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Aliases for NPHP3-ACAD11 Gene

Subcategory (RNA class) for NPHP3-ACAD11 Gene


Quality Score for this RNA gene is


Aliases for NPHP3-ACAD11 Gene

  • NPHP3-ACAD11 Readthrough (NMD Candidate) 2 3 5

External Ids for NPHP3-ACAD11 Gene

Previous GeneCards Identifiers for NPHP3-ACAD11 Gene

  • GC03U901738
  • GC03M132278

Summaries for NPHP3-ACAD11 Gene

Entrez Gene Summary for NPHP3-ACAD11 Gene

  • This locus represents naturally occurring read-through transcription between the neighboring NPHP3 (nephronophthisis 3, adolescent) and ACAD11 (acyl-CoA dehydrogenase family, member 11) genes on chromosome 3. The read-through transcript is a candidate for nonsense-mediated mRNA decay (NMD), and is thus unlikely to produce a protein product. [provided by RefSeq, Feb 2011]

GeneCards Summary for NPHP3-ACAD11 Gene

NPHP3-ACAD11 (NPHP3-ACAD11 Readthrough (NMD Candidate)) is an RNA Gene, and is affiliated with the ncRNA class. Diseases associated with NPHP3-ACAD11 include Nephronophthisis 3 and Nephronophthisis. An important paralog of this gene is NPHP3.

Additional gene information for NPHP3-ACAD11 Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NPHP3-ACAD11 Gene

Genomics for NPHP3-ACAD11 Gene

GeneHancer (GH) Regulatory Elements for NPHP3-ACAD11 Gene

Promoters and enhancers for NPHP3-ACAD11 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH03I132721 Promoter/Enhancer 1.9 EPDnew Ensembl ENCODE 550.8 -0.1 -83 3.1 HDGF ATF1 ARID4B SIN3A BRCA1 ZNF48 YY1 ETS1 ZNF121 GLIS2 NPHP3 NPHP3-ACAD11 NPHP3-AS1 LOC105374115
GH03I132726 Enhancer 0.6 ENCODE 0.8 -4.1 -4053 0.2 CTCF ZNF654 TEAD1 TEAD4 TRIM22 TEAD2 RAD21 ZNF592 RFX5 TEAD3 NPHP3 NPHP3-ACAD11 NPHP3-AS1 LOC105374115
GH03I132657 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 0.2 +62.5 62533 4.5 HDGF PKNOX1 FOXA2 ARNT ARID4B SIN3A DMAP1 ZNF2 YY1 POLR2B ACAD11 UBA5 NPHP3 DNAJC13 NPHP3-ACAD11
GH03I132654 Promoter/Enhancer 1.3 EPDnew ENCODE 0.2 +67.3 67274 2.2 HDAC1 ZBTB40 TCF12 ZNF766 CAVIN1 ZNF592 MEF2D NFIC NR2C1 KDM1A UBA5 NPHP3 ACAD11 NPHP3-ACAD11
GH03I132731 Enhancer 0.5 ENCODE 0.4 -8.8 -8833 0.1 CTCF ZNF654 SMC3 REST FEZF1 RAD21 BFSP2 TFP1 TOPBP1 NPHP3 NPHP3-ACAD11 NPHP3-AS1 LOC105374115
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around NPHP3-ACAD11 on UCSC Golden Path with GeneCards custom track

Genomic Locations for NPHP3-ACAD11 Gene

Genomic Locations for NPHP3-ACAD11 Gene
164,322 bases
Minus strand

Genomic View for NPHP3-ACAD11 Gene

Genes around NPHP3-ACAD11 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
NPHP3-ACAD11 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for NPHP3-ACAD11 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NPHP3-ACAD11 Gene

Proteins for NPHP3-ACAD11 Gene

  • Protein details for NPHP3-ACAD11 Gene (UniProtKB/TrEMBL)

    Protein Symbol:
    Recommended name:
    NPHP3-ACAD11 readthrough (NMD candidate)
    Protein Accession:

    Protein attributes for NPHP3-ACAD11 Gene

    232 amino acids
    Molecular mass:
    26042 Da
    Quaternary structure:
    No Data Available

neXtProt entry for NPHP3-ACAD11 Gene

Post-translational modifications for NPHP3-ACAD11 Gene

No Post-translational modifications

Other Protein References for NPHP3-ACAD11 Gene

ENSEMBL proteins:

No data available for DME Specific Peptides for NPHP3-ACAD11 Gene

Domains & Families for NPHP3-ACAD11 Gene

Gene Families for NPHP3-ACAD11 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with NPHP3-ACAD11: view

No data available for Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for NPHP3-ACAD11 Gene

Function for NPHP3-ACAD11 Gene

Phenotypes From GWAS Catalog for NPHP3-ACAD11 Gene

Animal Model Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for NPHP3-ACAD11 Gene

Localization for NPHP3-ACAD11 Gene

Gene Ontology (GO) - Cellular Components for NPHP3-ACAD11 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005871 kinesin complex IEA --
genes like me logo Genes that share ontologies with NPHP3-ACAD11: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Subcellular locations from the Human Protein Atlas (HPA) for NPHP3-ACAD11 Gene

Pathways & Interactions for NPHP3-ACAD11 Gene

SuperPathways for NPHP3-ACAD11 Gene

No Data Available

Interacting Proteins for NPHP3-ACAD11 Gene

Gene Ontology (GO) - Biological Process for NPHP3-ACAD11 Gene


No data available for Pathways by source and SIGNOR curated interactions for NPHP3-ACAD11 Gene

Drugs & Compounds for NPHP3-ACAD11 Gene

No Compound Related Data Available

Transcripts for NPHP3-ACAD11 Gene

mRNA/cDNA for NPHP3-ACAD11 Gene

(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for NPHP3-ACAD11 Gene

No ASD Table

Relevant External Links for NPHP3-ACAD11 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for NPHP3-ACAD11 Gene

No data available for mRNA expression in normal human tissues , mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for NPHP3-ACAD11 Gene

Orthologs for NPHP3-ACAD11 Gene

Evolution for NPHP3-ACAD11 Gene

Gene Tree for NPHP3-ACAD11 (if available)
Gene Tree for NPHP3-ACAD11 (if available)

No data available for Orthologs for NPHP3-ACAD11 Gene

Paralogs for NPHP3-ACAD11 Gene

Paralogs for NPHP3-ACAD11 Gene

genes like me logo Genes that share paralogs with NPHP3-ACAD11: view

Variants for NPHP3-ACAD11 Gene

Sequence variations from dbSNP and Humsavar for NPHP3-ACAD11 Gene

SNP ID Clin Chr 03 pos Variation AA Info Type
rs1060499938 pathogenic, Adolescent nephronophthisis 132,683,487(-) G/ non_coding_transcript_variant
rs1060503156 uncertain-significance, Nephronophthisis 132,688,797(-) C/T non_coding_transcript_variant
rs1060503157 uncertain-significance, Nephronophthisis 132,692,732(-) C/G non_coding_transcript_variant
rs1060504844 likely-benign, Nephronophthisis 132,700,361(-) G/C non_coding_transcript_variant
rs111727307 conflicting-interpretations-of-pathogenicity, likely-benign, not specified, Nephronophthisis 132,684,624(-) C/A/T non_coding_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for NPHP3-ACAD11 Gene

Variant ID Type Subtype PubMed ID
esv2669271 CNV deletion 23128226
esv2675190 CNV deletion 23128226
esv3569006 CNV loss 25503493
esv3597827 CNV loss 21293372
esv3597828 CNV loss 21293372
esv3893774 CNV loss 25118596
nsv1073681 CNV deletion 25765185
nsv1109545 CNV deletion 24896259
nsv1110768 CNV insertion 24896259
nsv1133563 CNV deletion 24896259
nsv1144051 CNV deletion 24896259
nsv1150596 CNV duplication 26484159
nsv4014 CNV insertion 18451855
nsv591796 CNV loss 21841781
nsv591797 CNV loss 21841781
nsv591798 CNV loss 21841781
nsv591799 CNV gain 21841781
nsv829728 CNV gain 17160897
nsv965409 CNV deletion 23825009
nsv979879 CNV duplication 23825009
nsv998211 CNV loss 25217958

Additional Variant Information for NPHP3-ACAD11 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for NPHP3-ACAD11 Gene

Disorders for NPHP3-ACAD11 Gene

MalaCards: The human disease database

(2) MalaCards diseases for NPHP3-ACAD11 Gene - From: GeneCards

Disorder Aliases PubMed IDs
nephronophthisis 3
  • nphp3
  • medullary cystic disease
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for NPHP3-ACAD11

genes like me logo Genes that share disorders with NPHP3-ACAD11: view

No data available for UniProtKB/Swiss-Prot and Genatlas for NPHP3-ACAD11 Gene

Publications for NPHP3-ACAD11 Gene

  1. Expression of conjoined genes: another mechanism for gene regulation in eukaryotes. (PMID: 20967262) Prakash T … Taylor TD (PloS one 2010) 3 58
  2. Mutations in a novel gene, NPHP3, cause adolescent nephronophthisis, tapeto-retinal degeneration and hepatic fibrosis. (PMID: 12872122) Olbrich H … Omran H (Nature genetics 2003) 3 58
  3. Characterization of size-fractionated cDNA libraries generated by the in vitro recombination-assisted method. (PMID: 12056414) Ohara O … Koseki H (DNA research : an international journal for rapid publication of reports on genes and genomes 2002) 3 58

Products for NPHP3-ACAD11 Gene

Sources for NPHP3-ACAD11 Gene

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