Aliases for NPFFR2 Gene
External Ids for NPFFR2 Gene
Previous HGNC Symbols for NPFFR2 Gene
Previous GeneCards Identifiers for NPFFR2 Gene
This gene encodes a member of a subfamily of G-protein-coupled neuropeptide receptors. This protein is activated by the neuropeptides A-18-amide (NPAF) and F-8-amide (NPFF) and may function in pain modulation and regulation of the opioid system. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2009]
GeneCards Summary for NPFFR2 Gene
NPFFR2 (Neuropeptide FF Receptor 2) is a Protein Coding gene. Diseases associated with NPFFR2 include Autosomal Recessive Non-Syndromic Intellectual Disability. Among its related pathways are Signaling by GPCR and Peptide ligand-binding receptors. Gene Ontology (GO) annotations related to this gene include G protein-coupled receptor activity and neuropeptide receptor activity. An important paralog of this gene is NPFFR1.
UniProtKB/Swiss-Prot Summary for NPFFR2 Gene
Receptor for NPAF (A-18-F-amide) and NPFF (F-8-F-amide) neuropeptides, also known as morphine-modulating peptides. Can also be activated by a variety of naturally occurring or synthetic FMRF-amide like ligands. This receptor mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system.
Neuropeptide FF/AF (NPFF) receptors are a group of Gi/Go-protein-coupled receptors that are divided into two subtypes; NPFF1 and NPFF2. NPFF receptors have been implicated in hormonal modulation, regulation of food intake, thermoregulation and nociception.