron_variant
rs1008731405 -- 14,713,507(+) G/A intron_variant
rs1008830821 -- 14,712,943(+) AAAA/AAAAA intron_variant
rs1010515544 -- 14,724,090(+) C/G intron_variant
rs1010568067 -- 14,718,627(+) T/C intron_variant

Structural Variations from Database of Genomic Variants (DGV) for NPIPA3 Gene

Variant ID Type Subtype PubMed ID
nsv984262 CNV duplication 23825009
nsv978187 CNV duplication 23825009
nsv952928 CNV deletion 24416366
nsv952927 CNV deletion 24416366
nsv833144 CNV gain 17160897
nsv821150 CNV deletion 20802225
nsv7277 OTHER inversion 18451855
nsv511045 OTHER complex 20534489
nsv510676 CNV deletion 20534489
nsv1740 CNV deletion 18451855
nsv1160345 CNV duplication 26073780
nsv1160344 CNV deletion 26073780
nsv1153585 CNV duplication 26484159
nsv1144757 CNV deletion 24896259
nsv1143811 CNV deletion 24896259
nsv1141277 CNV duplication 24896259
nsv1141276 CNV duplication 24896259
esv28787 CNV gain+loss 19812545
esv2762254 CNV gain+loss 21179565
esv2760416 CNV gain+loss 21179565
esv2758632 CNV gain+loss 17122850
dgv4916n54 CNV loss 21841781
dgv2742n100 CNV gain 25217958
dgv2741n100 CNV gain+loss 25217958
dgv2740n100 CNV loss 25217958
dgv2738n100 CNV gain 25217958

Additional Variant Information for NPIPA3 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
NPIPA3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for NPIPA3 Gene

Disorders for NPIPA3 Gene

Additional Disease Information for NPIPA3

No disorders were found for NPIPA3 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for NPIPA3 Gene

Publications for NPIPA3 Gene

  1. Novel retinal and cone photoreceptor transcripts revealed by human macular expression profiling. (PMID: 18055785) Hornan DM … Webster AR (Investigative ophthalmology & visual science 2007) 3 58
  2. The sequence and analysis of duplication-rich human chromosome 16. (PMID: 15616553) Martin J … Pennacchio LA (Nature 2004) 4 58

Products for NPIPA3 Gene

Sources for NPIPA3 Gene

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